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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HMGCR
Full Name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Alias:
Type:
Enzyme, cholesterol synthesis
Mass (Da):
97476
Number AA:
888
UniProt ID:
P04035
International Prot ID:
IPI00021770
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005789
GO:0016021
GO:0005777
Uniprot
OncoNet
Molecular Function:
GO:0050661
GO:0004420
PhosphoSite+
KinaseNET
Biological Process:
GO:0006695
GO:0015936
GO:0008354
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y48
N
K
I
C
G
W
N
Y
E
C
P
K
F
E
E
Site 2
S88
Q
N
L
R
Q
L
G
S
K
Y
I
L
G
I
A
Site 3
S146
T
L
A
K
F
A
L
S
S
N
S
Q
D
E
V
Site 4
S147
L
A
K
F
A
L
S
S
N
S
Q
D
E
V
R
Site 5
S223
V
S
L
V
L
E
L
S
R
E
S
R
E
G
R
Site 6
S226
V
L
E
L
S
R
E
S
R
E
G
R
P
I
W
Site 7
S236
G
R
P
I
W
Q
L
S
H
F
A
R
V
L
E
Site 8
T253
E
N
K
P
N
P
V
T
Q
R
V
K
M
I
M
Site 9
S261
Q
R
V
K
M
I
M
S
L
G
L
V
L
V
H
Site 10
S278
S
R
W
I
A
D
P
S
P
Q
N
S
T
A
D
Site 11
S282
A
D
P
S
P
Q
N
S
T
A
D
T
S
K
V
Site 12
T286
P
Q
N
S
T
A
D
T
S
K
V
S
L
G
L
Site 13
S298
L
G
L
D
E
N
V
S
K
R
I
E
P
S
V
Site 14
S304
V
S
K
R
I
E
P
S
V
S
L
W
Q
F
Y
Site 15
S306
K
R
I
E
P
S
V
S
L
W
Q
F
Y
L
S
Site 16
T342
K
Y
I
F
F
E
Q
T
E
T
E
S
T
L
S
Site 17
T344
I
F
F
E
Q
T
E
T
E
S
T
L
S
L
K
Site 18
T347
E
Q
T
E
T
E
S
T
L
S
L
K
N
P
I
Site 19
S349
T
E
T
E
S
T
L
S
L
K
N
P
I
T
S
Site 20
T355
L
S
L
K
N
P
I
T
S
P
V
V
T
Q
K
Site 21
S356
S
L
K
N
P
I
T
S
P
V
V
T
Q
K
K
Site 22
T360
P
I
T
S
P
V
V
T
Q
K
K
V
P
D
N
Site 23
S384
R
N
N
Q
K
C
D
S
V
E
E
E
T
G
I
Site 24
T389
C
D
S
V
E
E
E
T
G
I
N
R
E
R
K
Site 25
T409
P
L
V
A
E
T
D
T
P
N
R
A
T
F
V
Site 26
T414
T
D
T
P
N
R
A
T
F
V
V
G
N
S
S
Site 27
S420
A
T
F
V
V
G
N
S
S
L
L
D
T
S
S
Site 28
S427
S
S
L
L
D
T
S
S
V
L
V
T
Q
E
P
Site 29
T431
D
T
S
S
V
L
V
T
Q
E
P
E
I
E
L
Site 30
S463
E
K
G
A
K
F
L
S
D
A
E
I
I
Q
L
Site 31
S493
E
T
H
E
R
G
V
S
I
R
R
Q
L
L
S
Site 32
S500
S
I
R
R
Q
L
L
S
K
K
L
S
E
P
S
Site 33
S504
Q
L
L
S
K
K
L
S
E
P
S
S
L
Q
Y
Site 34
S507
S
K
K
L
S
E
P
S
S
L
Q
Y
L
P
Y
Site 35
S508
K
K
L
S
E
P
S
S
L
Q
Y
L
P
Y
R
Site 36
Y511
S
E
P
S
S
L
Q
Y
L
P
Y
R
D
Y
N
Site 37
Y514
S
S
L
Q
Y
L
P
Y
R
D
Y
N
Y
S
L
Site 38
Y517
Q
Y
L
P
Y
R
D
Y
N
Y
S
L
V
M
G
Site 39
Y519
L
P
Y
R
D
Y
N
Y
S
L
V
M
G
A
C
Site 40
S565
T
E
G
C
L
V
A
S
T
N
R
G
C
R
A
Site 41
S602
R
L
P
R
A
C
D
S
A
E
V
K
A
W
L
Site 42
S624
V
I
K
E
A
F
D
S
T
S
R
F
A
R
L
Site 43
S626
K
E
A
F
D
S
T
S
R
F
A
R
L
Q
K
Site 44
S637
R
L
Q
K
L
H
T
S
I
A
G
R
N
L
Y
Site 45
Y644
S
I
A
G
R
N
L
Y
I
R
F
Q
S
R
S
Site 46
S649
N
L
Y
I
R
F
Q
S
R
S
G
D
A
M
G
Site 47
S651
Y
I
R
F
Q
S
R
S
G
D
A
M
G
M
N
Site 48
S669
K
G
T
E
K
A
L
S
K
L
H
E
Y
F
P
Site 49
Y674
A
L
S
K
L
H
E
Y
F
P
E
M
Q
I
L
Site 50
Y792
G
P
T
N
E
D
L
Y
I
S
C
T
M
P
S
Site 51
S872
S
H
M
I
H
N
R
S
K
I
N
L
Q
D
L
Site 52
T884
Q
D
L
Q
G
A
C
T
K
K
T
A
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation