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Updated November 2019
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Protein Info
Short Name:
MCM3AP
Full Name:
80 kDa MCM3-associated protein
Alias:
80 kda MCM3-associated protein; GANP protein; KIAA0572; MAP80; MCM3A; Minichromosome maintenance complex component 3 associated protein; Protein GANP
Type:
Enzyme, Acetyltransferase, DNA primase
Mass (Da):
218405
Number AA:
1980
UniProt ID:
O60318
International Prot ID:
IPI00028954
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
GO:0006606
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
N
P
T
N
P
F
S
G
Q
Q
P
S
A
F
Site 2
S13
P
F
S
G
Q
Q
P
S
A
F
S
A
S
S
S
Site 3
S16
G
Q
Q
P
S
A
F
S
A
S
S
S
N
V
G
Site 4
S18
Q
P
S
A
F
S
A
S
S
S
N
V
G
T
L
Site 5
S19
P
S
A
F
S
A
S
S
S
N
V
G
T
L
P
Site 6
S20
S
A
F
S
A
S
S
S
N
V
G
T
L
P
S
Site 7
T24
A
S
S
S
N
V
G
T
L
P
S
K
P
P
F
Site 8
S27
S
N
V
G
T
L
P
S
K
P
P
F
R
F
G
Site 9
S37
P
F
R
F
G
Q
P
S
L
F
G
Q
N
S
T
Site 10
S43
P
S
L
F
G
Q
N
S
T
L
S
G
K
S
S
Site 11
T44
S
L
F
G
Q
N
S
T
L
S
G
K
S
S
G
Site 12
S46
F
G
Q
N
S
T
L
S
G
K
S
S
G
F
S
Site 13
S49
N
S
T
L
S
G
K
S
S
G
F
S
Q
V
S
Site 14
S50
S
T
L
S
G
K
S
S
G
F
S
Q
V
S
S
Site 15
S53
S
G
K
S
S
G
F
S
Q
V
S
S
F
P
A
Site 16
S56
S
S
G
F
S
Q
V
S
S
F
P
A
S
S
G
Site 17
S57
S
G
F
S
Q
V
S
S
F
P
A
S
S
G
V
Site 18
S61
Q
V
S
S
F
P
A
S
S
G
V
S
H
S
S
Site 19
S62
V
S
S
F
P
A
S
S
G
V
S
H
S
S
S
Site 20
S65
F
P
A
S
S
G
V
S
H
S
S
S
V
Q
T
Site 21
S67
A
S
S
G
V
S
H
S
S
S
V
Q
T
L
G
Site 22
S68
S
S
G
V
S
H
S
S
S
V
Q
T
L
G
F
Site 23
S69
S
G
V
S
H
S
S
S
V
Q
T
L
G
F
T
Site 24
T72
S
H
S
S
S
V
Q
T
L
G
F
T
Q
T
S
Site 25
T76
S
V
Q
T
L
G
F
T
Q
T
S
S
V
G
P
Site 26
T78
Q
T
L
G
F
T
Q
T
S
S
V
G
P
F
S
Site 27
S79
T
L
G
F
T
Q
T
S
S
V
G
P
F
S
G
Site 28
S85
T
S
S
V
G
P
F
S
G
L
E
H
T
S
T
Site 29
T92
S
G
L
E
H
T
S
T
F
V
A
T
S
G
P
Site 30
T96
H
T
S
T
F
V
A
T
S
G
P
S
S
S
S
Site 31
S97
T
S
T
F
V
A
T
S
G
P
S
S
S
S
V
Site 32
S101
V
A
T
S
G
P
S
S
S
S
V
L
G
N
T
Site 33
S102
A
T
S
G
P
S
S
S
S
V
L
G
N
T
G
Site 34
S103
T
S
G
P
S
S
S
S
V
L
G
N
T
G
F
Site 35
S114
N
T
G
F
S
F
K
S
P
T
S
V
G
A
F
Site 36
S117
F
S
F
K
S
P
T
S
V
G
A
F
P
S
T
Site 37
S123
T
S
V
G
A
F
P
S
T
S
A
F
G
Q
E
Site 38
S137
E
A
G
E
I
V
N
S
G
F
G
K
T
E
F
Site 39
S145
G
F
G
K
T
E
F
S
F
K
P
L
E
N
A
Site 40
T167
A
E
S
E
P
E
K
T
Q
S
Q
I
A
S
G
Site 41
S169
S
E
P
E
K
T
Q
S
Q
I
A
S
G
F
F
Site 42
S173
K
T
Q
S
Q
I
A
S
G
F
F
T
F
S
H
Site 43
S184
T
F
S
H
P
I
S
S
A
P
G
G
L
A
P
Site 44
S199
F
S
F
P
Q
V
T
S
S
S
A
T
T
S
N
Site 45
S200
S
F
P
Q
V
T
S
S
S
A
T
T
S
N
F
Site 46
S201
F
P
Q
V
T
S
S
S
A
T
T
S
N
F
T
Site 47
T203
Q
V
T
S
S
S
A
T
T
S
N
F
T
F
S
Site 48
T204
V
T
S
S
S
A
T
T
S
N
F
T
F
S
K
Site 49
S205
T
S
S
S
A
T
T
S
N
F
T
F
S
K
P
Site 50
T208
S
A
T
T
S
N
F
T
F
S
K
P
V
S
S
Site 51
S210
T
T
S
N
F
T
F
S
K
P
V
S
S
N
N
Site 52
S214
F
T
F
S
K
P
V
S
S
N
N
S
L
S
A
Site 53
S215
T
F
S
K
P
V
S
S
N
N
S
L
S
A
F
Site 54
S218
K
P
V
S
S
N
N
S
L
S
A
F
T
P
A
Site 55
T223
N
N
S
L
S
A
F
T
P
A
L
S
N
Q
N
Site 56
S227
S
A
F
T
P
A
L
S
N
Q
N
V
E
E
E
Site 57
S240
E
E
K
R
G
P
K
S
I
F
G
S
S
N
N
Site 58
S244
G
P
K
S
I
F
G
S
S
N
N
S
F
S
S
Site 59
S245
P
K
S
I
F
G
S
S
N
N
S
F
S
S
F
Site 60
S248
I
F
G
S
S
N
N
S
F
S
S
F
P
V
S
Site 61
S250
G
S
S
N
N
S
F
S
S
F
P
V
S
S
A
Site 62
S251
S
S
N
N
S
F
S
S
F
P
V
S
S
A
V
Site 63
S266
L
G
E
P
F
Q
A
S
K
A
G
V
R
Q
G
Site 64
S279
Q
G
C
E
E
A
V
S
Q
V
E
P
L
P
S
Site 65
S286
S
Q
V
E
P
L
P
S
L
M
K
G
L
K
R
Site 66
S300
R
K
E
D
Q
D
R
S
P
R
R
H
G
H
E
Site 67
S312
G
H
E
P
A
E
D
S
D
P
L
S
R
G
D
Site 68
S316
A
E
D
S
D
P
L
S
R
G
D
H
P
P
D
Site 69
T336
L
N
R
P
R
G
G
T
L
F
G
R
T
I
Q
Site 70
S348
T
I
Q
D
V
F
K
S
N
K
E
V
G
R
L
Site 71
S372
G
F
V
E
S
A
E
S
D
H
M
A
I
P
G
Site 72
S401
N
K
E
E
E
T
E
S
R
E
K
K
E
D
S
Site 73
S408
S
R
E
K
K
E
D
S
L
R
G
T
P
A
R
Site 74
T412
K
E
D
S
L
R
G
T
P
A
R
Q
S
N
R
Site 75
S417
R
G
T
P
A
R
Q
S
N
R
S
E
S
T
D
Site 76
S420
P
A
R
Q
S
N
R
S
E
S
T
D
S
L
G
Site 77
S422
R
Q
S
N
R
S
E
S
T
D
S
L
G
G
L
Site 78
S425
N
R
S
E
S
T
D
S
L
G
G
L
S
P
S
Site 79
S430
T
D
S
L
G
G
L
S
P
S
E
V
T
A
I
Site 80
Y445
Q
C
K
N
I
P
D
Y
L
N
D
R
T
I
L
Site 81
T450
P
D
Y
L
N
D
R
T
I
L
E
N
H
F
G
Site 82
T467
A
K
V
Q
R
I
F
T
R
R
S
K
K
L
A
Site 83
S470
Q
R
I
F
T
R
R
S
K
K
L
A
V
V
H
Site 84
S493
L
A
R
K
K
G
K
S
L
H
K
D
M
A
I
Site 85
S508
F
W
H
R
K
K
I
S
P
N
K
K
P
F
S
Site 86
S515
S
P
N
K
K
P
F
S
L
K
E
K
K
P
G
Site 87
S527
K
P
G
D
G
E
V
S
P
S
T
E
D
A
P
Site 88
S529
G
D
G
E
V
S
P
S
T
E
D
A
P
F
Q
Site 89
T530
D
G
E
V
S
P
S
T
E
D
A
P
F
Q
H
Site 90
S538
E
D
A
P
F
Q
H
S
P
L
G
K
A
A
G
Site 91
T547
L
G
K
A
A
G
R
T
G
A
S
S
L
L
N
Site 92
S551
A
G
R
T
G
A
S
S
L
L
N
K
S
S
P
Site 93
S556
A
S
S
L
L
N
K
S
S
P
V
K
K
P
S
Site 94
S557
S
S
L
L
N
K
S
S
P
V
K
K
P
S
L
Site 95
S563
S
S
P
V
K
K
P
S
L
L
K
A
H
Q
F
Site 96
S574
A
H
Q
F
E
G
D
S
F
D
S
A
S
E
G
Site 97
S577
F
E
G
D
S
F
D
S
A
S
E
G
S
E
G
Site 98
S579
G
D
S
F
D
S
A
S
E
G
S
E
G
L
G
Site 99
T598
S
L
S
T
L
I
G
T
V
A
E
T
S
K
E
Site 100
Y607
A
E
T
S
K
E
K
Y
R
L
L
D
Q
R
D
Site 101
T632
T
D
L
D
K
A
R
T
F
V
G
T
C
L
D
Site 102
Y647
M
C
P
E
K
E
R
Y
M
R
E
T
R
S
Q
Site 103
T651
K
E
R
Y
M
R
E
T
R
S
Q
L
S
V
F
Site 104
S653
R
Y
M
R
E
T
R
S
Q
L
S
V
F
E
V
Site 105
S679
A
V
K
E
Y
S
R
S
S
A
D
Q
E
E
P
Site 106
S680
V
K
E
Y
S
R
S
S
A
D
Q
E
E
P
L
Site 107
Y720
E
G
S
L
R
D
W
Y
D
F
V
W
N
R
T
Site 108
T735
R
G
I
R
K
D
I
T
Q
Q
H
L
C
D
P
Site 109
S802
N
K
G
V
F
C
A
S
E
A
E
F
Q
G
Y
Site 110
Y809
S
E
A
E
F
Q
G
Y
N
V
L
L
S
L
N
Site 111
S834
F
H
P
A
V
R
N
S
S
E
V
K
F
A
V
Site 112
S835
H
P
A
V
R
N
S
S
E
V
K
F
A
V
Q
Site 113
Y864
K
L
V
Q
S
A
S
Y
L
N
A
C
L
L
H
Site 114
Y873
N
A
C
L
L
H
C
Y
F
S
Q
I
R
K
D
Site 115
T890
R
A
L
N
F
A
Y
T
V
S
T
Q
R
S
T
Site 116
T893
N
F
A
Y
T
V
S
T
Q
R
S
T
I
F
P
Site 117
S896
Y
T
V
S
T
Q
R
S
T
I
F
P
L
D
G
Site 118
S937
G
C
V
E
L
N
R
S
A
F
L
E
P
E
G
Site 119
S946
F
L
E
P
E
G
L
S
K
T
R
K
S
V
F
Site 120
S951
G
L
S
K
T
R
K
S
V
F
I
T
R
K
L
Site 121
T955
T
R
K
S
V
F
I
T
R
K
L
T
V
S
V
Site 122
T978
L
P
P
V
P
R
H
T
P
V
C
S
F
N
S
Site 123
S985
T
P
V
C
S
F
N
S
Q
N
K
Y
I
G
E
Site 124
Y989
S
F
N
S
Q
N
K
Y
I
G
E
S
L
A
A
Site 125
S993
Q
N
K
Y
I
G
E
S
L
A
A
E
L
P
V
Site 126
S1001
L
A
A
E
L
P
V
S
T
Q
R
P
G
S
D
Site 127
T1002
A
A
E
L
P
V
S
T
Q
R
P
G
S
D
T
Site 128
S1007
V
S
T
Q
R
P
G
S
D
T
V
G
G
G
R
Site 129
T1009
T
Q
R
P
G
S
D
T
V
G
G
G
R
G
E
Site 130
S1027
V
E
P
D
A
P
L
S
S
L
P
Q
S
L
P
Site 131
S1028
E
P
D
A
P
L
S
S
L
P
Q
S
L
P
A
Site 132
S1032
P
L
S
S
L
P
Q
S
L
P
A
P
A
P
S
Site 133
S1061
A
P
S
L
F
Q
L
S
V
Q
P
E
P
P
P
Site 134
Y1075
P
P
E
P
V
P
M
Y
S
D
E
D
L
A
Q
Site 135
S1076
P
E
P
V
P
M
Y
S
D
E
D
L
A
Q
V
Site 136
S1101
R
D
C
E
E
V
G
S
A
G
A
A
Y
A
A
Site 137
S1166
Q
E
R
E
L
V
L
S
E
L
S
Q
G
L
A
Site 138
T1188
M
M
E
F
V
R
E
T
C
S
Q
E
L
K
N
Site 139
S1190
E
F
V
R
E
T
C
S
Q
E
L
K
N
A
V
Site 140
T1228
L
V
E
E
I
F
Q
T
A
K
E
T
L
Q
E
Site 141
Y1242
E
L
Q
C
F
C
K
Y
L
Q
R
W
R
E
A
Site 142
T1251
Q
R
W
R
E
A
V
T
A
R
K
K
L
R
R
Site 143
S1308
H
A
G
R
L
G
I
S
C
T
R
L
R
R
L
Site 144
T1310
G
R
L
G
I
S
C
T
R
L
R
R
L
R
N
Site 145
T1319
L
R
R
L
R
N
K
T
A
H
Q
M
K
V
Q
Site 146
S1373
L
P
D
V
E
E
Q
S
P
E
S
C
G
R
I
Site 147
S1376
V
E
E
Q
S
P
E
S
C
G
R
I
L
A
N
Site 148
S1395
K
F
M
G
D
E
G
S
V
D
D
T
S
S
D
Site 149
T1399
D
E
G
S
V
D
D
T
S
S
D
A
G
G
I
Site 150
S1400
E
G
S
V
D
D
T
S
S
D
A
G
G
I
Q
Site 151
S1401
G
S
V
D
D
T
S
S
D
A
G
G
I
Q
T
Site 152
S1414
Q
T
L
S
L
F
N
S
L
S
S
K
G
D
Q
Site 153
S1416
L
S
L
F
N
S
L
S
S
K
G
D
Q
M
I
Site 154
S1417
S
L
F
N
S
L
S
S
K
G
D
Q
M
I
S
Site 155
S1466
L
L
P
P
K
M
K
S
E
D
M
A
E
E
D
Site 156
Y1475
D
M
A
E
E
D
V
Y
W
L
S
A
L
L
Q
Site 157
S1478
E
E
D
V
Y
W
L
S
A
L
L
Q
L
K
Q
Site 158
Y1532
S
A
K
L
I
S
D
Y
T
V
T
E
I
P
D
Site 159
T1533
A
K
L
I
S
D
Y
T
V
T
E
I
P
D
T
Site 160
T1540
T
V
T
E
I
P
D
T
I
N
D
L
Q
G
S
Site 161
S1602
R
R
L
G
G
L
A
S
Q
E
P
G
A
I
I
Site 162
S1632
S
E
Q
L
C
D
L
S
W
P
V
T
E
F
A
Site 163
S1694
S
M
V
V
Q
Y
A
S
Q
I
P
S
S
R
Q
Site 164
S1698
Q
Y
A
S
Q
I
P
S
S
R
Q
T
Q
P
V
Site 165
S1699
Y
A
S
Q
I
P
S
S
R
Q
T
Q
P
V
L
Site 166
T1702
Q
I
P
S
S
R
Q
T
Q
P
V
L
Q
S
Q
Site 167
S1708
Q
T
Q
P
V
L
Q
S
Q
V
E
N
L
L
H
Site 168
Y1718
E
N
L
L
H
R
T
Y
C
R
W
K
S
K
S
Site 169
S1723
R
T
Y
C
R
W
K
S
K
S
P
S
P
V
H
Site 170
S1725
Y
C
R
W
K
S
K
S
P
S
P
V
H
G
A
Site 171
S1727
R
W
K
S
K
S
P
S
P
V
H
G
A
G
P
Site 172
S1735
P
V
H
G
A
G
P
S
V
M
E
I
P
W
D
Site 173
T1757
N
H
K
L
R
D
W
T
P
P
R
L
P
V
T
Site 174
T1764
T
P
P
R
L
P
V
T
S
E
A
L
S
E
D
Site 175
S1765
P
P
R
L
P
V
T
S
E
A
L
S
E
D
G
Site 176
Y1777
E
D
G
Q
I
C
V
Y
F
F
K
N
D
L
K
Site 177
Y1786
F
K
N
D
L
K
K
Y
D
V
P
L
S
W
E
Site 178
S1791
K
K
Y
D
V
P
L
S
W
E
Q
A
R
L
Q
Site 179
T1799
W
E
Q
A
R
L
Q
T
Q
K
E
L
Q
L
R
Site 180
S1818
A
I
K
P
F
H
P
S
A
N
N
F
P
I
P
Site 181
T1837
H
R
N
W
K
R
S
T
E
C
A
Q
E
G
R
Site 182
S1847
A
Q
E
G
R
I
P
S
T
E
D
L
M
R
G
Site 183
T1848
Q
E
G
R
I
P
S
T
E
D
L
M
R
G
A
Site 184
S1856
E
D
L
M
R
G
A
S
A
E
E
L
L
A
Q
Site 185
S1888
D
Q
L
Q
Q
W
L
S
E
D
S
G
A
F
T
Site 186
S1891
Q
Q
W
L
S
E
D
S
G
A
F
T
D
L
T
Site 187
T1895
S
E
D
S
G
A
F
T
D
L
T
S
L
P
L
Site 188
T1921
T
I
E
P
V
M
K
T
S
V
T
T
S
P
Q
Site 189
S1922
I
E
P
V
M
K
T
S
V
T
T
S
P
Q
S
Site 190
T1924
P
V
M
K
T
S
V
T
T
S
P
Q
S
D
M
Site 191
S1926
M
K
T
S
V
T
T
S
P
Q
S
D
M
M
R
Site 192
S1929
S
V
T
T
S
P
Q
S
D
M
M
R
E
Q
L
Site 193
S1939
M
R
E
Q
L
Q
L
S
E
A
T
G
T
C
L
Site 194
T1944
Q
L
S
E
A
T
G
T
C
L
G
E
R
L
K
Site 195
S1959
H
L
E
R
L
I
R
S
S
R
E
E
E
V
A
Site 196
S1960
L
E
R
L
I
R
S
S
R
E
E
E
V
A
S
Site 197
S1967
S
R
E
E
E
V
A
S
E
L
H
L
S
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation