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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GAK
Full Name:
Cyclin-G-associated kinase
Alias:
Cyclin G associated kinase; EC 2.7.11.1; Kinase GAK
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; NAK family
Mass (Da):
143191
Number AA:
1311
UniProt ID:
O14976
International Prot ID:
IPI00298949
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005925
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0031072
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
D
F
L
A
G
P
G
S
L
G
G
A
S
G
R
Site 2
S21
P
G
S
L
G
G
A
S
G
R
D
Q
S
D
F
Site 3
S26
G
A
S
G
R
D
Q
S
D
F
V
G
Q
T
V
Site 4
T32
Q
S
D
F
V
G
Q
T
V
E
L
G
E
L
R
Site 5
Y55
E
G
G
F
A
F
V
Y
E
A
Q
D
V
G
S
Site 6
S62
Y
E
A
Q
D
V
G
S
G
R
E
Y
A
L
K
Site 7
Y66
D
V
G
S
G
R
E
Y
A
L
K
R
L
L
S
Site 8
S73
Y
A
L
K
R
L
L
S
N
E
E
E
K
N
R
Site 9
S112
A
S
I
G
K
E
E
S
D
T
G
Q
A
E
F
Site 10
T114
I
G
K
E
E
S
D
T
G
Q
A
E
F
L
L
Site 11
S139
E
F
L
K
K
M
E
S
R
G
P
L
S
C
D
Site 12
S144
M
E
S
R
G
P
L
S
C
D
T
V
L
K
I
Site 13
Y153
D
T
V
L
K
I
F
Y
Q
T
C
R
A
V
Q
Site 14
S182
K
V
E
N
L
L
L
S
N
Q
G
T
I
K
L
Site 15
Y201
S
A
T
T
I
S
H
Y
P
D
Y
S
W
S
A
Site 16
Y204
T
I
S
H
Y
P
D
Y
S
W
S
A
Q
R
R
Site 17
S205
I
S
H
Y
P
D
Y
S
W
S
A
Q
R
R
A
Site 18
T219
A
L
V
E
E
E
I
T
R
N
T
T
P
M
Y
Site 19
T222
E
E
E
I
T
R
N
T
T
P
M
Y
R
T
P
Site 20
T223
E
E
I
T
R
N
T
T
P
M
Y
R
T
P
E
Site 21
Y226
T
R
N
T
T
P
M
Y
R
T
P
E
I
I
D
Site 22
T228
N
T
T
P
M
Y
R
T
P
E
I
I
D
L
Y
Site 23
Y235
T
P
E
I
I
D
L
Y
S
N
F
P
I
G
E
Site 24
S236
P
E
I
I
D
L
Y
S
N
F
P
I
G
E
K
Site 25
Y276
L
R
I
V
N
G
K
Y
S
I
P
P
H
D
T
Site 26
S277
R
I
V
N
G
K
Y
S
I
P
P
H
D
T
Q
Site 27
Y285
I
P
P
H
D
T
Q
Y
T
V
F
H
S
L
I
Site 28
T286
P
P
H
D
T
Q
Y
T
V
F
H
S
L
I
R
Site 29
S290
T
Q
Y
T
V
F
H
S
L
I
R
A
M
L
Q
Site 30
S305
V
N
P
E
E
R
L
S
I
A
E
V
V
H
Q
Site 31
S326
A
R
N
V
N
P
K
S
P
I
T
E
L
L
E
Site 32
Y338
L
L
E
Q
N
G
G
Y
G
S
A
T
L
S
R
Site 33
S340
E
Q
N
G
G
Y
G
S
A
T
L
S
R
G
P
Site 34
T342
N
G
G
Y
G
S
A
T
L
S
R
G
P
P
P
Site 35
S344
G
Y
G
S
A
T
L
S
R
G
P
P
P
P
V
Site 36
S356
P
P
V
G
P
A
G
S
G
Y
S
G
G
L
A
Site 37
Y367
G
G
L
A
L
A
E
Y
D
Q
P
Y
G
G
F
Site 38
Y371
L
A
E
Y
D
Q
P
Y
G
G
F
L
D
I
L
Site 39
T387
G
G
T
E
R
L
F
T
N
L
K
D
T
S
S
Site 40
S394
T
N
L
K
D
T
S
S
K
V
I
Q
S
V
A
Site 41
S399
T
S
S
K
V
I
Q
S
V
A
N
Y
A
K
G
Site 42
Y403
V
I
Q
S
V
A
N
Y
A
K
G
D
L
D
I
Site 43
S411
A
K
G
D
L
D
I
S
Y
I
T
S
R
I
A
Site 44
S421
T
S
R
I
A
V
M
S
F
P
A
E
G
V
E
Site 45
S444
D
V
R
L
F
L
D
S
K
H
P
G
H
Y
A
Site 46
S456
H
Y
A
V
Y
N
L
S
P
R
T
Y
R
P
S
Site 47
T459
V
Y
N
L
S
P
R
T
Y
R
P
S
R
F
H
Site 48
Y460
Y
N
L
S
P
R
T
Y
R
P
S
R
F
H
N
Site 49
S463
S
P
R
T
Y
R
P
S
R
F
H
N
R
V
S
Site 50
Y558
S
H
K
R
Y
I
E
Y
M
C
D
M
V
A
E
Site 51
T569
M
V
A
E
E
P
I
T
P
H
S
K
P
I
L
Site 52
S572
E
E
P
I
T
P
H
S
K
P
I
L
V
R
A
Site 53
S589
M
T
P
V
P
L
F
S
K
Q
R
S
G
C
R
Site 54
S593
P
L
F
S
K
Q
R
S
G
C
R
P
F
C
E
Site 55
Y602
C
R
P
F
C
E
V
Y
V
G
D
E
R
V
A
Site 56
S610
V
G
D
E
R
V
A
S
T
S
Q
E
Y
D
K
Site 57
S612
D
E
R
V
A
S
T
S
Q
E
Y
D
K
M
R
Site 58
Y615
V
A
S
T
S
Q
E
Y
D
K
M
R
D
F
K
Site 59
T650
V
I
Y
H
A
R
S
T
L
G
G
R
L
Q
A
Site 60
T679
G
F
V
P
R
N
A
T
T
V
K
F
A
K
Y
Site 61
Y686
T
T
V
K
F
A
K
Y
D
L
D
A
C
D
I
Site 62
Y697
A
C
D
I
Q
E
K
Y
P
D
L
F
Q
V
N
Site 63
S716
V
E
P
R
D
R
P
S
R
E
A
P
P
W
E
Site 64
S725
E
A
P
P
W
E
N
S
S
M
R
G
L
N
P
Site 65
S726
A
P
P
W
E
N
S
S
M
R
G
L
N
P
K
Site 66
S737
L
N
P
K
I
L
F
S
S
R
E
E
Q
Q
D
Site 67
S747
E
E
Q
Q
D
I
L
S
K
F
G
K
P
E
L
Site 68
S760
E
L
P
R
Q
P
G
S
T
A
Q
Y
D
A
G
Site 69
Y764
Q
P
G
S
T
A
Q
Y
D
A
G
A
G
S
P
Site 70
S770
Q
Y
D
A
G
A
G
S
P
E
A
E
P
T
D
Site 71
T776
G
S
P
E
A
E
P
T
D
S
D
S
P
P
S
Site 72
S778
P
E
A
E
P
T
D
S
D
S
P
P
S
S
S
Site 73
S780
A
E
P
T
D
S
D
S
P
P
S
S
S
A
D
Site 74
S783
T
D
S
D
S
P
P
S
S
S
A
D
A
S
R
Site 75
S784
D
S
D
S
P
P
S
S
S
A
D
A
S
R
F
Site 76
S785
S
D
S
P
P
S
S
S
A
D
A
S
R
F
L
Site 77
S789
P
S
S
S
A
D
A
S
R
F
L
H
T
L
D
Site 78
T805
Q
E
E
K
E
A
E
T
G
A
E
N
A
S
S
Site 79
S811
E
T
G
A
E
N
A
S
S
K
E
S
E
S
A
Site 80
S812
T
G
A
E
N
A
S
S
K
E
S
E
S
A
L
Site 81
S815
E
N
A
S
S
K
E
S
E
S
A
L
M
E
D
Site 82
S817
A
S
S
K
E
S
E
S
A
L
M
E
D
R
D
Site 83
S826
L
M
E
D
R
D
E
S
E
V
S
D
E
G
G
Site 84
S829
D
R
D
E
S
E
V
S
D
E
G
G
S
P
I
Site 85
S834
E
V
S
D
E
G
G
S
P
I
S
S
E
G
Q
Site 86
S837
D
E
G
G
S
P
I
S
S
E
G
Q
E
P
R
Site 87
S838
E
G
G
S
P
I
S
S
E
G
Q
E
P
R
A
Site 88
S906
Q
A
C
K
A
P
S
S
N
T
D
L
L
S
C
Site 89
S912
S
S
N
T
D
L
L
S
C
L
L
G
P
P
E
Site 90
S922
L
G
P
P
E
A
A
S
Q
G
P
P
E
D
L
Site 91
S931
G
P
P
E
D
L
L
S
E
D
P
L
L
L
A
Site 92
S939
E
D
P
L
L
L
A
S
P
A
P
P
L
S
V
Site 93
S945
A
S
P
A
P
P
L
S
V
Q
S
T
P
R
G
Site 94
S948
A
P
P
L
S
V
Q
S
T
P
R
G
G
P
P
Site 95
T949
P
P
L
S
V
Q
S
T
P
R
G
G
P
P
A
Site 96
S967
P
F
G
P
L
L
P
S
S
G
N
N
S
Q
P
Site 97
S968
F
G
P
L
L
P
S
S
G
N
N
S
Q
P
C
Site 98
S972
L
P
S
S
G
N
N
S
Q
P
C
S
N
P
D
Site 99
S976
G
N
N
S
Q
P
C
S
N
P
D
L
F
G
E
Site 100
S989
G
E
F
L
N
S
D
S
V
T
V
P
P
S
F
Site 101
T991
F
L
N
S
D
S
V
T
V
P
P
S
F
P
S
Site 102
S995
D
S
V
T
V
P
P
S
F
P
S
A
H
S
A
Site 103
S998
T
V
P
P
S
F
P
S
A
H
S
A
P
P
P
Site 104
S1001
P
S
F
P
S
A
H
S
A
P
P
P
S
C
S
Site 105
S1006
A
H
S
A
P
P
P
S
C
S
A
D
F
L
H
Site 106
S1008
S
A
P
P
P
S
C
S
A
D
F
L
H
L
G
Site 107
S1022
G
D
L
P
G
E
P
S
K
M
T
A
S
S
S
Site 108
T1025
P
G
E
P
S
K
M
T
A
S
S
S
N
P
D
Site 109
S1028
P
S
K
M
T
A
S
S
S
N
P
D
L
L
G
Site 110
S1029
S
K
M
T
A
S
S
S
N
P
D
L
L
G
G
Site 111
S1060
A
T
E
G
P
L
F
S
P
G
G
Q
P
A
P
Site 112
S1070
G
Q
P
A
P
C
G
S
Q
A
S
W
T
K
S
Site 113
S1073
A
P
C
G
S
Q
A
S
W
T
K
S
Q
N
P
Site 114
S1077
S
Q
A
S
W
T
K
S
Q
N
P
D
P
F
A
Site 115
S1090
F
A
D
L
G
D
L
S
S
G
L
Q
G
S
P
Site 116
S1091
A
D
L
G
D
L
S
S
G
L
Q
G
S
P
A
Site 117
S1096
L
S
S
G
L
Q
G
S
P
A
G
F
P
P
G
Site 118
T1109
P
G
G
F
I
P
K
T
A
T
T
P
K
G
S
Site 119
T1111
G
F
I
P
K
T
A
T
T
P
K
G
S
S
S
Site 120
T1112
F
I
P
K
T
A
T
T
P
K
G
S
S
S
W
Site 121
S1116
T
A
T
T
P
K
G
S
S
S
W
Q
T
S
R
Site 122
S1118
T
T
P
K
G
S
S
S
W
Q
T
S
R
P
P
Site 123
T1121
K
G
S
S
S
W
Q
T
S
R
P
P
A
Q
G
Site 124
S1122
G
S
S
S
W
Q
T
S
R
P
P
A
Q
G
A
Site 125
S1130
R
P
P
A
Q
G
A
S
W
P
P
Q
A
K
P
Site 126
T1143
K
P
P
P
K
A
C
T
Q
P
R
P
N
Y
A
Site 127
Y1149
C
T
Q
P
R
P
N
Y
A
S
N
F
S
V
I
Site 128
S1151
Q
P
R
P
N
Y
A
S
N
F
S
V
I
G
A
Site 129
S1168
E
R
G
V
R
A
P
S
F
A
Q
K
P
K
V
Site 130
S1176
F
A
Q
K
P
K
V
S
E
N
D
F
E
D
L
Site 131
S1185
N
D
F
E
D
L
L
S
N
Q
G
F
S
S
R
Site 132
S1190
L
L
S
N
Q
G
F
S
S
R
S
D
K
K
G
Site 133
S1191
L
S
N
Q
G
F
S
S
R
S
D
K
K
G
P
Site 134
T1200
S
D
K
K
G
P
K
T
I
A
E
M
R
K
Q
Site 135
T1213
K
Q
D
L
A
K
D
T
D
P
L
K
L
K
L
Site 136
T1250
W
D
G
E
S
R
W
T
P
V
G
M
A
D
L
Site 137
Y1267
P
E
Q
V
K
K
H
Y
R
R
A
V
L
A
V
Site 138
S1300
M
E
L
N
D
A
W
S
E
F
E
N
Q
G
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation