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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HCRTR1
Full Name:
Orexin receptor type 1
Alias:
Hypocretin (orexin) receptor 1; Hypocretin receptor type 1; Ox1r
Type:
Receptor, miscellaneous
Mass (Da):
47536
Number AA:
425
UniProt ID:
O43613
International Prot ID:
IPI00013375
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0016499
PhosphoSite+
KinaseNET
Biological Process:
GO:0007631
GO:0007218
GO:0007268
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
E
P
S
A
T
P
G
A
Q
M
G
V
Site 2
S17
Q
M
G
V
P
P
G
S
R
E
P
S
P
V
P
Site 3
S21
P
P
G
S
R
E
P
S
P
V
P
P
D
Y
E
Site 4
Y27
P
S
P
V
P
P
D
Y
E
D
E
F
L
R
Y
Site 5
Y34
Y
E
D
E
F
L
R
Y
L
W
R
D
Y
L
Y
Site 6
Y39
L
R
Y
L
W
R
D
Y
L
Y
P
K
Q
Y
E
Site 7
Y45
D
Y
L
Y
P
K
Q
Y
E
W
V
L
I
A
A
Site 8
Y83
H
M
R
T
V
T
N
Y
F
I
V
N
L
S
L
Site 9
S156
C
H
P
L
L
F
K
S
T
A
R
R
A
R
G
Site 10
T157
H
P
L
L
F
K
S
T
A
R
R
A
R
G
S
Site 11
S200
A
N
R
T
R
L
F
S
V
C
D
E
R
W
A
Site 12
Y211
E
R
W
A
D
D
L
Y
P
K
I
Y
H
S
C
Site 13
T250
W
G
R
Q
I
P
G
T
T
S
A
L
V
R
N
Site 14
S262
V
R
N
W
K
R
P
S
D
Q
L
G
D
L
E
Site 15
S273
G
D
L
E
Q
G
L
S
G
E
P
Q
P
R
A
Site 16
T296
Q
M
R
A
R
R
K
T
A
K
M
L
M
V
V
Site 17
S331
F
G
M
F
R
Q
A
S
D
R
E
A
V
Y
A
Site 18
Y337
A
S
D
R
E
A
V
Y
A
C
F
T
F
S
H
Site 19
Y358
S
A
A
N
P
I
I
Y
N
F
L
S
G
K
F
Site 20
S385
P
G
L
G
P
C
G
S
L
K
A
P
S
P
R
Site 21
S390
C
G
S
L
K
A
P
S
P
R
S
S
A
S
H
Site 22
S393
L
K
A
P
S
P
R
S
S
A
S
H
K
S
L
Site 23
S394
K
A
P
S
P
R
S
S
A
S
H
K
S
L
S
Site 24
S396
P
S
P
R
S
S
A
S
H
K
S
L
S
L
Q
Site 25
S399
R
S
S
A
S
H
K
S
L
S
L
Q
S
R
C
Site 26
S401
S
A
S
H
K
S
L
S
L
Q
S
R
C
S
I
Site 27
S404
H
K
S
L
S
L
Q
S
R
C
S
I
S
K
I
Site 28
S407
L
S
L
Q
S
R
C
S
I
S
K
I
S
E
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation