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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SH3BP5
Full Name:
SH3 domain-binding protein 5
Alias:
SH3 domain-binding protein that preferentially associates with BTK
Type:
Mass (Da):
50425
Number AA:
455
UniProt ID:
O60239
International Prot ID:
IPI00744182
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0017124
GO:0004860
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
A
A
L
K
R
S
R
S
E
E
P
A
E
I
L
Site 2
T64
D
D
I
N
R
R
E
T
E
L
E
D
A
R
Q
Site 3
S75
D
A
R
Q
K
F
R
S
V
L
V
E
A
T
V
Site 4
S98
I
G
K
A
V
E
D
S
K
P
Y
W
E
A
R
Site 5
T126
T
Q
D
F
Q
R
A
T
E
V
L
R
A
A
K
Site 6
T135
V
L
R
A
A
K
E
T
I
S
L
A
E
Q
R
Site 7
S137
R
A
A
K
E
T
I
S
L
A
E
Q
R
L
L
Site 8
T172
R
V
M
E
A
E
Q
T
K
T
R
S
E
L
V
Site 9
T174
M
E
A
E
Q
T
K
T
R
S
E
L
V
H
K
Site 10
Y187
H
K
E
T
A
A
R
Y
N
A
A
M
G
R
M
Site 11
S208
L
K
R
A
I
N
K
S
K
P
Y
F
E
L
K
Site 12
Y211
A
I
N
K
S
K
P
Y
F
E
L
K
A
K
Y
Site 13
Y218
Y
F
E
L
K
A
K
Y
Y
V
Q
L
E
Q
L
Site 14
Y219
F
E
L
K
A
K
Y
Y
V
Q
L
E
Q
L
K
Site 15
T228
Q
L
E
Q
L
K
K
T
V
D
D
L
Q
A
K
Site 16
T237
D
D
L
Q
A
K
L
T
L
A
K
G
E
Y
K
Site 17
S254
L
K
N
L
E
M
I
S
D
E
I
H
E
R
R
Site 18
S263
E
I
H
E
R
R
R
S
S
A
M
G
P
R
G
Site 19
S264
I
H
E
R
R
R
S
S
A
M
G
P
R
G
C
Site 20
T280
V
G
A
E
G
S
S
T
S
V
E
D
L
P
G
Site 21
S281
G
A
E
G
S
S
T
S
V
E
D
L
P
G
S
Site 22
S288
S
V
E
D
L
P
G
S
K
P
E
P
D
A
I
Site 23
S296
K
P
E
P
D
A
I
S
V
A
S
E
A
F
E
Site 24
S306
S
E
A
F
E
D
D
S
C
S
N
F
V
S
E
Site 25
S308
A
F
E
D
D
S
C
S
N
F
V
S
E
D
D
Site 26
S312
D
S
C
S
N
F
V
S
E
D
D
S
E
T
Q
Site 27
S316
N
F
V
S
E
D
D
S
E
T
Q
S
V
S
S
Site 28
T318
V
S
E
D
D
S
E
T
Q
S
V
S
S
F
S
Site 29
S320
E
D
D
S
E
T
Q
S
V
S
S
F
S
S
G
Site 30
S322
D
S
E
T
Q
S
V
S
S
F
S
S
G
P
T
Site 31
S323
S
E
T
Q
S
V
S
S
F
S
S
G
P
T
S
Site 32
S325
T
Q
S
V
S
S
F
S
S
G
P
T
S
P
S
Site 33
S326
Q
S
V
S
S
F
S
S
G
P
T
S
P
S
E
Site 34
T329
S
S
F
S
S
G
P
T
S
P
S
E
M
P
D
Site 35
S330
S
F
S
S
G
P
T
S
P
S
E
M
P
D
Q
Site 36
S332
S
S
G
P
T
S
P
S
E
M
P
D
Q
F
P
Site 37
S351
P
G
S
L
D
L
P
S
P
V
S
L
S
E
F
Site 38
S369
F
P
V
L
G
P
R
S
E
C
S
G
A
S
S
Site 39
S372
L
G
P
R
S
E
C
S
G
A
S
S
P
E
C
Site 40
S375
R
S
E
C
S
G
A
S
S
P
E
C
E
V
E
Site 41
S376
S
E
C
S
G
A
S
S
P
E
C
E
V
E
R
Site 42
S395
E
G
A
E
N
K
T
S
D
K
A
N
N
N
R
Site 43
S405
A
N
N
N
R
G
L
S
S
S
S
G
S
G
G
Site 44
S406
N
N
N
R
G
L
S
S
S
S
G
S
G
G
S
Site 45
S407
N
N
R
G
L
S
S
S
S
G
S
G
G
S
S
Site 46
S408
N
R
G
L
S
S
S
S
G
S
G
G
S
S
K
Site 47
S410
G
L
S
S
S
S
G
S
G
G
S
S
K
S
Q
Site 48
S413
S
S
S
G
S
G
G
S
S
K
S
Q
S
S
T
Site 49
S414
S
S
G
S
G
G
S
S
K
S
Q
S
S
T
S
Site 50
S416
G
S
G
G
S
S
K
S
Q
S
S
T
S
P
E
Site 51
S418
G
G
S
S
K
S
Q
S
S
T
S
P
E
G
Q
Site 52
S419
G
S
S
K
S
Q
S
S
T
S
P
E
G
Q
A
Site 53
T420
S
S
K
S
Q
S
S
T
S
P
E
G
Q
A
L
Site 54
S421
S
K
S
Q
S
S
T
S
P
E
G
Q
A
L
E
Site 55
S435
E
N
R
M
K
Q
L
S
L
Q
C
S
K
G
R
Site 56
S439
K
Q
L
S
L
Q
C
S
K
G
R
D
G
I
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation