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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Smad6
Full Name:
Mothers against decapentaplegic homolog 6
Alias:
HSMAD6; HsT17432; MADH6; MADH7; Mothers against decapentaplegic 6; Mothers against DPP 6; SMAD 6; SMAD family member 6
Type:
Transcription factor
Mass (Da):
53497
Number AA:
496
UniProt ID:
O43541
International Prot ID:
IPI00012869
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005667
Uniprot
OncoNet
Molecular Function:
GO:0070411
GO:0070412
GO:0070410
PhosphoSite+
KinaseNET
Biological Process:
GO:0030509
GO:0006955
GO:0030514
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
L
V
R
R
L
W
R
S
R
V
V
P
D
R
E
Site 2
S27
P
D
R
E
E
G
G
S
G
G
G
G
G
G
D
Site 3
S38
G
G
G
D
E
D
G
S
L
G
S
R
A
E
P
Site 4
S58
E
G
G
G
C
G
R
S
E
V
R
P
V
A
P
Site 5
S94
G
G
P
P
R
P
M
S
E
P
G
A
G
A
G
Site 6
S119
G
P
G
W
L
P
E
S
D
C
E
T
V
T
C
Site 7
T125
E
S
D
C
E
T
V
T
C
C
L
F
S
E
R
Site 8
S142
A
G
A
P
R
D
A
S
D
P
L
A
G
A
A
Site 9
S158
E
P
A
G
G
G
R
S
R
E
A
R
S
R
L
Site 10
T174
L
L
E
Q
E
L
K
T
V
T
Y
S
L
L
K
Site 11
Y177
Q
E
L
K
T
V
T
Y
S
L
L
K
R
L
K
Site 12
S187
L
K
R
L
K
E
R
S
L
D
T
L
L
E
A
Site 13
S274
S
R
L
C
G
P
E
S
P
P
P
P
Y
S
R
Site 14
Y279
P
E
S
P
P
P
P
Y
S
R
L
S
P
R
D
Site 15
S280
E
S
P
P
P
P
Y
S
R
L
S
P
R
D
E
Site 16
S283
P
P
P
Y
S
R
L
S
P
R
D
E
Y
K
P
Site 17
Y288
R
L
S
P
R
D
E
Y
K
P
L
D
L
S
D
Site 18
S294
E
Y
K
P
L
D
L
S
D
S
T
L
S
Y
T
Site 19
S296
K
P
L
D
L
S
D
S
T
L
S
Y
T
E
T
Site 20
T297
P
L
D
L
S
D
S
T
L
S
Y
T
E
T
E
Site 21
S299
D
L
S
D
S
T
L
S
Y
T
E
T
E
A
T
Site 22
T303
S
T
L
S
Y
T
E
T
E
A
T
N
S
L
I
Site 23
T306
S
Y
T
E
T
E
A
T
N
S
L
I
T
A
P
Site 24
S308
T
E
T
E
A
T
N
S
L
I
T
A
P
G
E
Site 25
S317
I
T
A
P
G
E
F
S
D
A
S
M
S
P
D
Site 26
S320
P
G
E
F
S
D
A
S
M
S
P
D
A
T
K
Site 27
S322
E
F
S
D
A
S
M
S
P
D
A
T
K
P
S
Site 28
T326
A
S
M
S
P
D
A
T
K
P
S
H
W
C
S
Site 29
Y347
R
T
R
V
G
R
L
Y
A
V
Y
D
Q
A
V
Site 30
Y358
D
Q
A
V
S
I
F
Y
D
L
P
Q
G
S
G
Site 31
S379
N
L
E
Q
R
S
E
S
V
R
R
T
R
S
K
Site 32
T383
R
S
E
S
V
R
R
T
R
S
K
I
G
F
G
Site 33
S385
E
S
V
R
R
T
R
S
K
I
G
F
G
I
L
Site 34
Y403
E
P
D
G
V
W
A
Y
N
R
G
E
H
P
I
Site 35
S414
E
H
P
I
F
V
N
S
P
T
L
D
A
P
G
Site 36
T416
P
I
F
V
N
S
P
T
L
D
A
P
G
G
R
Site 37
S435
R
K
V
P
P
G
Y
S
I
K
V
F
D
F
E
Site 38
Y459
P
D
A
A
D
G
P
Y
D
P
N
S
V
R
I
Site 39
S463
D
G
P
Y
D
P
N
S
V
R
I
S
F
A
K
Site 40
S467
D
P
N
S
V
R
I
S
F
A
K
G
W
G
P
Site 41
Y476
A
K
G
W
G
P
C
Y
S
R
Q
F
I
T
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation