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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAP3K7
Full Name:
Mitogen-activated protein kinase kinase kinase 7
Alias:
EC 2.7.11.25; M3K7; TGF-beta-activated kinase 1
Type:
EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; TAK1 subfamily
Mass (Da):
67196
Number AA:
606
UniProt ID:
O43318
International Prot ID:
IPI00218566
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004709
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0050852
GO:0007250
GO:0050870
Phosida
TranscriptoNet
STRING
Kinexus Products
TGF-beta-activated protein-serine kinase 1; Mitogen-activated protein kinase kinase kinase 7 pan-specific antibody AB-NK175-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK175-3#TGF-beta-activated protein-serine kinase 1; Mitogen-activated protein kinase kinase kinase 7 S439 phosphosite-specific antibody AB-PK824#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK824#TGF-beta-activated protein-serine kinase 1; Mitogen-activated protein kinase kinase kinase 7 T184+T187 phosphosite-specific antibody AB-PK825#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK825#TGF-beta-activated protein-serine kinase 1 / Mitogen-activated protein kinase kinase kinase 7 (R436-D442, human) pS439 phosphopeptide - Powder PE-04APV90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APV90#TGF-beta-activated protein-serine kinase 1 / Mitogen-activated protein kinase kinase kinase 7 (D181-K190, human) pT184+pT187 phosphopeptide - Powder PE-04APW99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APW99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
S
T
A
S
A
A
S
S
S
S
S
Site 2
S8
M
S
T
A
S
A
A
S
S
S
S
S
S
S
A
Site 3
S9
S
T
A
S
A
A
S
S
S
S
S
S
S
A
G
Site 4
S10
T
A
S
A
A
S
S
S
S
S
S
S
A
G
E
Site 5
S11
A
S
A
A
S
S
S
S
S
S
S
A
G
E
M
Site 6
S12
S
A
A
S
S
S
S
S
S
S
A
G
E
M
I
Site 7
S13
A
A
S
S
S
S
S
S
S
A
G
E
M
I
E
Site 8
S14
A
S
S
S
S
S
S
S
A
G
E
M
I
E
A
Site 9
Y33
L
N
F
E
E
I
D
Y
K
E
I
E
V
E
E
Site 10
S67
V
A
I
K
Q
I
E
S
E
S
E
R
K
A
F
Site 11
S69
I
K
Q
I
E
S
E
S
E
R
K
A
F
I
V
Site 12
S82
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
Site 13
S111
M
E
Y
A
E
G
G
S
L
Y
N
V
L
H
G
Site 14
Y113
Y
A
E
G
G
S
L
Y
N
V
L
H
G
A
E
Site 15
Y124
H
G
A
E
P
L
P
Y
Y
T
A
A
H
A
M
Site 16
Y125
G
A
E
P
L
P
Y
Y
T
A
A
H
A
M
S
Site 17
Y143
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
Site 18
T178
L
K
I
C
D
F
G
T
A
C
D
I
Q
T
H
Site 19
T184
G
T
A
C
D
I
Q
T
H
M
T
N
N
K
G
TGF-beta-activated protein-serine kinase 1; Mitogen-activated protein kinase kinase kinase 7 T184+T187 phosphosite-specific antibody AB-PK825#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK825#TGF-beta-activated protein-serine kinase 1 / Mitogen-activated protein kinase kinase kinase 7 (D181-K190, human) pT184+pT187 phosphopeptide - Powder PE-04APW99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APW99
Site 20
T187
C
D
I
Q
T
H
M
T
N
N
K
G
S
A
A
TGF-beta-activated protein-serine kinase 1; Mitogen-activated protein kinase kinase kinase 7 T184+T187 phosphosite-specific antibody AB-PK825#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK825#TGF-beta-activated protein-serine kinase 1 / Mitogen-activated protein kinase kinase kinase 7 (D181-K190, human) pT184+pT187 phosphopeptide - Powder PE-04APW99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APW99
Site 21
S192
H
M
T
N
N
K
G
S
A
A
W
M
A
P
E
Site 22
Y206
E
V
F
E
G
S
N
Y
S
E
K
C
D
V
F
Site 23
T264
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
Site 24
S268
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
Site 25
S272
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
Site 26
S276
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
Site 27
Y290
I
M
T
H
L
M
R
Y
F
P
G
A
D
E
P
Site 28
Y300
G
A
D
E
P
L
Q
Y
P
C
Q
Y
S
D
E
Site 29
S305
L
Q
Y
P
C
Q
Y
S
D
E
G
Q
S
N
S
Site 30
S312
S
D
E
G
Q
S
N
S
A
T
S
T
G
S
F
Site 31
T314
E
G
Q
S
N
S
A
T
S
T
G
S
F
M
D
Site 32
S315
G
Q
S
N
S
A
T
S
T
G
S
F
M
D
I
Site 33
T316
Q
S
N
S
A
T
S
T
G
S
F
M
D
I
A
Site 34
S318
N
S
A
T
S
T
G
S
F
M
D
I
A
S
T
Site 35
S324
G
S
F
M
D
I
A
S
T
N
T
S
N
K
S
Site 36
T325
S
F
M
D
I
A
S
T
N
T
S
N
K
S
D
Site 37
S328
D
I
A
S
T
N
T
S
N
K
S
D
T
N
M
Site 38
S331
S
T
N
T
S
N
K
S
D
T
N
M
E
Q
V
Site 39
T333
N
T
S
N
K
S
D
T
N
M
E
Q
V
P
A
Site 40
T344
Q
V
P
A
T
N
D
T
I
K
R
L
E
S
K
Site 41
S350
D
T
I
K
R
L
E
S
K
L
L
K
N
Q
A
Site 42
S361
K
N
Q
A
K
Q
Q
S
E
S
G
R
L
S
L
Site 43
S363
Q
A
K
Q
Q
S
E
S
G
R
L
S
L
G
A
Site 44
S367
Q
S
E
S
G
R
L
S
L
G
A
S
R
G
S
Site 45
S371
G
R
L
S
L
G
A
S
R
G
S
S
V
E
S
Site 46
S374
S
L
G
A
S
R
G
S
S
V
E
S
L
P
P
Site 47
S375
L
G
A
S
R
G
S
S
V
E
S
L
P
P
T
Site 48
S378
S
R
G
S
S
V
E
S
L
P
P
T
S
E
G
Site 49
T382
S
V
E
S
L
P
P
T
S
E
G
K
R
M
S
Site 50
S383
V
E
S
L
P
P
T
S
E
G
K
R
M
S
A
Site 51
S389
T
S
E
G
K
R
M
S
A
D
M
S
E
I
E
Site 52
S393
K
R
M
S
A
D
M
S
E
I
E
A
R
I
A
Site 53
T403
E
A
R
I
A
A
T
T
A
Y
S
K
P
K
R
Site 54
Y405
R
I
A
A
T
T
A
Y
S
K
P
K
R
G
H
Site 55
S406
I
A
A
T
T
A
Y
S
K
P
K
R
G
H
R
Site 56
T415
P
K
R
G
H
R
K
T
A
S
F
G
N
I
L
Site 57
S417
R
G
H
R
K
T
A
S
F
G
N
I
L
D
V
Site 58
S430
D
V
P
E
I
V
I
S
G
N
G
Q
P
R
R
Site 59
S439
N
G
Q
P
R
R
R
S
I
Q
D
L
T
V
T
TGF-beta-activated protein-serine kinase 1; Mitogen-activated protein kinase kinase kinase 7 S439 phosphosite-specific antibody AB-PK824#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK824#TGF-beta-activated protein-serine kinase 1 / Mitogen-activated protein kinase kinase kinase 7 (R436-D442, human) pS439 phosphopeptide - Powder PE-04APV90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APV90
Site 60
T444
R
R
S
I
Q
D
L
T
V
T
G
T
E
P
G
Site 61
T448
Q
D
L
T
V
T
G
T
E
P
G
Q
V
S
S
Site 62
S454
G
T
E
P
G
Q
V
S
S
R
S
S
S
P
S
Site 63
S455
T
E
P
G
Q
V
S
S
R
S
S
S
P
S
V
Site 64
S457
P
G
Q
V
S
S
R
S
S
S
P
S
V
R
M
Site 65
S458
G
Q
V
S
S
R
S
S
S
P
S
V
R
M
I
Site 66
S459
Q
V
S
S
R
S
S
S
P
S
V
R
M
I
T
Site 67
S461
S
S
R
S
S
S
P
S
V
R
M
I
T
T
S
Site 68
T466
S
P
S
V
R
M
I
T
T
S
G
P
T
S
E
Site 69
S468
S
V
R
M
I
T
T
S
G
P
T
S
E
K
P
Site 70
S472
I
T
T
S
G
P
T
S
E
K
P
T
R
S
H
Site 71
T476
G
P
T
S
E
K
P
T
R
S
H
P
W
T
P
Site 72
S478
T
S
E
K
P
T
R
S
H
P
W
T
P
D
D
Site 73
T482
P
T
R
S
H
P
W
T
P
D
D
S
T
D
T
Site 74
S486
H
P
W
T
P
D
D
S
T
D
T
N
G
S
D
Site 75
T487
P
W
T
P
D
D
S
T
D
T
N
G
S
D
N
Site 76
S492
D
S
T
D
T
N
G
S
D
N
S
I
P
M
A
Site 77
S495
D
T
N
G
S
D
N
S
I
P
M
A
Y
L
T
Site 78
T502
S
I
P
M
A
Y
L
T
L
D
H
Q
L
Q
P
Site 79
S516
P
L
A
P
C
P
N
S
K
E
S
M
A
V
F
Site 80
S519
P
C
P
N
S
K
E
S
M
A
V
F
E
Q
H
Site 81
S565
E
K
D
Q
Q
N
T
S
R
L
V
Q
E
H
K
Site 82
S580
K
L
L
D
E
N
K
S
L
S
T
Y
Y
Q
Q
Site 83
S582
L
D
E
N
K
S
L
S
T
Y
Y
Q
Q
C
K
Site 84
Y584
E
N
K
S
L
S
T
Y
Y
Q
Q
C
K
K
Q
Site 85
Y585
N
K
S
L
S
T
Y
Y
Q
Q
C
K
K
Q
L
Site 86
S597
K
Q
L
E
V
I
R
S
Q
Q
Q
K
R
Q
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation