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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RIPK2
Full Name:
Receptor-interacting serine/threonine-protein kinase 2
Alias:
CARD3; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta converting enzyme associated kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARDIAK; EC 2.7.11.1; Kinase RIPK2; Receptor-interacting protein 2; Receptor-interacting serine/threonine protein kinase 2; Receptor-interacting serine-threonine kinase 2; RICK; RIP2; RIP-2; RIP-like interacting CLARP kinase; RIP-like-interacting CLARP kinase
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; TKL group; RIPK family
Mass (Da):
61195
Number AA:
540
UniProt ID:
O43353
International Prot ID:
IPI00021917
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0050700
GO:0030274
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0006915
GO:0006954
Phosida
TranscriptoNet
STRING
Kinexus Products
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) S176 phosphosite-specific antibody AB-PK796#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK796#Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) Y381 phosphosite-specific antibody AB-PK797#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK797#Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) (M173-R179, human) pS176 phosphopeptide - Powder PE-04API75#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04API75#Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) (Q378-K384, human) pY381 phosphopeptide - Powder PE-04APJ90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APJ90
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y23
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
Site 2
S29
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
Site 3
T31
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
Site 4
S33
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
Site 5
S34
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
Site 6
T53
V
K
H
L
H
I
H
T
P
L
L
D
S
E
R
Site 7
S58
I
H
T
P
L
L
D
S
E
R
K
D
V
L
R
Site 8
S102
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
Site 9
T111
N
E
L
L
H
R
K
T
E
Y
P
D
V
A
W
Site 10
Y113
L
L
H
R
K
T
E
Y
P
D
V
A
W
P
L
Site 11
T139
V
N
Y
L
H
N
M
T
P
P
L
L
H
H
D
Site 12
T149
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
Site 13
S168
K
I
A
D
F
G
L
S
K
W
R
M
M
S
L
Site 14
S174
L
S
K
W
R
M
M
S
L
S
Q
S
R
S
S
Site 15
S176
K
W
R
M
M
S
L
S
Q
S
R
S
S
K
S
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) S176 phosphosite-specific antibody AB-PK796#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK796#Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) (M173-R179, human) pS176 phosphopeptide - Powder PE-04API75#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04API75
Site 16
S178
R
M
M
S
L
S
Q
S
R
S
S
K
S
A
P
Site 17
S180
M
S
L
S
Q
S
R
S
S
K
S
A
P
E
G
Site 18
S181
S
L
S
Q
S
R
S
S
K
S
A
P
E
G
G
Site 19
S183
S
Q
S
R
S
S
K
S
A
P
E
G
G
T
I
Site 20
Y192
P
E
G
G
T
I
I
Y
M
P
P
E
N
Y
E
Site 21
S204
N
Y
E
P
G
Q
K
S
R
A
S
I
K
H
D
Site 22
S207
P
G
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Site 23
T233
K
Q
P
F
E
D
V
T
N
P
L
Q
I
M
Y
Site 24
Y240
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
Site 25
S241
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
Site 26
Y257
I
N
E
E
S
L
P
Y
D
I
P
H
R
A
R
Site 27
S267
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Site 28
S271
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
Site 29
S282
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
Site 30
T312
A
V
I
Q
L
K
K
T
K
L
Q
S
V
S
S
Site 31
S316
L
K
K
T
K
L
Q
S
V
S
S
A
I
H
L
Site 32
S318
K
T
K
L
Q
S
V
S
S
A
I
H
L
C
D
Site 33
S319
T
K
L
Q
S
V
S
S
A
I
H
L
C
D
K
Site 34
S332
D
K
K
K
M
E
L
S
L
N
I
P
V
N
H
Site 35
S345
N
H
G
P
Q
E
E
S
C
G
S
S
Q
L
H
Site 36
S348
P
Q
E
E
S
C
G
S
S
Q
L
H
E
N
S
Site 37
S349
Q
E
E
S
C
G
S
S
Q
L
H
E
N
S
G
Site 38
S355
S
S
Q
L
H
E
N
S
G
S
P
E
T
S
R
Site 39
S357
Q
L
H
E
N
S
G
S
P
E
T
S
R
S
L
Site 40
T360
E
N
S
G
S
P
E
T
S
R
S
L
P
A
P
Site 41
S361
N
S
G
S
P
E
T
S
R
S
L
P
A
P
Q
Site 42
S363
G
S
P
E
T
S
R
S
L
P
A
P
Q
D
N
Site 43
Y381
S
R
K
A
Q
D
C
Y
F
M
K
L
H
H
C
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) Y381 phosphosite-specific antibody AB-PK797#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK797#Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) (Q378-K384, human) pY381 phosphopeptide - Powder PE-04APJ90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04APJ90
Site 44
S393
H
H
C
P
G
N
H
S
W
D
S
T
I
S
G
Site 45
S396
P
G
N
H
S
W
D
S
T
I
S
G
S
Q
R
Site 46
T397
G
N
H
S
W
D
S
T
I
S
G
S
Q
R
A
Site 47
S399
H
S
W
D
S
T
I
S
G
S
Q
R
A
A
F
Site 48
S401
W
D
S
T
I
S
G
S
Q
R
A
A
F
C
D
Site 49
T412
A
F
C
D
H
K
T
T
P
C
S
S
A
I
I
Site 50
S415
D
H
K
T
T
P
C
S
S
A
I
I
N
P
L
Site 51
S423
S
A
I
I
N
P
L
S
T
A
G
N
S
E
R
Site 52
S428
P
L
S
T
A
G
N
S
E
R
L
Q
P
G
I
Site 53
S459
T
E
A
C
L
N
Q
S
L
D
A
L
L
S
R
Site 54
S465
Q
S
L
D
A
L
L
S
R
D
L
I
M
K
E
Site 55
Y474
D
L
I
M
K
E
D
Y
E
L
V
S
T
K
P
Site 56
T479
E
D
Y
E
L
V
S
T
K
P
T
R
T
S
K
Site 57
T482
E
L
V
S
T
K
P
T
R
T
S
K
V
R
Q
Site 58
S485
S
T
K
P
T
R
T
S
K
V
R
Q
L
L
D
Site 59
T493
K
V
R
Q
L
L
D
T
T
D
I
Q
G
E
E
Site 60
T494
V
R
Q
L
L
D
T
T
D
I
Q
G
E
E
F
Site 61
Y520
K
Q
M
G
L
Q
P
Y
P
E
I
L
V
V
S
Site 62
S527
Y
P
E
I
L
V
V
S
R
S
P
S
L
N
L
Site 63
S529
E
I
L
V
V
S
R
S
P
S
L
N
L
L
Q
Site 64
S531
L
V
V
S
R
S
P
S
L
N
L
L
Q
N
K
Site 65
S539
L
N
L
L
Q
N
K
S
M
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation