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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Kv7.3
Full Name:
Potassium voltage-gated channel subfamily KQT member 3
Alias:
EBN2; KCNQ3; KQT-like 3; Potassium channel alpha subunit KvLQT3; Potassium voltage-gated channel, KQT-like subfamily, member 3; Voltage-gated potassium channel subunit Kv7.3
Type:
Channel protein, potassium
Mass (Da):
96742
Number AA:
872
UniProt ID:
O43525
International Prot ID:
IPI00012857
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0030955
GO:0005249
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
GO:0007268
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T66
A
G
A
D
K
D
G
T
L
L
L
E
G
G
G
Site 2
T81
R
D
E
G
Q
R
R
T
P
Q
G
I
G
L
L
Site 3
S94
L
L
A
K
T
P
L
S
R
P
V
K
R
N
N
Site 4
Y104
V
K
R
N
N
A
K
Y
R
R
I
Q
T
L
I
Site 5
T109
A
K
Y
R
R
I
Q
T
L
I
Y
D
A
L
E
Site 6
Y112
R
R
I
Q
T
L
I
Y
D
A
L
E
R
P
R
Site 7
Y125
P
R
G
W
A
L
L
Y
H
A
L
V
F
L
I
Site 8
Y148
V
L
T
T
F
K
E
Y
E
T
V
S
G
D
W
Site 9
T150
T
T
F
K
E
Y
E
T
V
S
G
D
W
L
L
Site 10
Y184
A
A
G
C
C
C
R
Y
K
G
W
R
G
R
L
Site 11
T224
N
Q
G
N
V
L
A
T
S
L
R
S
L
R
F
Site 12
T246
R
M
D
R
R
G
G
T
W
K
L
L
G
S
A
Site 13
Y303
M
K
E
E
F
E
T
Y
A
D
A
L
W
W
G
Site 14
T323
T
I
G
Y
G
D
K
T
P
K
T
W
E
G
R
Site 15
T326
Y
G
D
K
T
P
K
T
W
E
G
R
L
I
A
Site 16
Y385
L
I
Q
A
A
W
R
Y
Y
A
T
N
P
N
R
Site 17
Y386
I
Q
A
A
W
R
Y
Y
A
T
N
P
N
R
I
Site 18
S407
R
F
Y
E
S
V
V
S
F
P
F
F
R
K
E
Site 19
S421
E
Q
L
E
A
A
S
S
Q
K
L
G
L
L
D
Site 20
S433
L
L
D
R
V
R
L
S
N
P
R
G
S
N
T
Site 21
S438
R
L
S
N
P
R
G
S
N
T
K
G
K
L
F
Site 22
T446
N
T
K
G
K
L
F
T
P
L
N
V
D
A
I
Site 23
S456
N
V
D
A
I
E
E
S
P
S
K
E
P
K
P
Site 24
S458
D
A
I
E
E
S
P
S
K
E
P
K
P
V
G
Site 25
T474
N
N
K
E
R
F
R
T
A
F
R
M
K
A
Y
Site 26
S486
K
A
Y
A
F
W
Q
S
S
E
D
A
G
T
G
Site 27
S487
A
Y
A
F
W
Q
S
S
E
D
A
G
T
G
D
Site 28
T492
Q
S
S
E
D
A
G
T
G
D
P
M
A
E
D
Site 29
Y502
P
M
A
E
D
R
G
Y
G
N
D
F
P
I
E
Site 30
Y530
R
I
L
Q
F
R
L
Y
K
K
K
F
K
E
T
Site 31
T537
Y
K
K
K
F
K
E
T
L
R
P
Y
D
V
K
Site 32
Y541
F
K
E
T
L
R
P
Y
D
V
K
D
V
I
E
Site 33
S559
A
G
H
L
D
M
L
S
R
I
K
Y
L
Q
T
Site 34
Y563
D
M
L
S
R
I
K
Y
L
Q
T
R
I
D
M
Site 35
T573
T
R
I
D
M
I
F
T
P
G
P
P
S
T
P
Site 36
S578
I
F
T
P
G
P
P
S
T
P
K
H
K
K
S
Site 37
T579
F
T
P
G
P
P
S
T
P
K
H
K
K
S
Q
Site 38
S585
S
T
P
K
H
K
K
S
Q
K
G
S
A
F
T
Site 39
S589
H
K
K
S
Q
K
G
S
A
F
T
F
P
S
Q
Site 40
T592
S
Q
K
G
S
A
F
T
F
P
S
Q
Q
S
P
Site 41
S595
G
S
A
F
T
F
P
S
Q
Q
S
P
R
N
E
Site 42
S598
F
T
F
P
S
Q
Q
S
P
R
N
E
P
Y
V
Site 43
Y604
Q
S
P
R
N
E
P
Y
V
A
R
P
S
T
S
Site 44
S609
E
P
Y
V
A
R
P
S
T
S
E
I
E
D
Q
Site 45
T610
P
Y
V
A
R
P
S
T
S
E
I
E
D
Q
S
Site 46
S617
T
S
E
I
E
D
Q
S
M
M
G
K
F
V
K
Site 47
Y657
L
Q
V
Q
V
T
E
Y
Y
P
T
K
G
T
S
Site 48
Y658
Q
V
Q
V
T
E
Y
Y
P
T
K
G
T
S
S
Site 49
T660
Q
V
T
E
Y
Y
P
T
K
G
T
S
S
P
A
Site 50
S665
Y
P
T
K
G
T
S
S
P
A
E
A
E
K
K
Site 51
Y677
E
K
K
E
D
N
R
Y
S
D
L
K
T
I
I
Site 52
S678
K
K
E
D
N
R
Y
S
D
L
K
T
I
I
C
Site 53
T682
N
R
Y
S
D
L
K
T
I
I
C
N
Y
S
E
Site 54
Y687
L
K
T
I
I
C
N
Y
S
E
T
G
P
P
E
Site 55
S688
K
T
I
I
C
N
Y
S
E
T
G
P
P
E
P
Site 56
T690
I
I
C
N
Y
S
E
T
G
P
P
E
P
P
Y
Site 57
Y697
T
G
P
P
E
P
P
Y
S
F
H
Q
V
T
I
Site 58
S698
G
P
P
E
P
P
Y
S
F
H
Q
V
T
I
D
Site 59
T703
P
Y
S
F
H
Q
V
T
I
D
K
V
S
P
Y
Site 60
S727
L
P
R
G
G
P
S
S
G
K
V
Q
A
T
P
Site 61
T733
S
S
G
K
V
Q
A
T
P
P
S
S
A
T
T
Site 62
S737
V
Q
A
T
P
P
S
S
A
T
T
Y
V
E
R
Site 63
T740
T
P
P
S
S
A
T
T
Y
V
E
R
P
T
V
Site 64
Y741
P
P
S
S
A
T
T
Y
V
E
R
P
T
V
L
Site 65
S759
T
L
L
D
S
R
V
S
C
H
S
Q
A
D
L
Site 66
S762
D
S
R
V
S
C
H
S
Q
A
D
L
Q
G
P
Site 67
Y770
Q
A
D
L
Q
G
P
Y
S
D
R
I
S
P
R
Site 68
S771
A
D
L
Q
G
P
Y
S
D
R
I
S
P
R
Q
Site 69
S775
G
P
Y
S
D
R
I
S
P
R
Q
R
R
S
I
Site 70
S781
I
S
P
R
Q
R
R
S
I
T
R
D
S
D
T
Site 71
T783
P
R
Q
R
R
S
I
T
R
D
S
D
T
P
L
Site 72
S786
R
R
S
I
T
R
D
S
D
T
P
L
S
L
M
Site 73
T788
S
I
T
R
D
S
D
T
P
L
S
L
M
S
V
Site 74
S791
R
D
S
D
T
P
L
S
L
M
S
V
N
H
E
Site 75
S794
D
T
P
L
S
L
M
S
V
N
H
E
E
L
E
Site 76
S803
N
H
E
E
L
E
R
S
P
S
G
F
S
I
S
Site 77
S805
E
E
L
E
R
S
P
S
G
F
S
I
S
Q
D
Site 78
S810
S
P
S
G
F
S
I
S
Q
D
R
D
D
Y
V
Site 79
Y816
I
S
Q
D
R
D
D
Y
V
F
G
P
N
G
G
Site 80
S825
F
G
P
N
G
G
S
S
W
M
R
E
K
R
Y
Site 81
Y832
S
W
M
R
E
K
R
Y
L
A
E
G
E
T
D
Site 82
T842
E
G
E
T
D
T
D
T
D
P
F
T
P
S
G
Site 83
T846
D
T
D
T
D
P
F
T
P
S
G
S
M
P
L
Site 84
S848
D
T
D
P
F
T
P
S
G
S
M
P
L
S
S
Site 85
S850
D
P
F
T
P
S
G
S
M
P
L
S
S
T
G
Site 86
S854
P
S
G
S
M
P
L
S
S
T
G
D
G
I
S
Site 87
S855
S
G
S
M
P
L
S
S
T
G
D
G
I
S
D
Site 88
S861
S
S
T
G
D
G
I
S
D
S
V
W
T
P
S
Site 89
S863
T
G
D
G
I
S
D
S
V
W
T
P
S
N
K
Site 90
T866
G
I
S
D
S
V
W
T
P
S
N
K
P
I
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation