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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SERPINA1
Full Name:
Alpha-1-antitrypsin
Alias:
A1A; A1AT; AAT; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Alpha-1-antitrypsin; PI; PI1; Protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin; Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin) member 1
Type:
Inhibitor protein
Mass (Da):
46737
Number AA:
418
UniProt ID:
P01009
International Prot ID:
IPI00553177
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005615
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004857
GO:0004866
PhosphoSite+
KinaseNET
Biological Process:
GO:0002526
GO:0006950
GO:0006952
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T35
Q
G
D
A
A
Q
K
T
D
T
S
H
H
D
Q
Site 2
T51
H
P
T
F
N
K
I
T
P
N
L
A
E
F
A
Site 3
T96
S
L
G
T
K
A
D
T
H
D
E
I
L
E
G
Site 4
T109
E
G
L
N
F
N
L
T
E
I
P
E
A
Q
I
Site 5
T126
G
F
Q
E
L
L
R
T
L
N
Q
P
D
S
Q
Site 6
S132
R
T
L
N
Q
P
D
S
Q
L
Q
L
T
T
G
Site 7
T137
P
D
S
Q
L
Q
L
T
T
G
N
G
L
F
L
Site 8
Y162
L
E
D
V
K
K
L
Y
H
S
E
A
F
T
V
Site 9
T168
L
Y
H
S
E
A
F
T
V
N
F
G
D
T
E
Site 10
Y184
A
K
K
Q
I
N
D
Y
V
E
K
G
T
Q
G
Site 11
T204
V
K
E
L
D
R
D
T
V
F
A
L
V
N
Y
Site 12
T227
R
P
F
E
V
K
D
T
E
E
E
D
F
H
V
Site 13
S261
Q
H
C
K
K
L
S
S
W
V
L
L
M
K
Y
Site 14
T292
Q
H
L
E
N
E
L
T
H
D
I
I
T
K
F
Site 15
S307
L
E
N
E
D
R
R
S
A
S
L
H
L
P
K
Site 16
S309
N
E
D
R
R
S
A
S
L
H
L
P
K
L
S
Site 17
Y321
K
L
S
I
T
G
T
Y
D
L
K
S
V
L
G
Site 18
T333
V
L
G
Q
L
G
I
T
K
V
F
S
N
G
A
Site 19
S343
F
S
N
G
A
D
L
S
G
V
T
E
E
A
P
Site 20
S354
E
E
A
P
L
K
L
S
K
A
V
H
K
A
V
Site 21
S383
F
L
E
A
I
P
M
S
I
P
P
E
V
K
F
Site 22
S405
M
I
E
Q
N
T
K
S
P
L
F
M
G
K
V
Site 23
T416
M
G
K
V
V
N
P
T
Q
K
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation