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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
axin 1
Full Name:
Axin-1
Alias:
Axin; Axin1; Axis inhibition protein 1; AXN1
Type:
Adapter/scaffold protein
Mass (Da):
95635
Number AA:
862
UniProt ID:
O15169
International Prot ID:
IPI00747002
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030877
GO:0005829
GO:0016328
Uniprot
OncoNet
Molecular Function:
GO:0070411
GO:0070016
GO:0008013
PhosphoSite+
KinaseNET
Biological Process:
GO:0060070
GO:0006915
GO:0030178
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
F
P
L
D
L
G
A
S
F
T
E
D
A
P
R
Site 2
S34
G
E
E
G
E
L
V
S
T
D
P
R
P
A
S
Site 3
T35
E
E
G
E
L
V
S
T
D
P
R
P
A
S
Y
Site 4
S41
S
T
D
P
R
P
A
S
Y
S
F
C
S
G
K
Site 5
Y42
T
D
P
R
P
A
S
Y
S
F
C
S
G
K
G
Site 6
S43
D
P
R
P
A
S
Y
S
F
C
S
G
K
G
V
Site 7
S46
P
A
S
Y
S
F
C
S
G
K
G
V
G
I
K
Site 8
T58
G
I
K
G
E
T
S
T
A
T
P
R
R
S
D
Site 9
T60
K
G
E
T
S
T
A
T
P
R
R
S
D
L
D
Site 10
S64
S
T
A
T
P
R
R
S
D
L
D
L
G
Y
E
Site 11
Y70
R
S
D
L
D
L
G
Y
E
P
E
G
S
A
S
Site 12
S75
L
G
Y
E
P
E
G
S
A
S
P
T
P
P
Y
Site 13
S77
Y
E
P
E
G
S
A
S
P
T
P
P
Y
L
K
Site 14
T79
P
E
G
S
A
S
P
T
P
P
Y
L
K
W
A
Site 15
Y82
S
A
S
P
T
P
P
Y
L
K
W
A
E
S
L
Site 16
S88
P
Y
L
K
W
A
E
S
L
H
S
L
L
D
D
Site 17
S91
K
W
A
E
S
L
H
S
L
L
D
D
Q
D
G
Site 18
T104
D
G
I
S
L
F
R
T
F
L
K
Q
E
G
C
Site 19
S132
R
K
L
E
P
C
D
S
N
E
E
K
R
L
K
Site 20
Y145
L
K
L
A
R
A
I
Y
R
K
Y
I
L
D
N
Site 21
Y148
A
R
A
I
Y
R
K
Y
I
L
D
N
N
G
I
Site 22
T160
N
G
I
V
S
R
Q
T
K
P
A
T
K
S
F
Site 23
T164
S
R
Q
T
K
P
A
T
K
S
F
I
K
G
C
Site 24
T192
A
Q
T
E
I
Q
A
T
M
E
E
N
T
Y
P
Site 25
Y198
A
T
M
E
E
N
T
Y
P
S
F
L
K
S
D
Site 26
S200
M
E
E
N
T
Y
P
S
F
L
K
S
D
I
Y
Site 27
S204
T
Y
P
S
F
L
K
S
D
I
Y
L
E
Y
T
Site 28
Y207
S
F
L
K
S
D
I
Y
L
E
Y
T
R
T
G
Site 29
Y210
K
S
D
I
Y
L
E
Y
T
R
T
G
S
E
S
Site 30
T211
S
D
I
Y
L
E
Y
T
R
T
G
S
E
S
P
Site 31
T213
I
Y
L
E
Y
T
R
T
G
S
E
S
P
K
V
Site 32
S215
L
E
Y
T
R
T
G
S
E
S
P
K
V
C
S
Site 33
S217
Y
T
R
T
G
S
E
S
P
K
V
C
S
D
Q
Site 34
S222
S
E
S
P
K
V
C
S
D
Q
S
S
G
S
G
Site 35
S225
P
K
V
C
S
D
Q
S
S
G
S
G
T
G
K
Site 36
S226
K
V
C
S
D
Q
S
S
G
S
G
T
G
K
G
Site 37
S228
C
S
D
Q
S
S
G
S
G
T
G
K
G
I
S
Site 38
T230
D
Q
S
S
G
S
G
T
G
K
G
I
S
G
Y
Site 39
S235
S
G
T
G
K
G
I
S
G
Y
L
P
T
L
N
Site 40
Y237
T
G
K
G
I
S
G
Y
L
P
T
L
N
E
D
Site 41
T275
P
Q
K
L
L
L
E
T
A
A
P
R
V
S
S
Site 42
S281
E
T
A
A
P
R
V
S
S
S
R
R
Y
S
E
Site 43
S282
T
A
A
P
R
V
S
S
S
R
R
Y
S
E
G
Site 44
S283
A
A
P
R
V
S
S
S
R
R
Y
S
E
G
R
Site 45
Y286
R
V
S
S
S
R
R
Y
S
E
G
R
E
F
R
Site 46
S287
V
S
S
S
R
R
Y
S
E
G
R
E
F
R
Y
Site 47
Y294
S
E
G
R
E
F
R
Y
G
S
W
R
E
P
V
Site 48
S296
G
R
E
F
R
Y
G
S
W
R
E
P
V
N
P
Site 49
Y304
W
R
E
P
V
N
P
Y
Y
V
N
A
G
Y
A
Site 50
Y305
R
E
P
V
N
P
Y
Y
V
N
A
G
Y
A
L
Site 51
S317
Y
A
L
A
P
A
T
S
A
N
D
S
E
Q
Q
Site 52
S321
P
A
T
S
A
N
D
S
E
Q
Q
S
L
S
S
Site 53
S325
A
N
D
S
E
Q
Q
S
L
S
S
D
A
D
T
Site 54
S327
D
S
E
Q
Q
S
L
S
S
D
A
D
T
L
S
Site 55
S328
S
E
Q
Q
S
L
S
S
D
A
D
T
L
S
L
Site 56
T332
S
L
S
S
D
A
D
T
L
S
L
T
D
S
S
Site 57
S334
S
S
D
A
D
T
L
S
L
T
D
S
S
V
D
Site 58
T336
D
A
D
T
L
S
L
T
D
S
S
V
D
G
I
Site 59
S338
D
T
L
S
L
T
D
S
S
V
D
G
I
P
P
Site 60
S339
T
L
S
L
T
D
S
S
V
D
G
I
P
P
Y
Site 61
Y346
S
V
D
G
I
P
P
Y
R
I
R
K
Q
H
R
Site 62
S359
H
R
R
E
M
Q
E
S
V
Q
V
N
G
R
V
Site 63
T374
P
L
P
H
I
P
R
T
Y
R
V
P
K
E
V
Site 64
Y375
L
P
H
I
P
R
T
Y
R
V
P
K
E
V
R
Site 65
S428
E
G
E
D
G
D
P
S
S
G
P
P
G
P
C
Site 66
S429
G
E
D
G
D
P
S
S
G
P
P
G
P
C
H
Site 67
S469
A
H
E
E
N
P
E
S
I
L
D
E
H
V
Q
Site 68
T481
H
V
Q
R
V
L
R
T
P
G
R
Q
S
P
G
Site 69
S486
L
R
T
P
G
R
Q
S
P
G
P
G
H
R
S
Site 70
S493
S
P
G
P
G
H
R
S
P
D
S
G
H
V
A
Site 71
S496
P
G
H
R
S
P
D
S
G
H
V
A
K
M
P
Site 72
S520
H
G
K
H
V
P
K
S
G
A
K
L
D
A
A
Site 73
T555
E
Q
V
E
A
E
A
T
R
R
A
Q
S
S
F
Site 74
S560
E
A
T
R
R
A
Q
S
S
F
A
W
G
L
E
Site 75
S561
A
T
R
R
A
Q
S
S
F
A
W
G
L
E
P
Site 76
S570
A
W
G
L
E
P
H
S
H
G
A
R
S
R
G
Site 77
S575
P
H
S
H
G
A
R
S
R
G
Y
S
E
S
V
Site 78
Y578
H
G
A
R
S
R
G
Y
S
E
S
V
G
A
A
Site 79
S579
G
A
R
S
R
G
Y
S
E
S
V
G
A
A
P
Site 80
S581
R
S
R
G
Y
S
E
S
V
G
A
A
P
N
A
Site 81
S589
V
G
A
A
P
N
A
S
D
G
L
A
H
S
G
Site 82
S611
R
N
A
K
K
A
E
S
G
K
S
A
S
T
E
Site 83
S614
K
K
A
E
S
G
K
S
A
S
T
E
V
P
G
Site 84
S616
A
E
S
G
K
S
A
S
T
E
V
P
G
A
S
Site 85
T617
E
S
G
K
S
A
S
T
E
V
P
G
A
S
E
Site 86
S623
S
T
E
V
P
G
A
S
E
D
A
E
K
N
Q
Site 87
S644
I
E
G
E
K
E
I
S
R
H
R
R
T
G
H
Site 88
T649
E
I
S
R
H
R
R
T
G
H
G
S
S
G
T
Site 89
S653
H
R
R
T
G
H
G
S
S
G
T
R
K
P
Q
Site 90
S654
R
R
T
G
H
G
S
S
G
T
R
K
P
Q
P
Site 91
T656
T
G
H
G
S
S
G
T
R
K
P
Q
P
H
E
Site 92
S665
K
P
Q
P
H
E
N
S
R
P
L
S
L
E
H
Site 93
S669
H
E
N
S
R
P
L
S
L
E
H
P
W
A
G
Site 94
S682
A
G
P
Q
L
R
T
S
V
Q
P
S
H
L
F
Site 95
S686
L
R
T
S
V
Q
P
S
H
L
F
I
Q
D
P
Site 96
T694
H
L
F
I
Q
D
P
T
M
P
P
H
P
A
P
Site 97
T705
H
P
A
P
N
P
L
T
Q
L
E
E
A
R
R
Site 98
S722
E
E
E
E
K
R
A
S
R
A
P
S
K
Q
R
Site 99
S726
K
R
A
S
R
A
P
S
K
Q
R
Y
V
Q
E
Site 100
Y730
R
A
P
S
K
Q
R
Y
V
Q
E
V
M
R
R
Site 101
S762
A
V
S
D
M
E
L
S
E
T
E
T
R
S
Q
Site 102
T764
S
D
M
E
L
S
E
T
E
T
R
S
Q
R
K
Site 103
S768
L
S
E
T
E
T
R
S
Q
R
K
V
G
G
G
Site 104
S776
Q
R
K
V
G
G
G
S
A
Q
P
C
D
S
I
Site 105
Y787
C
D
S
I
V
V
A
Y
Y
F
C
G
E
P
I
Site 106
Y788
D
S
I
V
V
A
Y
Y
F
C
G
E
P
I
P
Site 107
Y796
F
C
G
E
P
I
P
Y
R
T
L
V
R
G
R
Site 108
T815
G
Q
F
K
E
L
L
T
K
K
G
S
Y
R
Y
Site 109
S819
E
L
L
T
K
K
G
S
Y
R
Y
Y
F
K
K
Site 110
Y822
T
K
K
G
S
Y
R
Y
Y
F
K
K
V
S
D
Site 111
Y823
K
K
G
S
Y
R
Y
Y
F
K
K
V
S
D
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation