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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TPP1
Full Name:
Tripeptidyl-peptidase 1
Alias:
cell growth-inhibiting gene 1 protein; CLN2; GIG1; LPIC; lysosomal pepstatin insensitive protease; lysosomal pepstatin-insensitive protease; TPP I; TPP-1; TPP-I; tripeptidyl aminopeptidase; tripeptidyl peptidase I; tripeptidyl-peptidase 1; tripeptidyl-peptidase I
Type:
Mitochondrial; EC 3.4.14.9; Protease
Mass (Da):
61250
Number AA:
UniProt ID:
O14773
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005764
GO:0042470
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0042277
GO:0005515
GO:0004252
PhosphoSite+
KinaseNET
Biological Process:
GO:0045453
GO:0008219
GO:0006629
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
L
I
L
S
G
K
C
S
Y
S
P
E
P
D
Q
Site 2
S22
L
S
G
K
C
S
Y
S
P
E
P
D
Q
R
R
Site 3
T30
P
E
P
D
Q
R
R
T
L
P
P
G
W
V
S
Site 4
S37
T
L
P
P
G
W
V
S
L
G
R
A
D
P
E
Site 5
S48
A
D
P
E
E
E
L
S
L
T
F
A
L
R
Q
Site 6
T50
P
E
E
E
L
S
L
T
F
A
L
R
Q
Q
N
Site 7
S62
Q
Q
N
V
E
R
L
S
E
L
V
Q
A
V
S
Site 8
S69
S
E
L
V
Q
A
V
S
D
P
S
S
P
Q
Y
Site 9
S73
Q
A
V
S
D
P
S
S
P
Q
Y
G
K
Y
L
Site 10
Y76
S
D
P
S
S
P
Q
Y
G
K
Y
L
T
L
E
Site 11
Y79
S
S
P
Q
Y
G
K
Y
L
T
L
E
N
V
A
Site 12
T95
L
V
R
P
S
P
L
T
L
H
T
V
Q
K
W
Site 13
Y141
P
G
A
E
F
H
H
Y
V
G
G
P
T
E
T
Site 14
S153
T
E
T
H
V
V
R
S
P
H
P
Y
Q
L
P
Site 15
Y157
V
V
R
S
P
H
P
Y
Q
L
P
Q
A
L
A
Site 16
S180
L
H
R
F
P
P
T
S
S
L
R
Q
R
P
E
Site 17
S181
H
R
F
P
P
T
S
S
L
R
Q
R
P
E
P
Site 18
T191
Q
R
P
E
P
Q
V
T
G
T
V
G
L
H
L
Site 19
T201
V
G
L
H
L
G
V
T
P
S
V
I
R
K
R
Site 20
S203
L
H
L
G
V
T
P
S
V
I
R
K
R
Y
N
Site 21
Y209
P
S
V
I
R
K
R
Y
N
L
T
S
Q
D
V
Site 22
S213
R
K
R
Y
N
L
T
S
Q
D
V
G
S
G
T
Site 23
S218
L
T
S
Q
D
V
G
S
G
T
S
N
N
S
Q
Site 24
T220
S
Q
D
V
G
S
G
T
S
N
N
S
Q
A
C
Site 25
S224
G
S
G
T
S
N
N
S
Q
A
C
A
Q
F
L
Site 26
Y234
C
A
Q
F
L
E
Q
Y
F
H
D
S
D
L
A
Site 27
S256
G
N
F
A
H
Q
A
S
V
A
R
V
V
G
Q
Site 28
Y279
E
A
S
L
D
V
Q
Y
L
M
S
A
G
A
N
Site 29
S288
M
S
A
G
A
N
I
S
T
W
V
Y
S
S
P
Site 30
T289
S
A
G
A
N
I
S
T
W
V
Y
S
S
P
G
Site 31
Y292
A
N
I
S
T
W
V
Y
S
S
P
G
R
H
E
Site 32
S293
N
I
S
T
W
V
Y
S
S
P
G
R
H
E
G
Site 33
S294
I
S
T
W
V
Y
S
S
P
G
R
H
E
G
Q
Site 34
S331
S
Y
G
D
D
E
D
S
L
S
S
A
Y
I
Q
Site 35
S333
G
D
D
E
D
S
L
S
S
A
Y
I
Q
R
V
Site 36
S367
D
S
G
A
G
C
W
S
V
S
G
R
H
Q
F
Site 37
T377
G
R
H
Q
F
R
P
T
F
P
A
S
S
P
Y
Site 38
S381
F
R
P
T
F
P
A
S
S
P
Y
V
T
T
V
Site 39
S382
R
P
T
F
P
A
S
S
P
Y
V
T
T
V
G
Site 40
S408
N
E
I
V
D
Y
I
S
G
G
G
F
S
N
V
Site 41
S413
Y
I
S
G
G
G
F
S
N
V
F
P
R
P
S
Site 42
S420
S
N
V
F
P
R
P
S
Y
Q
E
E
A
V
T
Site 43
Y421
N
V
F
P
R
P
S
Y
Q
E
E
A
V
T
K
Site 44
T427
S
Y
Q
E
E
A
V
T
K
F
L
S
S
S
P
Site 45
S431
E
A
V
T
K
F
L
S
S
S
P
H
L
P
P
Site 46
S432
A
V
T
K
F
L
S
S
S
P
H
L
P
P
S
Site 47
S433
V
T
K
F
L
S
S
S
P
H
L
P
P
S
S
Site 48
S439
S
S
P
H
L
P
P
S
S
Y
F
N
A
S
G
Site 49
S440
S
P
H
L
P
P
S
S
Y
F
N
A
S
G
R
Site 50
Y441
P
H
L
P
P
S
S
Y
F
N
A
S
G
R
A
Site 51
S445
P
S
S
Y
F
N
A
S
G
R
A
Y
P
D
V
Site 52
Y449
F
N
A
S
G
R
A
Y
P
D
V
A
A
L
S
Site 53
S472
R
V
P
I
P
W
V
S
G
T
S
A
S
T
P
Site 54
S495
I
N
E
H
R
I
L
S
G
R
P
P
L
G
F
Site 55
Y508
G
F
L
N
P
R
L
Y
Q
Q
H
G
A
G
L
Site 56
T519
G
A
G
L
F
D
V
T
R
G
C
H
E
S
C
Site 57
S525
V
T
R
G
C
H
E
S
C
L
D
E
E
V
E
Site 58
T546
G
P
G
W
D
P
V
T
G
W
G
T
P
N
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation