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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TERT (Telomerase Reverse Transcriptase)
Full Name:
Telomerase reverse transcriptase
Alias:
HEST2;Telomerase catalytic subunit;Telomerase-associated protein 2
Type:
Enzyme
Mass (Da):
126997
Number AA:
1132
UniProt ID:
O14746
International Prot ID:
IPI00298218
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000783
GO:0005654
GO:0005697
Uniprot
OncoNet
Molecular Function:
GO:0042803
GO:0042162
GO:0070034
PhosphoSite+
KinaseNET
Biological Process:
GO:0022616
GO:0006916
GO:0010149
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
P
R
C
R
A
V
R
S
L
L
R
S
H
Y
R
Site 2
S16
A
V
R
S
L
L
R
S
H
Y
R
E
V
L
P
Site 3
Y18
R
S
L
L
R
S
H
Y
R
E
V
L
P
L
A
Site 4
T26
R
E
V
L
P
L
A
T
F
V
R
R
L
G
P
Site 5
S70
R
P
P
P
A
A
P
S
F
R
Q
V
S
C
L
Site 6
T116
G
G
P
P
E
A
F
T
T
S
V
R
S
Y
L
Site 7
T117
G
P
P
E
A
F
T
T
S
V
R
S
Y
L
P
Site 8
S118
P
P
E
A
F
T
T
S
V
R
S
Y
L
P
N
Site 9
Y122
F
T
T
S
V
R
S
Y
L
P
N
T
V
T
D
Site 10
T126
V
R
S
Y
L
P
N
T
V
T
D
A
L
R
G
Site 11
T128
S
Y
L
P
N
T
V
T
D
A
L
R
G
S
G
Site 12
S134
V
T
D
A
L
R
G
S
G
A
W
G
L
L
L
Site 13
S191
A
R
P
P
P
H
A
S
G
P
R
R
R
L
G
Site 14
S206
C
E
R
A
W
N
H
S
V
R
E
A
G
V
P
Site 15
S227
G
A
R
R
R
G
G
S
A
S
R
S
L
P
L
Site 16
S229
R
R
R
G
G
S
A
S
R
S
L
P
L
P
K
Site 17
S231
R
G
G
S
A
S
R
S
L
P
L
P
K
R
P
Site 18
T249
A
A
P
E
P
E
R
T
P
V
G
Q
G
S
W
Site 19
S255
R
T
P
V
G
Q
G
S
W
A
H
P
G
R
T
Site 20
T262
S
W
A
H
P
G
R
T
R
G
P
S
D
R
G
Site 21
S266
P
G
R
T
R
G
P
S
D
R
G
F
C
V
V
Site 22
S274
D
R
G
F
C
V
V
S
P
A
R
P
A
E
E
Site 23
S284
R
P
A
E
E
A
T
S
L
E
G
A
L
S
G
Site 24
S290
T
S
L
E
G
A
L
S
G
T
R
H
S
H
P
Site 25
S295
A
L
S
G
T
R
H
S
H
P
S
V
G
R
Q
Site 26
S298
G
T
R
H
S
H
P
S
V
G
R
Q
H
H
A
Site 27
S309
Q
H
H
A
G
P
P
S
T
S
R
P
P
R
P
Site 28
T310
H
H
A
G
P
P
S
T
S
R
P
P
R
P
W
Site 29
S311
H
A
G
P
P
S
T
S
R
P
P
R
P
W
D
Site 30
T319
R
P
P
R
P
W
D
T
P
C
P
P
V
Y
A
Site 31
Y325
D
T
P
C
P
P
V
Y
A
E
T
K
H
F
L
Site 32
S335
T
K
H
F
L
Y
S
S
G
D
K
E
Q
L
R
Site 33
S344
D
K
E
Q
L
R
P
S
F
L
L
S
S
L
R
Site 34
S349
R
P
S
F
L
L
S
S
L
R
P
S
L
T
G
Site 35
S353
L
L
S
S
L
R
P
S
L
T
G
A
R
R
L
Site 36
T355
S
S
L
R
P
S
L
T
G
A
R
R
L
V
E
Site 37
T363
G
A
R
R
L
V
E
T
I
F
L
G
S
R
P
Site 38
T375
S
R
P
W
M
P
G
T
P
R
R
L
P
R
L
Site 39
Y386
L
P
R
L
P
Q
R
Y
W
Q
M
R
P
L
F
Site 40
T443
A
A
P
E
E
E
D
T
D
P
R
R
L
V
Q
Site 41
S456
V
Q
L
L
R
Q
H
S
S
P
W
Q
V
Y
G
Site 42
S457
Q
L
L
R
Q
H
S
S
P
W
Q
V
Y
G
F
Site 43
S480
V
P
P
G
L
W
G
S
R
H
N
E
R
R
F
Site 44
T491
E
R
R
F
L
R
N
T
K
K
F
I
S
L
G
Site 45
S504
L
G
K
H
A
K
L
S
L
Q
E
L
T
W
K
Site 46
T509
K
L
S
L
Q
E
L
T
W
K
M
S
V
R
D
Site 47
S523
D
C
A
W
L
R
R
S
P
G
V
G
C
V
P
Site 48
Y562
E
L
L
R
S
F
F
Y
V
T
E
T
T
F
Q
Site 49
Y576
Q
K
N
R
L
F
F
Y
R
K
S
V
W
S
K
Site 50
S579
R
L
F
F
Y
R
K
S
V
W
S
K
L
Q
S
Site 51
S582
F
Y
R
K
S
V
W
S
K
L
Q
S
I
G
I
Site 52
S586
S
V
W
S
K
L
Q
S
I
G
I
R
Q
H
L
Site 53
S602
R
V
Q
L
R
E
L
S
E
A
E
V
R
Q
H
Site 54
T618
E
A
R
P
A
L
L
T
S
R
L
R
F
I
P
Site 55
S619
A
R
P
A
L
L
T
S
R
L
R
F
I
P
K
Site 56
T644
D
Y
V
V
G
A
R
T
F
R
R
E
K
R
A
Site 57
T655
E
K
R
A
E
R
L
T
S
R
V
K
A
L
F
Site 58
S656
K
R
A
E
R
L
T
S
R
V
K
A
L
F
S
Site 59
Y667
A
L
F
S
V
L
N
Y
E
R
A
R
R
P
G
Site 60
T692
D
I
H
R
A
W
R
T
F
V
L
R
V
R
A
Site 61
Y707
Q
D
P
P
P
E
L
Y
F
V
K
V
D
V
T
Site 62
S731
R
L
T
E
V
I
A
S
I
I
K
P
Q
N
T
Site 63
T738
S
I
I
K
P
Q
N
T
Y
C
V
R
R
Y
A
Site 64
Y739
I
I
K
P
Q
N
T
Y
C
V
R
R
Y
A
V
Site 65
Y744
N
T
Y
C
V
R
R
Y
A
V
V
Q
K
A
A
Site 66
S761
H
V
R
K
A
F
K
S
H
V
S
T
L
T
D
Site 67
T765
A
F
K
S
H
V
S
T
L
T
D
L
Q
P
Y
Site 68
T767
K
S
H
V
S
T
L
T
D
L
Q
P
Y
M
R
Site 69
Y772
T
L
T
D
L
Q
P
Y
M
R
Q
F
V
A
H
Site 70
S797
V
V
I
E
Q
S
S
S
L
N
E
A
S
S
G
Site 71
S802
S
S
S
L
N
E
A
S
S
G
L
F
D
V
F
Site 72
S824
A
V
R
I
R
G
K
S
Y
V
Q
C
Q
G
I
Site 73
Y825
V
R
I
R
G
K
S
Y
V
Q
C
Q
G
I
P
Site 74
T882
P
H
L
T
H
A
K
T
F
L
R
T
L
V
R
Site 75
T939
G
L
L
L
D
T
R
T
L
E
V
Q
S
D
Y
Site 76
S944
T
R
T
L
E
V
Q
S
D
Y
S
S
Y
A
R
Site 77
Y946
T
L
E
V
Q
S
D
Y
S
S
Y
A
R
T
S
Site 78
S947
L
E
V
Q
S
D
Y
S
S
Y
A
R
T
S
I
Site 79
S948
E
V
Q
S
D
Y
S
S
Y
A
R
T
S
I
R
Site 80
Y949
V
Q
S
D
Y
S
S
Y
A
R
T
S
I
R
A
Site 81
T952
D
Y
S
S
Y
A
R
T
S
I
R
A
S
L
T
Site 82
S953
Y
S
S
Y
A
R
T
S
I
R
A
S
L
T
F
Site 83
S957
A
R
T
S
I
R
A
S
L
T
F
N
R
G
F
Site 84
T959
T
S
I
R
A
S
L
T
F
N
R
G
F
K
A
Site 85
S1045
D
T
A
S
L
C
Y
S
I
L
K
A
K
N
A
Site 86
S1055
K
A
K
N
A
G
M
S
L
G
A
K
G
A
A
Site 87
T1088
K
L
T
R
H
R
V
T
Y
V
P
L
L
G
S
Site 88
S1095
T
Y
V
P
L
L
G
S
L
R
T
A
Q
T
Q
Site 89
S1104
R
T
A
Q
T
Q
L
S
R
K
L
P
G
T
T
Site 90
T1113
K
L
P
G
T
T
L
T
A
L
E
A
A
A
N
Site 91
S1125
A
A
N
P
A
L
P
S
D
F
K
T
I
L
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation