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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RasGRP1
Full Name:
RAS guanyl-releasing protein 1
Alias:
Calcium and DAG-regulated guanine nucleotide exchange factor II;Ras guanyl-releasing protein
Type:
Guanine nucleotide exchange factor for Ras
Mass (Da):
90402
Number AA:
797
UniProt ID:
O95267
International Prot ID:
IPI00024733
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005829
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005085
GO:0008289
PhosphoSite+
KinaseNET
Biological Process:
GO:0007265
GO:0030154
GO:0051056
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
R
E
A
P
R
K
P
S
H
G
C
R
A
A
S
Site 2
S22
S
H
G
C
R
A
A
S
K
A
R
L
E
A
K
Site 3
S33
L
E
A
K
P
A
N
S
P
F
P
S
H
P
S
Site 4
S37
P
A
N
S
P
F
P
S
H
P
S
L
A
H
I
Site 5
S40
S
P
F
P
S
H
P
S
L
A
H
I
T
Q
F
Site 6
S61
G
H
L
A
K
G
A
S
L
D
D
L
I
D
S
Site 7
S118
K
D
A
L
A
K
N
S
P
G
L
C
L
K
I
Site 8
S145
V
M
F
K
M
D
A
S
L
T
D
T
M
E
E
Site 9
T149
M
D
A
S
L
T
D
T
M
E
E
F
Q
E
L
Site 10
S180
Q
I
N
A
R
D
W
S
R
K
L
T
Q
R
I
Site 11
T184
R
D
W
S
R
K
L
T
Q
R
I
K
S
N
T
Site 12
S189
K
L
T
Q
R
I
K
S
N
T
S
K
K
R
K
Site 13
T191
T
Q
R
I
K
S
N
T
S
K
K
R
K
V
S
Site 14
S192
Q
R
I
K
S
N
T
S
K
K
R
K
V
S
L
Site 15
S198
T
S
K
K
R
K
V
S
L
L
F
D
H
L
E
Site 16
T214
E
E
L
S
E
H
L
T
Y
L
E
F
K
S
F
Site 17
Y215
E
L
S
E
H
L
T
Y
L
E
F
K
S
F
R
Site 18
S220
L
T
Y
L
E
F
K
S
F
R
R
I
S
F
S
Site 19
S225
F
K
S
F
R
R
I
S
F
S
D
Y
Q
N
Y
Site 20
S227
S
F
R
R
I
S
F
S
D
Y
Q
N
Y
L
V
Site 21
Y229
R
R
I
S
F
S
D
Y
Q
N
Y
L
V
N
S
Site 22
Y232
S
F
S
D
Y
Q
N
Y
L
V
N
S
C
V
K
Site 23
T243
S
C
V
K
E
N
P
T
M
E
R
S
I
A
L
Site 24
S264
W
V
Q
L
M
V
L
S
R
P
T
P
Q
L
R
Site 25
S305
I
G
G
L
C
H
S
S
I
S
R
L
K
E
T
Site 26
S307
G
L
C
H
S
S
I
S
R
L
K
E
T
S
S
Site 27
T312
S
I
S
R
L
K
E
T
S
S
H
V
P
H
E
Site 28
S313
I
S
R
L
K
E
T
S
S
H
V
P
H
E
I
Site 29
S314
S
R
L
K
E
T
S
S
H
V
P
H
E
I
N
Site 30
T328
N
K
V
L
G
E
M
T
E
L
L
S
S
S
R
Site 31
S332
G
E
M
T
E
L
L
S
S
S
R
N
Y
D
N
Site 32
S333
E
M
T
E
L
L
S
S
S
R
N
Y
D
N
Y
Site 33
S334
M
T
E
L
L
S
S
S
R
N
Y
D
N
Y
R
Site 34
Y337
L
L
S
S
S
R
N
Y
D
N
Y
R
R
A
Y
Site 35
Y340
S
S
R
N
Y
D
N
Y
R
R
A
Y
G
E
C
Site 36
Y344
Y
D
N
Y
R
R
A
Y
G
E
C
T
D
F
K
Site 37
T348
R
R
A
Y
G
E
C
T
D
F
K
I
P
I
L
Site 38
Y372
L
Y
E
A
M
P
D
Y
L
E
D
G
K
V
N
Site 39
Y420
L
T
L
S
L
D
L
Y
Y
T
E
D
E
I
Y
Site 40
Y421
T
L
S
L
D
L
Y
Y
T
E
D
E
I
Y
E
Site 41
Y427
Y
Y
T
E
D
E
I
Y
E
L
S
Y
A
R
E
Site 42
S430
E
D
E
I
Y
E
L
S
Y
A
R
E
P
R
N
Site 43
T444
N
H
R
A
P
P
L
T
P
S
K
P
P
V
V
Site 44
S446
R
A
P
P
L
T
P
S
K
P
P
V
V
V
D
Site 45
S456
P
V
V
V
D
W
A
S
G
V
S
P
K
P
D
Site 46
S459
V
D
W
A
S
G
V
S
P
K
P
D
P
K
T
Site 47
T466
S
P
K
P
D
P
K
T
I
S
K
H
V
Q
R
Site 48
S468
K
P
D
P
K
T
I
S
K
H
V
Q
R
M
V
Site 49
Y482
V
D
S
V
F
K
N
Y
D
H
D
Q
D
G
Y
Site 50
Y489
Y
D
H
D
Q
D
G
Y
I
S
Q
E
E
F
E
Site 51
S491
H
D
Q
D
G
Y
I
S
Q
E
E
F
E
K
I
Site 52
S518
K
D
R
E
G
L
I
S
R
D
E
I
T
A
Y
Site 53
Y525
S
R
D
E
I
T
A
Y
F
M
R
A
S
S
I
Site 54
S530
T
A
Y
F
M
R
A
S
S
I
Y
S
K
L
G
Site 55
Y549
H
N
F
Q
E
T
T
Y
L
K
P
T
F
C
D
Site 56
S607
A
P
T
E
N
N
T
S
V
G
P
V
S
N
L
Site 57
T632
A
P
E
E
G
P
F
T
F
P
N
G
E
A
V
Site 58
T649
G
E
E
S
K
D
R
T
I
M
L
M
G
V
S
Site 59
S657
I
M
L
M
G
V
S
S
Q
K
I
S
L
R
L
Site 60
S661
G
V
S
S
Q
K
I
S
L
R
L
K
R
A
V
Site 61
S677
H
K
A
T
Q
T
E
S
Q
P
W
I
G
S
E
Site 62
S683
E
S
Q
P
W
I
G
S
E
G
P
S
G
P
F
Site 63
S687
W
I
G
S
E
G
P
S
G
P
F
V
L
S
S
Site 64
S693
P
S
G
P
F
V
L
S
S
P
R
K
T
A
Q
Site 65
S694
S
G
P
F
V
L
S
S
P
R
K
T
A
Q
D
Site 66
T698
V
L
S
S
P
R
K
T
A
Q
D
T
L
Y
V
Site 67
T702
P
R
K
T
A
Q
D
T
L
Y
V
L
P
S
P
Site 68
Y704
K
T
A
Q
D
T
L
Y
V
L
P
S
P
T
S
Site 69
S708
D
T
L
Y
V
L
P
S
P
T
S
P
C
P
S
Site 70
S715
S
P
T
S
P
C
P
S
P
V
L
V
R
K
R
Site 71
S732
V
K
W
E
N
K
D
S
L
I
K
S
K
E
E
Site 72
S736
N
K
D
S
L
I
K
S
K
E
E
L
R
H
L
Site 73
T747
L
R
H
L
R
L
P
T
Y
Q
E
L
E
Q
E
Site 74
Y748
R
H
L
R
L
P
T
Y
Q
E
L
E
Q
E
I
Site 75
S778
Y
A
Q
K
K
I
E
S
L
Q
L
E
K
S
N
Site 76
S784
E
S
L
Q
L
E
K
S
N
H
V
L
A
Q
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation