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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TPPP
Full Name:
Tubulin polymerization-promoting protein
Alias:
25 kDa brain-specific protein; Brain specific protein p25 alpha; Brain-specific protein p25 alpha; P24; P25; P25A; P25alpha; P25-alpha; TPPP/p25; TPPP1; Tubulin polymerization promoting protein
Type:
Cytoskeletal protein
Mass (Da):
23694
Number AA:
219
UniProt ID:
O94811
International Prot ID:
IPI00013043
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0048471
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0008017
PhosphoSite+
KinaseNET
Biological Process:
GO:0001578
GO:0046785
GO:0032273
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
P
A
K
A
A
N
R
T
P
P
K
S
P
G
D
Site 2
S18
A
N
R
T
P
P
K
S
P
G
D
P
S
K
D
Site 3
S23
P
K
S
P
G
D
P
S
K
D
R
A
A
K
R
Site 4
S32
D
R
A
A
K
R
L
S
L
E
S
E
G
A
G
Site 5
S35
A
K
R
L
S
L
E
S
E
G
A
G
E
G
A
Site 6
S45
A
G
E
G
A
A
A
S
P
E
L
S
A
L
E
Site 7
S49
A
A
A
S
P
E
L
S
A
L
E
E
A
F
R
Site 8
T67
V
H
G
D
A
R
A
T
G
R
E
M
H
G
K
Site 9
T92
V
I
D
G
R
N
V
T
V
T
D
V
D
I
V
Site 10
S107
F
S
K
I
K
G
K
S
C
R
T
I
T
F
E
Site 11
T112
G
K
S
C
R
T
I
T
F
E
Q
F
Q
E
A
Site 12
S132
K
K
R
F
K
D
K
S
S
E
E
A
V
R
E
Site 13
S133
K
R
F
K
D
K
S
S
E
E
A
V
R
E
V
Site 14
S152
E
G
K
A
P
I
I
S
G
V
T
K
A
I
S
Site 15
S159
S
G
V
T
K
A
I
S
S
P
T
V
S
R
L
Site 16
S160
G
V
T
K
A
I
S
S
P
T
V
S
R
L
T
Site 17
T162
T
K
A
I
S
S
P
T
V
S
R
L
T
D
T
Site 18
S164
A
I
S
S
P
T
V
S
R
L
T
D
T
T
K
Site 19
T167
S
P
T
V
S
R
L
T
D
T
T
K
F
T
G
Site 20
T169
T
V
S
R
L
T
D
T
T
K
F
T
G
S
H
Site 21
T170
V
S
R
L
T
D
T
T
K
F
T
G
S
H
K
Site 22
S183
H
K
E
R
F
D
P
S
G
K
G
K
G
K
A
Site 23
S199
R
V
D
L
V
D
E
S
G
Y
V
S
G
Y
K
Site 24
Y201
D
L
V
D
E
S
G
Y
V
S
G
Y
K
H
A
Site 25
S203
V
D
E
S
G
Y
V
S
G
Y
K
H
A
G
T
Site 26
Y205
E
S
G
Y
V
S
G
Y
K
H
A
G
T
Y
D
Site 27
T210
S
G
Y
K
H
A
G
T
Y
D
Q
K
V
Q
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation