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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PXR
Full Name:
Nuclear receptor subfamily 1 group I member 2
Alias:
Pregnane X receptor
Type:
Nucleus protein
Mass (Da):
49762
Number AA:
434
UniProt ID:
O75469
International Prot ID:
IPI00334983
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008144
GO:0043565
GO:0003707
PhosphoSite+
KinaseNET
Biological Process:
GO:0046618
GO:0042738
GO:0016481
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
E
V
R
P
K
E
S
W
N
H
A
D
F
V
Site 2
T20
D
F
V
H
C
E
D
T
E
S
V
P
G
K
P
Site 3
S22
V
H
C
E
D
T
E
S
V
P
G
K
P
S
V
Site 4
T57
G
Y
H
F
N
V
M
T
C
E
G
C
K
G
F
Site 5
T90
A
C
E
I
T
R
K
T
R
R
Q
C
Q
A
C
Site 6
S105
R
L
R
K
C
L
E
S
G
M
K
K
E
M
I
Site 7
S114
M
K
K
E
M
I
M
S
D
E
A
V
E
E
R
Site 8
S130
A
L
I
K
R
K
K
S
E
R
T
G
T
Q
P
Site 9
T135
K
K
S
E
R
T
G
T
Q
P
L
G
V
Q
G
Site 10
S180
R
L
P
G
V
L
S
S
G
C
E
L
P
E
S
Site 11
S187
S
G
C
E
L
P
E
S
L
Q
A
P
S
R
E
Site 12
S200
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
Site 13
S208
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
Site 14
S212
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
Site 15
S221
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
Site 16
Y225
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
Site 17
S238
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
Site 18
S256
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
Site 19
S274
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
Site 20
T290
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
Site 21
S305
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
A
Site 22
Y306
W
E
C
G
R
L
S
Y
C
L
E
D
T
A
G
Site 23
T311
L
S
Y
C
L
E
D
T
A
G
G
F
Q
Q
L
Site 24
Y328
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
Site 25
Y340
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
Site 26
S350
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Site 27
S402
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
Site 28
T408
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
Site 29
T422
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation