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Updated November 2019
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Protein Info
Short Name:
ACC2
Full Name:
Acetyl-CoA carboxylase 2
Alias:
ACACB; ACCB; ACC-beta; Acetyl-Coenzyme A carboxylase beta; COA2; HACC275
Type:
EC 6.3.4.14; Carbohydrate Metabolism - propanoate; Ligase; EC 6.4.1.2; Lipid Metabolism - fatty acid biosynthesis; Carbohydrate Metabolism - pyruvate; Mitochondrial
Mass (Da):
276555
Number AA:
2458
UniProt ID:
O00763
International Prot ID:
IPI00554642
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005829
GO:0012505
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003989
GO:0009374
PhosphoSite+
KinaseNET
Biological Process:
GO:0006633
GO:0046320
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
I
W
G
K
M
T
D
S
K
P
I
T
K
S
K
Site 2
T33
M
T
D
S
K
P
I
T
K
S
K
S
E
A
N
Site 3
S37
K
P
I
T
K
S
K
S
E
A
N
L
I
P
S
Site 4
S44
S
E
A
N
L
I
P
S
Q
E
P
F
P
A
S
Site 5
S51
S
Q
E
P
F
P
A
S
D
N
S
G
E
T
P
Site 6
T57
A
S
D
N
S
G
E
T
P
Q
R
N
G
E
G
Site 7
T66
Q
R
N
G
E
G
H
T
L
P
K
T
P
S
Q
Site 8
T70
E
G
H
T
L
P
K
T
P
S
Q
A
E
P
A
Site 9
S72
H
T
L
P
K
T
P
S
Q
A
E
P
A
S
H
Site 10
S78
P
S
Q
A
E
P
A
S
H
K
G
P
K
D
A
Site 11
S91
D
A
G
R
R
R
N
S
L
P
P
S
H
Q
K
Site 12
S95
R
R
N
S
L
P
P
S
H
Q
K
P
P
R
N
Site 13
S105
K
P
P
R
N
P
L
S
S
S
D
A
A
P
S
Site 14
S106
P
P
R
N
P
L
S
S
S
D
A
A
P
S
P
Site 15
S107
P
R
N
P
L
S
S
S
D
A
A
P
S
P
E
Site 16
S112
S
S
S
D
A
A
P
S
P
E
L
Q
A
N
G
Site 17
T130
Q
G
L
E
A
T
D
T
N
G
L
S
S
S
A
Site 18
S134
A
T
D
T
N
G
L
S
S
S
A
R
P
Q
G
Site 19
S136
D
T
N
G
L
S
S
S
A
R
P
Q
G
Q
Q
Site 20
S146
P
Q
G
Q
Q
A
G
S
P
S
K
E
D
K
K
Site 21
S169
M
T
N
F
I
L
G
S
F
D
D
Y
S
S
D
Site 22
Y173
I
L
G
S
F
D
D
Y
S
S
D
E
D
S
V
Site 23
S174
L
G
S
F
D
D
Y
S
S
D
E
D
S
V
A
Site 24
S175
G
S
F
D
D
Y
S
S
D
E
D
S
V
A
G
Site 25
S179
D
Y
S
S
D
E
D
S
V
A
G
S
S
R
E
Site 26
S183
D
E
D
S
V
A
G
S
S
R
E
S
T
R
K
Site 27
S187
V
A
G
S
S
R
E
S
T
R
K
G
S
R
A
Site 28
T188
A
G
S
S
R
E
S
T
R
K
G
S
R
A
S
Site 29
S192
R
E
S
T
R
K
G
S
R
A
S
L
G
A
L
Site 30
S195
T
R
K
G
S
R
A
S
L
G
A
L
S
L
E
Site 31
T206
L
S
L
E
A
Y
L
T
T
G
E
A
E
T
R
Site 32
T216
E
A
E
T
R
V
P
T
M
R
P
S
M
S
G
Site 33
S220
R
V
P
T
M
R
P
S
M
S
G
L
H
L
V
Site 34
S222
P
T
M
R
P
S
M
S
G
L
H
L
V
K
R
Site 35
T243
L
D
L
H
R
D
F
T
V
A
S
P
A
E
F
Site 36
S246
H
R
D
F
T
V
A
S
P
A
E
F
V
T
R
Site 37
Y284
R
S
I
R
R
W
A
Y
E
M
F
R
N
E
R
Site 38
Y317
Y
I
K
M
A
D
H
Y
V
P
V
P
G
G
P
Site 39
Y329
G
G
P
N
N
N
N
Y
A
N
V
E
L
I
V
Site 40
T399
A
Q
T
L
Q
V
P
T
L
P
W
S
G
S
G
Site 41
S403
Q
V
P
T
L
P
W
S
G
S
G
L
T
V
E
Site 42
S405
P
T
L
P
W
S
G
S
G
L
T
V
E
W
T
Site 43
T408
P
W
S
G
S
G
L
T
V
E
W
T
E
D
D
Site 44
T412
S
G
L
T
V
E
W
T
E
D
D
L
Q
Q
G
Site 45
S423
L
Q
Q
G
K
R
I
S
V
P
E
D
V
Y
D
Site 46
Y429
I
S
V
P
E
D
V
Y
D
K
G
C
V
K
D
Site 47
S456
F
P
L
M
I
K
A
S
E
G
G
G
G
K
G
Site 48
S469
K
G
I
R
K
A
E
S
A
E
D
F
P
I
L
Site 49
S515
D
Q
Y
G
N
A
V
S
L
F
G
R
D
C
S
Site 50
S522
S
L
F
G
R
D
C
S
I
Q
R
R
H
Q
K
Site 51
Y568
V
S
A
G
T
V
E
Y
L
Y
S
Q
D
G
S
Site 52
Y570
A
G
T
V
E
Y
L
Y
S
Q
D
G
S
F
H
Site 53
S571
G
T
V
E
Y
L
Y
S
Q
D
G
S
F
H
F
Site 54
S575
Y
L
Y
S
Q
D
G
S
F
H
F
L
E
L
N
Site 55
T592
L
Q
V
E
H
P
C
T
E
M
I
A
D
V
N
Site 56
Y623
L
K
D
I
R
L
L
Y
G
E
S
P
W
G
V
Site 57
T631
G
E
S
P
W
G
V
T
P
I
S
F
E
T
P
Site 58
S634
P
W
G
V
T
P
I
S
F
E
T
P
S
N
P
Site 59
T637
V
T
P
I
S
F
E
T
P
S
N
P
P
L
A
Site 60
S639
P
I
S
F
E
T
P
S
N
P
P
L
A
R
G
Site 61
T654
H
V
I
A
A
R
I
T
S
E
N
P
D
E
G
Site 62
S655
V
I
A
A
R
I
T
S
E
N
P
D
E
G
F
Site 63
S666
D
E
G
F
K
P
S
S
G
T
V
Q
E
L
N
Site 64
Y683
S
S
K
N
V
W
G
Y
F
S
V
A
A
T
G
Site 65
S715
E
N
R
E
E
A
I
S
N
M
V
V
A
L
K
Site 66
T732
S
I
R
G
D
F
R
T
T
V
E
Y
L
I
N
Site 67
S745
I
N
L
L
E
T
E
S
F
Q
N
N
D
I
D
Site 68
S860
N
D
G
G
L
L
L
S
Y
N
G
N
S
Y
T
Site 69
Y861
D
G
G
L
L
L
S
Y
N
G
N
S
Y
T
T
Site 70
S865
L
L
S
Y
N
G
N
S
Y
T
T
Y
M
K
E
Site 71
Y866
L
S
Y
N
G
N
S
Y
T
T
Y
M
K
E
E
Site 72
Y869
N
G
N
S
Y
T
T
Y
M
K
E
E
V
D
S
Site 73
Y877
M
K
E
E
V
D
S
Y
R
I
T
I
G
N
K
Site 74
T880
E
V
D
S
Y
R
I
T
I
G
N
K
T
C
V
Site 75
T885
R
I
T
I
G
N
K
T
C
V
F
E
K
E
N
Site 76
T895
F
E
K
E
N
D
P
T
V
L
R
S
P
S
A
Site 77
S899
N
D
P
T
V
L
R
S
P
S
A
G
K
L
T
Site 78
S901
P
T
V
L
R
S
P
S
A
G
K
L
T
Q
Y
Site 79
Y908
S
A
G
K
L
T
Q
Y
T
V
E
D
G
G
H
Site 80
T909
A
G
K
L
T
Q
Y
T
V
E
D
G
G
H
V
Site 81
S920
G
G
H
V
E
A
G
S
S
Y
A
E
M
E
V
Site 82
S921
G
H
V
E
A
G
S
S
Y
A
E
M
E
V
M
Site 83
Y944
Q
E
R
G
R
V
K
Y
I
K
R
P
G
A
V
Site 84
S967
R
L
E
L
D
D
P
S
K
V
H
P
A
E
P
Site 85
T984
G
E
L
P
A
Q
Q
T
L
P
I
L
G
E
K
Site 86
S998
K
L
H
Q
V
F
H
S
V
L
E
N
L
T
N
Site 87
S1008
E
N
L
T
N
V
M
S
G
F
C
L
P
E
P
Site 88
T1031
W
V
Q
K
L
M
M
T
L
R
H
P
S
L
P
Site 89
S1060
I
P
A
P
V
E
K
S
V
R
R
V
M
A
Q
Site 90
S1120
Q
L
V
Q
R
Y
R
S
G
I
R
G
Y
M
K
Site 91
Y1125
Y
R
S
G
I
R
G
Y
M
K
T
V
V
L
D
Site 92
Y1137
V
L
D
L
L
R
R
Y
L
R
V
E
H
H
F
Site 93
S1197
E
L
C
G
P
D
P
S
L
S
D
E
L
I
S
Site 94
T1210
I
S
I
L
N
E
L
T
Q
L
S
K
S
E
H
Site 95
S1213
L
N
E
L
T
Q
L
S
K
S
E
H
C
K
V
Site 96
S1215
E
L
T
Q
L
S
K
S
E
H
C
K
V
A
L
Site 97
S1235
L
I
A
S
H
L
P
S
Y
E
L
R
H
N
Q
Site 98
Y1236
I
A
S
H
L
P
S
Y
E
L
R
H
N
Q
V
Site 99
S1245
L
R
H
N
Q
V
E
S
I
F
L
S
A
I
D
Site 100
Y1301
E
V
Y
V
R
R
G
Y
I
A
Y
E
L
N
S
Site 101
Y1304
V
R
R
G
Y
I
A
Y
E
L
N
S
L
Q
H
Site 102
T1318
H
R
Q
L
P
D
G
T
C
V
V
E
F
Q
F
Site 103
T1336
S
S
H
P
N
R
M
T
V
P
I
S
I
T
N
Site 104
S1340
N
R
M
T
V
P
I
S
I
T
N
P
D
L
L
Site 105
T1342
M
T
V
P
I
S
I
T
N
P
D
L
L
R
H
Site 106
S1350
N
P
D
L
L
R
H
S
T
E
L
F
M
D
S
Site 107
T1351
P
D
L
L
R
H
S
T
E
L
F
M
D
S
G
Site 108
S1357
S
T
E
L
F
M
D
S
G
F
S
P
L
C
Q
Site 109
T1396
F
A
N
V
P
K
D
T
P
L
F
S
E
A
R
Site 110
S1400
P
K
D
T
P
L
F
S
E
A
R
T
S
L
Y
Site 111
T1404
P
L
F
S
E
A
R
T
S
L
Y
S
E
D
D
Site 112
S1405
L
F
S
E
A
R
T
S
L
Y
S
E
D
D
C
Site 113
Y1407
S
E
A
R
T
S
L
Y
S
E
D
D
C
K
S
Site 114
S1408
E
A
R
T
S
L
Y
S
E
D
D
C
K
S
L
Site 115
S1414
Y
S
E
D
D
C
K
S
L
R
E
E
P
I
H
Site 116
Y1456
K
K
N
I
L
V
D
Y
G
L
R
R
I
T
F
Site 117
T1462
D
Y
G
L
R
R
I
T
F
L
I
A
Q
E
K
Site 118
T1476
K
E
F
P
K
F
F
T
F
R
A
R
D
E
F
Site 119
Y1489
E
F
A
E
D
R
I
Y
R
H
L
E
P
A
L
Site 120
Y1523
A
N
H
K
M
H
L
Y
L
G
A
A
K
V
K
Site 121
S1549
I
R
A
I
I
R
H
S
D
L
I
T
K
E
A
Site 122
T1553
I
R
H
S
D
L
I
T
K
E
A
S
F
E
Y
Site 123
S1557
D
L
I
T
K
E
A
S
F
E
Y
L
Q
N
E
Site 124
Y1560
T
K
E
A
S
F
E
Y
L
Q
N
E
G
E
R
Site 125
Y1613
K
I
E
E
S
V
R
Y
M
V
M
R
Y
G
S
Site 126
Y1618
V
R
Y
M
V
M
R
Y
G
S
R
L
W
K
L
Site 127
T1639
V
K
I
N
I
R
Q
T
T
T
G
S
A
V
P
Site 128
T1640
K
I
N
I
R
Q
T
T
T
G
S
A
V
P
I
Site 129
T1641
I
N
I
R
Q
T
T
T
G
S
A
V
P
I
R
Site 130
Y1658
I
T
N
E
S
G
Y
Y
L
D
I
S
L
Y
K
Site 131
S1662
S
G
Y
Y
L
D
I
S
L
Y
K
E
V
T
D
Site 132
Y1664
Y
Y
L
D
I
S
L
Y
K
E
V
T
D
S
R
Site 133
T1668
I
S
L
Y
K
E
V
T
D
S
R
S
G
N
I
Site 134
S1670
L
Y
K
E
V
T
D
S
R
S
G
N
I
M
F
Site 135
S1672
K
E
V
T
D
S
R
S
G
N
I
M
F
H
S
Site 136
S1679
S
G
N
I
M
F
H
S
F
G
N
K
Q
G
P
Site 137
T1694
Q
H
G
M
L
I
N
T
P
Y
V
T
K
D
L
Site 138
T1711
A
K
R
F
Q
A
Q
T
L
G
T
T
Y
I
Y
Site 139
Y1716
A
Q
T
L
G
T
T
Y
I
Y
D
F
P
E
M
Site 140
Y1718
T
L
G
T
T
Y
I
Y
D
F
P
E
M
F
R
Site 141
S1734
A
L
F
K
L
W
G
S
P
D
K
Y
P
K
D
Site 142
Y1738
L
W
G
S
P
D
K
Y
P
K
D
I
L
T
Y
Site 143
T1744
K
Y
P
K
D
I
L
T
Y
T
E
L
V
L
D
Site 144
T1746
P
K
D
I
L
T
Y
T
E
L
V
L
D
S
Q
Site 145
S1752
Y
T
E
L
V
L
D
S
Q
G
Q
L
V
E
M
Site 146
T1779
A
F
K
M
R
F
K
T
Q
E
Y
P
E
G
R
Site 147
Y1782
M
R
F
K
T
Q
E
Y
P
E
G
R
D
V
I
Site 148
S1801
D
I
T
F
R
I
G
S
F
G
P
G
E
D
L
Site 149
Y1810
G
P
G
E
D
L
L
Y
L
R
A
S
E
M
A
Site 150
S1814
D
L
L
Y
L
R
A
S
E
M
A
R
A
E
G
Site 151
Y1861
D
P
H
K
G
F
K
Y
L
Y
L
T
P
Q
D
Site 152
Y1863
H
K
G
F
K
Y
L
Y
L
T
P
Q
D
Y
T
Site 153
T1865
G
F
K
Y
L
Y
L
T
P
Q
D
Y
T
R
I
Site 154
Y1869
L
Y
L
T
P
Q
D
Y
T
R
I
S
S
L
N
Site 155
T1870
Y
L
T
P
Q
D
Y
T
R
I
S
S
L
N
S
Site 156
S1873
P
Q
D
Y
T
R
I
S
S
L
N
S
V
H
C
Site 157
S1874
Q
D
Y
T
R
I
S
S
L
N
S
V
H
C
K
Site 158
S1877
T
R
I
S
S
L
N
S
V
H
C
K
H
I
E
Site 159
S1911
G
V
E
N
L
R
G
S
G
M
I
A
G
E
S
Site 160
T1960
E
N
S
H
I
I
L
T
G
A
S
A
L
N
K
Site 161
Y1974
K
V
L
G
R
E
V
Y
T
S
N
N
Q
L
G
Site 162
S1976
L
G
R
E
V
Y
T
S
N
N
Q
L
G
G
V
Site 163
Y1988
G
G
V
Q
I
M
H
Y
N
G
V
S
H
I
T
Site 164
T1995
Y
N
G
V
S
H
I
T
V
P
D
D
F
E
G
Site 165
Y2004
P
D
D
F
E
G
V
Y
T
I
L
E
W
L
S
Site 166
T2005
D
D
F
E
G
V
Y
T
I
L
E
W
L
S
Y
Site 167
Y2012
T
I
L
E
W
L
S
Y
M
P
K
D
N
H
S
Site 168
S2019
Y
M
P
K
D
N
H
S
P
V
P
I
I
T
P
Site 169
T2025
H
S
P
V
P
I
I
T
P
T
D
P
I
D
R
Site 170
S2039
R
E
I
E
F
L
P
S
R
A
P
Y
D
P
R
Site 171
Y2043
F
L
P
S
R
A
P
Y
D
P
R
W
M
L
A
Site 172
T2056
L
A
G
R
P
H
P
T
L
K
G
T
W
Q
S
Site 173
S2070
S
G
F
F
D
H
G
S
F
K
E
I
M
A
P
Site 174
T2084
P
W
A
Q
T
V
V
T
G
R
A
R
L
G
G
Site 175
S2133
G
Q
V
W
F
P
D
S
A
Y
K
T
A
Q
A
Site 176
Y2135
V
W
F
P
D
S
A
Y
K
T
A
Q
A
I
K
Site 177
T2137
F
P
D
S
A
Y
K
T
A
Q
A
I
K
D
F
Site 178
Y2168
S
G
G
M
K
D
M
Y
D
Q
V
L
K
F
G
Site 179
Y2219
N
P
L
C
I
E
M
Y
A
D
K
E
S
R
G
Site 180
T2234
G
V
L
E
P
E
G
T
V
E
I
K
F
R
K
Site 181
S2247
R
K
K
D
L
I
K
S
M
R
R
I
D
P
A
Site 182
Y2255
M
R
R
I
D
P
A
Y
K
K
L
M
E
Q
L
Site 183
S2268
Q
L
G
E
P
D
L
S
D
K
D
R
K
D
L
Site 184
T2303
Q
F
A
D
F
H
D
T
P
G
R
M
L
E
K
Site 185
Y2327
K
T
A
R
T
F
L
Y
W
R
L
R
R
L
L
Site 186
S2347
K
Q
E
I
L
Q
A
S
G
E
L
S
H
V
H
Site 187
S2351
L
Q
A
S
G
E
L
S
H
V
H
I
Q
S
M
Site 188
T2366
L
R
R
W
F
V
E
T
E
G
A
V
K
A
Y
Site 189
S2397
Q
A
G
D
G
P
R
S
T
I
R
E
N
I
T
Site 190
T2398
A
G
D
G
P
R
S
T
I
R
E
N
I
T
Y
Site 191
Y2405
T
I
R
E
N
I
T
Y
L
K
H
D
S
V
L
Site 192
S2410
I
T
Y
L
K
H
D
S
V
L
K
T
I
R
G
Site 193
T2414
K
H
D
S
V
L
K
T
I
R
G
L
V
E
E
Site 194
S2438
I
Y
L
S
Q
H
I
S
P
A
E
R
A
Q
V
Site 195
S2454
H
L
L
S
T
M
D
S
P
A
S
T
_
_
_
Site 196
T2458
T
M
D
S
P
A
S
T
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation