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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MEKK6
Full Name:
Mitogen-activated protein kinase kinase kinase 6
Alias:
Apoptosis signal regulating kinase 2; ASK2; EC 2.7.11.25; Kinase MAP3K6; M3K6; MAP3K6; MAPKKK6; MEK kinase 6
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25; STE group; STE11 family
Mass (Da):
142596
Number AA:
1288
UniProt ID:
O95382
International Prot ID:
IPI00418221
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004709
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0007257
Phosida
TranscriptoNet
STRING
Kinexus Products
Mitogen-activated protein kinase kinase kinase 6 pan-specific antibody AB-NK225-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK225-1#Mitogen-activated protein kinase kinase kinase 6 pan-specific antibody AB-NK225-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK225-2#Mitogen-activated protein kinase kinase kinase 6 pan-specific antibody AB-NK225-2P#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK225-2P#Mitogen-activated protein kinase kinase kinase 6 pan-specific antibody AB-NK225-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK225-3#Mitogen-activated protein kinase kinase kinase 6 pan-specific antibody AB-NK225-3P#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK225-3P#Mitogen-activated protein kinase kinase kinase 6 pan-specific antibody AB-NK225-4#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK225-4#Mitogen-activated protein kinase kinase kinase 6 (F409-C424, human) peptide - Powder PE-01ASQ99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ASQ99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
G
P
C
P
R
S
G
A
E
R
A
G
S
Site 2
S15
S
G
A
E
R
A
G
S
C
W
Q
D
P
L
A
Site 3
S42
P
G
R
G
C
A
R
S
R
P
L
S
V
V
Y
Site 4
Y49
S
R
P
L
S
V
V
Y
V
L
T
R
E
P
Q
Site 5
T65
G
L
E
P
R
E
G
T
E
A
E
P
L
P
L
Site 6
S93
R
P
P
P
Q
L
R
S
L
P
F
G
T
L
E
Site 7
S138
Y
H
L
G
V
R
E
S
F
S
M
T
N
N
V
Site 8
T227
L
A
R
L
L
E
A
T
P
T
D
S
C
G
Y
Site 9
T229
R
L
L
E
A
T
P
T
D
S
C
G
Y
F
R
Site 10
Y234
T
P
T
D
S
C
G
Y
F
R
E
T
I
R
R
Site 11
T238
S
C
G
Y
F
R
E
T
I
R
R
D
I
R
Q
Site 12
S251
R
Q
A
R
E
R
F
S
G
P
Q
L
R
Q
E
Site 13
S268
R
L
Q
R
R
L
D
S
V
E
L
L
S
P
D
Site 14
Y290
S
Y
R
D
V
Q
D
Y
S
A
I
I
E
L
V
Site 15
S367
Y
K
D
M
F
F
S
S
G
F
Q
D
A
G
H
Site 16
Y379
A
G
H
R
E
Q
A
Y
H
W
Y
R
K
A
F
Site 17
S391
K
A
F
D
V
E
P
S
L
H
S
G
I
N
A
Site 18
S412
A
G
Q
H
F
E
D
S
K
E
L
R
L
I
G
Site 19
Y484
V
M
E
T
F
L
L
Y
Q
H
F
R
P
T
P
Site 20
T490
L
Y
Q
H
F
R
P
T
P
E
P
P
G
G
P
Site 21
T546
A
K
L
E
V
R
G
T
D
P
V
S
T
V
T
Site 22
T561
L
S
L
L
E
P
E
T
Q
D
I
P
S
S
W
Site 23
S566
P
E
T
Q
D
I
P
S
S
W
T
F
P
V
A
Site 24
S567
E
T
Q
D
I
P
S
S
W
T
F
P
V
A
S
Site 25
S579
V
A
S
I
C
G
V
S
A
S
K
R
D
E
R
Site 26
S581
S
I
C
G
V
S
A
S
K
R
D
E
R
C
C
Site 27
Y591
D
E
R
C
C
F
L
Y
A
L
P
P
A
Q
D
Site 28
T621
G
L
I
Q
A
W
V
T
N
P
D
S
T
A
P
Site 29
S625
A
W
V
T
N
P
D
S
T
A
P
A
E
E
A
Site 30
Y643
G
E
M
L
E
F
D
Y
E
Y
T
E
T
G
E
Site 31
Y645
M
L
E
F
D
Y
E
Y
T
E
T
G
E
R
L
Site 32
T648
F
D
Y
E
Y
T
E
T
G
E
R
L
V
L
G
Site 33
Y663
K
G
T
Y
G
V
V
Y
A
G
R
D
R
H
T
Site 34
T670
Y
A
G
R
D
R
H
T
R
V
R
I
A
I
K
Site 35
S684
K
E
I
P
E
R
D
S
R
F
S
Q
P
L
H
Site 36
S687
P
E
R
D
S
R
F
S
Q
P
L
H
E
E
I
Site 37
Y708
R
H
K
N
I
V
R
Y
L
G
S
A
S
Q
G
Site 38
S711
N
I
V
R
Y
L
G
S
A
S
Q
G
G
Y
L
Site 39
S713
V
R
Y
L
G
S
A
S
Q
G
G
Y
L
K
I
Site 40
Y717
G
S
A
S
Q
G
G
Y
L
K
I
F
M
E
E
Site 41
S729
M
E
E
V
P
G
G
S
L
S
S
L
L
R
S
Site 42
S736
S
L
S
S
L
L
R
S
V
W
G
P
L
K
D
Site 43
S746
G
P
L
K
D
N
E
S
T
I
S
F
Y
T
R
Site 44
S749
K
D
N
E
S
T
I
S
F
Y
T
R
Q
I
L
Site 45
Y751
N
E
S
T
I
S
F
Y
T
R
Q
I
L
Q
G
Site 46
T781
G
D
N
V
L
I
N
T
F
S
G
L
L
K
I
Site 47
S789
F
S
G
L
L
K
I
S
D
F
G
T
S
K
R
Site 48
S794
K
I
S
D
F
G
T
S
K
R
L
A
G
I
T
Site 49
T801
S
K
R
L
A
G
I
T
P
C
T
E
T
F
T
Site 50
T804
L
A
G
I
T
P
C
T
E
T
F
T
G
T
L
Site 51
T806
G
I
T
P
C
T
E
T
F
T
G
T
L
Q
Y
Site 52
T810
C
T
E
T
F
T
G
T
L
Q
Y
M
A
P
E
Site 53
Y826
I
D
Q
G
P
R
G
Y
G
K
A
A
D
I
W
Site 54
T844
C
T
V
I
E
M
A
T
G
R
P
P
F
H
E
Site 55
S854
P
P
F
H
E
L
G
S
P
Q
A
A
M
F
Q
Site 56
S874
V
H
P
P
M
P
S
S
L
S
A
E
A
Q
A
Site 57
T886
A
Q
A
F
L
L
R
T
F
E
P
D
P
R
L
Site 58
S896
P
D
P
R
L
R
A
S
A
Q
T
L
L
G
D
Site 59
T899
R
L
R
A
S
A
Q
T
L
L
G
D
P
F
L
Site 60
S912
F
L
Q
P
G
K
R
S
R
S
P
S
S
P
R
Site 61
S914
Q
P
G
K
R
S
R
S
P
S
S
P
R
H
A
Site 62
S916
G
K
R
S
R
S
P
S
S
P
R
H
A
P
R
Site 63
S917
K
R
S
R
S
P
S
S
P
R
H
A
P
R
P
Site 64
S925
P
R
H
A
P
R
P
S
D
A
P
S
A
S
P
Site 65
S929
P
R
P
S
D
A
P
S
A
S
P
T
P
S
A
Site 66
S931
P
S
D
A
P
S
A
S
P
T
P
S
A
N
S
Site 67
T933
D
A
P
S
A
S
P
T
P
S
A
N
S
T
T
Site 68
S935
P
S
A
S
P
T
P
S
A
N
S
T
T
Q
S
Site 69
S938
S
P
T
P
S
A
N
S
T
T
Q
S
Q
T
F
Site 70
T939
P
T
P
S
A
N
S
T
T
Q
S
Q
T
F
P
Site 71
S942
S
A
N
S
T
T
Q
S
Q
T
F
P
C
P
Q
Site 72
T944
N
S
T
T
Q
S
Q
T
F
P
C
P
Q
A
P
Site 73
S952
F
P
C
P
Q
A
P
S
Q
H
P
P
S
P
P
Site 74
S957
A
P
S
Q
H
P
P
S
P
P
K
R
C
L
S
Site 75
S964
S
P
P
K
R
C
L
S
Y
G
G
T
S
Q
L
Site 76
Y965
P
P
K
R
C
L
S
Y
G
G
T
S
Q
L
R
Site 77
T968
R
C
L
S
Y
G
G
T
S
Q
L
R
V
P
E
Site 78
S969
C
L
S
Y
G
G
T
S
Q
L
R
V
P
E
E
Site 79
S984
P
A
A
E
E
P
A
S
P
E
E
S
S
G
L
Site 80
S988
E
P
A
S
P
E
E
S
S
G
L
S
L
L
H
Site 81
S989
P
A
S
P
E
E
S
S
G
L
S
L
L
H
Q
Site 82
S992
P
E
E
S
S
G
L
S
L
L
H
Q
E
S
K
Site 83
S998
L
S
L
L
H
Q
E
S
K
R
R
A
M
L
A
Site 84
T1049
C
L
G
A
H
I
H
T
P
N
R
R
Q
L
A
Site 85
S1129
E
V
E
K
E
A
V
S
P
R
S
E
E
L
S
Site 86
S1132
K
E
A
V
S
P
R
S
E
E
L
S
N
E
G
Site 87
S1136
S
P
R
S
E
E
L
S
N
E
G
D
S
Q
Q
Site 88
S1141
E
L
S
N
E
G
D
S
Q
Q
S
P
G
Q
Q
Site 89
S1144
N
E
G
D
S
Q
Q
S
P
G
Q
Q
S
P
L
Site 90
S1149
Q
Q
S
P
G
Q
Q
S
P
L
P
V
E
P
E
Site 91
T1173
L
S
L
L
R
A
E
T
D
R
L
R
E
I
L
Site 92
Y1187
L
A
G
K
E
R
E
Y
Q
A
L
V
Q
R
A
Site 93
T1204
R
L
N
E
E
A
R
T
Y
V
L
A
P
E
P
Site 94
Y1205
L
N
E
E
A
R
T
Y
V
L
A
P
E
P
P
Site 95
S1216
P
E
P
P
T
A
L
S
T
D
Q
G
L
V
Q
Site 96
T1234
E
L
N
V
D
S
G
T
I
Q
M
L
L
N
H
Site 97
Y1259
A
T
R
D
D
L
I
Y
T
R
I
R
G
G
M
Site 98
T1260
T
R
D
D
L
I
Y
T
R
I
R
G
G
M
V
Site 99
S1281
I
L
A
Q
R
A
G
S
T
P
V
T
S
G
P
Site 100
T1282
L
A
Q
R
A
G
S
T
P
V
T
S
G
P
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation