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Updated November 2019
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Protein Info
Short Name:
MAST3
Full Name:
Microtubule-associated serine/threonine-protein kinase 3
Alias:
EC 2.7.11.1; KIAA0561; Microtubule associated serine/threonine kinase 3
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; AGC group; MAST family
Mass (Da):
143137
Number AA:
1309
UniProt ID:
O60307
International Prot ID:
IPI00028932
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
D
E
S
S
L
L
R
R
R
G
L
Site 2
S17
R
G
L
Q
K
E
L
S
L
P
R
R
G
R
G
Site 3
S27
R
R
G
R
G
C
R
S
G
N
R
K
S
L
V
Site 4
S32
C
R
S
G
N
R
K
S
L
V
V
G
T
P
S
Site 5
T37
R
K
S
L
V
V
G
T
P
S
P
T
L
S
R
Site 6
T41
V
V
G
T
P
S
P
T
L
S
R
P
L
S
P
Site 7
S43
G
T
P
S
P
T
L
S
R
P
L
S
P
L
S
Site 8
S47
P
T
L
S
R
P
L
S
P
L
S
V
P
T
A
Site 9
S50
S
R
P
L
S
P
L
S
V
P
T
A
G
S
S
Site 10
S56
L
S
V
P
T
A
G
S
S
P
L
D
S
P
R
Site 11
S57
S
V
P
T
A
G
S
S
P
L
D
S
P
R
N
Site 12
S61
A
G
S
S
P
L
D
S
P
R
N
F
S
A
A
Site 13
S66
L
D
S
P
R
N
F
S
A
A
S
A
L
N
F
Site 14
S85
R
A
D
G
R
R
W
S
L
A
S
L
P
S
S
Site 15
S88
G
R
R
W
S
L
A
S
L
P
S
S
G
Y
G
Site 16
S92
S
L
A
S
L
P
S
S
G
Y
G
T
N
T
P
Site 17
Y94
A
S
L
P
S
S
G
Y
G
T
N
T
P
S
S
Site 18
T96
L
P
S
S
G
Y
G
T
N
T
P
S
S
T
L
Site 19
T98
S
S
G
Y
G
T
N
T
P
S
S
T
L
S
S
Site 20
S100
G
Y
G
T
N
T
P
S
S
T
L
S
S
S
S
Site 21
S101
Y
G
T
N
T
P
S
S
T
L
S
S
S
S
S
Site 22
T102
G
T
N
T
P
S
S
T
L
S
S
S
S
S
S
Site 23
S104
N
T
P
S
S
T
L
S
S
S
S
S
S
R
E
Site 24
S105
T
P
S
S
T
L
S
S
S
S
S
S
R
E
R
Site 25
S106
P
S
S
T
L
S
S
S
S
S
S
R
E
R
L
Site 26
S107
S
S
T
L
S
S
S
S
S
S
R
E
R
L
H
Site 27
S108
S
T
L
S
S
S
S
S
S
R
E
R
L
H
Q
Site 28
S109
T
L
S
S
S
S
S
S
R
E
R
L
H
Q
L
Site 29
T121
H
Q
L
P
F
Q
P
T
P
D
E
L
H
F
L
Site 30
S129
P
D
E
L
H
F
L
S
K
H
F
R
S
S
E
Site 31
S134
F
L
S
K
H
F
R
S
S
E
N
V
L
D
E
Site 32
S135
L
S
K
H
F
R
S
S
E
N
V
L
D
E
E
Site 33
S146
L
D
E
E
G
G
R
S
P
R
L
R
P
R
S
Site 34
S153
S
P
R
L
R
P
R
S
R
S
L
S
P
G
R
Site 35
S155
R
L
R
P
R
S
R
S
L
S
P
G
R
A
T
Site 36
S157
R
P
R
S
R
S
L
S
P
G
R
A
T
G
T
Site 37
T162
S
L
S
P
G
R
A
T
G
T
F
D
N
E
I
Site 38
T164
S
P
G
R
A
T
G
T
F
D
N
E
I
V
M
Site 39
Y176
I
V
M
M
N
H
V
Y
R
E
R
F
P
K
A
Site 40
T184
R
E
R
F
P
K
A
T
A
Q
M
E
G
R
L
Site 41
T196
G
R
L
Q
E
F
L
T
A
Y
A
P
G
A
R
Site 42
S229
A
R
D
C
L
A
K
S
G
E
N
L
V
T
S
Site 43
T235
K
S
G
E
N
L
V
T
S
R
Y
F
L
E
M
Site 44
Y238
E
N
L
V
T
S
R
Y
F
L
E
M
Q
E
K
Site 45
S257
L
Q
D
A
H
E
R
S
D
S
E
E
V
S
F
Site 46
S259
D
A
H
E
R
S
D
S
E
E
V
S
F
I
V
Site 47
S263
R
S
D
S
E
E
V
S
F
I
V
Q
L
V
R
Site 48
S277
R
K
L
L
I
I
I
S
R
P
A
R
L
L
E
Site 49
T312
R
E
G
Q
G
I
K
T
D
L
P
Q
Y
I
I
Site 50
S336
L
E
E
M
V
P
L
S
H
L
E
E
E
Q
P
Site 51
S348
E
Q
P
P
A
P
E
S
P
E
S
R
A
L
V
Site 52
S351
P
A
P
E
S
P
E
S
R
A
L
V
G
Q
S
Site 53
S358
S
R
A
L
V
G
Q
S
R
R
K
P
C
E
S
Site 54
S365
S
R
R
K
P
C
E
S
D
F
E
T
I
K
L
Site 55
T369
P
C
E
S
D
F
E
T
I
K
L
I
S
N
G
Site 56
Y382
N
G
A
Y
G
A
V
Y
L
V
R
H
R
D
T
Site 57
T389
Y
L
V
R
H
R
D
T
R
Q
R
F
A
I
K
Site 58
T454
V
E
G
G
D
C
A
T
L
L
K
N
M
G
P
Site 59
Y484
A
L
E
Y
L
H
N
Y
G
I
V
H
R
D
L
Site 60
Y524
M
S
M
A
T
N
L
Y
E
G
H
I
E
K
D
Site 61
T543
I
D
K
Q
V
C
G
T
P
E
Y
I
A
P
E
Site 62
Y546
Q
V
C
G
T
P
E
Y
I
A
P
E
V
I
F
Site 63
Y557
E
V
I
F
R
Q
G
Y
G
K
P
V
D
W
W
Site 64
T584
C
V
P
F
F
G
D
T
P
E
E
L
F
G
Q
Site 65
S594
E
L
F
G
Q
V
V
S
D
E
I
M
W
P
E
Site 66
S621
I
T
R
L
L
R
Q
S
P
L
D
R
L
G
T
Site 67
T628
S
P
L
D
R
L
G
T
G
G
T
H
E
V
K
Site 68
T631
D
R
L
G
T
G
G
T
H
E
V
K
Q
H
P
Site 69
T665
Q
L
E
A
E
D
D
T
S
Y
F
D
T
R
S
Site 70
S666
L
E
A
E
D
D
T
S
Y
F
D
T
R
S
E
Site 71
Y667
E
A
E
D
D
T
S
Y
F
D
T
R
S
E
R
Site 72
T670
D
D
T
S
Y
F
D
T
R
S
E
R
Y
R
H
Site 73
S672
T
S
Y
F
D
T
R
S
E
R
Y
R
H
L
G
Site 74
S680
E
R
Y
R
H
L
G
S
E
D
D
E
T
N
D
Site 75
T685
L
G
S
E
D
D
E
T
N
D
E
E
S
S
T
Site 76
S690
D
E
T
N
D
E
E
S
S
T
E
I
P
Q
F
Site 77
T692
T
N
D
E
E
S
S
T
E
I
P
Q
F
S
S
Site 78
S698
S
T
E
I
P
Q
F
S
S
C
S
H
R
F
S
Site 79
S699
T
E
I
P
Q
F
S
S
C
S
H
R
F
S
K
Site 80
S701
I
P
Q
F
S
S
C
S
H
R
F
S
K
V
Y
Site 81
S705
S
S
C
S
H
R
F
S
K
V
Y
S
S
S
E
Site 82
Y708
S
H
R
F
S
K
V
Y
S
S
S
E
F
L
A
Site 83
S709
H
R
F
S
K
V
Y
S
S
S
E
F
L
A
V
Site 84
S710
R
F
S
K
V
Y
S
S
S
E
F
L
A
V
Q
Site 85
S711
F
S
K
V
Y
S
S
S
E
F
L
A
V
Q
P
Site 86
T719
E
F
L
A
V
Q
P
T
P
T
F
A
E
R
S
Site 87
T721
L
A
V
Q
P
T
P
T
F
A
E
R
S
F
S
Site 88
S726
T
P
T
F
A
E
R
S
F
S
E
D
R
E
E
Site 89
S728
T
F
A
E
R
S
F
S
E
D
R
E
E
G
W
Site 90
S738
R
E
E
G
W
E
R
S
E
V
D
Y
G
R
R
Site 91
Y742
W
E
R
S
E
V
D
Y
G
R
R
L
S
A
D
Site 92
S747
V
D
Y
G
R
R
L
S
A
D
I
R
L
R
S
Site 93
S754
S
A
D
I
R
L
R
S
W
T
S
S
G
S
S
Site 94
T756
D
I
R
L
R
S
W
T
S
S
G
S
S
C
Q
Site 95
S757
I
R
L
R
S
W
T
S
S
G
S
S
C
Q
S
Site 96
S758
R
L
R
S
W
T
S
S
G
S
S
C
Q
S
S
Site 97
S760
R
S
W
T
S
S
G
S
S
C
Q
S
S
S
S
Site 98
S761
S
W
T
S
S
G
S
S
C
Q
S
S
S
S
Q
Site 99
S764
S
S
G
S
S
C
Q
S
S
S
S
Q
P
E
R
Site 100
S765
S
G
S
S
C
Q
S
S
S
S
Q
P
E
R
G
Site 101
S766
G
S
S
C
Q
S
S
S
S
Q
P
E
R
G
P
Site 102
S767
S
S
C
Q
S
S
S
S
Q
P
E
R
G
P
S
Site 103
S774
S
Q
P
E
R
G
P
S
P
S
L
L
N
T
I
Site 104
S776
P
E
R
G
P
S
P
S
L
L
N
T
I
S
L
Site 105
T780
P
S
P
S
L
L
N
T
I
S
L
D
T
M
P
Site 106
S782
P
S
L
L
N
T
I
S
L
D
T
M
P
K
F
Site 107
S792
T
M
P
K
F
A
F
S
S
E
D
E
G
V
G
Site 108
S793
M
P
K
F
A
F
S
S
E
D
E
G
V
G
P
Site 109
T822
P
D
P
P
P
A
A
T
P
V
M
P
K
P
S
Site 110
S830
P
V
M
P
K
P
S
S
L
S
A
D
T
A
A
Site 111
T835
P
S
S
L
S
A
D
T
A
A
L
S
H
A
R
Site 112
S839
S
A
D
T
A
A
L
S
H
A
R
L
R
S
N
Site 113
S845
L
S
H
A
R
L
R
S
N
S
I
G
A
R
H
Site 114
S847
H
A
R
L
R
S
N
S
I
G
A
R
H
S
T
Site 115
S853
N
S
I
G
A
R
H
S
T
P
R
P
L
D
A
Site 116
T854
S
I
G
A
R
H
S
T
P
R
P
L
D
A
G
Site 117
S877
R
D
P
A
P
E
K
S
R
A
S
S
S
G
G
Site 118
S880
A
P
E
K
S
R
A
S
S
S
G
G
S
G
G
Site 119
S881
P
E
K
S
R
A
S
S
S
G
G
S
G
G
G
Site 120
S882
E
K
S
R
A
S
S
S
G
G
S
G
G
G
S
Site 121
S885
R
A
S
S
S
G
G
S
G
G
G
S
G
G
R
Site 122
S889
S
G
G
S
G
G
G
S
G
G
R
V
P
K
S
Site 123
S896
S
G
G
R
V
P
K
S
A
S
V
S
A
L
S
Site 124
S898
G
R
V
P
K
S
A
S
V
S
A
L
S
L
I
Site 125
S912
I
I
T
A
D
D
G
S
G
G
P
L
M
S
P
Site 126
S918
G
S
G
G
P
L
M
S
P
L
S
P
R
S
L
Site 127
S921
G
P
L
M
S
P
L
S
P
R
S
L
S
S
N
Site 128
S924
M
S
P
L
S
P
R
S
L
S
S
N
P
S
S
Site 129
S926
P
L
S
P
R
S
L
S
S
N
P
S
S
R
D
Site 130
S927
L
S
P
R
S
L
S
S
N
P
S
S
R
D
S
Site 131
S930
R
S
L
S
S
N
P
S
S
R
D
S
S
P
S
Site 132
S931
S
L
S
S
N
P
S
S
R
D
S
S
P
S
R
Site 133
S934
S
N
P
S
S
R
D
S
S
P
S
R
D
P
S
Site 134
S935
N
P
S
S
R
D
S
S
P
S
R
D
P
S
P
Site 135
S937
S
S
R
D
S
S
P
S
R
D
P
S
P
V
C
Site 136
S941
S
S
P
S
R
D
P
S
P
V
C
G
S
L
R
Site 137
S955
R
P
P
I
V
I
H
S
S
G
K
K
Y
G
F
Site 138
S956
P
P
I
V
I
H
S
S
G
K
K
Y
G
F
S
Site 139
Y960
I
H
S
S
G
K
K
Y
G
F
S
L
R
A
I
Site 140
S963
S
G
K
K
Y
G
F
S
L
R
A
I
R
V
Y
Site 141
Y970
S
L
R
A
I
R
V
Y
M
G
D
S
D
V
Y
Site 142
Y977
Y
M
G
D
S
D
V
Y
T
V
H
H
V
V
W
Site 143
S985
T
V
H
H
V
V
W
S
V
E
D
G
S
P
A
Site 144
S990
V
W
S
V
E
D
G
S
P
A
Q
E
A
G
L
Site 145
S1031
L
K
S
G
N
K
I
S
L
R
T
T
A
L
E
Site 146
T1035
N
K
I
S
L
R
T
T
A
L
E
N
T
S
I
Site 147
S1060
K
G
R
M
A
R
R
S
K
R
S
R
R
R
E
Site 148
S1063
M
A
R
R
S
K
R
S
R
R
R
E
T
Q
D
Site 149
T1068
K
R
S
R
R
R
E
T
Q
D
R
R
K
S
L
Site 150
S1074
E
T
Q
D
R
R
K
S
L
F
K
K
I
S
K
Site 151
S1080
K
S
L
F
K
K
I
S
K
Q
T
S
V
L
H
Site 152
S1084
K
K
I
S
K
Q
T
S
V
L
H
T
S
R
S
Site 153
T1088
K
Q
T
S
V
L
H
T
S
R
S
F
S
S
G
Site 154
S1089
Q
T
S
V
L
H
T
S
R
S
F
S
S
G
L
Site 155
S1091
S
V
L
H
T
S
R
S
F
S
S
G
L
H
H
Site 156
S1093
L
H
T
S
R
S
F
S
S
G
L
H
H
S
L
Site 157
S1099
F
S
S
G
L
H
H
S
L
S
S
S
E
S
L
Site 158
S1101
S
G
L
H
H
S
L
S
S
S
E
S
L
P
G
Site 159
S1102
G
L
H
H
S
L
S
S
S
E
S
L
P
G
S
Site 160
S1103
L
H
H
S
L
S
S
S
E
S
L
P
G
S
P
Site 161
S1105
H
S
L
S
S
S
E
S
L
P
G
S
P
T
H
Site 162
S1109
S
S
E
S
L
P
G
S
P
T
H
S
L
S
P
Site 163
T1111
E
S
L
P
G
S
P
T
H
S
L
S
P
S
P
Site 164
S1113
L
P
G
S
P
T
H
S
L
S
P
S
P
T
T
Site 165
S1115
G
S
P
T
H
S
L
S
P
S
P
T
T
P
C
Site 166
S1117
P
T
H
S
L
S
P
S
P
T
T
P
C
R
S
Site 167
T1119
H
S
L
S
P
S
P
T
T
P
C
R
S
P
A
Site 168
T1120
S
L
S
P
S
P
T
T
P
C
R
S
P
A
P
Site 169
S1124
S
P
T
T
P
C
R
S
P
A
P
D
V
P
A
Site 170
T1133
A
P
D
V
P
A
D
T
T
A
S
P
P
S
A
Site 171
T1134
P
D
V
P
A
D
T
T
A
S
P
P
S
A
S
Site 172
S1136
V
P
A
D
T
T
A
S
P
P
S
A
S
P
S
Site 173
S1139
D
T
T
A
S
P
P
S
A
S
P
S
S
S
S
Site 174
S1141
T
A
S
P
P
S
A
S
P
S
S
S
S
P
A
Site 175
S1143
S
P
P
S
A
S
P
S
S
S
S
P
A
S
P
Site 176
S1144
P
P
S
A
S
P
S
S
S
S
P
A
S
P
A
Site 177
S1145
P
S
A
S
P
S
S
S
S
P
A
S
P
A
A
Site 178
S1146
S
A
S
P
S
S
S
S
P
A
S
P
A
A
A
Site 179
S1149
P
S
S
S
S
P
A
S
P
A
A
A
G
H
T
Site 180
T1156
S
P
A
A
A
G
H
T
R
P
S
S
L
H
G
Site 181
S1159
A
A
G
H
T
R
P
S
S
L
H
G
L
A
A
Site 182
S1160
A
G
H
T
R
P
S
S
L
H
G
L
A
A
K
Site 183
T1175
L
G
P
P
R
P
K
T
G
R
R
K
S
T
S
Site 184
S1180
P
K
T
G
R
R
K
S
T
S
S
I
P
P
S
Site 185
T1181
K
T
G
R
R
K
S
T
S
S
I
P
P
S
P
Site 186
S1182
T
G
R
R
K
S
T
S
S
I
P
P
S
P
L
Site 187
S1183
G
R
R
K
S
T
S
S
I
P
P
S
P
L
A
Site 188
S1195
P
L
A
C
P
P
I
S
A
P
P
P
R
S
P
Site 189
S1201
I
S
A
P
P
P
R
S
P
S
P
L
P
G
H
Site 190
S1203
A
P
P
P
R
S
P
S
P
L
P
G
H
P
P
Site 191
S1215
H
P
P
A
P
A
R
S
P
R
L
R
R
G
Q
Site 192
S1223
P
R
L
R
R
G
Q
S
A
D
K
L
G
T
G
Site 193
T1241
D
G
E
A
G
R
R
T
R
G
P
E
A
E
L
Site 194
S1257
V
M
R
R
L
H
L
S
E
R
R
D
S
F
K
Site 195
S1262
H
L
S
E
R
R
D
S
F
K
K
Q
E
A
V
Site 196
S1273
Q
E
A
V
Q
E
V
S
F
D
E
P
Q
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation