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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PROM1
Full Name:
Prominin-1
Alias:
AC133; CD133; hematopoietic stem cell antigen; prominin-like 1; PROML1
Type:
Cell surface protein
Mass (Da):
97202
Number AA:
865
UniProt ID:
O43490
International Prot ID:
IPI00012540
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0042995
GO:0009986
GO:0005887
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0050896
GO:0007601
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
G
L
C
G
N
S
F
S
G
G
Q
P
S
S
T
Site 2
S24
S
F
S
G
G
Q
P
S
S
T
D
A
P
K
A
Site 3
S25
F
S
G
G
Q
P
S
S
T
D
A
P
K
A
W
Site 4
T26
S
G
G
Q
P
S
S
T
D
A
P
K
A
W
N
Site 5
Y34
D
A
P
K
A
W
N
Y
E
L
P
A
T
N
Y
Site 6
Y41
Y
E
L
P
A
T
N
Y
E
T
Q
D
S
H
K
Site 7
S46
T
N
Y
E
T
Q
D
S
H
K
A
G
P
I
G
Site 8
T75
P
R
D
F
P
E
D
T
L
R
K
F
L
Q
K
Site 9
Y84
R
K
F
L
Q
K
A
Y
E
S
K
I
D
Y
D
Site 10
Y90
A
Y
E
S
K
I
D
Y
D
K
P
E
T
V
I
Site 11
S196
R
S
R
K
L
A
D
S
N
F
K
D
L
R
T
Site 12
T203
S
N
F
K
D
L
R
T
L
L
N
E
T
P
E
Site 13
T208
L
R
T
L
L
N
E
T
P
E
Q
I
K
Y
I
Site 14
Y214
E
T
P
E
Q
I
K
Y
I
L
A
Q
Y
N
T
Site 15
Y219
I
K
Y
I
L
A
Q
Y
N
T
T
K
D
K
A
Site 16
S258
P
V
L
D
E
I
K
S
M
A
T
A
I
K
E
Site 17
T266
M
A
T
A
I
K
E
T
K
E
A
L
E
N
M
Site 18
S275
E
A
L
E
N
M
N
S
T
L
K
S
L
H
Q
Site 19
T276
A
L
E
N
M
N
S
T
L
K
S
L
H
Q
Q
Site 20
S279
N
M
N
S
T
L
K
S
L
H
Q
Q
S
T
Q
Site 21
S284
L
K
S
L
H
Q
Q
S
T
Q
L
S
S
S
L
Site 22
T285
K
S
L
H
Q
Q
S
T
Q
L
S
S
S
L
T
Site 23
S288
H
Q
Q
S
T
Q
L
S
S
S
L
T
S
V
K
Site 24
S290
Q
S
T
Q
L
S
S
S
L
T
S
V
K
T
S
Site 25
T292
T
Q
L
S
S
S
L
T
S
V
K
T
S
L
R
Site 26
S293
Q
L
S
S
S
L
T
S
V
K
T
S
L
R
S
Site 27
T296
S
S
L
T
S
V
K
T
S
L
R
S
S
L
N
Site 28
S297
S
L
T
S
V
K
T
S
L
R
S
S
L
N
D
Site 29
S301
V
K
T
S
L
R
S
S
L
N
D
P
L
C
L
Site 30
S313
L
C
L
V
H
P
S
S
E
T
C
N
S
I
R
Site 31
S318
P
S
S
E
T
C
N
S
I
R
L
S
L
S
Q
Site 32
S322
T
C
N
S
I
R
L
S
L
S
Q
L
N
S
N
Site 33
S324
N
S
I
R
L
S
L
S
Q
L
N
S
N
P
E
Site 34
S328
L
S
L
S
Q
L
N
S
N
P
E
L
R
Q
L
Site 35
Y361
D
G
L
V
Q
Q
G
Y
Q
S
L
N
D
I
P
Site 36
S363
L
V
Q
Q
G
Y
Q
S
L
N
D
I
P
D
R
Site 37
T375
P
D
R
V
Q
R
Q
T
T
T
V
V
A
G
I
Site 38
T376
D
R
V
Q
R
Q
T
T
T
V
V
A
G
I
K
Site 39
T377
R
V
Q
R
Q
T
T
T
V
V
A
G
I
K
R
Site 40
S391
R
V
L
N
S
I
G
S
D
I
D
N
V
T
Q
Site 41
T397
G
S
D
I
D
N
V
T
Q
R
L
P
I
Q
D
Site 42
T426
Y
I
H
R
N
L
P
T
L
E
E
Y
D
S
Y
Site 43
Y430
N
L
P
T
L
E
E
Y
D
S
Y
W
W
L
G
Site 44
Y433
T
L
E
E
Y
D
S
Y
W
W
L
G
G
L
V
Site 45
T468
C
G
Y
D
R
H
A
T
P
T
T
R
G
C
V
Site 46
T470
Y
D
R
H
A
T
P
T
T
R
G
C
V
S
N
Site 47
Y519
E
K
L
I
C
E
P
Y
T
S
K
E
L
F
R
Site 48
T530
E
L
F
R
V
L
D
T
P
Y
L
L
N
E
D
Site 49
Y532
F
R
V
L
D
T
P
Y
L
L
N
E
D
W
E
Site 50
Y540
L
L
N
E
D
W
E
Y
Y
L
S
G
K
L
F
Site 51
Y541
L
N
E
D
W
E
Y
Y
L
S
G
K
L
F
N
Site 52
S543
E
D
W
E
Y
Y
L
S
G
K
L
F
N
K
S
Site 53
S550
S
G
K
L
F
N
K
S
K
M
K
L
T
F
E
Site 54
T555
N
K
S
K
M
K
L
T
F
E
Q
V
Y
S
D
Site 55
S561
L
T
F
E
Q
V
Y
S
D
C
K
K
N
R
G
Site 56
T569
D
C
K
K
N
R
G
T
Y
G
T
L
H
L
Q
Site 57
Y570
C
K
K
N
R
G
T
Y
G
T
L
H
L
Q
N
Site 58
T572
K
N
R
G
T
Y
G
T
L
H
L
Q
N
S
F
Site 59
S578
G
T
L
H
L
Q
N
S
F
N
I
S
E
H
L
Site 60
S582
L
Q
N
S
F
N
I
S
E
H
L
N
I
N
E
Site 61
T591
H
L
N
I
N
E
H
T
G
S
I
S
S
E
L
Site 62
S593
N
I
N
E
H
T
G
S
I
S
S
E
L
E
S
Site 63
S595
N
E
H
T
G
S
I
S
S
E
L
E
S
L
K
Site 64
S600
S
I
S
S
E
L
E
S
L
K
V
N
L
N
I
Site 65
Y631
C
G
I
D
R
M
N
Y
D
S
Y
L
A
Q
T
Site 66
S633
I
D
R
M
N
Y
D
S
Y
L
A
Q
T
G
K
Site 67
Y634
D
R
M
N
Y
D
S
Y
L
A
Q
T
G
K
S
Site 68
S669
P
P
G
N
L
R
N
S
L
K
R
D
A
Q
T
Site 69
S691
R
V
L
P
I
E
Q
S
L
S
T
L
Y
Q
S
Site 70
S693
L
P
I
E
Q
S
L
S
T
L
Y
Q
S
V
K
Site 71
T694
P
I
E
Q
S
L
S
T
L
Y
Q
S
V
K
I
Site 72
Y696
E
Q
S
L
S
T
L
Y
Q
S
V
K
I
L
Q
Site 73
S698
S
L
S
T
L
Y
Q
S
V
K
I
L
Q
R
T
Site 74
S719
R
V
T
R
I
L
A
S
L
D
F
A
Q
N
F
Site 75
T728
D
F
A
Q
N
F
I
T
N
N
T
S
S
V
I
Site 76
S733
F
I
T
N
N
T
S
S
V
I
I
E
E
T
K
Site 77
T739
S
S
V
I
I
E
E
T
K
K
Y
G
R
T
I
Site 78
Y742
I
I
E
E
T
K
K
Y
G
R
T
I
I
G
Y
Site 79
Y749
Y
G
R
T
I
I
G
Y
F
E
H
Y
L
Q
W
Site 80
Y818
F
A
V
K
L
A
K
Y
Y
R
R
M
D
S
E
Site 81
Y819
A
V
K
L
A
K
Y
Y
R
R
M
D
S
E
D
Site 82
S824
K
Y
Y
R
R
M
D
S
E
D
V
Y
D
D
V
Site 83
Y828
R
M
D
S
E
D
V
Y
D
D
V
E
T
I
P
Site 84
Y852
G
Y
H
K
D
H
V
Y
G
I
H
N
P
V
M
Site 85
S863
N
P
V
M
T
S
P
S
Q
H
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation