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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NBN
Full Name:
Nibrin
Alias:
Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1
Type:
DNA binding protein
Mass (Da):
84959
Number AA:
754
UniProt ID:
O60934
International Prot ID:
IPI00299463
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0030870
GO:0000784
Uniprot
OncoNet
Molecular Function:
GO:0047485
GO:0008134
GO:0003684
PhosphoSite+
KinaseNET
Biological Process:
GO:0030330
GO:0032508
GO:0031575
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
G
P
A
G
G
E
P
Y
R
L
L
T
G
V
E
Site 2
Y24
R
L
L
T
G
V
E
Y
V
V
G
R
K
N
C
Site 3
S40
I
L
I
E
N
D
Q
S
I
S
R
N
H
A
V
Site 4
T49
S
R
N
H
A
V
L
T
A
N
F
S
V
T
N
Site 5
S58
N
F
S
V
T
N
L
S
Q
T
D
E
I
P
V
Site 6
T60
S
V
T
N
L
S
Q
T
D
E
I
P
V
L
T
Site 7
T67
T
D
E
I
P
V
L
T
L
K
D
N
S
K
Y
Site 8
T76
K
D
N
S
K
Y
G
T
F
V
N
E
E
K
M
Site 9
S88
E
K
M
Q
N
G
F
S
R
T
L
K
S
G
D
Site 10
S93
G
F
S
R
T
L
K
S
G
D
G
I
T
F
G
Site 11
Y110
G
S
K
F
R
I
E
Y
E
P
L
V
A
C
S
Site 12
S123
C
S
S
C
L
D
V
S
G
K
T
A
L
N
Q
Site 13
Y176
R
P
I
V
K
P
E
Y
F
T
E
F
L
K
A
Site 14
S186
E
F
L
K
A
V
E
S
K
K
Q
P
P
Q
I
Site 15
S195
K
Q
P
P
Q
I
E
S
F
Y
P
P
L
D
E
Site 16
Y197
P
P
Q
I
E
S
F
Y
P
P
L
D
E
P
S
Site 17
S204
Y
P
P
L
D
E
P
S
I
G
S
K
N
V
D
Site 18
S207
L
D
E
P
S
I
G
S
K
N
V
D
L
S
G
Site 19
S213
G
S
K
N
V
D
L
S
G
R
Q
E
R
K
Q
Site 20
T226
K
Q
I
F
K
G
K
T
F
I
F
L
N
A
K
Site 21
S239
A
K
Q
H
K
K
L
S
S
A
V
V
F
G
G
Site 22
S240
K
Q
H
K
K
L
S
S
A
V
V
F
G
G
G
Site 23
T253
G
G
E
A
R
L
I
T
E
E
N
E
E
E
H
Site 24
S278
V
D
T
G
I
T
N
S
Q
T
L
I
P
D
C
Site 25
T280
T
G
I
T
N
S
Q
T
L
I
P
D
C
Q
K
Site 26
S292
C
Q
K
K
W
I
Q
S
I
M
D
M
L
Q
R
Site 27
Y322
I
F
M
T
T
K
N
Y
C
D
P
Q
G
H
P
Site 28
T335
H
P
S
T
G
L
K
T
T
T
P
G
P
S
L
Site 29
T336
P
S
T
G
L
K
T
T
T
P
G
P
S
L
S
Site 30
T337
S
T
G
L
K
T
T
T
P
G
P
S
L
S
Q
Site 31
S341
K
T
T
T
P
G
P
S
L
S
Q
G
V
S
V
Site 32
S343
T
T
P
G
P
S
L
S
Q
G
V
S
V
D
E
Site 33
S347
P
S
L
S
Q
G
V
S
V
D
E
K
L
M
P
Site 34
Y363
A
P
V
N
T
T
T
Y
V
A
D
T
E
S
E
Site 35
S369
T
Y
V
A
D
T
E
S
E
Q
A
D
T
W
D
Site 36
T374
T
E
S
E
Q
A
D
T
W
D
L
S
E
R
P
Site 37
S378
Q
A
D
T
W
D
L
S
E
R
P
K
E
I
K
Site 38
S387
R
P
K
E
I
K
V
S
K
M
E
Q
K
F
R
Site 39
S397
E
Q
K
F
R
M
L
S
Q
D
A
P
T
V
K
Site 40
T402
M
L
S
Q
D
A
P
T
V
K
E
S
C
K
T
Site 41
S406
D
A
P
T
V
K
E
S
C
K
T
S
S
N
N
Site 42
T409
T
V
K
E
S
C
K
T
S
S
N
N
N
S
M
Site 43
S410
V
K
E
S
C
K
T
S
S
N
N
N
S
M
V
Site 44
S411
K
E
S
C
K
T
S
S
N
N
N
S
M
V
S
Site 45
S415
K
T
S
S
N
N
N
S
M
V
S
N
T
L
A
Site 46
Y429
A
K
M
R
I
P
N
Y
Q
L
S
P
T
K
L
Site 47
S432
R
I
P
N
Y
Q
L
S
P
T
K
L
P
S
I
Site 48
T434
P
N
Y
Q
L
S
P
T
K
L
P
S
I
N
K
Site 49
S438
L
S
P
T
K
L
P
S
I
N
K
S
K
D
R
Site 50
S442
K
L
P
S
I
N
K
S
K
D
R
A
S
Q
Q
Site 51
S447
N
K
S
K
D
R
A
S
Q
Q
Q
Q
T
N
S
Site 52
Y458
Q
T
N
S
I
R
N
Y
F
Q
P
S
T
K
K
Site 53
S480
Q
E
M
S
S
C
K
S
A
R
I
E
T
S
C
Site 54
T485
C
K
S
A
R
I
E
T
S
C
S
L
L
E
Q
Site 55
S486
K
S
A
R
I
E
T
S
C
S
L
L
E
Q
T
Site 56
S488
A
R
I
E
T
S
C
S
L
L
E
Q
T
Q
P
Site 57
T493
S
C
S
L
L
E
Q
T
Q
P
A
T
P
S
L
Site 58
T497
L
E
Q
T
Q
P
A
T
P
S
L
W
K
N
K
Site 59
S499
Q
T
Q
P
A
T
P
S
L
W
K
N
K
E
Q
Site 60
S509
K
N
K
E
Q
H
L
S
E
N
E
P
V
D
T
Site 61
T516
S
E
N
E
P
V
D
T
N
S
D
N
N
L
F
Site 62
S518
N
E
P
V
D
T
N
S
D
N
N
L
F
T
D
Site 63
T526
D
N
N
L
F
T
D
T
D
L
K
S
I
V
K
Site 64
S530
F
T
D
T
D
L
K
S
I
V
K
N
S
A
S
Site 65
S535
L
K
S
I
V
K
N
S
A
S
K
S
H
A
A
Site 66
S539
V
K
N
S
A
S
K
S
H
A
A
E
K
L
R
Site 67
S547
H
A
A
E
K
L
R
S
N
K
K
R
E
M
D
Site 68
T599
R
P
R
M
D
I
E
T
N
D
T
F
S
D
E
Site 69
T602
M
D
I
E
T
N
D
T
F
S
D
E
A
V
P
Site 70
S604
I
E
T
N
D
T
F
S
D
E
A
V
P
E
S
Site 71
S611
S
D
E
A
V
P
E
S
S
K
I
S
Q
E
N
Site 72
S612
D
E
A
V
P
E
S
S
K
I
S
Q
E
N
E
Site 73
S615
V
P
E
S
S
K
I
S
Q
E
N
E
I
G
K
Site 74
S630
K
R
E
L
K
E
D
S
L
W
S
A
K
E
I
Site 75
S633
L
K
E
D
S
L
W
S
A
K
E
I
S
N
N
Site 76
S661
L
L
L
T
E
F
R
S
L
V
I
K
N
S
T
Site 77
S667
R
S
L
V
I
K
N
S
T
S
R
N
P
S
G
Site 78
S669
L
V
I
K
N
S
T
S
R
N
P
S
G
I
N
Site 79
S673
N
S
T
S
R
N
P
S
G
I
N
D
D
Y
G
Site 80
Y679
P
S
G
I
N
D
D
Y
G
Q
L
K
N
F
K
Site 81
Y693
K
K
F
K
K
V
T
Y
P
G
A
G
K
L
P
Site 82
S706
L
P
H
I
I
G
G
S
D
L
I
A
H
H
A
Site 83
T717
A
H
H
A
R
K
N
T
E
L
E
E
W
L
R
Site 84
S738
N
Q
H
A
K
E
E
S
L
A
D
D
L
F
R
Site 85
Y746
L
A
D
D
L
F
R
Y
N
P
Y
L
K
R
R
Site 86
Y749
D
L
F
R
Y
N
P
Y
L
K
R
R
R
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation