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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IRAK2
Full Name:
Interleukin-1 receptor-associated kinase-like 2
Alias:
Type:
Mass (Da):
69433
Number AA:
625
UniProt ID:
O43187
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y4
_
_
_
_
M
A
C
Y
I
Y
Q
L
P
S
W
Site 2
Y6
_
_
M
A
C
Y
I
Y
Q
L
P
S
W
V
L
Site 3
Y34
D
W
M
E
F
A
S
Y
V
I
T
D
L
T
Q
Site 4
T37
E
F
A
S
Y
V
I
T
D
L
T
Q
L
R
K
Site 5
T40
S
Y
V
I
T
D
L
T
Q
L
R
K
I
K
S
Site 6
S47
T
Q
L
R
K
I
K
S
M
E
R
V
Q
G
V
Site 7
S55
M
E
R
V
Q
G
V
S
I
T
R
E
L
L
W
Site 8
S109
P
I
P
A
F
P
D
S
V
K
P
E
K
P
L
Site 9
S119
P
E
K
P
L
A
A
S
V
R
K
A
E
D
E
Site 10
T137
G
Q
P
V
R
M
A
T
F
P
G
P
G
S
S
Site 11
S143
A
T
F
P
G
P
G
S
S
P
A
R
A
H
Q
Site 12
S144
T
F
P
G
P
G
S
S
P
A
R
A
H
Q
P
Site 13
S164
P
E
E
D
A
P
H
S
L
R
S
D
L
P
T
Site 14
S167
D
A
P
H
S
L
R
S
D
L
P
T
S
S
D
Site 15
T171
S
L
R
S
D
L
P
T
S
S
D
S
K
D
F
Site 16
S172
L
R
S
D
L
P
T
S
S
D
S
K
D
F
S
Site 17
S173
R
S
D
L
P
T
S
S
D
S
K
D
F
S
T
Site 18
S175
D
L
P
T
S
S
D
S
K
D
F
S
T
S
I
Site 19
S179
S
S
D
S
K
D
F
S
T
S
I
P
K
Q
E
Site 20
T180
S
D
S
K
D
F
S
T
S
I
P
K
Q
E
K
Site 21
S190
P
K
Q
E
K
L
L
S
L
A
G
D
S
L
F
Site 22
S217
F
N
Q
N
R
K
I
S
Q
G
T
F
A
D
V
Site 23
T220
N
R
K
I
S
Q
G
T
F
A
D
V
Y
R
G
Site 24
Y225
Q
G
T
F
A
D
V
Y
R
G
H
R
H
G
K
Site 25
T242
V
F
K
K
L
R
E
T
A
C
S
S
P
G
S
Site 26
S245
K
L
R
E
T
A
C
S
S
P
G
S
I
E
R
Site 27
S246
L
R
E
T
A
C
S
S
P
G
S
I
E
R
F
Site 28
S249
T
A
C
S
S
P
G
S
I
E
R
F
F
Q
A
Site 29
Y286
R
Q
F
H
S
F
I
Y
P
Y
M
A
N
G
S
Site 30
Y288
F
H
S
F
I
Y
P
Y
M
A
N
G
S
L
Q
Site 31
S293
Y
P
Y
M
A
N
G
S
L
Q
D
R
L
Q
G
Site 32
S334
H
G
L
E
I
I
H
S
N
V
K
S
S
N
V
Site 33
S338
I
I
H
S
N
V
K
S
S
N
V
L
L
D
Q
Site 34
Y367
P
V
N
K
R
S
K
Y
T
M
M
K
T
H
L
Site 35
T372
S
K
Y
T
M
M
K
T
H
L
L
R
T
S
A
Site 36
S378
K
T
H
L
L
R
T
S
A
A
Y
L
P
E
D
Site 37
S420
P
A
M
D
N
N
R
S
P
V
Y
L
K
D
L
Site 38
Y423
D
N
N
R
S
P
V
Y
L
K
D
L
L
L
S
Site 39
S430
Y
L
K
D
L
L
L
S
D
I
P
S
S
T
A
Site 40
S434
L
L
L
S
D
I
P
S
S
T
A
S
L
C
S
Site 41
T436
L
S
D
I
P
S
S
T
A
S
L
C
S
R
K
Site 42
S438
D
I
P
S
S
T
A
S
L
C
S
R
K
T
G
Site 43
T444
A
S
L
C
S
R
K
T
G
V
E
N
V
M
A
Site 44
Y458
A
K
E
I
C
Q
K
Y
L
E
K
G
A
G
R
Site 45
T487
L
C
L
R
R
R
N
T
S
L
Q
E
V
C
G
Site 46
S488
C
L
R
R
R
N
T
S
L
Q
E
V
C
G
S
Site 47
S495
S
L
Q
E
V
C
G
S
V
A
A
V
E
E
R
Site 48
T508
E
R
L
R
G
R
E
T
L
L
P
W
S
G
L
Site 49
S513
R
E
T
L
L
P
W
S
G
L
S
E
G
T
G
Site 50
S516
L
L
P
W
S
G
L
S
E
G
T
G
S
S
S
Site 51
S521
G
L
S
E
G
T
G
S
S
S
N
T
P
E
E
Site 52
S523
S
E
G
T
G
S
S
S
N
T
P
E
E
T
D
Site 53
T525
G
T
G
S
S
S
N
T
P
E
E
T
D
D
V
Site 54
S535
E
T
D
D
V
D
N
S
S
L
D
A
S
S
S
Site 55
S536
T
D
D
V
D
N
S
S
L
D
A
S
S
S
M
Site 56
S540
D
N
S
S
L
D
A
S
S
S
M
S
V
A
P
Site 57
S541
N
S
S
L
D
A
S
S
S
M
S
V
A
P
W
Site 58
S542
S
S
L
D
A
S
S
S
M
S
V
A
P
W
A
Site 59
T553
A
P
W
A
G
A
A
T
P
L
L
P
T
E
N
Site 60
S576
V
G
R
E
A
D
S
S
S
E
A
C
V
G
L
Site 61
S577
G
R
E
A
D
S
S
S
E
A
C
V
G
L
E
Site 62
T590
L
E
P
P
Q
D
V
T
E
T
S
W
Q
I
E
Site 63
S619
Y
K
E
E
K
V
D
S
I
E
L
F
G
P
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation