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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Doublecortin
Full Name:
Neuronal migration protein doublecortin
Alias:
DBCN; DCX; Doublin; Lissencephalin-X; LISX; Lis-X
Type:
Cytoskeletal protein
Mass (Da):
49318
Number AA:
441
UniProt ID:
O43602
International Prot ID:
IPI00746702
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005875
Uniprot
OncoNet
Molecular Function:
GO:0008017
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S58
M
C
E
E
T
D
A
S
F
N
V
F
S
P
K
Site 2
S63
D
A
S
F
N
V
F
S
P
K
F
Q
F
D
R
Site 3
S71
P
K
F
Q
F
D
R
S
H
C
Q
S
L
R
F
Site 4
T95
H
F
D
E
R
D
K
T
S
R
N
M
R
G
S
Site 5
S102
T
S
R
N
M
R
G
S
R
M
N
G
L
P
S
Site 6
S109
S
R
M
N
G
L
P
S
P
T
H
S
A
H
C
Site 7
T111
M
N
G
L
P
S
P
T
H
S
A
H
C
S
F
Site 8
S113
G
L
P
S
P
T
H
S
A
H
C
S
F
Y
R
Site 9
S117
P
T
H
S
A
H
C
S
F
Y
R
T
R
T
L
Site 10
Y119
H
S
A
H
C
S
F
Y
R
T
R
T
L
Q
A
Site 11
T123
C
S
F
Y
R
T
R
T
L
Q
A
L
S
N
E
Site 12
S128
T
R
T
L
Q
A
L
S
N
E
K
K
A
K
K
Site 13
Y139
K
A
K
K
V
R
F
Y
R
N
G
D
R
Y
F
Site 14
Y145
F
Y
R
N
G
D
R
Y
F
K
G
I
V
Y
A
Site 15
Y151
R
Y
F
K
G
I
V
Y
A
V
S
S
D
R
F
Site 16
S154
K
G
I
V
Y
A
V
S
S
D
R
F
R
S
F
Site 17
S155
G
I
V
Y
A
V
S
S
D
R
F
R
S
F
D
Site 18
S160
V
S
S
D
R
F
R
S
F
D
A
L
L
A
D
Site 19
S173
A
D
L
T
R
S
L
S
D
N
I
N
L
P
Q
Site 20
Y184
N
L
P
Q
G
V
R
Y
I
Y
T
I
D
G
S
Site 21
Y186
P
Q
G
V
R
Y
I
Y
T
I
D
G
S
R
K
Site 22
T187
Q
G
V
R
Y
I
Y
T
I
D
G
S
R
K
I
Site 23
S196
D
G
S
R
K
I
G
S
M
D
E
L
E
E
G
Site 24
S205
D
E
L
E
E
G
E
S
Y
V
C
S
S
D
N
Site 25
Y206
E
L
E
E
G
E
S
Y
V
C
S
S
D
N
F
Site 26
S209
E
G
E
S
Y
V
C
S
S
D
N
F
F
K
K
Site 27
S210
G
E
S
Y
V
C
S
S
D
N
F
F
K
K
V
Site 28
S228
K
N
V
N
P
N
W
S
V
N
V
K
T
S
A
Site 29
S242
A
N
M
K
A
P
Q
S
L
A
S
S
N
S
A
Site 30
S246
A
P
Q
S
L
A
S
S
N
S
A
Q
A
R
E
Site 31
S248
Q
S
L
A
S
S
N
S
A
Q
A
R
E
N
K
Site 32
T284
R
V
L
L
N
K
K
T
A
H
S
F
E
Q
V
Site 33
S287
L
N
K
K
T
A
H
S
F
E
Q
V
L
T
D
Site 34
T293
H
S
F
E
Q
V
L
T
D
I
T
E
A
I
K
Site 35
T296
E
Q
V
L
T
D
I
T
E
A
I
K
L
E
T
Site 36
T303
T
E
A
I
K
L
E
T
G
V
V
K
K
L
Y
Site 37
Y310
T
G
V
V
K
K
L
Y
T
L
D
G
K
Q
V
Site 38
Y340
C
G
P
E
K
F
R
Y
A
Q
D
D
F
S
L
Site 39
S346
R
Y
A
Q
D
D
F
S
L
D
E
N
E
C
R
Site 40
S368
A
T
A
G
P
K
A
S
P
T
P
Q
K
T
S
Site 41
T370
A
G
P
K
A
S
P
T
P
Q
K
T
S
A
K
Site 42
T374
A
S
P
T
P
Q
K
T
S
A
K
S
P
G
P
Site 43
S375
S
P
T
P
Q
K
T
S
A
K
S
P
G
P
M
Site 44
S378
P
Q
K
T
S
A
K
S
P
G
P
M
R
R
S
Site 45
S385
S
P
G
P
M
R
R
S
K
S
P
A
D
S
A
Site 46
S387
G
P
M
R
R
S
K
S
P
A
D
S
A
N
G
Site 47
S391
R
S
K
S
P
A
D
S
A
N
G
T
S
S
S
Site 48
T395
P
A
D
S
A
N
G
T
S
S
S
Q
L
S
T
Site 49
S396
A
D
S
A
N
G
T
S
S
S
Q
L
S
T
P
Site 50
S397
D
S
A
N
G
T
S
S
S
Q
L
S
T
P
K
Site 51
S398
S
A
N
G
T
S
S
S
Q
L
S
T
P
K
S
Site 52
S401
G
T
S
S
S
Q
L
S
T
P
K
S
K
Q
S
Site 53
T402
T
S
S
S
Q
L
S
T
P
K
S
K
Q
S
P
Site 54
S405
S
Q
L
S
T
P
K
S
K
Q
S
P
I
S
T
Site 55
S408
S
T
P
K
S
K
Q
S
P
I
S
T
P
T
S
Site 56
S411
K
S
K
Q
S
P
I
S
T
P
T
S
P
G
S
Site 57
T412
S
K
Q
S
P
I
S
T
P
T
S
P
G
S
L
Site 58
T414
Q
S
P
I
S
T
P
T
S
P
G
S
L
R
K
Site 59
S415
S
P
I
S
T
P
T
S
P
G
S
L
R
K
H
Site 60
S418
S
T
P
T
S
P
G
S
L
R
K
H
K
D
L
Site 61
Y426
L
R
K
H
K
D
L
Y
L
P
L
S
L
D
D
Site 62
S430
K
D
L
Y
L
P
L
S
L
D
D
S
D
S
L
Site 63
S434
L
P
L
S
L
D
D
S
D
S
L
G
D
S
M
Site 64
S436
L
S
L
D
D
S
D
S
L
G
D
S
M
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation