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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MITF
Full Name:
Microphthalmia-associated transcription factor
Alias:
BHLHe32; BW; Homolog of mouse microphthalmia; MI; VIT; WS2A
Type:
Transcription protein
Mass (Da):
58795
Number AA:
526
UniProt ID:
O75030
International Prot ID:
IPI00023896
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0016563
PhosphoSite+
KinaseNET
Biological Process:
GO:0030318
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
E
F
H
E
E
P
K
T
Y
Y
E
L
K
S
Q
Site 2
Y24
F
H
E
E
P
K
T
Y
Y
E
L
K
S
Q
P
Site 3
Y25
H
E
E
P
K
T
Y
Y
E
L
K
S
Q
P
L
Site 4
S29
K
T
Y
Y
E
L
K
S
Q
P
L
K
S
S
S
Site 5
S34
L
K
S
Q
P
L
K
S
S
S
S
A
E
H
P
Site 6
S35
K
S
Q
P
L
K
S
S
S
S
A
E
H
P
G
Site 7
S36
S
Q
P
L
K
S
S
S
S
A
E
H
P
G
A
Site 8
S37
Q
P
L
K
S
S
S
S
A
E
H
P
G
A
S
Site 9
S44
S
A
E
H
P
G
A
S
K
P
P
I
S
S
S
Site 10
S49
G
A
S
K
P
P
I
S
S
S
S
M
T
S
R
Site 11
S50
A
S
K
P
P
I
S
S
S
S
M
T
S
R
I
Site 12
S51
S
K
P
P
I
S
S
S
S
M
T
S
R
I
L
Site 13
S52
K
P
P
I
S
S
S
S
M
T
S
R
I
L
L
Site 14
T54
P
I
S
S
S
S
M
T
S
R
I
L
L
R
Q
Site 15
S55
I
S
S
S
S
M
T
S
R
I
L
L
R
Q
Q
Site 16
S93
M
Q
Q
R
V
P
V
S
Q
T
P
A
I
N
V
Site 17
S108
S
V
P
T
T
L
P
S
A
T
Q
V
P
M
E
Site 18
Y129
H
L
E
N
P
T
K
Y
H
I
Q
Q
A
Q
R
Site 19
Y142
Q
R
Q
Q
V
K
Q
Y
L
S
T
T
L
A
N
Site 20
S157
K
H
A
N
Q
V
L
S
L
P
C
P
N
Q
P
Site 21
S175
M
P
P
V
P
G
S
S
A
P
N
S
P
M
A
Site 22
S176
M
P
P
V
P
G
S
S
A
P
N
S
P
M
A
Site 23
S180
P
G
S
S
A
P
N
S
P
M
A
M
L
T
L
Site 24
T186
N
S
P
M
A
M
L
T
L
N
S
N
C
E
K
Site 25
S207
E
E
Q
N
R
A
E
S
E
C
P
G
M
N
T
Site 26
S232
D
V
I
D
D
I
I
S
L
E
S
S
Y
N
E
Site 27
S236
D
I
I
S
L
E
S
S
Y
N
E
E
I
L
G
Site 28
Y265
S
G
N
L
I
D
L
Y
G
N
Q
G
L
P
P
Site 29
S278
P
P
P
G
L
T
I
S
N
S
C
P
A
N
L
Site 30
S280
P
G
L
T
I
S
N
S
C
P
A
N
L
P
N
Site 31
T293
P
N
I
K
R
E
L
T
A
C
I
F
P
T
E
Site 32
T336
D
R
I
K
E
L
G
T
L
I
P
K
S
N
D
Site 33
S341
L
G
T
L
I
P
K
S
N
D
P
D
M
R
W
Site 34
T352
D
M
R
W
N
K
G
T
I
L
K
A
S
V
D
Site 35
S357
K
G
T
I
L
K
A
S
V
D
Y
I
R
K
L
Site 36
Y360
I
L
K
A
S
V
D
Y
I
R
K
L
Q
R
E
Site 37
S405
Q
A
R
A
H
G
L
S
L
I
P
S
T
G
L
Site 38
S414
I
P
S
T
G
L
C
S
P
D
L
V
N
R
I
Site 39
S432
E
P
V
L
E
N
C
S
Q
D
L
L
Q
H
H
Site 40
T443
L
Q
H
H
A
D
L
T
C
T
T
T
L
D
L
Site 41
T454
T
L
D
L
T
D
G
T
I
T
F
N
N
N
L
Site 42
T456
D
L
T
D
G
T
I
T
F
N
N
N
L
G
T
Site 43
Y471
G
T
E
A
N
Q
A
Y
S
V
P
T
K
M
G
Site 44
S472
T
E
A
N
Q
A
Y
S
V
P
T
K
M
G
S
Site 45
S491
I
L
M
D
D
T
L
S
P
V
G
V
T
D
P
Site 46
S502
V
T
D
P
L
L
S
S
V
S
P
G
A
S
K
Site 47
S504
D
P
L
L
S
S
V
S
P
G
A
S
K
T
S
Site 48
S508
S
S
V
S
P
G
A
S
K
T
S
S
R
R
S
Site 49
T510
V
S
P
G
A
S
K
T
S
S
R
R
S
S
M
Site 50
S511
S
P
G
A
S
K
T
S
S
R
R
S
S
M
S
Site 51
S512
P
G
A
S
K
T
S
S
R
R
S
S
M
S
M
Site 52
S515
S
K
T
S
S
R
R
S
S
M
S
M
E
E
T
Site 53
S516
K
T
S
S
R
R
S
S
M
S
M
E
E
T
E
Site 54
S518
S
S
R
R
S
S
M
S
M
E
E
T
E
H
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation