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Updated November 2019
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Protein Info
Short Name:
PPP1R12A
Full Name:
Protein phosphatase 1 regulatory subunit 12A
Alias:
MBS; Myosin phosphatase-targeting subunit 1; MYPT1
Type:
Protein phosphatase, regulatory subunit
Mass (Da):
115281
Number AA:
1030
UniProt ID:
O14974
International Prot ID:
IPI00183002
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
Q
L
K
R
W
I
G
S
E
T
D
L
E
P
P
Site 2
T22
K
R
W
I
G
S
E
T
D
L
E
P
P
V
V
Site 3
T34
P
V
V
K
R
Q
K
T
K
V
K
F
D
D
G
Site 4
Y68
H
R
G
A
D
I
N
Y
A
N
V
D
G
L
T
Site 5
S137
A
H
V
G
A
V
N
S
E
G
D
T
P
L
D
Site 6
T141
A
V
N
S
E
G
D
T
P
L
D
I
A
E
E
Site 7
S198
N
D
V
R
H
A
K
S
G
G
T
A
L
H
V
Site 8
Y223
K
L
L
I
Q
A
G
Y
D
V
N
I
K
D
Y
Site 9
Y230
Y
D
V
N
I
K
D
Y
D
G
W
T
P
L
H
Site 10
T234
I
K
D
Y
D
G
W
T
P
L
H
A
A
A
H
Site 11
S292
K
K
Q
N
L
L
H
S
E
K
R
D
K
K
S
Site 12
S299
S
E
K
R
D
K
K
S
P
L
I
E
S
T
A
Site 13
S304
K
K
S
P
L
I
E
S
T
A
N
M
D
N
N
Site 14
S313
A
N
M
D
N
N
Q
S
Q
K
T
F
K
N
K
Site 15
T316
D
N
N
Q
S
Q
K
T
F
K
N
K
E
T
L
Site 16
S332
I
E
P
E
K
N
A
S
R
I
E
S
L
E
Q
Site 17
S336
K
N
A
S
R
I
E
S
L
E
Q
E
K
V
D
Site 18
S353
E
E
G
K
K
D
E
S
S
C
S
S
E
E
D
Site 19
S354
E
G
K
K
D
E
S
S
C
S
S
E
E
D
E
Site 20
S356
K
K
D
E
S
S
C
S
S
E
E
D
E
E
D
Site 21
S357
K
D
E
S
S
C
S
S
E
E
D
E
E
D
D
Site 22
S365
E
E
D
E
E
D
D
S
E
S
E
A
E
T
D
Site 23
S367
D
E
E
D
D
S
E
S
E
A
E
T
D
K
T
Site 24
T371
D
S
E
S
E
A
E
T
D
K
T
K
P
L
A
Site 25
T374
S
E
A
E
T
D
K
T
K
P
L
A
S
V
T
Site 26
S379
D
K
T
K
P
L
A
S
V
T
N
A
N
T
S
Site 27
T381
T
K
P
L
A
S
V
T
N
A
N
T
S
S
T
Site 28
S387
V
T
N
A
N
T
S
S
T
Q
A
A
P
V
A
Site 29
S402
V
T
T
P
T
V
S
S
G
Q
A
T
P
T
S
Site 30
T406
T
V
S
S
G
Q
A
T
P
T
S
P
I
K
K
Site 31
S409
S
G
Q
A
T
P
T
S
P
I
K
K
F
P
T
Site 32
T416
S
P
I
K
K
F
P
T
T
A
T
K
I
S
P
Site 33
T417
P
I
K
K
F
P
T
T
A
T
K
I
S
P
K
Site 34
T419
K
K
F
P
T
T
A
T
K
I
S
P
K
E
E
Site 35
S422
P
T
T
A
T
K
I
S
P
K
E
E
E
R
K
Site 36
S432
E
E
E
R
K
D
E
S
P
A
T
W
R
L
G
Site 37
T435
R
K
D
E
S
P
A
T
W
R
L
G
L
R
K
Site 38
T443
W
R
L
G
L
R
K
T
G
S
Y
G
A
L
A
Site 39
S445
L
G
L
R
K
T
G
S
Y
G
A
L
A
E
I
Site 40
Y446
G
L
R
K
T
G
S
Y
G
A
L
A
E
I
T
Site 41
T453
Y
G
A
L
A
E
I
T
A
S
K
E
G
Q
K
Site 42
S455
A
L
A
E
I
T
A
S
K
E
G
Q
K
E
K
Site 43
T464
E
G
Q
K
E
K
D
T
A
G
V
T
R
S
A
Site 44
T468
E
K
D
T
A
G
V
T
R
S
A
S
S
P
R
Site 45
S470
D
T
A
G
V
T
R
S
A
S
S
P
R
L
S
Site 46
S472
A
G
V
T
R
S
A
S
S
P
R
L
S
S
S
Site 47
S473
G
V
T
R
S
A
S
S
P
R
L
S
S
S
L
Site 48
S477
S
A
S
S
P
R
L
S
S
S
L
D
N
K
E
Site 49
S478
A
S
S
P
R
L
S
S
S
L
D
N
K
E
K
Site 50
S479
S
S
P
R
L
S
S
S
L
D
N
K
E
K
E
Site 51
Y496
S
K
G
T
R
L
A
Y
V
A
P
T
I
P
R
Site 52
T500
R
L
A
Y
V
A
P
T
I
P
R
R
L
A
S
Site 53
S507
T
I
P
R
R
L
A
S
T
S
D
I
E
E
K
Site 54
T508
I
P
R
R
L
A
S
T
S
D
I
E
E
K
E
Site 55
S509
P
R
R
L
A
S
T
S
D
I
E
E
K
E
N
Site 56
S519
E
E
K
E
N
R
D
S
S
S
L
R
T
S
S
Site 57
S520
E
K
E
N
R
D
S
S
S
L
R
T
S
S
S
Site 58
S521
K
E
N
R
D
S
S
S
L
R
T
S
S
S
Y
Site 59
T524
R
D
S
S
S
L
R
T
S
S
S
Y
T
R
R
Site 60
S525
D
S
S
S
L
R
T
S
S
S
Y
T
R
R
K
Site 61
S526
S
S
S
L
R
T
S
S
S
Y
T
R
R
K
W
Site 62
S527
S
S
L
R
T
S
S
S
Y
T
R
R
K
W
E
Site 63
Y528
S
L
R
T
S
S
S
Y
T
R
R
K
W
E
D
Site 64
T529
L
R
T
S
S
S
Y
T
R
R
K
W
E
D
D
Site 65
S541
E
D
D
L
K
K
N
S
S
V
N
E
G
S
T
Site 66
S542
D
D
L
K
K
N
S
S
V
N
E
G
S
T
Y
Site 67
S547
N
S
S
V
N
E
G
S
T
Y
H
K
S
C
S
Site 68
T548
S
S
V
N
E
G
S
T
Y
H
K
S
C
S
F
Site 69
Y549
S
V
N
E
G
S
T
Y
H
K
S
C
S
F
G
Site 70
S552
E
G
S
T
Y
H
K
S
C
S
F
G
R
R
Q
Site 71
S554
S
T
Y
H
K
S
C
S
F
G
R
R
Q
D
D
Site 72
S564
R
R
Q
D
D
L
I
S
S
S
V
P
S
T
T
Site 73
S565
R
Q
D
D
L
I
S
S
S
V
P
S
T
T
S
Site 74
S566
Q
D
D
L
I
S
S
S
V
P
S
T
T
S
T
Site 75
T570
I
S
S
S
V
P
S
T
T
S
T
P
T
V
T
Site 76
T571
S
S
S
V
P
S
T
T
S
T
P
T
V
T
S
Site 77
S572
S
S
V
P
S
T
T
S
T
P
T
V
T
S
A
Site 78
T573
S
V
P
S
T
T
S
T
P
T
V
T
S
A
A
Site 79
T575
P
S
T
T
S
T
P
T
V
T
S
A
A
G
L
Site 80
S578
T
S
T
P
T
V
T
S
A
A
G
L
Q
K
S
Site 81
S585
S
A
A
G
L
Q
K
S
L
L
S
S
T
S
T
Site 82
S588
G
L
Q
K
S
L
L
S
S
T
S
T
T
T
K
Site 83
S589
L
Q
K
S
L
L
S
S
T
S
T
T
T
K
I
Site 84
T590
Q
K
S
L
L
S
S
T
S
T
T
T
K
I
T
Site 85
S591
K
S
L
L
S
S
T
S
T
T
T
K
I
T
T
Site 86
T592
S
L
L
S
S
T
S
T
T
T
K
I
T
T
G
Site 87
T593
L
L
S
S
T
S
T
T
T
K
I
T
T
G
S
Site 88
T597
T
S
T
T
T
K
I
T
T
G
S
S
S
A
G
Site 89
T598
S
T
T
T
K
I
T
T
G
S
S
S
A
G
T
Site 90
S601
T
K
I
T
T
G
S
S
S
A
G
T
Q
S
S
Site 91
S602
K
I
T
T
G
S
S
S
A
G
T
Q
S
S
T
Site 92
T605
T
G
S
S
S
A
G
T
Q
S
S
T
S
N
R
Site 93
S607
S
S
S
A
G
T
Q
S
S
T
S
N
R
L
W
Site 94
S608
S
S
A
G
T
Q
S
S
T
S
N
R
L
W
A
Site 95
S610
A
G
T
Q
S
S
T
S
N
R
L
W
A
E
D
Site 96
S618
N
R
L
W
A
E
D
S
T
E
K
E
K
D
S
Site 97
T619
R
L
W
A
E
D
S
T
E
K
E
K
D
S
V
Site 98
T631
D
S
V
P
T
A
V
T
I
P
V
A
P
T
V
Site 99
T645
V
V
N
A
A
A
S
T
T
T
L
T
T
T
T
Site 100
T647
N
A
A
A
S
T
T
T
L
T
T
T
T
A
G
Site 101
T652
T
T
T
L
T
T
T
T
A
G
T
V
S
S
T
Site 102
S668
E
V
R
E
R
R
R
S
Y
L
T
P
V
R
D
Site 103
Y669
V
R
E
R
R
R
S
Y
L
T
P
V
R
D
E
Site 104
T671
E
R
R
R
S
Y
L
T
P
V
R
D
E
E
S
Site 105
S678
T
P
V
R
D
E
E
S
E
S
Q
R
K
A
R
Site 106
S680
V
R
D
E
E
S
E
S
Q
R
K
A
R
S
R
Site 107
S692
R
S
R
Q
A
R
Q
S
R
R
S
T
Q
G
V
Site 108
S695
Q
A
R
Q
S
R
R
S
T
Q
G
V
T
L
T
Site 109
T696
A
R
Q
S
R
R
S
T
Q
G
V
T
L
T
D
Site 110
T700
R
R
S
T
Q
G
V
T
L
T
D
L
Q
E
A
Site 111
T702
S
T
Q
G
V
T
L
T
D
L
Q
E
A
E
K
Site 112
T710
D
L
Q
E
A
E
K
T
I
G
R
S
R
S
T
Site 113
S716
K
T
I
G
R
S
R
S
T
R
T
R
E
Q
E
Site 114
T717
T
I
G
R
S
R
S
T
R
T
R
E
Q
E
N
Site 115
S746
K
Q
E
E
K
K
E
S
E
T
S
R
E
D
E
Site 116
T748
E
E
K
K
E
S
E
T
S
R
E
D
E
Y
K
Site 117
S749
E
K
K
E
S
E
T
S
R
E
D
E
Y
K
Q
Site 118
Y754
E
T
S
R
E
D
E
Y
K
Q
K
Y
S
R
T
Site 119
Y758
E
D
E
Y
K
Q
K
Y
S
R
T
Y
D
E
T
Site 120
S759
D
E
Y
K
Q
K
Y
S
R
T
Y
D
E
T
Y
Site 121
T761
Y
K
Q
K
Y
S
R
T
Y
D
E
T
Y
Q
R
Site 122
Y762
K
Q
K
Y
S
R
T
Y
D
E
T
Y
Q
R
Y
Site 123
T765
Y
S
R
T
Y
D
E
T
Y
Q
R
Y
R
P
V
Site 124
Y766
S
R
T
Y
D
E
T
Y
Q
R
Y
R
P
V
S
Site 125
Y769
Y
D
E
T
Y
Q
R
Y
R
P
V
S
T
S
S
Site 126
S773
Y
Q
R
Y
R
P
V
S
T
S
S
S
T
T
P
Site 127
S775
R
Y
R
P
V
S
T
S
S
S
T
T
P
S
S
Site 128
S776
Y
R
P
V
S
T
S
S
S
T
T
P
S
S
S
Site 129
S777
R
P
V
S
T
S
S
S
T
T
P
S
S
S
L
Site 130
T778
P
V
S
T
S
S
S
T
T
P
S
S
S
L
S
Site 131
T779
V
S
T
S
S
S
T
T
P
S
S
S
L
S
T
Site 132
S781
T
S
S
S
T
T
P
S
S
S
L
S
T
M
S
Site 133
S782
S
S
S
T
T
P
S
S
S
L
S
T
M
S
S
Site 134
S783
S
S
T
T
P
S
S
S
L
S
T
M
S
S
S
Site 135
S785
T
T
P
S
S
S
L
S
T
M
S
S
S
L
Y
Site 136
T786
T
P
S
S
S
L
S
T
M
S
S
S
L
Y
A
Site 137
S788
S
S
S
L
S
T
M
S
S
S
L
Y
A
S
S
Site 138
S789
S
S
L
S
T
M
S
S
S
L
Y
A
S
S
Q
Site 139
S790
S
L
S
T
M
S
S
S
L
Y
A
S
S
Q
L
Site 140
Y792
S
T
M
S
S
S
L
Y
A
S
S
Q
L
N
R
Site 141
S794
M
S
S
S
L
Y
A
S
S
Q
L
N
R
P
N
Site 142
S795
S
S
S
L
Y
A
S
S
Q
L
N
R
P
N
S
Site 143
S802
S
Q
L
N
R
P
N
S
L
V
G
I
T
S
A
Site 144
Y810
L
V
G
I
T
S
A
Y
S
R
G
I
T
K
E
Site 145
S811
V
G
I
T
S
A
Y
S
R
G
I
T
K
E
N
Site 146
T815
S
A
Y
S
R
G
I
T
K
E
N
E
R
E
G
Site 147
S835
E
K
E
G
E
D
K
S
Q
P
K
S
I
R
E
Site 148
S839
E
D
K
S
Q
P
K
S
I
R
E
R
R
R
P
Site 149
S852
R
P
R
E
K
R
R
S
T
G
V
S
F
W
T
Site 150
T853
P
R
E
K
R
R
S
T
G
V
S
F
W
T
Q
Site 151
S856
K
R
R
S
T
G
V
S
F
W
T
Q
D
S
D
Site 152
T859
S
T
G
V
S
F
W
T
Q
D
S
D
E
N
E
Site 153
S862
V
S
F
W
T
Q
D
S
D
E
N
E
Q
E
Q
Site 154
S871
E
N
E
Q
E
Q
Q
S
D
T
E
E
G
S
N
Site 155
T873
E
Q
E
Q
Q
S
D
T
E
E
G
S
N
K
K
Site 156
S877
Q
S
D
T
E
E
G
S
N
K
K
E
T
Q
T
Site 157
T882
E
G
S
N
K
K
E
T
Q
T
D
S
I
S
R
Site 158
T884
S
N
K
K
E
T
Q
T
D
S
I
S
R
Y
E
Site 159
S886
K
K
E
T
Q
T
D
S
I
S
R
Y
E
T
S
Site 160
S888
E
T
Q
T
D
S
I
S
R
Y
E
T
S
S
T
Site 161
Y890
Q
T
D
S
I
S
R
Y
E
T
S
S
T
S
A
Site 162
T892
D
S
I
S
R
Y
E
T
S
S
T
S
A
G
D
Site 163
S893
S
I
S
R
Y
E
T
S
S
T
S
A
G
D
R
Site 164
S894
I
S
R
Y
E
T
S
S
T
S
A
G
D
R
Y
Site 165
T895
S
R
Y
E
T
S
S
T
S
A
G
D
R
Y
D
Site 166
S896
R
Y
E
T
S
S
T
S
A
G
D
R
Y
D
S
Site 167
Y901
S
T
S
A
G
D
R
Y
D
S
L
L
G
R
S
Site 168
S903
S
A
G
D
R
Y
D
S
L
L
G
R
S
G
S
Site 169
S908
Y
D
S
L
L
G
R
S
G
S
Y
S
Y
L
E
Site 170
S910
S
L
L
G
R
S
G
S
Y
S
Y
L
E
E
R
Site 171
Y911
L
L
G
R
S
G
S
Y
S
Y
L
E
E
R
K
Site 172
S912
L
G
R
S
G
S
Y
S
Y
L
E
E
R
K
P
Site 173
Y913
G
R
S
G
S
Y
S
Y
L
E
E
R
K
P
Y
Site 174
Y920
Y
L
E
E
R
K
P
Y
S
S
R
L
E
K
D
Site 175
S921
L
E
E
R
K
P
Y
S
S
R
L
E
K
D
D
Site 176
S922
E
E
R
K
P
Y
S
S
R
L
E
K
D
D
S
Site 177
S929
S
R
L
E
K
D
D
S
T
D
F
K
K
L
Y
Site 178
T930
R
L
E
K
D
D
S
T
D
F
K
K
L
Y
E
Site 179
Y936
S
T
D
F
K
K
L
Y
E
Q
I
L
A
E
N
Site 180
T953
L
K
A
Q
L
H
D
T
N
M
E
L
T
D
L
Site 181
S978
Q
E
R
F
A
D
R
S
L
L
E
M
E
K
R
Site 182
S995
R
A
L
E
R
R
I
S
E
M
E
E
E
L
K
Site 183
S1029
I
R
V
I
S
K
L
S
K
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation