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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CDC7
Full Name:
Cell division cycle 7-related protein kinase
Alias:
CDC7- related kinase; CDC7L1; Cell division cycle 7; EC 2.7.11.1; HsCdc7; Hsk1; HuCdc7; Kinase CDC7; MuCdc7
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; CDC7 family
Mass (Da):
63888
Number AA:
574
UniProt ID:
O00311
International Prot ID:
IPI00448121
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
GO:0000082
GO:0051301
Phosida
TranscriptoNet
STRING
Kinexus Products
Cell division cycle 7-related protein kinase T376 phosphosite-specific antibody AB-PK558#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK558#Cell division cycle 7-related protein kinase (R373-F379, human) pT376 phosphopeptide - Powder PE-04AJE99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AJE99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
M
D
E
P
M
A
F
S
P
Q
R
D
R
F
Q
Site 2
S27
D
R
F
Q
A
E
G
S
L
K
K
N
E
Q
N
Site 3
Y48
K
K
D
I
E
K
L
Y
E
A
V
P
Q
L
S
Site 4
S55
Y
E
A
V
P
Q
L
S
N
V
F
K
I
E
D
Site 5
T68
E
D
K
I
G
E
G
T
F
S
S
V
Y
L
A
Site 6
Y122
D
N
V
M
G
V
K
Y
C
F
R
K
N
D
H
Site 7
S141
M
P
Y
L
E
H
E
S
F
L
D
I
L
N
S
Site 8
S150
L
D
I
L
N
S
L
S
F
Q
E
V
R
E
Y
Site 9
Y157
S
F
Q
E
V
R
E
Y
M
L
N
L
F
K
A
Site 10
S181
V
H
R
D
V
K
P
S
N
F
L
Y
N
R
R
Site 11
Y185
V
K
P
S
N
F
L
Y
N
R
R
L
K
K
Y
Site 12
Y192
Y
N
R
R
L
K
K
Y
A
L
V
D
F
G
L
Site 13
S216
E
L
L
K
F
V
Q
S
E
A
Q
Q
E
R
C
Site 14
S224
E
A
Q
Q
E
R
C
S
Q
N
K
S
H
I
I
Site 15
S228
E
R
C
S
Q
N
K
S
H
I
I
T
G
N
K
Site 16
T232
Q
N
K
S
H
I
I
T
G
N
K
I
P
L
S
Site 17
S239
T
G
N
K
I
P
L
S
G
P
V
P
K
E
L
Site 18
S250
P
K
E
L
D
Q
Q
S
T
T
K
A
S
V
K
Site 19
Y260
K
A
S
V
K
R
P
Y
T
N
A
Q
I
Q
I
Site 20
T261
A
S
V
K
R
P
Y
T
N
A
Q
I
Q
I
K
Site 21
S277
G
K
D
G
K
E
G
S
V
G
L
S
V
Q
R
Site 22
S281
K
E
G
S
V
G
L
S
V
Q
R
S
V
F
G
Site 23
S285
V
G
L
S
V
Q
R
S
V
F
G
E
R
N
F
Site 24
S296
E
R
N
F
N
I
H
S
S
I
S
H
E
S
P
Site 25
S297
R
N
F
N
I
H
S
S
I
S
H
E
S
P
A
Site 26
S302
H
S
S
I
S
H
E
S
P
A
V
K
L
M
K
Site 27
T313
K
L
M
K
Q
S
K
T
V
D
V
L
S
R
K
Site 28
S318
S
K
T
V
D
V
L
S
R
K
L
A
T
K
K
Site 29
T341
N
S
A
V
M
R
K
T
A
S
S
C
P
A
S
Site 30
T350
S
S
C
P
A
S
L
T
C
D
C
Y
A
T
D
Site 31
S365
K
V
C
S
I
C
L
S
R
R
Q
Q
V
A
P
Site 32
T376
Q
V
A
P
R
A
G
T
P
G
F
R
A
P
E
Cell division cycle 7-related protein kinase T376 phosphosite-specific antibody AB-PK558#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK558#Cell division cycle 7-related protein kinase (R373-F379, human) pT376 phosphopeptide - Powder PE-04AJE99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AJE99
Site 33
T386
F
R
A
P
E
V
L
T
K
C
P
N
Q
T
T
Site 34
Y412
L
S
L
L
S
G
R
Y
P
F
Y
K
A
S
D
Site 35
Y415
L
S
G
R
Y
P
F
Y
K
A
S
D
D
L
T
Site 36
S418
R
Y
P
F
Y
K
A
S
D
D
L
T
A
L
A
Site 37
T429
T
A
L
A
Q
I
M
T
I
R
G
S
R
E
T
Site 38
S433
Q
I
M
T
I
R
G
S
R
E
T
I
Q
A
A
Site 39
T436
T
I
R
G
S
R
E
T
I
Q
A
A
K
T
F
Site 40
S450
F
G
K
S
I
L
C
S
K
E
V
P
A
Q
D
Site 41
S470
E
R
L
R
G
M
D
S
S
T
P
K
L
T
S
Site 42
S471
R
L
R
G
M
D
S
S
T
P
K
L
T
S
D
Site 43
T472
L
R
G
M
D
S
S
T
P
K
L
T
S
D
I
Site 44
S477
S
S
T
P
K
L
T
S
D
I
Q
G
H
A
S
Site 45
S484
S
D
I
Q
G
H
A
S
H
Q
P
A
I
S
E
Site 46
S498
E
K
T
D
H
K
A
S
C
L
V
Q
T
P
P
Site 47
T503
K
A
S
C
L
V
Q
T
P
P
G
Q
Y
S
G
Site 48
Y508
V
Q
T
P
P
G
Q
Y
S
G
N
S
F
K
K
Site 49
S509
Q
T
P
P
G
Q
Y
S
G
N
S
F
K
K
G
Site 50
S512
P
G
Q
Y
S
G
N
S
F
K
K
G
D
S
N
Site 51
Y543
N
E
V
P
D
E
A
Y
D
L
L
D
K
L
L
Site 52
S556
L
L
D
L
N
P
A
S
R
I
T
A
E
E
A
Site 53
T559
L
N
P
A
S
R
I
T
A
E
E
A
L
L
H
Site 54
S573
H
P
F
F
K
D
M
S
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation