KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SPT5
Full Name:
Transcription elongation factor SPT5
Alias:
DRB sensitivity-inducing factor large subunit; DSIF large subunit; DSIF p160; FLJ34157; SPT5H; Suppressor of Ty 5; Tat-cotransactivator 1; Tat-CT1
Type:
Transcription, coactivator/corepressor
Mass (Da):
121000
Number AA:
1087
UniProt ID:
O00267
International Prot ID:
IPI00298058
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0019899
GO:0008148
GO:0008159
PhosphoSite+
KinaseNET
Biological Process:
GO:0006368
GO:0007049
GO:0006338
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
D
S
E
D
S
N
F
S
E
E
E
D
Site 2
S10
D
S
E
D
S
N
F
S
E
E
E
D
S
E
R
Site 3
S15
N
F
S
E
E
E
D
S
E
R
S
S
D
G
E
Site 4
S19
E
E
D
S
E
R
S
S
D
G
E
E
A
E
V
Site 5
S32
E
V
D
E
E
R
R
S
A
A
G
S
E
K
E
Site 6
S36
E
R
R
S
A
A
G
S
E
K
E
E
E
P
E
Site 7
Y54
E
E
E
E
E
E
E
Y
D
E
E
E
E
E
E
Site 8
Y86
E
A
D
V
D
D
E
Y
E
D
E
D
Q
W
E
Site 9
S108
E
K
E
E
I
E
A
S
N
I
D
N
V
V
L
Site 10
S120
V
V
L
D
E
D
R
S
G
A
R
R
L
Q
N
Site 11
Y140
R
E
E
E
L
G
E
Y
Y
M
K
K
Y
A
K
Site 12
Y141
E
E
E
L
G
E
Y
Y
M
K
K
Y
A
K
S
Site 13
Y145
G
E
Y
Y
M
K
K
Y
A
K
S
S
V
G
E
Site 14
S148
Y
M
K
K
Y
A
K
S
S
V
G
E
T
V
Y
Site 15
T153
A
K
S
S
V
G
E
T
V
Y
G
G
S
D
E
Site 16
S158
G
E
T
V
Y
G
G
S
D
E
L
S
D
D
I
Site 17
S162
Y
G
G
S
D
E
L
S
D
D
I
T
Q
Q
Q
Site 18
T166
D
E
L
S
D
D
I
T
Q
Q
Q
L
L
P
G
Site 19
T192
K
I
G
E
E
R
A
T
A
I
S
L
M
R
K
Site 20
T206
K
F
I
A
Y
Q
F
T
D
T
P
L
Q
I
K
Site 21
T208
I
A
Y
Q
F
T
D
T
P
L
Q
I
K
S
V
Site 22
S214
D
T
P
L
Q
I
K
S
V
V
A
P
E
H
V
Site 23
Y224
A
P
E
H
V
K
G
Y
I
Y
V
E
A
Y
K
Site 24
Y226
E
H
V
K
G
Y
I
Y
V
E
A
Y
K
Q
T
Site 25
Y230
G
Y
I
Y
V
E
A
Y
K
Q
T
H
V
K
Q
Site 26
Y249
V
G
N
L
R
L
G
Y
W
N
Q
Q
M
V
P
Site 27
S277
V
A
N
L
K
P
K
S
W
V
R
L
K
R
G
Site 28
Y286
V
R
L
K
R
G
I
Y
K
D
D
I
A
Q
V
Site 29
Y295
D
D
I
A
Q
V
D
Y
V
E
P
S
Q
N
T
Site 30
S299
Q
V
D
Y
V
E
P
S
Q
N
T
I
S
L
K
Site 31
S304
E
P
S
Q
N
T
I
S
L
K
M
I
P
R
I
Site 32
Y313
K
M
I
P
R
I
D
Y
D
R
I
K
A
R
M
Site 33
S321
D
R
I
K
A
R
M
S
L
K
D
W
F
A
K
Site 34
S347
F
D
A
E
K
I
R
S
L
G
G
D
V
A
S
Site 35
Y366
L
I
F
E
G
N
R
Y
S
R
K
G
F
L
F
Site 36
S367
I
F
E
G
N
R
Y
S
R
K
G
F
L
F
K
Site 37
S375
R
K
G
F
L
F
K
S
F
A
M
S
A
V
I
Site 38
S391
E
G
V
K
P
T
L
S
E
L
E
K
F
E
D
Site 39
S442
N
L
Q
G
K
I
L
S
V
D
G
N
K
I
T
Site 40
T449
S
V
D
G
N
K
I
T
I
M
P
K
H
E
D
Site 41
Y471
P
A
Q
E
L
R
K
Y
F
K
M
G
D
H
V
Site 42
T489
A
G
R
F
E
G
D
T
G
L
I
V
R
V
E
Site 43
S522
P
R
D
L
Q
L
C
S
E
T
A
S
G
V
D
Site 44
S526
Q
L
C
S
E
T
A
S
G
V
D
V
G
G
Q
Site 45
T557
I
V
R
L
E
R
E
T
F
Q
V
L
N
M
Y
Site 46
T569
N
M
Y
G
K
V
V
T
V
R
H
Q
A
V
T
Site 47
S589
R
F
A
V
A
L
D
S
E
Q
N
N
I
H
V
Site 48
S608
K
V
I
D
G
P
H
S
G
R
E
G
E
I
R
Site 49
T655
G
S
K
P
R
D
V
T
N
F
T
V
G
G
F
Site 50
S666
V
G
G
F
A
P
M
S
P
R
I
S
S
P
M
Site 51
S670
A
P
M
S
P
R
I
S
S
P
M
H
P
S
A
Site 52
S671
P
M
S
P
R
I
S
S
P
M
H
P
S
A
G
Site 53
S676
I
S
S
P
M
H
P
S
A
G
G
Q
R
G
G
Site 54
S686
G
Q
R
G
G
F
G
S
P
G
G
G
S
G
G
Site 55
S691
F
G
S
P
G
G
G
S
G
G
M
S
R
G
R
Site 56
S695
G
G
G
S
G
G
M
S
R
G
R
G
R
R
D
Site 57
T709
D
N
E
L
I
G
Q
T
V
R
I
S
Q
G
P
Site 58
S713
I
G
Q
T
V
R
I
S
Q
G
P
Y
K
G
Y
Site 59
T728
I
G
V
V
K
D
A
T
E
S
T
A
R
V
E
Site 60
T731
V
K
D
A
T
E
S
T
A
R
V
E
L
H
S
Site 61
T739
A
R
V
E
L
H
S
T
C
Q
T
I
S
V
D
Site 62
T742
E
L
H
S
T
C
Q
T
I
S
V
D
R
Q
R
Site 63
S744
H
S
T
C
Q
T
I
S
V
D
R
Q
R
L
T
Site 64
T751
S
V
D
R
Q
R
L
T
T
V
G
S
R
R
P
Site 65
T752
V
D
R
Q
R
L
T
T
V
G
S
R
R
P
G
Site 66
S755
Q
R
L
T
T
V
G
S
R
R
P
G
G
M
T
Site 67
T762
S
R
R
P
G
G
M
T
S
T
Y
G
R
T
P
Site 68
S763
R
R
P
G
G
M
T
S
T
Y
G
R
T
P
M
Site 69
T764
R
P
G
G
M
T
S
T
Y
G
R
T
P
M
Y
Site 70
Y765
P
G
G
M
T
S
T
Y
G
R
T
P
M
Y
G
Site 71
T768
M
T
S
T
Y
G
R
T
P
M
Y
G
S
Q
T
Site 72
Y771
T
Y
G
R
T
P
M
Y
G
S
Q
T
P
M
Y
Site 73
S773
G
R
T
P
M
Y
G
S
Q
T
P
M
Y
G
S
Site 74
T775
T
P
M
Y
G
S
Q
T
P
M
Y
G
S
G
S
Site 75
Y778
Y
G
S
Q
T
P
M
Y
G
S
G
S
R
T
P
Site 76
S780
S
Q
T
P
M
Y
G
S
G
S
R
T
P
M
Y
Site 77
S782
T
P
M
Y
G
S
G
S
R
T
P
M
Y
G
S
Site 78
T784
M
Y
G
S
G
S
R
T
P
M
Y
G
S
Q
T
Site 79
Y787
S
G
S
R
T
P
M
Y
G
S
Q
T
P
L
Q
Site 80
S789
S
R
T
P
M
Y
G
S
Q
T
P
L
Q
D
G
Site 81
T791
T
P
M
Y
G
S
Q
T
P
L
Q
D
G
S
R
Site 82
S797
Q
T
P
L
Q
D
G
S
R
T
P
H
Y
G
S
Site 83
T799
P
L
Q
D
G
S
R
T
P
H
Y
G
S
Q
T
Site 84
Y802
D
G
S
R
T
P
H
Y
G
S
Q
T
P
L
H
Site 85
S804
S
R
T
P
H
Y
G
S
Q
T
P
L
H
D
G
Site 86
T806
T
P
H
Y
G
S
Q
T
P
L
H
D
G
S
R
Site 87
S812
Q
T
P
L
H
D
G
S
R
T
P
A
Q
S
G
Site 88
T814
P
L
H
D
G
S
R
T
P
A
Q
S
G
A
W
Site 89
S818
G
S
R
T
P
A
Q
S
G
A
W
D
P
N
N
Site 90
T828
W
D
P
N
N
P
N
T
P
S
R
A
E
E
E
Site 91
S830
P
N
N
P
N
T
P
S
R
A
E
E
E
Y
E
Site 92
Y836
P
S
R
A
E
E
E
Y
E
Y
A
F
D
D
E
Site 93
Y838
R
A
E
E
E
Y
E
Y
A
F
D
D
E
P
T
Site 94
T845
Y
A
F
D
D
E
P
T
P
S
P
Q
A
Y
G
Site 95
S847
F
D
D
E
P
T
P
S
P
Q
A
Y
G
G
T
Site 96
T854
S
P
Q
A
Y
G
G
T
P
N
P
Q
T
P
G
Site 97
T859
G
G
T
P
N
P
Q
T
P
G
Y
P
D
P
S
Site 98
Y862
P
N
P
Q
T
P
G
Y
P
D
P
S
S
P
Q
Site 99
S866
T
P
G
Y
P
D
P
S
S
P
Q
V
N
P
Q
Site 100
S867
P
G
Y
P
D
P
S
S
P
Q
V
N
P
Q
Y
Site 101
Y874
S
P
Q
V
N
P
Q
Y
N
P
Q
T
P
G
T
Site 102
T878
N
P
Q
Y
N
P
Q
T
P
G
T
P
A
M
Y
Site 103
T881
Y
N
P
Q
T
P
G
T
P
A
M
Y
N
T
D
Site 104
Y885
T
P
G
T
P
A
M
Y
N
T
D
Q
F
S
P
Site 105
T887
G
T
P
A
M
Y
N
T
D
Q
F
S
P
Y
A
Site 106
S891
M
Y
N
T
D
Q
F
S
P
Y
A
A
P
S
P
Site 107
Y893
N
T
D
Q
F
S
P
Y
A
A
P
S
P
Q
G
Site 108
S897
F
S
P
Y
A
A
P
S
P
Q
G
S
Y
Q
P
Site 109
S901
A
A
P
S
P
Q
G
S
Y
Q
P
S
P
S
P
Site 110
S905
P
Q
G
S
Y
Q
P
S
P
S
P
Q
S
Y
H
Site 111
S907
G
S
Y
Q
P
S
P
S
P
Q
S
Y
H
Q
V
Site 112
S910
Q
P
S
P
S
P
Q
S
Y
H
Q
V
A
P
S
Site 113
Y911
P
S
P
S
P
Q
S
Y
H
Q
V
A
P
S
P
Site 114
S917
S
Y
H
Q
V
A
P
S
P
A
G
Y
Q
N
T
Site 115
Y921
V
A
P
S
P
A
G
Y
Q
N
T
H
S
P
A
Site 116
T924
S
P
A
G
Y
Q
N
T
H
S
P
A
S
Y
H
Site 117
S926
A
G
Y
Q
N
T
H
S
P
A
S
Y
H
P
T
Site 118
S929
Q
N
T
H
S
P
A
S
Y
H
P
T
P
S
P
Site 119
T933
S
P
A
S
Y
H
P
T
P
S
P
M
A
Y
Q
Site 120
S935
A
S
Y
H
P
T
P
S
P
M
A
Y
Q
A
S
Site 121
Y939
P
T
P
S
P
M
A
Y
Q
A
S
P
S
P
S
Site 122
S942
S
P
M
A
Y
Q
A
S
P
S
P
S
P
V
G
Site 123
S944
M
A
Y
Q
A
S
P
S
P
S
P
V
G
Y
S
Site 124
S946
Y
Q
A
S
P
S
P
S
P
V
G
Y
S
P
M
Site 125
Y950
P
S
P
S
P
V
G
Y
S
P
M
T
P
G
A
Site 126
S951
S
P
S
P
V
G
Y
S
P
M
T
P
G
A
P
Site 127
T954
P
V
G
Y
S
P
M
T
P
G
A
P
S
P
G
Site 128
S959
P
M
T
P
G
A
P
S
P
G
G
Y
N
P
H
Site 129
Y963
G
A
P
S
P
G
G
Y
N
P
H
T
P
G
S
Site 130
T967
P
G
G
Y
N
P
H
T
P
G
S
G
I
E
Q
Site 131
S970
Y
N
P
H
T
P
G
S
G
I
E
Q
N
S
S
Site 132
S977
S
G
I
E
Q
N
S
S
D
W
V
T
T
D
I
Site 133
T981
Q
N
S
S
D
W
V
T
T
D
I
Q
V
K
V
Site 134
T991
I
Q
V
K
V
R
D
T
Y
L
D
T
Q
V
V
Site 135
Y992
Q
V
K
V
R
D
T
Y
L
D
T
Q
V
V
G
Site 136
T995
V
R
D
T
Y
L
D
T
Q
V
V
G
Q
T
G
Site 137
S1013
S
V
T
G
G
M
C
S
V
Y
L
K
D
S
E
Site 138
Y1015
T
G
G
M
C
S
V
Y
L
K
D
S
E
K
V
Site 139
S1024
K
D
S
E
K
V
V
S
I
S
S
E
H
L
E
Site 140
S1026
S
E
K
V
V
S
I
S
S
E
H
L
E
P
I
Site 141
S1027
E
K
V
V
S
I
S
S
E
H
L
E
P
I
T
Site 142
T1034
S
E
H
L
E
P
I
T
P
T
K
N
N
K
V
Site 143
T1036
H
L
E
P
I
T
P
T
K
N
N
K
V
K
V
Site 144
T1052
L
G
E
D
R
E
A
T
G
V
L
L
S
I
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation