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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NDC80
Full Name:
Kinetochore protein NDC80 homolog
Alias:
HEC; Highly expressed in cancer, rich in leucine heptad repeats; Kinetochore associated 2; KNTC2; NDC80, kinetochore complex component; Retinoblastoma-associated protein HEC; TID3
Type:
Cell cycle regulation
Mass (Da):
73913
Number AA:
642
UniProt ID:
O14777
International Prot ID:
IPI00005791
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031262
GO:0000777
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008608
GO:0051301
GO:0000132
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
K
R
S
S
V
S
S
G
G
A
G
Site 2
S8
M
K
R
S
S
V
S
S
G
G
A
G
R
L
S
Site 3
S15
S
G
G
A
G
R
L
S
M
Q
E
L
R
S
Q
Site 4
S21
L
S
M
Q
E
L
R
S
Q
D
V
N
K
Q
G
Site 5
Y30
D
V
N
K
Q
G
L
Y
T
P
Q
T
K
E
K
Site 6
T31
V
N
K
Q
G
L
Y
T
P
Q
T
K
E
K
P
Site 7
T34
Q
G
L
Y
T
P
Q
T
K
E
K
P
T
F
G
Site 8
T39
P
Q
T
K
E
K
P
T
F
G
K
L
S
I
N
Site 9
S44
K
P
T
F
G
K
L
S
I
N
K
P
T
S
E
Site 10
T49
K
L
S
I
N
K
P
T
S
E
R
K
V
S
L
Site 11
S50
L
S
I
N
K
P
T
S
E
R
K
V
S
L
F
Site 12
S55
P
T
S
E
R
K
V
S
L
F
G
K
R
T
S
Site 13
S62
S
L
F
G
K
R
T
S
G
H
G
S
R
N
S
Site 14
S66
K
R
T
S
G
H
G
S
R
N
S
Q
L
G
I
Site 15
S69
S
G
H
G
S
R
N
S
Q
L
G
I
F
S
S
Site 16
S76
S
Q
L
G
I
F
S
S
S
E
K
I
K
D
P
Site 17
S77
Q
L
G
I
F
S
S
S
E
K
I
K
D
P
R
Site 18
Y108
E
F
L
T
E
N
G
Y
A
H
N
V
S
M
K
Site 19
S116
A
H
N
V
S
M
K
S
L
Q
A
P
S
V
K
Site 20
S121
M
K
S
L
Q
A
P
S
V
K
D
F
L
K
I
Site 21
S139
L
Y
G
F
L
C
P
S
Y
E
L
P
D
T
K
Site 22
Y140
Y
G
F
L
C
P
S
Y
E
L
P
D
T
K
F
Site 23
T145
P
S
Y
E
L
P
D
T
K
F
E
E
E
V
P
Site 24
Y160
R
I
F
K
D
L
G
Y
P
F
A
L
S
K
S
Site 25
S165
L
G
Y
P
F
A
L
S
K
S
S
M
Y
T
V
Site 26
Y170
A
L
S
K
S
S
M
Y
T
V
G
A
P
H
T
Site 27
T171
L
S
K
S
S
M
Y
T
V
G
A
P
H
T
W
Site 28
S202
H
T
A
M
K
E
S
S
P
L
F
D
D
G
Q
Site 29
Y228
H
N
K
L
F
L
D
Y
T
I
K
C
Y
E
S
Site 30
Y233
L
D
Y
T
I
K
C
Y
E
S
F
M
S
G
A
Site 31
S238
K
C
Y
E
S
F
M
S
G
A
D
S
F
D
E
Site 32
S242
S
F
M
S
G
A
D
S
F
D
E
M
N
A
E
Site 33
S267
V
D
A
F
K
L
E
S
L
E
A
K
N
R
A
Site 34
S295
K
E
P
N
R
L
E
S
L
R
K
L
K
A
S
Site 35
S302
S
L
R
K
L
K
A
S
L
Q
G
D
V
Q
K
Site 36
Y310
L
Q
G
D
V
Q
K
Y
Q
A
Y
M
S
N
L
Site 37
Y313
D
V
Q
K
Y
Q
A
Y
M
S
N
L
E
S
H
Site 38
S315
Q
K
Y
Q
A
Y
M
S
N
L
E
S
H
S
A
Site 39
S319
A
Y
M
S
N
L
E
S
H
S
A
I
L
D
Q
Site 40
Y361
N
I
I
D
N
Q
K
Y
S
V
A
D
I
E
R
Site 41
S362
I
I
D
N
Q
K
Y
S
V
A
D
I
E
R
I
Site 42
T379
E
R
N
E
L
Q
Q
T
I
N
K
L
T
K
D
Site 43
Y401
L
W
N
E
E
L
K
Y
A
R
G
K
E
A
I
Site 44
T410
R
G
K
E
A
I
E
T
Q
L
A
E
Y
H
K
Site 45
Y458
V
K
Y
R
A
Q
V
Y
V
P
L
K
E
L
L
Site 46
T485
K
K
M
G
L
E
D
T
L
E
Q
L
N
A
M
Site 47
T494
E
Q
L
N
A
M
I
T
E
S
K
R
S
V
R
Site 48
S496
L
N
A
M
I
T
E
S
K
R
S
V
R
T
L
Site 49
S499
M
I
T
E
S
K
R
S
V
R
T
L
K
E
E
Site 50
T502
E
S
K
R
S
V
R
T
L
K
E
E
V
Q
K
Site 51
Y514
V
Q
K
L
D
D
L
Y
Q
Q
K
I
K
E
A
Site 52
S530
E
E
D
E
K
C
A
S
E
L
E
S
L
E
K
Site 53
S534
K
C
A
S
E
L
E
S
L
E
K
H
K
H
L
Site 54
T545
H
K
H
L
L
E
S
T
V
N
Q
G
L
S
E
Site 55
Y564
L
D
A
V
Q
R
E
Y
Q
L
V
V
Q
T
T
Site 56
Y611
I
A
K
V
D
R
E
Y
E
E
C
M
S
E
D
Site 57
S616
R
E
Y
E
E
C
M
S
E
D
L
S
E
N
I
Site 58
S620
E
C
M
S
E
D
L
S
E
N
I
K
E
I
R
Site 59
Y630
I
K
E
I
R
D
K
Y
E
K
K
A
T
L
I
Site 60
T635
D
K
Y
E
K
K
A
T
L
I
K
S
S
E
E
Site 61
S639
K
K
A
T
L
I
K
S
S
E
E
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation