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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Per2
Full Name:
Period circadian protein homolog 2
Alias:
Circadian clock protein PERIOD 2; HPER2; KIAA0347; Period 2; Period circadian protein 2
Type:
Transcription protein
Mass (Da):
136579
Number AA:
1255
UniProt ID:
O15055
International Prot ID:
IPI00004516
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007623
GO:0006355
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
A
E
F
P
P
S
P
S
N
P
T
K
E
P
V
Site 2
T15
P
P
S
P
S
N
P
T
K
E
P
V
E
P
Q
Site 3
S24
E
P
V
E
P
Q
P
S
Q
V
P
L
Q
E
D
Site 4
S35
L
Q
E
D
V
D
M
S
S
G
S
S
G
H
E
Site 5
S36
Q
E
D
V
D
M
S
S
G
S
S
G
H
E
T
Site 6
S39
V
D
M
S
S
G
S
S
G
H
E
T
N
E
N
Site 7
T43
S
G
S
S
G
H
E
T
N
E
N
C
S
T
G
Site 8
S48
H
E
T
N
E
N
C
S
T
G
R
D
S
Q
G
Site 9
T49
E
T
N
E
N
C
S
T
G
R
D
S
Q
G
S
Site 10
S53
N
C
S
T
G
R
D
S
Q
G
S
D
C
D
D
Site 11
S56
T
G
R
D
S
Q
G
S
D
C
D
D
S
G
K
Site 12
S61
Q
G
S
D
C
D
D
S
G
K
E
L
G
M
L
Site 13
S77
E
P
P
D
A
R
Q
S
P
D
T
F
S
L
M
Site 14
T80
D
A
R
Q
S
P
D
T
F
S
L
M
M
A
K
Site 15
S82
R
Q
S
P
D
T
F
S
L
M
M
A
K
S
E
Site 16
S88
F
S
L
M
M
A
K
S
E
H
N
P
S
T
S
Site 17
S93
A
K
S
E
H
N
P
S
T
S
G
C
S
S
D
Site 18
T94
K
S
E
H
N
P
S
T
S
G
C
S
S
D
Q
Site 19
S95
S
E
H
N
P
S
T
S
G
C
S
S
D
Q
S
Site 20
S99
P
S
T
S
G
C
S
S
D
Q
S
S
K
V
D
Site 21
S102
S
G
C
S
S
D
Q
S
S
K
V
D
T
H
K
Site 22
S103
G
C
S
S
D
Q
S
S
K
V
D
T
H
K
E
Site 23
T107
D
Q
S
S
K
V
D
T
H
K
E
L
I
K
T
Site 24
T114
T
H
K
E
L
I
K
T
L
K
E
L
K
V
H
Site 25
S133
K
K
A
K
G
K
A
S
T
L
A
T
L
K
Y
Site 26
T137
G
K
A
S
T
L
A
T
L
K
Y
A
L
R
S
Site 27
Y140
S
T
L
A
T
L
K
Y
A
L
R
S
V
K
Q
Site 28
Y155
V
K
A
N
E
E
Y
Y
Q
L
L
M
S
S
E
Site 29
S160
E
Y
Y
Q
L
L
M
S
S
E
G
H
P
C
G
Site 30
S172
P
C
G
A
D
V
P
S
Y
T
V
E
E
M
E
Site 31
Y173
C
G
A
D
V
P
S
Y
T
V
E
E
M
E
S
Site 32
T174
G
A
D
V
P
S
Y
T
V
E
E
M
E
S
V
Site 33
S180
Y
T
V
E
E
M
E
S
V
T
S
E
H
I
V
Site 34
S223
H
C
K
R
D
A
F
S
D
A
K
F
V
E
F
Site 35
S241
H
D
V
G
V
F
H
S
F
T
S
P
Y
K
L
Site 36
Y246
F
H
S
F
T
S
P
Y
K
L
P
L
W
S
M
Site 37
S252
P
Y
K
L
P
L
W
S
M
C
S
G
A
D
S
Site 38
S259
S
M
C
S
G
A
D
S
F
T
Q
E
C
M
E
Site 39
T261
C
S
G
A
D
S
F
T
Q
E
C
M
E
E
K
Site 40
S275
K
S
F
F
C
R
V
S
V
R
K
S
H
E
N
Site 41
S279
C
R
V
S
V
R
K
S
H
E
N
E
I
R
Y
Site 42
Y286
S
H
E
N
E
I
R
Y
H
P
F
R
M
T
P
Site 43
T292
R
Y
H
P
F
R
M
T
P
Y
L
V
K
V
R
Site 44
Y294
H
P
F
R
M
T
P
Y
L
V
K
V
R
D
Q
Site 45
S306
R
D
Q
Q
G
A
E
S
Q
L
C
C
L
L
L
Site 46
S319
L
L
A
E
R
V
H
S
G
Y
E
A
P
R
I
Site 47
Y321
A
E
R
V
H
S
G
Y
E
A
P
R
I
P
P
Site 48
T334
P
P
E
K
R
I
F
T
T
T
H
T
P
N
C
Site 49
T336
E
K
R
I
F
T
T
T
H
T
P
N
C
L
F
Site 50
T338
R
I
F
T
T
T
H
T
P
N
C
L
F
Q
D
Site 51
Y395
S
G
G
Q
P
F
D
Y
S
P
I
R
F
R
A
Site 52
S396
G
G
Q
P
F
D
Y
S
P
I
R
F
R
A
R
Site 53
T409
A
R
N
G
E
Y
I
T
L
D
T
S
W
S
S
Site 54
T412
G
E
Y
I
T
L
D
T
S
W
S
S
F
I
N
Site 55
S413
E
Y
I
T
L
D
T
S
W
S
S
F
I
N
P
Site 56
S416
T
L
D
T
S
W
S
S
F
I
N
P
W
S
R
Site 57
S426
N
P
W
S
R
K
I
S
F
I
I
G
R
H
K
Site 58
T450
V
F
A
A
H
P
C
T
E
E
K
A
L
H
P
Site 59
S477
L
L
Q
P
V
P
H
S
G
S
S
G
Y
G
S
Site 60
S479
Q
P
V
P
H
S
G
S
S
G
Y
G
S
L
G
Site 61
S480
P
V
P
H
S
G
S
S
G
Y
G
S
L
G
S
Site 62
Y482
P
H
S
G
S
S
G
Y
G
S
L
G
S
N
G
Site 63
S484
S
G
S
S
G
Y
G
S
L
G
S
N
G
S
H
Site 64
S487
S
G
Y
G
S
L
G
S
N
G
S
H
E
H
L
Site 65
S490
G
S
L
G
S
N
G
S
H
E
H
L
M
S
Q
Site 66
S496
G
S
H
E
H
L
M
S
Q
T
S
S
S
D
S
Site 67
S499
E
H
L
M
S
Q
T
S
S
S
D
S
N
G
H
Site 68
S500
H
L
M
S
Q
T
S
S
S
D
S
N
G
H
E
Site 69
S501
L
M
S
Q
T
S
S
S
D
S
N
G
H
E
D
Site 70
S503
S
Q
T
S
S
S
D
S
N
G
H
E
D
S
R
Site 71
S509
D
S
N
G
H
E
D
S
R
R
R
R
A
E
I
Site 72
S527
G
N
K
T
K
N
R
S
H
Y
S
H
E
S
G
Site 73
Y529
K
T
K
N
R
S
H
Y
S
H
E
S
G
E
Q
Site 74
S530
T
K
N
R
S
H
Y
S
H
E
S
G
E
Q
K
Site 75
S533
R
S
H
Y
S
H
E
S
G
E
Q
K
K
K
S
Site 76
S540
S
G
E
Q
K
K
K
S
V
T
E
M
Q
T
N
Site 77
T546
K
S
V
T
E
M
Q
T
N
P
P
A
E
K
K
Site 78
S562
V
P
A
M
E
K
D
S
L
G
V
S
F
P
E
Site 79
S566
E
K
D
S
L
G
V
S
F
P
E
E
L
A
C
Site 80
Y581
K
N
Q
P
T
C
S
Y
Q
Q
I
S
C
L
D
Site 81
S589
Q
Q
I
S
C
L
D
S
V
I
R
Y
L
E
S
Site 82
Y593
C
L
D
S
V
I
R
Y
L
E
S
C
N
E
A
Site 83
S619
N
V
P
A
L
R
S
S
D
K
R
K
A
T
V
Site 84
T625
S
S
D
K
R
K
A
T
V
S
P
G
P
H
A
Site 85
S627
D
K
R
K
A
T
V
S
P
G
P
H
A
G
E
Site 86
S639
A
G
E
A
E
P
P
S
R
V
N
S
R
T
G
Site 87
S643
E
P
P
S
R
V
N
S
R
T
G
V
G
T
H
Site 88
T645
P
S
R
V
N
S
R
T
G
V
G
T
H
L
T
Site 89
T649
N
S
R
T
G
V
G
T
H
L
T
S
L
A
L
Site 90
S662
A
L
P
G
K
A
E
S
V
A
S
L
T
S
Q
Site 91
S665
G
K
A
E
S
V
A
S
L
T
S
Q
C
S
Y
Site 92
T667
A
E
S
V
A
S
L
T
S
Q
C
S
Y
S
S
Site 93
S668
E
S
V
A
S
L
T
S
Q
C
S
Y
S
S
T
Site 94
S671
A
S
L
T
S
Q
C
S
Y
S
S
T
I
V
H
Site 95
T675
S
Q
C
S
Y
S
S
T
I
V
H
V
G
D
K
Site 96
S696
E
M
V
E
D
A
A
S
G
P
E
S
L
D
C
Site 97
S700
D
A
A
S
G
P
E
S
L
D
C
L
A
G
P
Site 98
S714
P
A
L
A
C
G
L
S
Q
E
K
E
P
F
K
Site 99
S740
H
T
Q
K
E
E
Q
S
F
L
Q
K
F
K
E
Site 100
Y760
I
F
Q
S
H
C
H
Y
Y
L
Q
E
R
S
K
Site 101
Y761
F
Q
S
H
C
H
Y
Y
L
Q
E
R
S
K
G
Site 102
S771
E
R
S
K
G
Q
P
S
E
R
T
A
P
G
L
Site 103
T774
K
G
Q
P
S
E
R
T
A
P
G
L
R
N
T
Site 104
T781
T
A
P
G
L
R
N
T
S
G
I
D
S
P
W
Site 105
S782
A
P
G
L
R
N
T
S
G
I
D
S
P
W
K
Site 106
S786
R
N
T
S
G
I
D
S
P
W
K
K
T
G
K
Site 107
S799
G
K
N
R
K
L
K
S
K
R
V
K
P
R
D
Site 108
S807
K
R
V
K
P
R
D
S
S
E
S
T
G
S
G
Site 109
S808
R
V
K
P
R
D
S
S
E
S
T
G
S
G
G
Site 110
S810
K
P
R
D
S
S
E
S
T
G
S
G
G
P
V
Site 111
T811
P
R
D
S
S
E
S
T
G
S
G
G
P
V
S
Site 112
S813
D
S
S
E
S
T
G
S
G
G
P
V
S
A
R
Site 113
S818
T
G
S
G
G
P
V
S
A
R
P
P
L
V
G
Site 114
S832
G
L
N
A
T
A
W
S
P
S
D
T
S
Q
S
Site 115
S834
N
A
T
A
W
S
P
S
D
T
S
Q
S
S
C
Site 116
T836
T
A
W
S
P
S
D
T
S
Q
S
S
C
P
A
Site 117
S837
A
W
S
P
S
D
T
S
Q
S
S
C
P
A
V
Site 118
S839
S
P
S
D
T
S
Q
S
S
C
P
A
V
P
F
Site 119
S840
P
S
D
T
S
Q
S
S
C
P
A
V
P
F
P
Site 120
T864
P
V
F
P
A
P
G
T
V
A
A
P
P
A
P
Site 121
S912
A
F
M
L
P
S
Y
S
F
P
S
G
T
P
N
Site 122
S915
L
P
S
Y
S
F
P
S
G
T
P
N
L
P
Q
Site 123
T917
S
Y
S
F
P
S
G
T
P
N
L
P
Q
A
F
Site 124
S927
L
P
Q
A
F
F
P
S
Q
P
Q
F
P
S
H
Site 125
S933
P
S
Q
P
Q
F
P
S
H
P
T
L
T
S
E
Site 126
S939
P
S
H
P
T
L
T
S
E
M
A
S
A
S
Q
Site 127
S943
T
L
T
S
E
M
A
S
A
S
Q
P
E
F
P
Site 128
S945
T
S
E
M
A
S
A
S
Q
P
E
F
P
S
R
Site 129
S951
A
S
Q
P
E
F
P
S
R
T
S
I
P
R
Q
Site 130
S954
P
E
F
P
S
R
T
S
I
P
R
Q
P
C
A
Site 131
T965
Q
P
C
A
C
P
A
T
R
A
T
P
P
S
A
Site 132
T968
A
C
P
A
T
R
A
T
P
P
S
A
M
G
R
Site 133
S971
A
T
R
A
T
P
P
S
A
M
G
R
A
S
P
Site 134
S977
P
S
A
M
G
R
A
S
P
P
L
F
Q
S
R
Site 135
S983
A
S
P
P
L
F
Q
S
R
S
S
S
P
L
Q
Site 136
S985
P
P
L
F
Q
S
R
S
S
S
P
L
Q
L
N
Site 137
S986
P
L
F
Q
S
R
S
S
S
P
L
Q
L
N
L
Site 138
S987
L
F
Q
S
R
S
S
S
P
L
Q
L
N
L
L
Site 139
T1004
E
E
A
P
E
G
G
T
G
A
M
G
T
T
G
Site 140
T1026
G
A
D
C
K
P
G
T
S
R
D
Q
Q
P
K
Site 141
T1037
Q
Q
P
K
A
P
L
T
R
D
E
P
S
D
T
Site 142
S1042
P
L
T
R
D
E
P
S
D
T
Q
N
S
D
A
Site 143
T1044
T
R
D
E
P
S
D
T
Q
N
S
D
A
L
S
Site 144
S1047
E
P
S
D
T
Q
N
S
D
A
L
S
T
S
S
Site 145
S1051
T
Q
N
S
D
A
L
S
T
S
S
G
L
L
N
Site 146
S1069
N
E
D
L
C
S
A
S
G
S
A
A
S
E
S
Site 147
S1071
D
L
C
S
A
S
G
S
A
A
S
E
S
L
G
Site 148
S1074
S
A
S
G
S
A
A
S
E
S
L
G
S
G
S
Site 149
S1076
S
G
S
A
A
S
E
S
L
G
S
G
S
L
G
Site 150
S1081
S
E
S
L
G
S
G
S
L
G
C
D
A
S
P
Site 151
S1087
G
S
L
G
C
D
A
S
P
S
G
A
G
S
S
Site 152
S1089
L
G
C
D
A
S
P
S
G
A
G
S
S
D
T
Site 153
S1093
A
S
P
S
G
A
G
S
S
D
T
S
H
T
S
Site 154
S1094
S
P
S
G
A
G
S
S
D
T
S
H
T
S
K
Site 155
T1096
S
G
A
G
S
S
D
T
S
H
T
S
K
Y
F
Site 156
S1097
G
A
G
S
S
D
T
S
H
T
S
K
Y
F
G
Site 157
S1100
S
S
D
T
S
H
T
S
K
Y
F
G
S
I
D
Site 158
Y1102
D
T
S
H
T
S
K
Y
F
G
S
I
D
S
S
Site 159
S1105
H
T
S
K
Y
F
G
S
I
D
S
S
E
N
N
Site 160
S1108
K
Y
F
G
S
I
D
S
S
E
N
N
H
K
A
Site 161
S1109
Y
F
G
S
I
D
S
S
E
N
N
H
K
A
K
Site 162
T1150
A
D
S
S
V
M
M
T
Y
Q
L
P
S
R
N
Site 163
Y1151
D
S
S
V
M
M
T
Y
Q
L
P
S
R
N
L
Site 164
T1180
Q
K
L
Q
P
R
F
T
E
S
Q
K
Q
E
L
Site 165
S1182
L
Q
P
R
F
T
E
S
Q
K
Q
E
L
R
E
Site 166
Y1223
K
G
N
I
C
I
P
Y
E
E
D
I
P
S
L
Site 167
S1229
P
Y
E
E
D
I
P
S
L
G
L
S
E
V
S
Site 168
S1233
D
I
P
S
L
G
L
S
E
V
S
D
T
K
E
Site 169
S1236
S
L
G
L
S
E
V
S
D
T
K
E
D
E
N
Site 170
T1238
G
L
S
E
V
S
D
T
K
E
D
E
N
G
S
Site 171
S1245
T
K
E
D
E
N
G
S
P
L
N
H
R
I
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation