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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Rb
Full Name:
Retinoblastoma-associated protein
Alias:
P105-Rb; Pp110; PRb
Type:
Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor
Mass (Da):
106159
Number AA:
928
UniProt ID:
P06400
International Prot ID:
IPI00302829
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016605
GO:0035189
GO:0016514
Uniprot
OncoNet
Molecular Function:
GO:0050681
GO:0019900
GO:0051219
PhosphoSite+
KinaseNET
Biological Process:
GO:0051318
GO:0000279
GO:0030521
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
P
P
K
T
P
R
K
T
A
A
T
Site 2
T9
P
P
K
T
P
R
K
T
A
A
T
A
A
A
A
Site 3
S37
E
E
D
P
E
Q
D
S
G
P
E
D
L
P
L
Site 4
T52
V
R
L
E
F
E
E
T
E
E
P
D
F
T
A
Site 5
T58
E
T
E
E
P
D
F
T
A
L
C
Q
K
L
K
Site 6
T77
V
R
E
R
A
W
L
T
W
E
K
V
S
S
V
Site 7
T116
D
L
D
E
M
S
F
T
F
T
E
L
Q
K
N
Site 8
T118
D
E
M
S
F
T
F
T
E
L
Q
K
N
I
E
Site 9
T140
N
L
L
K
E
I
D
T
S
T
K
V
D
N
A
Site 10
S141
L
L
K
E
I
D
T
S
T
K
V
D
N
A
M
Site 11
S163
D
V
L
F
A
L
F
S
K
L
E
R
T
C
E
Site 12
Y173
E
R
T
C
E
L
I
Y
L
T
Q
P
S
S
S
Site 13
S179
I
Y
L
T
Q
P
S
S
S
I
S
T
E
I
N
Site 14
S180
Y
L
T
Q
P
S
S
S
I
S
T
E
I
N
S
Site 15
S182
T
Q
P
S
S
S
I
S
T
E
I
N
S
A
L
Site 16
T183
Q
P
S
S
S
I
S
T
E
I
N
S
A
L
V
Site 17
S230
L
D
Y
F
I
K
L
S
P
P
M
L
L
K
E
Site 18
Y239
P
M
L
L
K
E
P
Y
K
T
A
V
I
P
I
Site 19
S249
A
V
I
P
I
N
G
S
P
R
T
P
R
R
G
Site 20
T252
P
I
N
G
S
P
R
T
P
R
R
G
Q
N
R
Site 21
S260
P
R
R
G
Q
N
R
S
A
R
I
A
K
Q
L
Site 22
S318
L
P
E
V
E
N
L
S
K
R
Y
E
E
I
Y
Site 23
Y321
V
E
N
L
S
K
R
Y
E
E
I
Y
L
K
N
Site 24
Y325
S
K
R
Y
E
E
I
Y
L
K
N
K
D
L
D
Site 25
T342
L
F
L
D
H
D
K
T
L
Q
T
D
S
I
D
Site 26
S347
D
K
T
L
Q
T
D
S
I
D
S
F
E
T
Q
Site 27
S350
L
Q
T
D
S
I
D
S
F
E
T
Q
R
T
P
Site 28
T353
D
S
I
D
S
F
E
T
Q
R
T
P
R
K
S
Site 29
T356
D
S
F
E
T
Q
R
T
P
R
K
S
N
L
D
Site 30
S360
T
Q
R
T
P
R
K
S
N
L
D
E
E
V
N
Site 31
T373
V
N
V
I
P
P
H
T
P
V
R
T
V
M
N
Site 32
T377
P
P
H
T
P
V
R
T
V
M
N
T
I
Q
Q
Site 33
S391
Q
L
M
M
I
L
N
S
A
S
D
Q
P
S
E
Site 34
S393
M
M
I
L
N
S
A
S
D
Q
P
S
E
N
L
Site 35
S397
N
S
A
S
D
Q
P
S
E
N
L
I
S
Y
F
Site 36
Y403
P
S
E
N
L
I
S
Y
F
N
N
C
T
V
N
Site 37
Y424
K
R
V
K
D
I
G
Y
I
F
K
E
K
F
A
Site 38
S443
Q
G
C
V
E
I
G
S
Q
R
Y
K
L
G
V
Site 39
Y453
Y
K
L
G
V
R
L
Y
Y
R
V
M
E
S
M
Site 40
S459
L
Y
Y
R
V
M
E
S
M
L
K
S
E
E
E
Site 41
S463
V
M
E
S
M
L
K
S
E
E
E
R
L
S
I
Site 42
S469
K
S
E
E
E
R
L
S
I
Q
N
F
S
K
L
Site 43
T497
A
L
E
V
V
M
A
T
Y
S
R
S
T
S
Q
Site 44
Y498
L
E
V
V
M
A
T
Y
S
R
S
T
S
Q
N
Site 45
S499
E
V
V
M
A
T
Y
S
R
S
T
S
Q
N
L
Site 46
T502
M
A
T
Y
S
R
S
T
S
Q
N
L
D
S
G
Site 47
S503
A
T
Y
S
R
S
T
S
Q
N
L
D
S
G
T
Site 48
S508
S
T
S
Q
N
L
D
S
G
T
D
L
S
F
P
Site 49
T510
S
Q
N
L
D
S
G
T
D
L
S
F
P
W
I
Site 50
S534
D
F
Y
K
V
I
E
S
F
I
K
A
E
G
N
Site 51
T543
I
K
A
E
G
N
L
T
R
E
M
I
K
H
L
Site 52
S560
C
E
H
R
I
M
E
S
L
A
W
L
S
D
S
Site 53
S567
S
L
A
W
L
S
D
S
P
L
F
D
L
I
K
Site 54
S576
L
F
D
L
I
K
Q
S
K
D
R
E
G
P
T
Site 55
T583
S
K
D
R
E
G
P
T
D
H
L
E
S
A
C
Site 56
S588
G
P
T
D
H
L
E
S
A
C
P
L
N
L
P
Site 57
T601
L
P
L
Q
N
N
H
T
A
A
D
M
Y
L
S
Site 58
Y606
N
H
T
A
A
D
M
Y
L
S
P
V
R
S
P
Site 59
S608
T
A
A
D
M
Y
L
S
P
V
R
S
P
K
K
Site 60
S612
M
Y
L
S
P
V
R
S
P
K
K
K
G
S
T
Site 61
S618
R
S
P
K
K
K
G
S
T
T
R
V
N
S
T
Site 62
T619
S
P
K
K
K
G
S
T
T
R
V
N
S
T
A
Site 63
T620
P
K
K
K
G
S
T
T
R
V
N
S
T
A
N
Site 64
S624
G
S
T
T
R
V
N
S
T
A
N
A
E
T
Q
Site 65
T625
S
T
T
R
V
N
S
T
A
N
A
E
T
Q
A
Site 66
T633
A
N
A
E
T
Q
A
T
S
A
F
Q
T
Q
K
Site 67
T638
Q
A
T
S
A
F
Q
T
Q
K
P
L
K
S
T
Site 68
S644
Q
T
Q
K
P
L
K
S
T
S
L
S
L
F
Y
Site 69
S646
Q
K
P
L
K
S
T
S
L
S
L
F
Y
K
K
Site 70
S648
P
L
K
S
T
S
L
S
L
F
Y
K
K
V
Y
Site 71
Y651
S
T
S
L
S
L
F
Y
K
K
V
Y
R
L
A
Site 72
Y659
K
K
V
Y
R
L
A
Y
L
R
L
N
T
L
C
Site 73
S671
T
L
C
E
R
L
L
S
E
H
P
E
L
E
H
Site 74
T738
L
P
H
A
V
Q
E
T
F
K
R
V
L
I
K
Site 75
T766
V
F
M
Q
R
L
K
T
N
I
L
Q
Y
A
S
Site 76
Y771
L
K
T
N
I
L
Q
Y
A
S
T
R
P
P
T
Site 77
S773
T
N
I
L
Q
Y
A
S
T
R
P
P
T
L
S
Site 78
T774
N
I
L
Q
Y
A
S
T
R
P
P
T
L
S
P
Site 79
T778
Y
A
S
T
R
P
P
T
L
S
P
I
P
H
I
Site 80
S780
S
T
R
P
P
T
L
S
P
I
P
H
I
P
R
Site 81
S788
P
I
P
H
I
P
R
S
P
Y
K
F
P
S
S
Site 82
Y790
P
H
I
P
R
S
P
Y
K
F
P
S
S
P
L
Site 83
S794
R
S
P
Y
K
F
P
S
S
P
L
R
I
P
G
Site 84
S795
S
P
Y
K
F
P
S
S
P
L
R
I
P
G
G
Site 85
Y805
R
I
P
G
G
N
I
Y
I
S
P
L
K
S
P
Site 86
S807
P
G
G
N
I
Y
I
S
P
L
K
S
P
Y
K
Site 87
S811
I
Y
I
S
P
L
K
S
P
Y
K
I
S
E
G
Site 88
Y813
I
S
P
L
K
S
P
Y
K
I
S
E
G
L
P
Site 89
S816
L
K
S
P
Y
K
I
S
E
G
L
P
T
P
T
Site 90
T821
K
I
S
E
G
L
P
T
P
T
K
M
T
P
R
Site 91
T823
S
E
G
L
P
T
P
T
K
M
T
P
R
S
R
Site 92
T826
L
P
T
P
T
K
M
T
P
R
S
R
I
L
V
Site 93
S829
P
T
K
M
T
P
R
S
R
I
L
V
S
I
G
Site 94
S834
P
R
S
R
I
L
V
S
I
G
E
S
F
G
T
Site 95
S838
I
L
V
S
I
G
E
S
F
G
T
S
E
K
F
Site 96
T841
S
I
G
E
S
F
G
T
S
E
K
F
Q
K
I
Site 97
S842
I
G
E
S
F
G
T
S
E
K
F
Q
K
I
N
Site 98
S855
I
N
Q
M
V
C
N
S
D
R
V
L
K
R
S
Site 99
S862
S
D
R
V
L
K
R
S
A
E
G
S
N
P
P
Site 100
S866
L
K
R
S
A
E
G
S
N
P
P
K
P
L
K
Site 101
S882
L
R
F
D
I
E
G
S
D
E
A
D
G
S
K
Site 102
S888
G
S
D
E
A
D
G
S
K
H
L
P
G
E
S
Site 103
S895
S
K
H
L
P
G
E
S
K
F
Q
Q
K
L
A
Site 104
T905
Q
Q
K
L
A
E
M
T
S
T
R
T
R
M
Q
Site 105
S906
Q
K
L
A
E
M
T
S
T
R
T
R
M
Q
K
Site 106
T907
K
L
A
E
M
T
S
T
R
T
R
M
Q
K
Q
Site 107
S919
Q
K
Q
K
M
N
D
S
M
D
T
S
N
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation