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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRP4
Full Name:
Low-density lipoprotein receptor-related protein 4
Alias:
low density lipoprotein receptor-related protein 4; low-density lipoprotein receptor-related 4; LRP10; MEGF7; multiple epidermal growth factor-like domains 7
Type:
Cell surface protein, receptor
Mass (Da):
212045
Number AA:
1905
UniProt ID:
O75096
International Prot ID:
IPI00306851
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004872
PhosphoSite+
KinaseNET
Biological Process:
GO:0006897
Phosida
TranscriptoNet
STRING
Kinexus Products
Low-density lipoprotein receptor-related protein 4 pan-specific antibody AB-NN286-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN286-1#Low-density lipoprotein receptor-related protein 4 pan-specific antibody AB-NN287-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN287-2
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S733
T
G
F
R
K
I
S
S
H
A
C
A
Q
S
L
Site 2
S1113
S
R
A
N
L
D
G
S
Q
H
E
D
I
I
T
Site 3
T1126
I
T
T
G
L
Q
T
T
D
G
L
A
V
D
A
Site 4
Y1355
C
D
P
S
P
E
T
Y
L
L
F
S
S
R
G
Site 5
Y1400
C
D
P
S
P
E
T
Y
L
L
F
S
S
R
G
Site 6
Y1484
A
V
F
P
R
K
G
Y
L
F
W
T
D
W
G
Site 7
T1763
D
P
G
M
G
N
L
T
Y
S
N
P
S
Y
R
Site 8
Y1764
P
G
M
G
N
L
T
Y
S
N
P
S
Y
R
T
Site 9
S1765
G
M
G
N
L
T
Y
S
N
P
S
Y
R
T
S
Site 10
S1768
N
L
T
Y
S
N
P
S
Y
R
T
S
T
Q
E
Site 11
Y1769
L
T
Y
S
N
P
S
Y
R
T
S
T
Q
E
V
Site 12
S1772
S
N
P
S
Y
R
T
S
T
Q
E
V
K
I
E
Site 13
T1773
N
P
S
Y
R
T
S
T
Q
E
V
K
I
E
A
Site 14
Y1787
A
I
P
K
P
A
M
Y
N
Q
L
C
Y
K
K
Site 15
Y1792
A
M
Y
N
Q
L
C
Y
K
K
E
G
G
P
D
Site 16
Y1802
E
G
G
P
D
H
N
Y
T
K
E
K
I
K
I
Site 17
S1817
V
E
G
I
C
L
L
S
G
D
D
A
E
W
D
Site 18
S1831
D
D
L
K
Q
L
R
S
S
R
G
G
L
L
R
Site 19
S1832
D
L
K
Q
L
R
S
S
R
G
G
L
L
R
D
Site 20
T1845
R
D
H
V
C
M
K
T
D
T
V
S
I
Q
A
Site 21
T1847
H
V
C
M
K
T
D
T
V
S
I
Q
A
S
S
Site 22
S1849
C
M
K
T
D
T
V
S
I
Q
A
S
S
G
S
Site 23
S1853
D
T
V
S
I
Q
A
S
S
G
S
L
D
D
T
Site 24
S1856
S
I
Q
A
S
S
G
S
L
D
D
T
E
T
E
Site 25
T1860
S
S
G
S
L
D
D
T
E
T
E
Q
L
L
Q
Site 26
T1862
G
S
L
D
D
T
E
T
E
Q
L
L
Q
E
E
Site 27
S1871
Q
L
L
Q
E
E
Q
S
E
C
S
S
V
H
T
Site 28
S1875
E
E
Q
S
E
C
S
S
V
H
T
A
A
T
P
Site 29
T1878
S
E
C
S
S
V
H
T
A
A
T
P
E
R
R
Site 30
T1881
S
S
V
H
T
A
A
T
P
E
R
R
G
S
L
Site 31
S1887
A
T
P
E
R
R
G
S
L
P
D
T
G
W
K
Site 32
T1891
R
R
G
S
L
P
D
T
G
W
K
H
E
R
K
Site 33
S1900
W
K
H
E
R
K
L
S
S
E
S
Q
V
_
_
Site 34
S1901
K
H
E
R
K
L
S
S
E
S
Q
V
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation