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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TNKS
Full Name:
Tankyrase-1
Alias:
PARP5A; PARP-5a; PARPL; TANK1; Tankyrase I; Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase; TIN1; TINF1; TNKS1; TNKS-1; TRF1- interacting ankyrin-related ADP-ribose polymerase
Type:
EC 2.4.2.30; Transferase
Mass (Da):
142039
Number AA:
1327
UniProt ID:
O95271
International Prot ID:
IPI00021493
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0019898
GO:0005792
Uniprot
OncoNet
Molecular Function:
GO:0003950
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0051028
GO:0007052
GO:0043392
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
L
Q
P
A
P
G
A
S
A
P
P
P
P
P
P
Site 2
S36
P
P
P
P
P
P
L
S
P
G
L
A
P
G
T
Site 3
T43
S
P
G
L
A
P
G
T
T
P
A
S
P
T
A
Site 4
T44
P
G
L
A
P
G
T
T
P
A
S
P
T
A
S
Site 5
S47
A
P
G
T
T
P
A
S
P
T
A
S
G
L
A
Site 6
T49
G
T
T
P
A
S
P
T
A
S
G
L
A
P
F
Site 7
S71
A
L
P
E
G
D
G
S
R
D
P
P
D
R
P
Site 8
S80
D
P
P
D
R
P
R
S
P
D
P
V
D
G
T
Site 9
T87
S
P
D
P
V
D
G
T
S
C
C
S
T
T
S
Site 10
S88
P
D
P
V
D
G
T
S
C
C
S
T
T
S
T
Site 11
S123
V
A
P
N
P
A
G
S
G
S
N
N
S
P
S
Site 12
S125
P
N
P
A
G
S
G
S
N
N
S
P
S
S
S
Site 13
S128
A
G
S
G
S
N
N
S
P
S
S
S
S
S
P
Site 14
S130
S
G
S
N
N
S
P
S
S
S
S
S
P
T
S
Site 15
S131
G
S
N
N
S
P
S
S
S
S
S
P
T
S
S
Site 16
S132
S
N
N
S
P
S
S
S
S
S
P
T
S
S
S
Site 17
S133
N
N
S
P
S
S
S
S
S
P
T
S
S
S
S
Site 18
S134
N
S
P
S
S
S
S
S
P
T
S
S
S
S
S
Site 19
T136
P
S
S
S
S
S
P
T
S
S
S
S
S
S
P
Site 20
S137
S
S
S
S
S
P
T
S
S
S
S
S
S
P
S
Site 21
S138
S
S
S
S
P
T
S
S
S
S
S
S
P
S
S
Site 22
S139
S
S
S
P
T
S
S
S
S
S
S
P
S
S
P
Site 23
S140
S
S
P
T
S
S
S
S
S
S
P
S
S
P
G
Site 24
S141
S
P
T
S
S
S
S
S
S
P
S
S
P
G
S
Site 25
S142
P
T
S
S
S
S
S
S
P
S
S
P
G
S
S
Site 26
S144
S
S
S
S
S
S
P
S
S
P
G
S
S
L
A
Site 27
S145
S
S
S
S
S
P
S
S
P
G
S
S
L
A
E
Site 28
S148
S
S
P
S
S
P
G
S
S
L
A
E
S
P
E
Site 29
S149
S
P
S
S
P
G
S
S
L
A
E
S
P
E
A
Site 30
S153
P
G
S
S
L
A
E
S
P
E
A
A
G
V
S
Site 31
S161
P
E
A
A
G
V
S
S
T
A
P
L
G
P
G
Site 32
S196
A
C
R
N
G
D
V
S
R
V
K
R
L
V
D
Site 33
S217
K
D
M
A
G
R
K
S
S
P
L
H
F
A
A
Site 34
S218
D
M
A
G
R
K
S
S
P
L
H
F
A
A
G
Site 35
Y283
N
A
R
D
N
W
N
Y
T
P
L
H
E
A
A
Site 36
T284
A
R
D
N
W
N
Y
T
P
L
H
E
A
A
I
Site 37
T313
A
D
P
N
I
R
N
T
D
G
K
S
A
L
D
Site 38
S345
E
L
L
E
A
A
R
S
G
N
E
E
K
L
M
Site 39
S365
L
N
V
N
C
H
A
S
D
G
R
K
S
T
P
Site 40
S370
H
A
S
D
G
R
K
S
T
P
L
H
L
A
A
Site 41
T371
A
S
D
G
R
K
S
T
P
L
H
L
A
A
G
Site 42
Y379
P
L
H
L
A
A
G
Y
N
R
V
R
I
V
Q
Site 43
T437
A
M
D
L
W
Q
F
T
P
L
H
E
A
A
S
Site 44
S444
T
P
L
H
E
A
A
S
K
N
R
V
E
V
C
Site 45
T462
L
S
H
G
A
D
P
T
L
V
N
C
H
G
K
Site 46
T477
S
A
V
D
M
A
P
T
P
E
L
R
E
R
L
Site 47
T485
P
E
L
R
E
R
L
T
Y
E
F
K
G
H
S
Site 48
Y486
E
L
R
E
R
L
T
Y
E
F
K
G
H
S
L
Site 49
T560
E
K
N
K
D
F
M
T
P
L
H
V
A
A
E
Site 50
T589
A
K
M
N
A
L
D
T
L
G
Q
T
A
L
H
Site 51
S612
Q
T
C
R
L
L
L
S
Y
G
S
D
P
S
I
Site 52
S640
E
A
V
Q
Q
I
L
S
E
S
T
P
I
R
T
Site 53
S642
V
Q
Q
I
L
S
E
S
T
P
I
R
T
S
D
Site 54
T643
Q
Q
I
L
S
E
S
T
P
I
R
T
S
D
V
Site 55
S648
E
S
T
P
I
R
T
S
D
V
D
Y
R
L
L
Site 56
Y652
I
R
T
S
D
V
D
Y
R
L
L
E
A
S
K
Site 57
S658
D
Y
R
L
L
E
A
S
K
A
G
D
L
E
T
Site 58
T665
S
K
A
G
D
L
E
T
V
K
Q
L
C
S
S
Site 59
S672
T
V
K
Q
L
C
S
S
Q
N
V
N
C
R
D
Site 60
S685
R
D
L
E
G
R
H
S
T
P
L
H
F
A
A
Site 61
T686
D
L
E
G
R
H
S
T
P
L
H
F
A
A
G
Site 62
Y702
N
R
V
S
V
V
E
Y
L
L
H
H
G
A
D
Site 63
S726
V
P
L
H
N
A
C
S
Y
G
H
Y
E
V
A
Site 64
Y727
P
L
H
N
A
C
S
Y
G
H
Y
E
V
A
E
Site 65
S742
L
L
V
R
H
G
A
S
V
N
V
A
D
L
W
Site 66
T777
L
K
H
G
A
D
P
T
K
K
N
R
D
G
N
Site 67
T785
K
K
N
R
D
G
N
T
P
L
D
L
V
K
E
Site 68
T824
A
R
V
Q
K
L
C
T
P
E
N
I
N
C
R
Site 69
T833
E
N
I
N
C
R
D
T
Q
G
R
N
S
T
P
Site 70
S838
R
D
T
Q
G
R
N
S
T
P
L
H
L
A
A
Site 71
T839
D
T
Q
G
R
N
S
T
P
L
H
L
A
A
G
Site 72
Y855
N
N
L
E
V
A
E
Y
L
L
E
H
G
A
D
Site 73
T905
A
T
D
K
W
A
F
T
P
L
H
E
A
A
Q
Site 74
T930
L
A
H
G
A
D
P
T
M
K
N
Q
E
G
Q
Site 75
T938
M
K
N
Q
E
G
Q
T
P
L
D
L
A
T
A
Site 76
T963
M
P
P
E
A
L
P
T
C
F
K
P
Q
A
T
Site 77
S978
V
V
S
A
S
L
I
S
P
A
S
T
P
S
C
Site 78
T982
S
L
I
S
P
A
S
T
P
S
C
L
S
A
A
Site 79
S987
A
S
T
P
S
C
L
S
A
A
S
S
I
D
N
Site 80
S991
S
C
L
S
A
A
S
S
I
D
N
L
T
G
P
Site 81
T1017
A
G
D
G
A
A
G
T
E
R
K
E
G
E
V
Site 82
S1037
N
I
S
Q
F
L
K
S
L
G
L
E
H
L
R
Site 83
T1049
H
L
R
D
I
F
E
T
E
Q
I
T
L
D
V
Site 84
Y1096
G
Q
Q
G
T
N
P
Y
L
T
F
H
C
V
N
Site 85
Y1118
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Site 86
S1120
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
Site 87
S1127
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
Site 88
T1128
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
Site 89
Y1145
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
Site 90
Y1203
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
Site 91
Y1213
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
Site 92
S1221
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
Site 93
Y1224
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
Site 94
Y1226
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
Site 95
T1232
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
Site 96
T1236
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
Site 97
Y1243
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
Site 98
S1264
G
K
S
F
L
Q
F
S
T
M
K
M
A
H
A
Site 99
S1277
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
Site 100
Y1289
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
Site 101
Y1292
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
Site 102
Y1295
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
Site 103
Y1301
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Site 104
Y1304
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
Site 105
T1307
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
Site 106
Y1308
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
A
Site 107
T1321
E
A
P
S
Q
T
A
T
A
A
E
Q
K
T
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation