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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACTN4
Full Name:
Alpha-actinin-4
Alias:
AAC4; actinin, alpha 4; Alpha-actinin 4; F-actin cross linking protein; Non-muscle alpha-actinin 4
Type:
Cytoskeletal protein
Mass (Da):
104854
Number AA:
911
UniProt ID:
O43707
International Prot ID:
IPI00013808
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005730
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0051015
GO:0005509
GO:0005178
PhosphoSite+
KinaseNET
Biological Process:
GO:0051272
GO:0032417
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y4
_
_
_
_
M
V
D
Y
H
A
A
N
Q
S
Y
Site 2
S10
D
Y
H
A
A
N
Q
S
Y
Q
Y
G
P
S
S
Site 3
Y13
A
A
N
Q
S
Y
Q
Y
G
P
S
S
A
G
N
Site 4
S16
Q
S
Y
Q
Y
G
P
S
S
A
G
N
G
A
G
Site 5
S17
S
Y
Q
Y
G
P
S
S
A
G
N
G
A
G
G
Site 6
S27
N
G
A
G
G
G
G
S
M
G
D
Y
M
A
Q
Site 7
Y31
G
G
G
S
M
G
D
Y
M
A
Q
E
D
D
W
Site 8
T69
S
H
L
R
K
A
G
T
Q
I
E
N
I
D
E
Site 9
S92
M
L
L
L
E
V
I
S
G
E
R
L
P
K
P
Site 10
T142
V
D
G
N
A
K
M
T
L
G
M
I
W
T
I
Site 11
S159
R
F
A
I
Q
D
I
S
V
E
E
T
S
A
K
Site 12
T163
Q
D
I
S
V
E
E
T
S
A
K
E
G
L
L
Site 13
Y180
C
Q
R
K
T
A
P
Y
K
N
V
N
V
Q
N
Site 14
Y212
H
R
P
E
L
I
E
Y
D
K
L
R
K
D
D
Site 15
T222
L
R
K
D
D
P
V
T
N
L
N
N
A
F
E
Site 16
Y234
A
F
E
V
A
E
K
Y
L
D
I
P
K
M
L
Site 17
T249
D
A
E
D
I
V
N
T
A
R
P
D
E
K
A
Site 18
T259
P
D
E
K
A
I
M
T
Y
V
S
S
F
Y
H
Site 19
Y260
D
E
K
A
I
M
T
Y
V
S
S
F
Y
H
A
Site 20
S262
K
A
I
M
T
Y
V
S
S
F
Y
H
A
F
S
Site 21
S263
A
I
M
T
Y
V
S
S
F
Y
H
A
F
S
G
Site 22
Y265
M
T
Y
V
S
S
F
Y
H
A
F
S
G
A
Q
Site 23
S269
S
S
F
Y
H
A
F
S
G
A
Q
K
A
E
T
Site 24
T276
S
G
A
Q
K
A
E
T
A
A
N
R
I
C
K
Site 25
Y298
N
E
H
L
M
E
D
Y
E
K
L
A
S
D
L
Site 26
S303
E
D
Y
E
K
L
A
S
D
L
L
E
W
I
R
Site 27
T312
L
L
E
W
I
R
R
T
I
P
W
L
E
D
R
Site 28
T324
E
D
R
V
P
Q
K
T
I
Q
E
M
Q
Q
K
Site 29
Y338
K
L
E
D
F
R
D
Y
R
R
V
H
K
P
P
Site 30
S367
L
Q
T
K
L
R
L
S
N
R
P
A
F
M
P
Site 31
S375
N
R
P
A
F
M
P
S
E
G
K
M
V
S
D
Site 32
S381
P
S
E
G
K
M
V
S
D
I
N
N
G
W
Q
Site 33
S423
E
K
F
R
Q
K
A
S
I
H
E
A
W
T
D
Site 34
Y441
A
M
L
K
H
R
D
Y
E
T
A
T
L
S
D
Site 35
T443
L
K
H
R
D
Y
E
T
A
T
L
S
D
I
K
Site 36
S447
D
Y
E
T
A
T
L
S
D
I
K
A
L
I
R
Site 37
S461
R
K
H
E
A
F
E
S
D
L
A
A
H
Q
D
Site 38
Y485
Q
E
L
N
E
L
D
Y
Y
D
S
H
N
V
N
Site 39
Y486
E
L
N
E
L
D
Y
Y
D
S
H
N
V
N
T
Site 40
S488
N
E
L
D
Y
Y
D
S
H
N
V
N
T
R
C
Site 41
T493
Y
D
S
H
N
V
N
T
R
C
Q
K
I
C
D
Site 42
S507
D
Q
W
D
A
L
G
S
L
T
H
S
R
R
E
Site 43
T509
W
D
A
L
G
S
L
T
H
S
R
R
E
A
L
Site 44
S511
A
L
G
S
L
T
H
S
R
R
E
A
L
E
K
Site 45
S568
E
E
I
E
G
L
I
S
A
H
D
Q
F
K
S
Site 46
S575
S
A
H
D
Q
F
K
S
T
L
P
D
A
D
R
Site 47
S600
E
A
Q
R
I
A
E
S
N
H
I
K
L
S
G
Site 48
S606
E
S
N
H
I
K
L
S
G
S
N
P
Y
T
T
Site 49
S608
N
H
I
K
L
S
G
S
N
P
Y
T
T
V
T
Site 50
T612
L
S
G
S
N
P
Y
T
T
V
T
P
Q
I
I
Site 51
T613
S
G
S
N
P
Y
T
T
V
T
P
Q
I
I
N
Site 52
T615
S
N
P
Y
T
T
V
T
P
Q
I
I
N
S
K
Site 53
S621
V
T
P
Q
I
I
N
S
K
W
E
K
V
Q
Q
Site 54
S642
H
A
L
L
E
E
Q
S
K
Q
Q
S
N
E
H
Site 55
S646
E
E
Q
S
K
Q
Q
S
N
E
H
L
R
R
Q
Site 56
S656
H
L
R
R
Q
F
A
S
Q
A
N
V
V
G
P
Site 57
T667
V
V
G
P
W
I
Q
T
K
M
E
E
I
G
R
Site 58
S676
M
E
E
I
G
R
I
S
I
E
M
N
G
T
L
Site 59
T682
I
S
I
E
M
N
G
T
L
E
D
Q
L
S
H
Site 60
S688
G
T
L
E
D
Q
L
S
H
L
K
Q
Y
E
R
Site 61
Y693
Q
L
S
H
L
K
Q
Y
E
R
S
I
V
D
Y
Site 62
Y700
Y
E
R
S
I
V
D
Y
K
P
N
L
D
L
L
Site 63
Y727
F
D
N
K
H
T
N
Y
T
M
E
H
I
R
V
Site 64
T756
E
V
E
N
Q
I
L
T
R
D
A
K
G
I
S
Site 65
S763
T
R
D
A
K
G
I
S
Q
E
Q
M
Q
E
F
Site 66
S816
A
E
F
N
R
I
M
S
L
V
D
P
N
H
S
Site 67
S836
Q
A
F
I
D
F
M
S
R
E
T
T
D
T
D
Site 68
T839
I
D
F
M
S
R
E
T
T
D
T
D
T
A
D
Site 69
T840
D
F
M
S
R
E
T
T
D
T
D
T
A
D
Q
Site 70
T842
M
S
R
E
T
T
D
T
D
T
A
D
Q
V
I
Site 71
T844
R
E
T
T
D
T
D
T
A
D
Q
V
I
A
S
Site 72
Y878
L
P
P
D
Q
A
E
Y
C
I
A
R
M
A
P
Site 73
Y886
C
I
A
R
M
A
P
Y
Q
G
P
D
A
V
P
Site 74
S900
P
G
A
L
D
Y
K
S
F
S
T
A
L
Y
G
Site 75
Y906
K
S
F
S
T
A
L
Y
G
E
S
D
L
_
_
Site 76
S909
S
T
A
L
Y
G
E
S
D
L
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation