KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CACNA1H
Full Name:
Voltage-dependent T-type calcium channel subunit alpha-1H
Alias:
CAC1H; CACNA1HB; calcium channel, voltage-dependent, alpha 1H subunit; calcium channel, voltage-dependent, T type, alpha 1H subunit; Cav3.2; FLJ90484
Type:
Cell development/differentiation; Channel, calcium
Mass (Da):
259163
Number AA:
2353
UniProt ID:
O95180
International Prot ID:
IPI00028915
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005891
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0008332
PhosphoSite+
KinaseNET
Biological Process:
GO:0006816
GO:0006936
GO:0007520
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
L
V
G
A
S
P
E
S
P
G
A
P
G
R
E
Site 2
S44
G
R
E
A
E
R
G
S
E
L
G
V
S
P
S
Site 3
S49
R
G
S
E
L
G
V
S
P
S
E
S
P
A
A
Site 4
S51
S
E
L
G
V
S
P
S
E
S
P
A
A
E
R
Site 5
S53
L
G
V
S
P
S
E
S
P
A
A
E
R
G
A
Site 6
Y72
D
E
E
Q
R
V
P
Y
P
A
L
A
A
T
V
Site 7
S91
G
Q
T
T
R
P
R
S
W
C
L
R
L
V
C
Site 8
Y166
G
L
F
G
Q
K
C
Y
L
G
D
T
W
N
R
Site 9
S187
V
A
G
M
M
E
Y
S
L
D
G
H
N
V
S
Site 10
S196
D
G
H
N
V
S
L
S
A
I
R
T
V
R
V
Site 11
T273
F
V
R
N
N
N
L
T
F
L
R
P
Y
Y
Q
Site 12
Y278
N
L
T
F
L
R
P
Y
Y
Q
T
E
E
G
E
Site 13
Y279
L
T
F
L
R
P
Y
Y
Q
T
E
E
G
E
E
Site 14
T281
F
L
R
P
Y
Y
Q
T
E
E
G
E
E
N
P
Site 15
S292
E
E
N
P
F
I
C
S
S
R
R
D
N
G
M
Site 16
T316
R
E
L
R
M
P
C
T
L
G
W
E
A
Y
T
Site 17
Y322
C
T
L
G
W
E
A
Y
T
Q
P
Q
A
E
G
Site 18
S352
N
V
C
R
S
G
D
S
N
P
H
N
G
A
I
Site 19
S430
S
E
T
K
Q
R
E
S
Q
L
M
R
E
Q
R
Site 20
S442
E
Q
R
A
R
H
L
S
N
D
S
T
L
A
S
Site 21
S445
A
R
H
L
S
N
D
S
T
L
A
S
F
S
E
Site 22
T446
R
H
L
S
N
D
S
T
L
A
S
F
S
E
P
Site 23
S449
S
N
D
S
T
L
A
S
F
S
E
P
G
S
C
Site 24
S451
D
S
T
L
A
S
F
S
E
P
G
S
C
Y
E
Site 25
S455
A
S
F
S
E
P
G
S
C
Y
E
E
L
L
K
Site 26
Y463
C
Y
E
E
L
L
K
Y
V
G
H
I
F
R
K
Site 27
S475
F
R
K
V
K
R
R
S
L
R
L
Y
A
R
W
Site 28
Y479
K
R
R
S
L
R
L
Y
A
R
W
Q
S
R
W
Site 29
S493
W
R
K
K
V
D
P
S
A
V
Q
G
Q
G
P
Site 30
T511
Q
R
R
A
G
R
H
T
A
S
V
H
H
L
V
Site 31
S513
R
A
G
R
H
T
A
S
V
H
H
L
V
Y
H
Site 32
S535
H
Y
H
F
S
H
G
S
P
R
R
P
G
P
E
Site 33
S558
V
R
A
G
A
P
P
S
P
P
S
P
G
R
G
Site 34
S561
G
A
P
P
S
P
P
S
P
G
R
G
P
P
D
Site 35
S571
R
G
P
P
D
A
E
S
V
H
S
I
Y
H
A
Site 36
Y576
A
E
S
V
H
S
I
Y
H
A
D
C
H
I
E
Site 37
T615
L
G
T
M
N
Y
P
T
I
L
P
S
G
V
G
Site 38
S619
N
Y
P
T
I
L
P
S
G
V
G
S
G
K
G
Site 39
S623
I
L
P
S
G
V
G
S
G
K
G
S
T
S
P
Site 40
S627
G
V
G
S
G
K
G
S
T
S
P
G
P
K
G
Site 41
S629
G
S
G
K
G
S
T
S
P
G
P
K
G
K
W
Site 42
S650
T
G
G
H
G
P
L
S
L
N
S
P
D
P
Y
Site 43
S653
H
G
P
L
S
L
N
S
P
D
P
Y
E
K
I
Site 44
Y657
S
L
N
S
P
D
P
Y
E
K
I
P
H
V
V
Site 45
S677
G
Q
A
P
G
H
L
S
G
L
S
V
P
C
P
Site 46
T694
S
P
P
A
G
T
L
T
C
E
L
K
S
C
P
Site 47
Y702
C
E
L
K
S
C
P
Y
C
T
R
A
L
E
D
Site 48
S715
E
D
P
E
G
E
L
S
G
S
E
S
G
D
S
Site 49
S717
P
E
G
E
L
S
G
S
E
S
G
D
S
D
G
Site 50
S719
G
E
L
S
G
S
E
S
G
D
S
D
G
R
G
Site 51
S722
S
G
S
E
S
G
D
S
D
G
R
G
V
Y
E
Site 52
Y728
D
S
D
G
R
G
V
Y
E
F
T
Q
D
V
R
Site 53
T743
H
G
D
R
W
D
P
T
R
P
P
R
A
T
D
Site 54
T749
P
T
R
P
P
R
A
T
D
T
P
G
P
G
P
Site 55
T751
R
P
P
R
A
T
D
T
P
G
P
G
P
G
S
Site 56
S758
T
P
G
P
G
P
G
S
P
Q
R
R
A
Q
Q
Site 57
S783
G
R
L
W
V
T
F
S
G
K
L
R
R
I
V
Site 58
S792
K
L
R
R
I
V
D
S
K
Y
F
S
R
G
I
Site 59
Y794
R
R
I
V
D
S
K
Y
F
S
R
G
I
M
M
Site 60
S942
H
L
F
G
C
K
F
S
L
K
T
D
T
G
D
Site 61
T947
K
F
S
L
K
T
D
T
G
D
T
V
P
D
R
Site 62
T950
L
K
T
D
T
G
D
T
V
P
D
R
K
N
F
Site 63
S959
P
D
R
K
N
F
D
S
L
L
W
A
I
V
T
Site 64
Y981
E
D
W
N
V
V
L
Y
N
G
M
A
S
T
S
Site 65
T1029
G
D
A
N
R
S
D
T
D
E
D
K
T
S
V
Site 66
T1034
S
D
T
D
E
D
K
T
S
V
H
F
E
E
D
Site 67
S1035
D
T
D
E
D
K
T
S
V
H
F
E
E
D
F
Site 68
T1051
K
L
R
E
L
Q
T
T
E
L
K
M
C
S
L
Site 69
T1061
K
M
C
S
L
A
V
T
P
N
G
H
L
E
G
Site 70
S1071
G
H
L
E
G
R
G
S
L
S
P
P
L
I
M
Site 71
T1087
T
A
A
T
P
M
P
T
P
K
S
S
P
F
L
Site 72
S1090
T
P
M
P
T
P
K
S
S
P
F
L
D
A
A
Site 73
S1091
P
M
P
T
P
K
S
S
P
F
L
D
A
A
P
Site 74
S1099
P
F
L
D
A
A
P
S
L
P
D
S
R
R
G
Site 75
S1103
A
A
P
S
L
P
D
S
R
R
G
S
S
S
S
Site 76
S1107
L
P
D
S
R
R
G
S
S
S
S
G
D
P
P
Site 77
S1108
P
D
S
R
R
G
S
S
S
S
G
D
P
P
L
Site 78
S1109
D
S
R
R
G
S
S
S
S
G
D
P
P
L
G
Site 79
S1110
S
R
R
G
S
S
S
S
G
D
P
P
L
G
D
Site 80
S1123
G
D
Q
K
P
P
A
S
L
R
S
S
P
C
A
Site 81
S1126
K
P
P
A
S
L
R
S
S
P
C
A
P
W
G
Site 82
S1127
P
P
A
S
L
R
S
S
P
C
A
P
W
G
P
Site 83
S1135
P
C
A
P
W
G
P
S
G
A
W
S
S
R
R
Site 84
S1139
W
G
P
S
G
A
W
S
S
R
R
S
S
W
S
Site 85
S1140
G
P
S
G
A
W
S
S
R
R
S
S
W
S
S
Site 86
S1143
G
A
W
S
S
R
R
S
S
W
S
S
L
G
R
Site 87
S1144
A
W
S
S
R
R
S
S
W
S
S
L
G
R
A
Site 88
S1146
S
S
R
R
S
S
W
S
S
L
G
R
A
P
S
Site 89
S1147
S
R
R
S
S
W
S
S
L
G
R
A
P
S
L
Site 90
S1153
S
S
L
G
R
A
P
S
L
K
R
R
G
Q
C
Site 91
S1165
G
Q
C
G
E
R
E
S
L
L
S
G
E
G
K
Site 92
S1168
G
E
R
E
S
L
L
S
G
E
G
K
G
S
T
Site 93
S1174
L
S
G
E
G
K
G
S
T
D
D
E
A
E
D
Site 94
T1191
A
A
P
G
P
R
A
T
P
L
R
R
A
E
S
Site 95
S1198
T
P
L
R
R
A
E
S
L
D
P
R
P
L
R
Site 96
T1212
R
P
A
A
L
P
P
T
K
C
R
D
R
D
G
Site 97
S1234
D
F
F
L
R
I
D
S
H
R
E
D
A
A
E
Site 98
S1246
A
A
E
L
D
D
D
S
E
D
S
C
C
L
R
Site 99
S1249
L
D
D
D
S
E
D
S
C
C
L
R
L
H
K
Site 100
Y1275
S
R
E
A
W
A
L
Y
L
F
S
P
Q
N
R
Site 101
S1278
A
W
A
L
Y
L
F
S
P
Q
N
R
F
R
V
Site 102
S1322
R
P
D
I
D
P
G
S
T
E
R
V
F
L
S
Site 103
T1323
P
D
I
D
P
G
S
T
E
R
V
F
L
S
V
Site 104
Y1359
L
L
S
G
E
H
A
Y
L
Q
S
S
W
N
L
Site 105
S1362
G
E
H
A
Y
L
Q
S
S
W
N
L
L
D
G
Site 106
Y1457
Q
L
F
K
G
K
F
Y
Y
C
E
G
P
D
T
Site 107
Y1458
L
F
K
G
K
F
Y
Y
C
E
G
P
D
T
R
Site 108
T1464
Y
Y
C
E
G
P
D
T
R
N
I
S
T
K
A
Site 109
S1468
G
P
D
T
R
N
I
S
T
K
A
Q
C
R
A
Site 110
Y1485
Y
R
W
V
R
R
K
Y
N
F
D
N
L
G
Q
Site 111
S1587
R
L
E
R
R
R
R
S
T
F
P
S
P
E
A
Site 112
T1588
L
E
R
R
R
R
S
T
F
P
S
P
E
A
Q
Site 113
S1591
R
R
R
S
T
F
P
S
P
E
A
Q
R
R
P
Site 114
Y1599
P
E
A
Q
R
R
P
Y
Y
A
D
Y
S
P
T
Site 115
Y1600
E
A
Q
R
R
P
Y
Y
A
D
Y
S
P
T
R
Site 116
Y1603
R
R
P
Y
Y
A
D
Y
S
P
T
R
R
S
I
Site 117
S1604
R
P
Y
Y
A
D
Y
S
P
T
R
R
S
I
H
Site 118
S1609
D
Y
S
P
T
R
R
S
I
H
S
L
C
T
S
Site 119
S1612
P
T
R
R
S
I
H
S
L
C
T
S
H
Y
L
Site 120
Y1639
I
T
M
S
M
E
H
Y
N
Q
P
K
S
L
D
Site 121
S1644
E
H
Y
N
Q
P
K
S
L
D
E
A
L
K
Y
Site 122
S1786
D
N
P
C
E
G
L
S
R
H
A
T
F
S
N
Site 123
T1790
E
G
L
S
R
H
A
T
F
S
N
F
G
M
A
Site 124
T1806
L
T
L
F
R
V
S
T
G
D
N
W
N
G
I
Site 125
S1822
K
D
T
L
R
E
C
S
R
E
D
K
H
C
L
Site 126
S1830
R
E
D
K
H
C
L
S
Y
L
P
A
L
S
P
Site 127
Y1831
E
D
K
H
C
L
S
Y
L
P
A
L
S
P
V
Site 128
S1890
E
M
A
Q
G
P
G
S
A
R
R
V
D
A
D
Site 129
S1905
R
P
P
L
P
Q
E
S
P
G
A
R
D
A
P
Site 130
S1926
V
S
V
S
R
M
L
S
L
P
N
D
S
Y
M
Site 131
Y1932
L
S
L
P
N
D
S
Y
M
F
R
P
V
V
P
Site 132
S1941
F
R
P
V
V
P
A
S
A
P
H
P
R
P
L
Site 133
Y1956
Q
E
V
E
M
E
T
Y
G
A
G
T
P
L
G
Site 134
S1967
T
P
L
G
S
V
A
S
V
H
S
P
P
A
E
Site 135
S1970
G
S
V
A
S
V
H
S
P
P
A
E
S
C
A
Site 136
S1975
V
H
S
P
P
A
E
S
C
A
S
L
Q
I
P
Site 137
S1987
Q
I
P
L
A
V
S
S
P
A
R
S
G
E
P
Site 138
S1991
A
V
S
S
P
A
R
S
G
E
P
L
H
A
L
Site 139
S1999
G
E
P
L
H
A
L
S
P
R
G
T
A
R
S
Site 140
T2003
H
A
L
S
P
R
G
T
A
R
S
P
S
L
S
Site 141
S2006
S
P
R
G
T
A
R
S
P
S
L
S
R
L
L
Site 142
S2008
R
G
T
A
R
S
P
S
L
S
R
L
L
C
R
Site 143
S2010
T
A
R
S
P
S
L
S
R
L
L
C
R
Q
E
Site 144
T2021
C
R
Q
E
A
V
H
T
D
S
L
E
G
K
I
Site 145
S2023
Q
E
A
V
H
T
D
S
L
E
G
K
I
D
S
Site 146
S2030
S
L
E
G
K
I
D
S
P
R
D
T
L
D
P
Site 147
T2034
K
I
D
S
P
R
D
T
L
D
P
A
E
P
G
Site 148
T2044
P
A
E
P
G
E
K
T
P
V
R
P
V
T
Q
Site 149
T2050
K
T
P
V
R
P
V
T
Q
G
G
S
L
Q
S
Site 150
S2054
R
P
V
T
Q
G
G
S
L
Q
S
P
P
R
S
Site 151
S2057
T
Q
G
G
S
L
Q
S
P
P
R
S
P
R
P
Site 152
S2061
S
L
Q
S
P
P
R
S
P
R
P
A
S
V
R
Site 153
S2066
P
R
S
P
R
P
A
S
V
R
T
R
K
H
T
Site 154
T2073
S
V
R
T
R
K
H
T
F
G
Q
R
C
V
S
Site 155
S2080
T
F
G
Q
R
C
V
S
S
R
P
A
A
P
G
Site 156
S2081
F
G
Q
R
C
V
S
S
R
P
A
A
P
G
G
Site 157
S2094
G
G
E
E
A
E
A
S
D
P
A
D
E
E
V
Site 158
S2102
D
P
A
D
E
E
V
S
H
I
T
S
S
A
C
Site 159
S2106
E
E
V
S
H
I
T
S
S
A
C
P
W
Q
P
Site 160
S2107
E
V
S
H
I
T
S
S
A
C
P
W
Q
P
T
Site 161
T2114
S
A
C
P
W
Q
P
T
A
E
P
H
G
P
E
Site 162
S2123
E
P
H
G
P
E
A
S
P
V
A
G
G
E
R
Site 163
Y2136
E
R
D
L
R
R
L
Y
S
V
D
A
Q
G
F
Site 164
S2137
R
D
L
R
R
L
Y
S
V
D
A
Q
G
F
L
Site 165
S2157
A
D
E
Q
W
R
P
S
A
E
L
G
S
G
E
Site 166
S2162
R
P
S
A
E
L
G
S
G
E
P
G
E
A
K
Site 167
S2188
A
R
R
K
K
K
M
S
P
P
C
I
S
V
E
Site 168
S2193
K
M
S
P
P
C
I
S
V
E
P
P
A
E
D
Site 169
S2203
P
P
A
E
D
E
G
S
A
R
P
S
A
A
E
Site 170
S2207
D
E
G
S
A
R
P
S
A
A
E
G
G
S
T
Site 171
T2214
S
A
A
E
G
G
S
T
T
L
R
R
R
T
P
Site 172
T2215
A
A
E
G
G
S
T
T
L
R
R
R
T
P
S
Site 173
T2220
S
T
T
L
R
R
R
T
P
S
C
E
A
T
P
Site 174
S2222
T
L
R
R
R
T
P
S
C
E
A
T
P
H
R
Site 175
T2226
R
T
P
S
C
E
A
T
P
H
R
D
S
L
E
Site 176
S2231
E
A
T
P
H
R
D
S
L
E
P
T
E
G
S
Site 177
T2235
H
R
D
S
L
E
P
T
E
G
S
G
A
G
G
Site 178
S2255
G
E
R
W
G
Q
A
S
C
R
A
E
H
L
T
Site 179
T2262
S
C
R
A
E
H
L
T
V
P
S
F
A
F
E
Site 180
S2277
P
L
D
L
G
V
P
S
G
D
P
F
L
D
G
Site 181
S2285
G
D
P
F
L
D
G
S
H
S
V
T
P
E
S
Site 182
S2287
P
F
L
D
G
S
H
S
V
T
P
E
S
R
A
Site 183
T2289
L
D
G
S
H
S
V
T
P
E
S
R
A
S
S
Site 184
S2292
S
H
S
V
T
P
E
S
R
A
S
S
S
G
A
Site 185
S2295
V
T
P
E
S
R
A
S
S
S
G
A
I
V
P
Site 186
S2296
T
P
E
S
R
A
S
S
S
G
A
I
V
P
L
Site 187
S2297
P
E
S
R
A
S
S
S
G
A
I
V
P
L
E
Site 188
S2308
V
P
L
E
P
P
E
S
E
P
P
M
P
V
G
Site 189
Y2325
P
E
K
R
R
G
L
Y
L
T
V
P
Q
C
P
Site 190
T2327
K
R
R
G
L
Y
L
T
V
P
Q
C
P
L
E
Site 191
S2338
C
P
L
E
K
P
G
S
P
S
A
T
P
A
P
Site 192
S2340
L
E
K
P
G
S
P
S
A
T
P
A
P
G
G
Site 193
T2342
K
P
G
S
P
S
A
T
P
A
P
G
G
G
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation