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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
p53
Full Name:
Cellular tumor antigen p53
Alias:
Antigen NY-CO-13; Cellular tumor antigen p53; LFS1; Li-Fraumeni syndrome; Phosphoprotein p53; TP53; Tumor protein p53; Tumor suppressor p53; Tumour suppressor p53
Type:
Tumor suppressor; Nuclear receptor co-regulator; Activator protein; Transcription factor
Mass (Da):
43653
Number AA:
393
UniProt ID:
P04637
International Prot ID:
IPI00025087
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016605
GO:0005783
GO:0005626
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000739
GO:0051087
PhosphoSite+
KinaseNET
Biological Process:
GO:0042771
GO:0006983
GO:0008635
Phosida
TranscriptoNet
STRING
Kinexus Products
Cellular tumour antigen p53 pan-specific antibody AB-NN082-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN082-2#Cellular tumour antigen p53 pan-specific antibody AB-NN082-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN082-3
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
E
E
P
Q
S
D
P
S
V
E
P
P
Site 2
S9
E
E
P
Q
S
D
P
S
V
E
P
P
L
S
Q
Site 3
S15
P
S
V
E
P
P
L
S
Q
E
T
F
S
D
L
Site 4
T18
E
P
P
L
S
Q
E
T
F
S
D
L
W
K
L
Site 5
S20
P
L
S
Q
E
T
F
S
D
L
W
K
L
L
P
Site 6
S33
L
P
E
N
N
V
L
S
P
L
P
S
Q
A
M
Site 7
S37
N
V
L
S
P
L
P
S
Q
A
M
D
D
L
M
Site 8
S46
A
M
D
D
L
M
L
S
P
D
D
I
E
Q
W
Site 9
T55
D
D
I
E
Q
W
F
T
E
D
P
G
P
D
E
Site 10
T81
A
P
A
P
A
A
P
T
P
A
A
P
A
P
A
Site 11
S94
P
A
P
S
W
P
L
S
S
S
V
P
S
Q
K
Site 12
S95
A
P
S
W
P
L
S
S
S
V
P
S
Q
K
T
Site 13
S96
P
S
W
P
L
S
S
S
V
P
S
Q
K
T
Y
Site 14
S99
P
L
S
S
S
V
P
S
Q
K
T
Y
Q
G
S
Site 15
T102
S
S
V
P
S
Q
K
T
Y
Q
G
S
Y
G
F
Site 16
Y103
S
V
P
S
Q
K
T
Y
Q
G
S
Y
G
F
R
Site 17
S106
S
Q
K
T
Y
Q
G
S
Y
G
F
R
L
G
F
Site 18
Y107
Q
K
T
Y
Q
G
S
Y
G
F
R
L
G
F
L
Site 19
S121
L
H
S
G
T
A
K
S
V
T
C
T
Y
S
P
Site 20
T123
S
G
T
A
K
S
V
T
C
T
Y
S
P
A
L
Site 21
T125
T
A
K
S
V
T
C
T
Y
S
P
A
L
N
K
Site 22
S127
K
S
V
T
C
T
Y
S
P
A
L
N
K
M
F
Site 23
S149
P
V
Q
L
W
V
D
S
T
P
P
P
G
T
R
Site 24
T150
V
Q
L
W
V
D
S
T
P
P
P
G
T
R
V
Site 25
T155
D
S
T
P
P
P
G
T
R
V
R
A
M
A
I
Site 26
Y163
R
V
R
A
M
A
I
Y
K
Q
S
Q
H
M
T
Site 27
S183
C
P
H
H
E
R
C
S
D
S
D
G
L
A
P
Site 28
S185
H
H
E
R
C
S
D
S
D
G
L
A
P
P
Q
Site 29
Y205
E
G
N
L
R
V
E
Y
L
D
D
R
N
T
F
Site 30
T211
E
Y
L
D
D
R
N
T
F
R
H
S
V
V
V
Site 31
S215
D
R
N
T
F
R
H
S
V
V
V
P
Y
E
P
Site 32
Y220
R
H
S
V
V
V
P
Y
E
P
P
E
V
G
S
Site 33
T253
M
N
R
R
P
I
L
T
I
I
T
L
E
D
S
Site 34
T256
R
P
I
L
T
I
I
T
L
E
D
S
S
G
N
Site 35
S260
T
I
I
T
L
E
D
S
S
G
N
L
L
G
R
Site 36
S269
G
N
L
L
G
R
N
S
F
E
V
R
V
C
A
Site 37
T284
C
P
G
R
D
R
R
T
E
E
E
N
L
R
K
Site 38
S303
H
H
E
L
P
P
G
S
T
K
R
A
L
P
N
Site 39
T304
H
E
L
P
P
G
S
T
K
R
A
L
P
N
N
Site 40
T312
K
R
A
L
P
N
N
T
S
S
S
P
Q
P
K
Site 41
S313
R
A
L
P
N
N
T
S
S
S
P
Q
P
K
K
Site 42
S314
A
L
P
N
N
T
S
S
S
P
Q
P
K
K
K
Site 43
S315
L
P
N
N
T
S
S
S
P
Q
P
K
K
K
P
Site 44
Y327
K
K
P
L
D
G
E
Y
F
T
L
Q
I
R
G
Site 45
S362
A
G
K
E
P
G
G
S
R
A
H
S
S
H
L
Site 46
S366
P
G
G
S
R
A
H
S
S
H
L
K
S
K
K
Site 47
S367
G
G
S
R
A
H
S
S
H
L
K
S
K
K
G
Site 48
S371
A
H
S
S
H
L
K
S
K
K
G
Q
S
T
S
Site 49
S376
L
K
S
K
K
G
Q
S
T
S
R
H
K
K
L
Site 50
T377
K
S
K
K
G
Q
S
T
S
R
H
K
K
L
M
Site 51
S378
S
K
K
G
Q
S
T
S
R
H
K
K
L
M
F
Site 52
T387
H
K
K
L
M
F
K
T
E
G
P
D
S
D
_
Site 53
S392
F
K
T
E
G
P
D
S
D
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation