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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PKD3
Full Name:
Serine/threonine-protein kinase D3
Alias:
EC 2.7.11.13; EPK2; KPCD3; NPKC-nu; PRKCN; PRKD3; Protein kinase C, nu type; Protein kinase D3; Protein kinase EPK2
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.13; CAMK group; PKD family
Mass (Da):
100471
Number AA:
890
UniProt ID:
O94806
International Prot ID:
IPI00015538
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004697
PhosphoSite+
KinaseNET
Biological Process:
GO:0007205
GO:0007242
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Protein-serine kinase C nu; Serine/threonine-protein kinase D3 pan-specific antibody AB-NK139-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK139-2#Protein-serine kinase C nu / Serine/threonine-protein kinase D3 (T490-N507, human) peptide - Powder PE-01BEU80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BEU80
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
A
N
N
S
P
P
S
Site 2
S6
_
_
M
S
A
N
N
S
P
P
S
A
Q
K
S
Site 3
S9
S
A
N
N
S
P
P
S
A
Q
K
S
V
L
P
Site 4
S13
S
P
P
S
A
Q
K
S
V
L
P
T
A
I
P
Site 5
S27
P
A
V
L
P
A
A
S
P
C
S
S
P
K
T
Site 6
S30
L
P
A
A
S
P
C
S
S
P
K
T
G
L
S
Site 7
S31
P
A
A
S
P
C
S
S
P
K
T
G
L
S
A
Site 8
T34
S
P
C
S
S
P
K
T
G
L
S
A
R
L
S
Site 9
S37
S
S
P
K
T
G
L
S
A
R
L
S
N
G
S
Site 10
S41
T
G
L
S
A
R
L
S
N
G
S
F
S
A
P
Site 11
S44
S
A
R
L
S
N
G
S
F
S
A
P
S
L
T
Site 12
S46
R
L
S
N
G
S
F
S
A
P
S
L
T
N
S
Site 13
S49
N
G
S
F
S
A
P
S
L
T
N
S
R
G
S
Site 14
T51
S
F
S
A
P
S
L
T
N
S
R
G
S
V
H
Site 15
S53
S
A
P
S
L
T
N
S
R
G
S
V
H
T
V
Site 16
S56
S
L
T
N
S
R
G
S
V
H
T
V
S
F
L
Site 17
S72
Q
I
G
L
T
R
E
S
V
T
I
E
A
Q
E
Site 18
S127
N
I
L
Q
L
I
T
S
A
D
E
I
H
E
G
Site 19
T156
D
F
Q
I
R
P
H
T
L
Y
V
H
S
Y
K
Site 20
Y158
Q
I
R
P
H
T
L
Y
V
H
S
Y
K
A
P
Site 21
Y162
H
T
L
Y
V
H
S
Y
K
A
P
T
F
C
D
Site 22
Y192
C
E
G
C
G
L
N
Y
H
K
R
C
A
F
K
Site 23
S205
F
K
I
P
N
N
C
S
G
V
R
K
R
R
L
Site 24
S213
G
V
R
K
R
R
L
S
N
V
S
L
P
G
P
Site 25
S216
K
R
R
L
S
N
V
S
L
P
G
P
G
L
S
Site 26
S223
S
L
P
G
P
G
L
S
V
P
R
P
L
Q
P
Site 27
Y232
P
R
P
L
Q
P
E
Y
V
A
L
P
S
E
E
Site 28
S237
P
E
Y
V
A
L
P
S
E
E
S
H
V
H
Q
Site 29
S240
V
A
L
P
S
E
E
S
H
V
H
Q
E
P
S
Site 30
S247
S
H
V
H
Q
E
P
S
K
R
I
P
S
W
S
Site 31
S252
E
P
S
K
R
I
P
S
W
S
G
R
P
I
W
Site 32
S254
S
K
R
I
P
S
W
S
G
R
P
I
W
M
E
Site 33
T273
C
R
V
K
V
P
H
T
F
A
V
H
S
Y
T
Site 34
Y279
H
T
F
A
V
H
S
Y
T
R
P
T
I
C
Q
Site 35
Y287
T
R
P
T
I
C
Q
Y
C
K
R
L
L
K
G
Site 36
T326
R
D
C
L
G
E
V
T
F
N
G
E
P
S
S
Site 37
S333
T
F
N
G
E
P
S
S
L
G
T
D
T
D
I
Site 38
T336
G
E
P
S
S
L
G
T
D
T
D
I
P
M
D
Site 39
T338
P
S
S
L
G
T
D
T
D
I
P
M
D
I
D
Site 40
S351
I
D
N
N
D
I
N
S
D
S
S
R
G
L
D
Site 41
S353
N
N
D
I
N
S
D
S
S
R
G
L
D
D
T
Site 42
T360
S
S
R
G
L
D
D
T
E
E
P
S
P
P
E
Site 43
S364
L
D
D
T
E
E
P
S
P
P
E
D
K
M
F
Site 44
S376
K
M
F
F
L
D
P
S
D
L
D
V
E
R
D
Site 45
T389
R
D
E
E
A
V
K
T
I
S
P
S
T
S
N
Site 46
S391
E
E
A
V
K
T
I
S
P
S
T
S
N
N
I
Site 47
S393
A
V
K
T
I
S
P
S
T
S
N
N
I
P
L
Site 48
T394
V
K
T
I
S
P
S
T
S
N
N
I
P
L
M
Site 49
S395
K
T
I
S
P
S
T
S
N
N
I
P
L
M
R
Site 50
T410
V
V
Q
S
I
K
H
T
K
R
K
S
S
T
M
Site 51
S414
I
K
H
T
K
R
K
S
S
T
M
V
K
E
G
Site 52
S415
K
H
T
K
R
K
S
S
T
M
V
K
E
G
W
Site 53
Y426
K
E
G
W
M
V
H
Y
T
S
R
D
N
L
R
Site 54
Y437
D
N
L
R
K
R
H
Y
W
R
L
D
S
K
C
Site 55
T446
R
L
D
S
K
C
L
T
L
F
Q
N
E
S
G
Site 56
S452
L
T
L
F
Q
N
E
S
G
S
K
Y
Y
K
E
Site 57
S454
L
F
Q
N
E
S
G
S
K
Y
Y
K
E
I
P
Site 58
Y456
Q
N
E
S
G
S
K
Y
Y
K
E
I
P
L
S
Site 59
Y457
N
E
S
G
S
K
Y
Y
K
E
I
P
L
S
E
Site 60
S463
Y
Y
K
E
I
P
L
S
E
I
L
R
I
S
S
Site 61
S469
L
S
E
I
L
R
I
S
S
P
R
D
F
T
N
Site 62
S470
S
E
I
L
R
I
S
S
P
R
D
F
T
N
I
Site 63
T475
I
S
S
P
R
D
F
T
N
I
S
Q
G
S
N
Site 64
S478
P
R
D
F
T
N
I
S
Q
G
S
N
P
H
C
Site 65
S505
G
E
N
N
G
D
S
S
H
N
P
V
L
A
A
Site 66
S522
V
G
L
D
V
A
Q
S
W
E
K
A
I
R
Q
Site 67
T535
R
Q
A
L
M
P
V
T
P
Q
A
S
V
C
T
Site 68
S539
M
P
V
T
P
Q
A
S
V
C
T
S
P
G
Q
Site 69
T542
T
P
Q
A
S
V
C
T
S
P
G
Q
G
K
D
Site 70
S543
P
Q
A
S
V
C
T
S
P
G
Q
G
K
D
H
Site 71
S554
G
K
D
H
K
D
L
S
T
S
I
S
V
S
N
Site 72
T555
K
D
H
K
D
L
S
T
S
I
S
V
S
N
C
Site 73
S556
D
H
K
D
L
S
T
S
I
S
V
S
N
C
Q
Site 74
S558
K
D
L
S
T
S
I
S
V
S
N
C
Q
I
Q
Site 75
S560
L
S
T
S
I
S
V
S
N
C
Q
I
Q
E
N
Site 76
T572
Q
E
N
V
D
I
S
T
V
Y
Q
I
F
A
D
Site 77
Y591
S
G
Q
F
G
I
V
Y
G
G
K
H
R
K
T
Site 78
T598
Y
G
G
K
H
R
K
T
G
R
D
V
A
I
K
Site 79
T614
I
D
K
M
R
F
P
T
K
Q
E
S
Q
L
R
Site 80
S618
R
F
P
T
K
Q
E
S
Q
L
R
N
E
V
A
Site 81
S665
D
M
L
E
M
I
L
S
S
E
K
S
R
L
P
Site 82
S666
M
L
E
M
I
L
S
S
E
K
S
R
L
P
E
Site 83
S669
M
I
L
S
S
E
K
S
R
L
P
E
R
I
T
Site 84
T676
S
R
L
P
E
R
I
T
K
F
M
V
T
Q
I
Site 85
S731
A
R
I
I
G
E
K
S
F
R
R
S
V
V
G
Site 86
S735
G
E
K
S
F
R
R
S
V
V
G
T
P
A
Y
Site 87
T739
F
R
R
S
V
V
G
T
P
A
Y
L
A
P
E
Site 88
Y742
S
V
V
G
T
P
A
Y
L
A
P
E
V
L
R
Site 89
S750
L
A
P
E
V
L
R
S
K
G
Y
N
R
S
L
Site 90
Y753
E
V
L
R
S
K
G
Y
N
R
S
L
D
M
W
Site 91
S756
R
S
K
G
Y
N
R
S
L
D
M
W
S
V
G
Site 92
T773
I
Y
V
S
L
S
G
T
F
P
F
N
E
D
E
Site 93
S802
P
N
P
W
R
E
I
S
G
E
A
I
D
L
I
Site 94
Y821
Q
V
K
M
R
K
R
Y
S
V
D
K
S
L
S
Site 95
S822
V
K
M
R
K
R
Y
S
V
D
K
S
L
S
H
Site 96
S826
K
R
Y
S
V
D
K
S
L
S
H
P
W
L
Q
Site 97
S828
Y
S
V
D
K
S
L
S
H
P
W
L
Q
D
Y
Site 98
Y835
S
H
P
W
L
Q
D
Y
Q
T
W
L
D
L
R
Site 99
Y852
E
T
R
I
G
E
R
Y
I
T
H
E
S
D
D
Site 100
T854
R
I
G
E
R
Y
I
T
H
E
S
D
D
A
R
Site 101
Y867
A
R
W
E
I
H
A
Y
T
H
N
L
V
Y
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation