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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
p73
Full Name:
Tumor protein p73
Alias:
p53-like transcription factor; p53-related protein; P73; P73 alpha protein; p73-alpha; TP73; TRP73
Type:
Transcription protein
Mass (Da):
69623
Number AA:
636
UniProt ID:
O15350
International Prot ID:
IPI00006160
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003700
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0008630
GO:0006298
GO:0030308
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
Q
S
T
A
T
S
P
D
G
G
T
T
F
Site 2
T14
T
S
P
D
G
G
T
T
F
E
H
L
W
S
S
Site 3
S20
T
T
F
E
H
L
W
S
S
L
E
P
D
S
T
Site 4
S21
T
F
E
H
L
W
S
S
L
E
P
D
S
T
Y
Site 5
S26
W
S
S
L
E
P
D
S
T
Y
F
D
L
P
Q
Site 6
T27
S
S
L
E
P
D
S
T
Y
F
D
L
P
Q
S
Site 7
Y28
S
L
E
P
D
S
T
Y
F
D
L
P
Q
S
S
Site 8
S34
T
Y
F
D
L
P
Q
S
S
R
G
N
N
E
V
Site 9
S47
E
V
V
G
G
T
D
S
S
M
D
V
F
H
L
Site 10
S69
M
A
Q
F
N
L
L
S
S
T
M
D
Q
M
S
Site 11
S70
A
Q
F
N
L
L
S
S
T
M
D
Q
M
S
S
Site 12
T71
Q
F
N
L
L
S
S
T
M
D
Q
M
S
S
R
Site 13
S76
S
S
T
M
D
Q
M
S
S
R
A
A
S
A
S
Site 14
S77
S
T
M
D
Q
M
S
S
R
A
A
S
A
S
P
Site 15
S81
Q
M
S
S
R
A
A
S
A
S
P
Y
T
P
E
Site 16
S83
S
S
R
A
A
S
A
S
P
Y
T
P
E
H
A
Site 17
Y85
R
A
A
S
A
S
P
Y
T
P
E
H
A
A
S
Site 18
T86
A
A
S
A
S
P
Y
T
P
E
H
A
A
S
V
Site 19
S92
Y
T
P
E
H
A
A
S
V
P
T
H
S
P
Y
Site 20
S97
A
A
S
V
P
T
H
S
P
Y
A
Q
P
S
S
Site 21
Y99
S
V
P
T
H
S
P
Y
A
Q
P
S
S
T
F
Site 22
S103
H
S
P
Y
A
Q
P
S
S
T
F
D
T
M
S
Site 23
S104
S
P
Y
A
Q
P
S
S
T
F
D
T
M
S
P
Site 24
T105
P
Y
A
Q
P
S
S
T
F
D
T
M
S
P
A
Site 25
T108
Q
P
S
S
T
F
D
T
M
S
P
A
P
V
I
Site 26
S110
S
S
T
F
D
T
M
S
P
A
P
V
I
P
S
Site 27
S117
S
P
A
P
V
I
P
S
N
T
D
Y
P
G
P
Site 28
T119
A
P
V
I
P
S
N
T
D
Y
P
G
P
H
H
Site 29
Y121
V
I
P
S
N
T
D
Y
P
G
P
H
H
F
E
Site 30
T130
G
P
H
H
F
E
V
T
F
Q
Q
S
S
T
A
Site 31
S135
E
V
T
F
Q
Q
S
S
T
A
K
S
A
T
W
Site 32
S139
Q
Q
S
S
T
A
K
S
A
T
W
T
Y
S
P
Site 33
T141
S
S
T
A
K
S
A
T
W
T
Y
S
P
L
L
Site 34
T143
T
A
K
S
A
T
W
T
Y
S
P
L
L
K
K
Site 35
S145
K
S
A
T
W
T
Y
S
P
L
L
K
K
L
Y
Site 36
S166
C
P
I
Q
I
K
V
S
T
P
P
P
P
G
T
Site 37
T167
P
I
Q
I
K
V
S
T
P
P
P
P
G
T
A
Site 38
T173
S
T
P
P
P
P
G
T
A
I
R
A
M
P
V
Site 39
Y181
A
I
R
A
M
P
V
Y
K
K
A
E
H
V
T
Site 40
S208
R
D
F
N
E
G
Q
S
A
P
A
S
H
L
I
Site 41
S212
E
G
Q
S
A
P
A
S
H
L
I
R
V
E
G
Site 42
S223
R
V
E
G
N
N
L
S
Q
Y
V
D
D
P
V
Site 43
Y225
E
G
N
N
L
S
Q
Y
V
D
D
P
V
T
G
Site 44
T231
Q
Y
V
D
D
P
V
T
G
R
Q
S
V
V
V
Site 45
S235
D
P
V
T
G
R
Q
S
V
V
V
P
Y
E
P
Site 46
Y240
R
Q
S
V
V
V
P
Y
E
P
P
Q
V
G
T
Site 47
S289
G
Q
V
L
G
R
R
S
F
E
G
R
I
C
A
Site 48
Y309
R
K
A
D
E
D
H
Y
R
E
Q
Q
A
L
N
Site 49
S326
S
A
K
N
G
A
A
S
K
R
A
F
K
Q
S
Site 50
S333
S
K
R
A
F
K
Q
S
P
P
A
V
P
A
L
Site 51
T354
R
R
H
G
D
E
D
T
Y
Y
L
Q
V
R
G
Site 52
Y355
R
H
G
D
E
D
T
Y
Y
L
Q
V
R
G
R
Site 53
Y356
H
G
D
E
D
T
Y
Y
L
Q
V
R
G
R
E
Site 54
S388
V
P
Q
P
L
V
D
S
Y
R
Q
Q
Q
Q
L
Site 55
Y389
P
Q
P
L
V
D
S
Y
R
Q
Q
Q
Q
L
L
Site 56
S400
Q
Q
L
L
Q
R
P
S
H
L
Q
P
P
S
Y
Site 57
S406
P
S
H
L
Q
P
P
S
Y
G
P
V
L
S
P
Site 58
Y407
S
H
L
Q
P
P
S
Y
G
P
V
L
S
P
M
Site 59
S412
P
S
Y
G
P
V
L
S
P
M
N
K
V
H
G
Site 60
S426
G
G
M
N
K
L
P
S
V
N
Q
L
V
G
Q
Site 61
S438
V
G
Q
P
P
P
H
S
S
A
A
T
P
N
L
Site 62
S439
G
Q
P
P
P
H
S
S
A
A
T
P
N
L
G
Site 63
T442
P
P
H
S
S
A
A
T
P
N
L
G
P
V
G
Site 64
S467
V
P
A
N
G
E
M
S
S
S
H
S
A
Q
S
Site 65
S468
P
A
N
G
E
M
S
S
S
H
S
A
Q
S
M
Site 66
S469
A
N
G
E
M
S
S
S
H
S
A
Q
S
M
V
Site 67
S471
G
E
M
S
S
S
H
S
A
Q
S
M
V
S
G
Site 68
S474
S
S
S
H
S
A
Q
S
M
V
S
G
S
H
C
Site 69
S477
H
S
A
Q
S
M
V
S
G
S
H
C
T
P
P
Site 70
S479
A
Q
S
M
V
S
G
S
H
C
T
P
P
P
P
Site 71
T482
M
V
S
G
S
H
C
T
P
P
P
P
Y
H
A
Site 72
Y487
H
C
T
P
P
P
P
Y
H
A
D
P
S
L
V
Site 73
S492
P
P
Y
H
A
D
P
S
L
V
S
F
L
T
G
Site 74
Y508
G
C
P
N
C
I
E
Y
F
T
S
Q
G
L
Q
Site 75
Y518
S
Q
G
L
Q
S
I
Y
H
L
Q
N
L
T
I
Site 76
Y554
D
L
K
Q
G
H
D
Y
S
T
A
Q
Q
L
L
Site 77
S555
L
K
Q
G
H
D
Y
S
T
A
Q
Q
L
L
R
Site 78
T556
K
Q
G
H
D
Y
S
T
A
Q
Q
L
L
R
S
Site 79
T568
L
R
S
S
N
A
A
T
I
S
I
G
G
S
G
Site 80
S574
A
T
I
S
I
G
G
S
G
E
L
Q
R
Q
R
Site 81
T593
V
H
F
R
V
R
H
T
I
T
I
P
N
R
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation