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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LMNA
Full Name:
Prelamin-A/C
Alias:
70 kDa lamin; CMD1A; HGPS; LAMA; LGMD1B; LMN1; PRO1
Type:
Cytoskeletal protein, membranes
Mass (Da):
74139
Number AA:
664
UniProt ID:
P02545
International Prot ID:
IPI00021405
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005638
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005198
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007517
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T3
_
_
_
_
_
M
E
T
P
S
Q
R
R
A
T
Site 2
S5
_
_
_
M
E
T
P
S
Q
R
R
A
T
R
S
Site 3
T10
T
P
S
Q
R
R
A
T
R
S
G
A
Q
A
S
Site 4
S12
S
Q
R
R
A
T
R
S
G
A
Q
A
S
S
T
Site 5
S17
T
R
S
G
A
Q
A
S
S
T
P
L
S
P
T
Site 6
S18
R
S
G
A
Q
A
S
S
T
P
L
S
P
T
R
Site 7
T19
S
G
A
Q
A
S
S
T
P
L
S
P
T
R
I
Site 8
S22
Q
A
S
S
T
P
L
S
P
T
R
I
T
R
L
Site 9
T24
S
S
T
P
L
S
P
T
R
I
T
R
L
Q
E
Site 10
T27
P
L
S
P
T
R
I
T
R
L
Q
E
K
E
D
Site 11
Y45
L
N
D
R
L
A
V
Y
I
D
R
V
R
S
L
Site 12
S51
V
Y
I
D
R
V
R
S
L
E
T
E
N
A
G
Site 13
T64
A
G
L
R
L
R
I
T
E
S
E
E
V
V
S
Site 14
S66
L
R
L
R
I
T
E
S
E
E
V
V
S
R
E
Site 15
S71
T
E
S
E
E
V
V
S
R
E
V
S
G
I
K
Site 16
S75
E
V
V
S
R
E
V
S
G
I
K
A
A
Y
E
Site 17
Y81
V
S
G
I
K
A
A
Y
E
A
E
L
G
D
A
Site 18
T91
E
L
G
D
A
R
K
T
L
D
S
V
A
K
E
Site 19
S94
D
A
R
K
T
L
D
S
V
A
K
E
R
A
R
Site 20
S107
A
R
L
Q
L
E
L
S
K
V
R
E
E
F
K
Site 21
T121
K
E
L
K
A
R
N
T
K
K
E
G
D
L
I
Site 22
S149
N
S
K
E
A
A
L
S
T
A
L
S
E
K
R
Site 23
S153
A
A
L
S
T
A
L
S
E
K
R
T
L
E
G
Site 24
T157
T
A
L
S
E
K
R
T
L
E
G
E
L
H
D
Site 25
T199
D
A
E
N
R
L
Q
T
M
K
E
E
L
D
F
Site 26
S212
D
F
Q
K
N
I
Y
S
E
E
L
R
E
T
K
Site 27
T218
Y
S
E
E
L
R
E
T
K
R
R
H
E
T
R
Site 28
T224
E
T
K
R
R
H
E
T
R
L
V
E
I
D
N
Site 29
T266
Y
K
K
E
L
E
K
T
Y
S
A
K
L
D
N
Site 30
S268
K
E
L
E
K
T
Y
S
A
K
L
D
N
A
R
Site 31
S277
K
L
D
N
A
R
Q
S
A
E
R
N
S
N
L
Site 32
S282
R
Q
S
A
E
R
N
S
N
L
V
G
A
A
H
Site 33
S295
A
H
E
E
L
Q
Q
S
R
I
R
I
D
S
L
Site 34
S301
Q
S
R
I
R
I
D
S
L
S
A
Q
L
S
Q
Site 35
S303
R
I
R
I
D
S
L
S
A
Q
L
S
Q
L
Q
Site 36
S307
D
S
L
S
A
Q
L
S
Q
L
Q
K
Q
L
A
Site 37
S326
K
L
R
D
L
E
D
S
L
A
R
E
R
D
T
Site 38
T333
S
L
A
R
E
R
D
T
S
R
R
L
L
A
E
Site 39
S334
L
A
R
E
R
D
T
S
R
R
L
L
A
E
K
Site 40
Y359
M
Q
Q
Q
L
D
E
Y
Q
E
L
L
D
I
K
Site 41
Y376
L
D
M
E
I
H
A
Y
R
K
L
L
E
G
E
Site 42
S390
E
E
E
R
L
R
L
S
P
S
P
T
S
Q
R
Site 43
S392
E
R
L
R
L
S
P
S
P
T
S
Q
R
S
R
Site 44
T394
L
R
L
S
P
S
P
T
S
Q
R
S
R
G
R
Site 45
S395
R
L
S
P
S
P
T
S
Q
R
S
R
G
R
A
Site 46
S398
P
S
P
T
S
Q
R
S
R
G
R
A
S
S
H
Site 47
S403
Q
R
S
R
G
R
A
S
S
H
S
S
Q
T
Q
Site 48
S404
R
S
R
G
R
A
S
S
H
S
S
Q
T
Q
G
Site 49
S406
R
G
R
A
S
S
H
S
S
Q
T
Q
G
G
G
Site 50
S407
G
R
A
S
S
H
S
S
Q
T
Q
G
G
G
S
Site 51
T409
A
S
S
H
S
S
Q
T
Q
G
G
G
S
V
T
Site 52
S414
S
Q
T
Q
G
G
G
S
V
T
K
K
R
K
L
Site 53
T416
T
Q
G
G
G
S
V
T
K
K
R
K
L
E
S
Site 54
S423
T
K
K
R
K
L
E
S
T
E
S
R
S
S
F
Site 55
T424
K
K
R
K
L
E
S
T
E
S
R
S
S
F
S
Site 56
S426
R
K
L
E
S
T
E
S
R
S
S
F
S
Q
H
Site 57
S428
L
E
S
T
E
S
R
S
S
F
S
Q
H
A
R
Site 58
S429
E
S
T
E
S
R
S
S
F
S
Q
H
A
R
T
Site 59
S431
T
E
S
R
S
S
F
S
Q
H
A
R
T
S
G
Site 60
S437
F
S
Q
H
A
R
T
S
G
R
V
A
V
E
E
Site 61
S458
F
V
R
L
R
N
K
S
N
E
D
Q
S
M
G
Site 62
S463
N
K
S
N
E
D
Q
S
M
G
N
W
Q
I
K
Site 63
T480
N
G
D
D
P
L
L
T
Y
R
F
P
P
K
F
Site 64
Y481
G
D
D
P
L
L
T
Y
R
F
P
P
K
F
T
Site 65
T496
L
K
A
G
Q
V
V
T
I
W
A
A
G
A
G
Site 66
T505
W
A
A
G
A
G
A
T
H
S
P
P
T
D
L
Site 67
S507
A
G
A
G
A
T
H
S
P
P
T
D
L
V
W
Site 68
T510
G
A
T
H
S
P
P
T
D
L
V
W
K
A
Q
Site 69
S525
N
T
W
G
C
G
N
S
L
R
T
A
L
I
N
Site 70
S533
L
R
T
A
L
I
N
S
T
G
E
E
V
A
M
Site 71
S546
A
M
R
K
L
V
R
S
V
T
V
V
E
D
D
Site 72
T548
R
K
L
V
R
S
V
T
V
V
E
D
D
E
D
Site 73
S568
L
L
H
H
H
H
G
S
H
C
S
S
S
G
D
Site 74
S571
H
H
H
G
S
H
C
S
S
S
G
D
P
A
E
Site 75
S572
H
H
G
S
H
C
S
S
S
G
D
P
A
E
Y
Site 76
S573
H
G
S
H
C
S
S
S
G
D
P
A
E
Y
N
Site 77
Y579
S
S
G
D
P
A
E
Y
N
L
R
S
R
T
V
Site 78
S583
P
A
E
Y
N
L
R
S
R
T
V
L
C
G
T
Site 79
T585
E
Y
N
L
R
S
R
T
V
L
C
G
T
C
G
Site 80
T590
S
R
T
V
L
C
G
T
C
G
Q
P
A
D
K
Site 81
S599
G
Q
P
A
D
K
A
S
A
S
G
S
G
A
Q
Site 82
S601
P
A
D
K
A
S
A
S
G
S
G
A
Q
V
G
Site 83
S603
D
K
A
S
A
S
G
S
G
A
Q
V
G
G
P
Site 84
S612
A
Q
V
G
G
P
I
S
S
G
S
S
A
S
S
Site 85
S613
Q
V
G
G
P
I
S
S
G
S
S
A
S
S
V
Site 86
S615
G
G
P
I
S
S
G
S
S
A
S
S
V
T
V
Site 87
S616
G
P
I
S
S
G
S
S
A
S
S
V
T
V
T
Site 88
S618
I
S
S
G
S
S
A
S
S
V
T
V
T
R
S
Site 89
S619
S
S
G
S
S
A
S
S
V
T
V
T
R
S
Y
Site 90
T621
G
S
S
A
S
S
V
T
V
T
R
S
Y
R
S
Site 91
T623
S
A
S
S
V
T
V
T
R
S
Y
R
S
V
G
Site 92
S625
S
S
V
T
V
T
R
S
Y
R
S
V
G
G
S
Site 93
Y626
S
V
T
V
T
R
S
Y
R
S
V
G
G
S
G
Site 94
S628
T
V
T
R
S
Y
R
S
V
G
G
S
G
G
G
Site 95
S632
S
Y
R
S
V
G
G
S
G
G
G
S
F
G
D
Site 96
S636
V
G
G
S
G
G
G
S
F
G
D
N
L
V
T
Site 97
T643
S
F
G
D
N
L
V
T
R
S
Y
L
L
G
N
Site 98
Y646
D
N
L
V
T
R
S
Y
L
L
G
N
S
S
P
Site 99
S651
R
S
Y
L
L
G
N
S
S
P
R
T
Q
S
P
Site 100
S652
S
Y
L
L
G
N
S
S
P
R
T
Q
S
P
Q
Site 101
T655
L
G
N
S
S
P
R
T
Q
S
P
Q
N
C
S
Site 102
S657
N
S
S
P
R
T
Q
S
P
Q
N
C
S
I
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation