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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LAT
Full Name:
Linker for activation of T-cells family member 1
Alias:
36 kDa phospho-tyrosine adaptor protein; LAT1; Linker for activation of T cells; p36-38; pp36
Type:
Adapter/scaffold protein
Mass (Da):
27930
Number AA:
262
UniProt ID:
O43561
International Prot ID:
IPI00012888
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0001772
GO:0016021
GO:0045121
Uniprot
OncoNet
Molecular Function:
GO:0005070
PhosphoSite+
KinaseNET
Biological Process:
GO:0007265
GO:0019722
GO:0007229
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S35
H
C
H
R
L
P
G
S
Y
D
S
T
S
S
D
Site 2
Y36
C
H
R
L
P
G
S
Y
D
S
T
S
S
D
S
Site 3
S38
R
L
P
G
S
Y
D
S
T
S
S
D
S
L
Y
Site 4
T39
L
P
G
S
Y
D
S
T
S
S
D
S
L
Y
P
Site 5
S40
P
G
S
Y
D
S
T
S
S
D
S
L
Y
P
R
Site 6
S41
G
S
Y
D
S
T
S
S
D
S
L
Y
P
R
G
Site 7
S43
Y
D
S
T
S
S
D
S
L
Y
P
R
G
I
Q
Site 8
Y45
S
T
S
S
D
S
L
Y
P
R
G
I
Q
F
K
Site 9
T56
I
Q
F
K
R
P
H
T
V
A
P
W
P
P
A
Site 10
Y64
V
A
P
W
P
P
A
Y
P
P
V
T
S
Y
P
Site 11
T68
P
P
A
Y
P
P
V
T
S
Y
P
P
L
S
Q
Site 12
S69
P
A
Y
P
P
V
T
S
Y
P
P
L
S
Q
P
Site 13
Y70
A
Y
P
P
V
T
S
Y
P
P
L
S
Q
P
D
Site 14
S74
V
T
S
Y
P
P
L
S
Q
P
D
L
L
P
I
Site 15
S84
D
L
L
P
I
P
R
S
P
Q
P
L
G
G
S
Site 16
S91
S
P
Q
P
L
G
G
S
H
R
T
P
S
S
R
Site 17
T94
P
L
G
G
S
H
R
T
P
S
S
R
R
D
S
Site 18
S96
G
G
S
H
R
T
P
S
S
R
R
D
S
D
G
Site 19
S97
G
S
H
R
T
P
S
S
R
R
D
S
D
G
A
Site 20
S101
T
P
S
S
R
R
D
S
D
G
A
N
S
V
A
Site 21
S106
R
D
S
D
G
A
N
S
V
A
S
Y
E
N
E
Site 22
S109
D
G
A
N
S
V
A
S
Y
E
N
E
G
A
S
Site 23
Y110
G
A
N
S
V
A
S
Y
E
N
E
G
A
S
G
Site 24
T136
G
P
S
W
T
R
L
T
P
V
S
L
P
P
E
Site 25
S139
W
T
R
L
T
P
V
S
L
P
P
E
P
A
C
Site 26
Y156
A
D
E
D
E
D
D
Y
H
N
P
G
Y
L
V
Site 27
Y161
D
D
Y
H
N
P
G
Y
L
V
V
L
P
D
S
Site 28
T172
L
P
D
S
T
P
A
T
S
T
A
A
P
S
A
Site 29
S173
P
D
S
T
P
A
T
S
T
A
A
P
S
A
P
Site 30
T174
D
S
T
P
A
T
S
T
A
A
P
S
A
P
A
Site 31
S183
A
P
S
A
P
A
L
S
T
P
G
I
R
D
S
Site 32
T184
P
S
A
P
A
L
S
T
P
G
I
R
D
S
A
Site 33
S190
S
T
P
G
I
R
D
S
A
F
S
M
E
S
I
Site 34
S193
G
I
R
D
S
A
F
S
M
E
S
I
D
D
Y
Site 35
Y200
S
M
E
S
I
D
D
Y
V
N
V
P
E
S
G
Site 36
S206
D
Y
V
N
V
P
E
S
G
E
S
A
E
A
S
Site 37
S209
N
V
P
E
S
G
E
S
A
E
A
S
L
D
G
Site 38
S213
S
G
E
S
A
E
A
S
L
D
G
S
R
E
Y
Site 39
S217
A
E
A
S
L
D
G
S
R
E
Y
V
N
V
S
Site 40
Y220
S
L
D
G
S
R
E
Y
V
N
V
S
Q
E
L
Site 41
S224
S
R
E
Y
V
N
V
S
Q
E
L
H
P
G
A
Site 42
T234
L
H
P
G
A
A
K
T
E
P
A
A
L
S
S
Site 43
S240
K
T
E
P
A
A
L
S
S
Q
E
A
E
E
V
Site 44
S241
T
E
P
A
A
L
S
S
Q
E
A
E
E
V
E
Site 45
Y255
E
E
E
G
A
P
D
Y
E
N
L
Q
E
L
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation