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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CASK
Full Name:
Peripheral plasma membrane protein CASK
Alias:
CAGH39; Calcium/calmodulin-dependent serine protein kinase; CSKP; EC 2.7.11.1; Kinase CASK; LIN2; Lin-2; Lin-2 homolog; TNRC8
Type:
EC 2.7.11.1; Adaptor/scaffold; Protein kinase, Ser/Thr (non-receptor); CAMK group; CASK family
Mass (Da):
105123
Number AA:
926
UniProt ID:
O14936
International Prot ID:
IPI00024726
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
GO:0019898
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005516
GO:0004385
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T34
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
Site 2
T49
I
V
D
V
A
K
F
T
S
S
P
G
L
S
T
Site 3
S50
V
D
V
A
K
F
T
S
S
P
G
L
S
T
E
Site 4
S51
D
V
A
K
F
T
S
S
P
G
L
S
T
E
D
Site 5
S55
F
T
S
S
P
G
L
S
T
E
D
L
K
R
E
Site 6
S64
E
D
L
K
R
E
A
S
I
C
H
M
L
K
H
Site 7
Y113
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Site 8
S119
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
Site 9
Y121
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
Site 10
Y131
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
Site 11
S151
P
H
C
V
L
L
A
S
K
E
N
S
A
P
V
Site 12
S155
L
L
A
S
K
E
N
S
A
P
V
K
L
G
G
Site 13
T182
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
Site 14
Y196
E
V
V
K
R
E
P
Y
G
K
P
V
D
V
W
Site 15
T222
G
C
L
P
F
Y
G
T
K
E
R
L
F
E
G
Site 16
Y235
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
Site 17
S243
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
Site 18
T266
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
Site 19
Y268
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
Site 20
Y282
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
Site 21
Y284
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
Site 22
T291
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
Site 23
S313
G
A
V
L
A
A
V
S
S
H
K
F
N
S
F
Site 24
S319
V
S
S
H
K
F
N
S
F
Y
G
D
P
P
E
Site 25
Y321
S
H
K
F
N
S
F
Y
G
D
P
P
E
E
L
Site 26
S332
P
E
E
L
P
D
F
S
E
D
P
T
S
S
G
Site 27
T336
P
D
F
S
E
D
P
T
S
S
G
L
L
A
A
Site 28
S337
D
F
S
E
D
P
T
S
S
G
L
L
A
A
E
Site 29
S348
L
A
A
E
R
A
V
S
Q
V
L
D
S
L
E
Site 30
S353
A
V
S
Q
V
L
D
S
L
E
E
I
H
A
L
Site 31
S373
K
D
L
D
F
L
H
S
V
F
Q
D
Q
H
L
Site 32
Y387
L
H
T
L
L
D
L
Y
D
K
I
N
T
K
S
Site 33
S394
Y
D
K
I
N
T
K
S
S
P
Q
I
R
N
P
Site 34
S395
D
K
I
N
T
K
S
S
P
Q
I
R
N
P
P
Site 35
S403
P
Q
I
R
N
P
P
S
D
A
V
Q
R
A
K
Site 36
S417
K
E
V
L
E
E
I
S
C
Y
P
E
N
N
D
Site 37
Y419
V
L
E
E
I
S
C
Y
P
E
N
N
D
A
K
Site 38
T433
K
E
L
K
R
I
L
T
Q
P
H
F
M
A
L
Site 39
T460
S
D
E
A
L
R
V
T
P
P
P
T
S
P
Y
Site 40
S465
R
V
T
P
P
P
T
S
P
Y
L
N
G
D
S
Site 41
Y467
T
P
P
P
T
S
P
Y
L
N
G
D
S
P
E
Site 42
S472
S
P
Y
L
N
G
D
S
P
E
S
A
N
G
D
Site 43
S475
L
N
G
D
S
P
E
S
A
N
G
D
M
D
M
Site 44
T497
L
V
Q
F
Q
K
N
T
D
E
P
M
G
I
T
Site 45
T529
G
M
I
H
R
Q
G
T
L
H
V
G
D
E
I
Site 46
T564
R
E
M
R
G
S
I
T
F
K
I
V
P
S
Y
Site 47
S570
I
T
F
K
I
V
P
S
Y
R
T
Q
S
S
S
Site 48
Y571
T
F
K
I
V
P
S
Y
R
T
Q
S
S
S
C
Site 49
T573
K
I
V
P
S
Y
R
T
Q
S
S
S
C
E
R
Site 50
S575
V
P
S
Y
R
T
Q
S
S
S
C
E
R
D
S
Site 51
S576
P
S
Y
R
T
Q
S
S
S
C
E
R
D
S
P
Site 52
S577
S
Y
R
T
Q
S
S
S
C
E
R
D
S
P
S
Site 53
S582
S
S
S
C
E
R
D
S
P
S
T
S
R
Q
S
Site 54
S584
S
C
E
R
D
S
P
S
T
S
R
Q
S
P
A
Site 55
T585
C
E
R
D
S
P
S
T
S
R
Q
S
P
A
N
Site 56
S586
E
R
D
S
P
S
T
S
R
Q
S
P
A
N
G
Site 57
S589
S
P
S
T
S
R
Q
S
P
A
N
G
H
S
S
Site 58
S596
S
P
A
N
G
H
S
S
T
N
N
S
V
S
D
Site 59
T597
P
A
N
G
H
S
S
T
N
N
S
V
S
D
L
Site 60
S600
G
H
S
S
T
N
N
S
V
S
D
L
P
S
T
Site 61
S602
S
S
T
N
N
S
V
S
D
L
P
S
T
T
Q
Site 62
S606
N
S
V
S
D
L
P
S
T
T
Q
P
K
G
R
Site 63
T607
S
V
S
D
L
P
S
T
T
Q
P
K
G
R
Q
Site 64
Y616
Q
P
K
G
R
Q
I
Y
V
R
A
Q
F
E
Y
Site 65
Y623
Y
V
R
A
Q
F
E
Y
D
P
A
K
D
D
L
Site 66
S650
G
D
I
I
Q
I
I
S
K
D
D
H
N
W
W
Site 67
S664
W
Q
G
K
L
E
N
S
K
N
G
T
A
G
L
Site 68
T668
L
E
N
S
K
N
G
T
A
G
L
I
P
S
P
Site 69
S674
G
T
A
G
L
I
P
S
P
E
L
Q
E
W
R
Site 70
Y708
F
G
K
K
K
K
Q
Y
K
D
K
Y
L
A
K
Site 71
Y712
K
K
Q
Y
K
D
K
Y
L
A
K
H
N
A
V
Site 72
Y728
D
Q
L
D
L
V
T
Y
E
E
V
V
K
L
P
Site 73
T741
L
P
A
F
K
R
K
T
L
V
L
L
G
A
H
Site 74
T758
G
R
R
H
I
K
N
T
L
I
T
K
H
P
D
Site 75
Y769
K
H
P
D
R
F
A
Y
P
I
P
H
T
T
R
Site 76
T774
F
A
Y
P
I
P
H
T
T
R
P
P
K
K
D
Site 77
T775
A
Y
P
I
P
H
T
T
R
P
P
K
K
D
E
Site 78
Y788
D
E
E
N
G
K
N
Y
Y
F
V
S
H
D
Q
Site 79
Y789
E
E
N
G
K
N
Y
Y
F
V
S
H
D
Q
M
Site 80
Y805
Q
D
I
S
N
N
E
Y
L
E
Y
G
S
H
E
Site 81
Y808
S
N
N
E
Y
L
E
Y
G
S
H
E
D
A
M
Site 82
Y816
G
S
H
E
D
A
M
Y
G
T
K
L
E
T
I
Site 83
T863
F
I
A
A
P
T
I
T
P
G
L
N
E
D
E
Site 84
S871
P
G
L
N
E
D
E
S
L
Q
R
L
Q
K
E
Site 85
S879
L
Q
R
L
Q
K
E
S
D
I
L
Q
R
T
Y
Site 86
Y886
S
D
I
L
Q
R
T
Y
A
H
Y
F
D
L
T
Site 87
Y889
L
Q
R
T
Y
A
H
Y
F
D
L
T
I
I
N
Site 88
T902
I
N
N
E
I
D
E
T
I
R
H
L
E
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation