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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TK1
Full Name:
Thymidine kinase, cytosolic
Alias:
Cytosolic; KITH; Thymidine kinase 1, soluble; TK-1
Type:
EC 2.7.1.21; Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - pyrimidine; Kinase (non-protein)
Mass (Da):
25469
Number AA:
234
UniProt ID:
P04183
International Prot ID:
IPI00299214
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004797
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
L
P
T
V
L
P
G
S
P
S
K
T
R
G
Q
Site 2
S15
T
V
L
P
G
S
P
S
K
T
R
G
Q
I
Q
Site 3
T17
L
P
G
S
P
S
K
T
R
G
Q
I
Q
V
I
Site 4
S33
G
P
M
F
S
G
K
S
T
E
L
M
R
R
V
Site 5
T34
P
M
F
S
G
K
S
T
E
L
M
R
R
V
R
Site 6
Y48
R
R
F
Q
I
A
Q
Y
K
C
L
V
I
K
Y
Site 7
Y55
Y
K
C
L
V
I
K
Y
A
K
D
T
R
Y
S
Site 8
T59
V
I
K
Y
A
K
D
T
R
Y
S
S
S
F
C
Site 9
Y61
K
Y
A
K
D
T
R
Y
S
S
S
F
C
T
H
Site 10
S62
Y
A
K
D
T
R
Y
S
S
S
F
C
T
H
D
Site 11
S63
A
K
D
T
R
Y
S
S
S
F
C
T
H
D
R
Site 12
S64
K
D
T
R
Y
S
S
S
F
C
T
H
D
R
N
Site 13
T67
R
Y
S
S
S
F
C
T
H
D
R
N
T
M
E
Site 14
T72
F
C
T
H
D
R
N
T
M
E
A
L
P
A
C
Site 15
T127
I
V
A
A
L
D
G
T
F
Q
R
K
P
F
G
Site 16
Y162
E
C
F
R
E
A
A
Y
T
K
R
L
G
T
E
Site 17
T163
C
F
R
E
A
A
Y
T
K
R
L
G
T
E
K
Site 18
T168
A
Y
T
K
R
L
G
T
E
K
E
V
E
V
I
Site 19
Y181
V
I
G
G
A
D
K
Y
H
S
V
C
R
L
C
Site 20
Y189
H
S
V
C
R
L
C
Y
F
K
K
A
S
G
Q
Site 21
S231
P
Q
Q
I
L
Q
C
S
P
A
N
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation