PhosphoNET

           
Protein Info 
   
Short Name:  DDX3
Full Name:  ATP-dependent RNA helicase DDX3X
Alias:  D1PAS1-RS2; DBX; DDX14; DDX3X; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DEAD3; DEAD-box, X isoform; ERH; Helicase-like protein 2; HLP2; Protein name DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
Type:  Helicase; RNA binding protein; EC 3.6.1.-
Mass (Da):  73243
Number AA:  662
UniProt ID:  O00571
International Prot ID:  IPI00215637
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737  GO:0016607  GO:0005886 Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0004004  GO:0003677 PhosphoSite+ KinaseNET
Biological Process:  GO:0044419     Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S2______MSHVAVENA
Site 2S23FAGLDLNSSDNQSGG
Site 3S24AGLDLNSSDNQSGGS
Site 4S28LNSSDNQSGGSTASK
Site 5S31SDNQSGGSTASKGRY
Site 6T32DNQSGGSTASKGRYI
Site 7S34QSGGSTASKGRYIPP
Site 8Y38STASKGRYIPPHLRN
Site 9T49HLRNREATKGFYDKD
Site 10Y53REATKGFYDKDSSGW
Site 11S57KGFYDKDSSGWSSSK
Site 12S58GFYDKDSSGWSSSKD
Site 13S61DKDSSGWSSSKDKDA
Site 14S62KDSSGWSSSKDKDAY
Site 15S63DSSGWSSSKDKDAYS
Site 16Y69SSKDKDAYSSFGSRS
Site 17S70SKDKDAYSSFGSRSD
Site 18S71KDKDAYSSFGSRSDS
Site 19S74DAYSSFGSRSDSRGK
Site 20S76YSSFGSRSDSRGKSS
Site 21S78SFGSRSDSRGKSSFF
Site 22S82RSDSRGKSSFFSDRG
Site 23S83SDSRGKSSFFSDRGS
Site 24S86RGKSSFFSDRGSGSR
Site 25S90SFFSDRGSGSRGRFD
Site 26S92FSDRGSGSRGRFDDR
Site 27S102RFDDRGRSDYDGIGS
Site 28Y104DDRGRSDYDGIGSRG
Site 29S109SDYDGIGSRGDRSGF
Site 30S114IGSRGDRSGFGKFER
Site 31S125KFERGGNSRWCDKSD
Site 32S131NSRWCDKSDEDDWSK
Site 33S137KSDEDDWSKPLPPSE
Site 34S143WSKPLPPSERLEQEL
Site 35S152RLEQELFSGGNTGIN
Site 36T156ELFSGGNTGINFEKY
Site 37Y163TGINFEKYDDIPVEA
Site 38S181NCPPHIESFSDVEMG
Site 39S183PPHIESFSDVEMGEI
Site 40Y200GNIELTRYTRPTPVQ
Site 41T201NIELTRYTRPTPVQK
Site 42T204LTRYTRPTPVQKHAI
Site 43Y243LPILSQIYSDGPGEA
Site 44S244PILSQIYSDGPGEAL
Site 45Y260AMKENGRYGRRKQYP
Site 46Y266RYGRRKQYPISLVLA
Site 47S269RRKQYPISLVLAPTR
Site 48Y283RELAVQIYEEARKFS
Site 49S290YEEARKFSYRSRVRP
Site 50S293ARKFSYRSRVRPCVV
Site 51Y301RVRPCVVYGGADIGQ
Site 52T323GCHLLVATPGRLVDM
Site 53Y343IGLDFCKYLVLDEAD
Site 54T369RRIVEQDTMPPKGVR
Site 55T378PPKGVRHTMMFSATF
Site 56S410LAVGRVGSTSENITQ
Site 57S412VGRVGSTSENITQKV
Site 58T416GSTSENITQKVVWVE
Site 59S425KVVWVEESDKRSFLL
Site 60S429VEESDKRSFLLDLLN
Site 61T438LLDLLNATGKDSLTL
Site 62S456ETKKGADSLEDFLYH
Site 63Y462DSLEDFLYHEGYACT
Site 64Y466DFLYHEGYACTSIHG
Site 65S476TSIHGDRSQRDREEA
Site 66S489EALHQFRSGKSPILV
Site 67S492HQFRSGKSPILVATA
Site 68S520VINFDLPSDIEEYVH
Site 69Y525LPSDIEEYVHRIGRT
Site 70S543GNLGLATSFFNERNI
Site 71S569EAKQEVPSWLENMAY
Site 72Y576SWLENMAYEHHYKGS
Site 73Y580NMAYEHHYKGSSRGR
Site 74S583YEHHYKGSSRGRSKS
Site 75S584EHHYKGSSRGRSKSS
Site 76S588KGSSRGRSKSSRFSG
Site 77S590SRGRSKSSRFSGGFG
Site 78S591SRGRSKSSRFSGGFG
Site 79S594RSKSSRFSGGFGARD
Site 80Y602GGFGARDYRQSSGAS
Site 81S605GARDYRQSSGASSSS
Site 82S606ARDYRQSSGASSSSF
Site 83S609YRQSSGASSSSFSSS
Site 84S610RQSSGASSSSFSSSR
Site 85S611SSGASSSSFSSSRAS
Site 86S612GASSSSFSSSRASSS
Site 87S614GASSSSFSSSRASSS
Site 88S615ASSSSFSSSRASSSR
Site 89S616SSSSFSSSRASSSRS
Site 90S619SFSSSRASSSRSGGG
Site 91S620FSSSRASSSRSGGGG
Site 92S621SSSRASSSRSGGGGH
Site 93S623SRASSSRSGGGGHGS
Site 94S630SGGGGHGSSRGFGGG
Site 95S631GGGGHGSSRGFGGGG
Site 96Y639RGFGGGGYGGFYNSD
Site 97Y643GGGYGGFYNSDGYGG
Site 98Y648GFYNSDGYGGNYNSQ
Site 99Y652SDGYGGNYNSQGVDW
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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