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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CD3EAP
Full Name:
DNA-directed RNA polymerase I subunit RPA34
Alias:
Antisense to ERCC 1; Antisense to ERCC-1; CAST; CD3 epsilon associated protein; CD3e molecule, epsilon associated protein; CD3e-associated protein; CD3-epsilon-associated protein; DNA-directed RNA polymerase I RPA34; PAF49; RNA polymerase I-associated factor PAF49; RPA34
Type:
Transcription initiation complex
Mass (Da):
54986
Number AA:
510
UniProt ID:
O15446
International Prot ID:
IPI00645816
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000120
Uniprot
OncoNet
Molecular Function:
GO:0003899
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0009303
GO:0007169
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
A
G
D
A
A
R
F
S
C
P
P
N
F
T
A
Site 2
S25
F
T
A
K
P
P
A
S
E
S
P
R
F
S
L
Site 3
S27
A
K
P
P
A
S
E
S
P
R
F
S
L
E
A
Site 4
S31
A
S
E
S
P
R
F
S
L
E
A
L
T
G
P
Site 5
S64
N
G
R
H
V
P
L
S
G
S
Q
I
V
K
G
Site 6
S66
R
H
V
P
L
S
G
S
Q
I
V
K
G
K
L
Site 7
Y80
L
A
G
K
R
H
R
Y
R
V
L
S
S
C
P
Site 8
S84
R
H
R
Y
R
V
L
S
S
C
P
Q
A
G
E
Site 9
S109
G
G
G
L
T
C
A
S
A
P
Q
G
T
L
R
Site 10
S124
I
L
E
G
P
Q
Q
S
L
S
G
S
P
L
Q
Site 11
S126
E
G
P
Q
Q
S
L
S
G
S
P
L
Q
P
I
Site 12
S128
P
Q
Q
S
L
S
G
S
P
L
Q
P
I
P
A
Site 13
S136
P
L
Q
P
I
P
A
S
P
P
P
Q
I
P
P
Site 14
T159
F
G
G
N
P
P
V
T
G
P
R
S
A
L
A
Site 15
S163
P
P
V
T
G
P
R
S
A
L
A
P
N
L
L
Site 16
T171
A
L
A
P
N
L
L
T
S
G
K
K
K
K
E
Site 17
S172
L
A
P
N
L
L
T
S
G
K
K
K
K
E
M
Site 18
T182
K
K
K
E
M
Q
V
T
E
A
P
V
T
Q
E
Site 19
T187
Q
V
T
E
A
P
V
T
Q
E
A
V
N
G
H
Site 20
S205
E
V
D
M
A
L
G
S
P
E
M
D
V
R
K
Site 21
T235
G
P
V
G
T
E
P
T
V
E
T
L
E
P
L
Site 22
S248
P
L
G
V
L
F
P
S
T
T
K
K
R
K
K
Site 23
T249
L
G
V
L
F
P
S
T
T
K
K
R
K
K
P
Site 24
T250
G
V
L
F
P
S
T
T
K
K
R
K
K
P
K
Site 25
T261
K
K
P
K
G
K
E
T
F
E
P
E
D
K
T
Site 26
T268
T
F
E
P
E
D
K
T
V
K
Q
E
Q
I
N
Site 27
T276
V
K
Q
E
Q
I
N
T
E
P
L
E
D
T
V
Site 28
T282
N
T
E
P
L
E
D
T
V
L
S
P
T
K
K
Site 29
S285
P
L
E
D
T
V
L
S
P
T
K
K
R
K
R
Site 30
T287
E
D
T
V
L
S
P
T
K
K
R
K
R
Q
K
Site 31
T306
M
E
P
E
E
G
V
T
V
E
S
Q
P
Q
V
Site 32
S309
E
E
G
V
T
V
E
S
Q
P
Q
V
K
V
E
Site 33
T327
E
A
I
P
L
P
P
T
K
K
R
K
K
E
K
Site 34
S359
P
E
M
K
P
L
E
S
P
G
G
T
M
A
P
Site 35
T363
P
L
E
S
P
G
G
T
M
A
P
Q
Q
P
E
Site 36
T396
K
E
K
Q
Q
D
A
T
V
E
P
E
T
E
V
Site 37
T401
D
A
T
V
E
P
E
T
E
V
V
G
P
E
L
Site 38
T419
L
E
P
Q
A
A
P
T
S
T
K
K
K
K
K
Site 39
S420
E
P
Q
A
A
P
T
S
T
K
K
K
K
K
K
Site 40
T421
P
Q
A
A
P
T
S
T
K
K
K
K
K
K
K
Site 41
T433
K
K
K
E
R
G
H
T
V
T
E
P
I
Q
P
Site 42
T435
K
E
R
G
H
T
V
T
E
P
I
Q
P
L
E
Site 43
T456
G
Q
P
E
A
R
A
T
P
G
S
T
K
K
R
Site 44
S459
E
A
R
A
T
P
G
S
T
K
K
R
K
K
Q
Site 45
S467
T
K
K
R
K
K
Q
S
Q
E
S
R
M
P
E
Site 46
S470
R
K
K
Q
S
Q
E
S
R
M
P
E
T
V
P
Site 47
T475
Q
E
S
R
M
P
E
T
V
P
Q
E
E
M
P
Site 48
S488
M
P
G
P
P
L
N
S
E
S
G
E
E
A
P
Site 49
S490
G
P
P
L
N
S
E
S
G
E
E
A
P
T
G
Site 50
T496
E
S
G
E
E
A
P
T
G
R
D
K
K
R
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation