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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PR (Progesterone)
Full Name:
Progesterone receptor
Alias:
Nuclear receptor subfamily 3 group C member 3
Type:
Transcription protein (receptor)
Mass (Da):
98981
Number AA:
933
UniProt ID:
P06401
International Prot ID:
IPI00297419
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0047485
GO:0005102
GO:0043565
PhosphoSite+
KinaseNET
Biological Process:
GO:0007267
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
H
V
A
G
G
P
P
S
P
E
V
G
S
P
L
Site 2
S25
P
P
S
P
E
V
G
S
P
L
L
C
R
P
A
Site 3
S39
A
A
G
P
F
P
G
S
Q
T
S
D
T
L
P
Site 4
T44
P
G
S
Q
T
S
D
T
L
P
E
V
S
A
I
Site 5
S70
P
C
Q
G
Q
D
P
S
D
E
K
T
Q
D
Q
Site 6
T74
Q
D
P
S
D
E
K
T
Q
D
Q
Q
S
L
S
Site 7
S79
E
K
T
Q
D
Q
Q
S
L
S
D
V
E
G
A
Site 8
S81
T
Q
D
Q
Q
S
L
S
D
V
E
G
A
Y
S
Site 9
Y87
L
S
D
V
E
G
A
Y
S
R
A
E
A
T
R
Site 10
S88
S
D
V
E
G
A
Y
S
R
A
E
A
T
R
G
Site 11
S99
A
T
R
G
A
G
G
S
S
S
S
P
P
E
K
Site 12
S101
R
G
A
G
G
S
S
S
S
P
P
E
K
D
S
Site 13
S102
G
A
G
G
S
S
S
S
P
P
E
K
D
S
G
Site 14
S108
S
S
P
P
E
K
D
S
G
L
L
D
S
V
L
Site 15
S122
L
D
T
L
L
A
P
S
G
P
G
Q
S
Q
P
Site 16
S127
A
P
S
G
P
G
Q
S
Q
P
S
P
P
A
C
Site 17
S130
G
P
G
Q
S
Q
P
S
P
P
A
C
E
V
T
Site 18
T157
D
P
P
A
A
P
A
T
Q
R
V
L
S
P
L
Site 19
S162
P
A
T
Q
R
V
L
S
P
L
M
S
R
S
G
Site 20
S166
R
V
L
S
P
L
M
S
R
S
G
C
K
V
G
Site 21
S168
L
S
P
L
M
S
R
S
G
C
K
V
G
D
S
Site 22
S175
S
G
C
K
V
G
D
S
S
G
T
A
A
A
H
Site 23
S176
G
C
K
V
G
D
S
S
G
T
A
A
A
H
K
Site 24
S190
K
V
L
P
R
G
L
S
P
A
R
Q
L
L
L
Site 25
S200
R
Q
L
L
L
P
A
S
E
S
P
H
W
S
G
Site 26
S202
L
L
L
P
A
S
E
S
P
H
W
S
G
A
P
Site 27
S206
A
S
E
S
P
H
W
S
G
A
P
V
K
P
S
Site 28
S213
S
G
A
P
V
K
P
S
P
Q
A
A
A
V
E
Site 29
S227
E
V
E
E
E
D
G
S
E
S
E
E
S
A
G
Site 30
S229
E
E
E
D
G
S
E
S
E
E
S
A
G
P
L
Site 31
S232
D
G
S
E
S
E
E
S
A
G
P
L
L
K
G
Site 32
S273
A
L
V
P
K
E
D
S
R
F
S
A
P
R
V
Site 33
S276
P
K
E
D
S
R
F
S
A
P
R
V
A
L
V
Site 34
S294
A
P
M
A
P
G
R
S
P
L
A
T
T
V
M
Site 35
S328
R
Q
L
L
E
D
E
S
Y
D
G
G
A
G
A
Site 36
Y329
Q
L
L
E
D
E
S
Y
D
G
G
A
G
A
A
Site 37
S337
D
G
G
A
G
A
A
S
A
F
A
P
P
R
S
Site 38
S344
S
A
F
A
P
P
R
S
S
P
C
A
S
S
T
Site 39
S345
A
F
A
P
P
R
S
S
P
C
A
S
S
T
P
Site 40
S349
P
R
S
S
P
C
A
S
S
T
P
V
A
V
G
Site 41
S350
R
S
S
P
C
A
S
S
T
P
V
A
V
G
D
Site 42
Y363
G
D
F
P
D
C
A
Y
P
P
D
A
E
P
K
Site 43
Y374
A
E
P
K
D
D
A
Y
P
L
Y
S
D
F
Q
Site 44
Y377
K
D
D
A
Y
P
L
Y
S
D
F
Q
P
P
A
Site 45
S378
D
D
A
Y
P
L
Y
S
D
F
Q
P
P
A
L
Site 46
S397
E
E
E
G
A
E
A
S
A
R
S
P
R
S
Y
Site 47
S400
G
A
E
A
S
A
R
S
P
R
S
Y
L
V
A
Site 48
S403
A
S
A
R
S
P
R
S
Y
L
V
A
G
A
N
Site 49
Y404
S
A
R
S
P
R
S
Y
L
V
A
G
A
N
P
Site 50
T430
P
P
L
P
P
R
A
T
P
S
R
P
G
E
A
Site 51
S432
L
P
P
R
A
T
P
S
R
P
G
E
A
A
V
Site 52
T440
R
P
G
E
A
A
V
T
A
A
P
A
S
A
S
Site 53
S447
T
A
A
P
A
S
A
S
V
S
S
A
S
S
S
Site 54
S449
A
P
A
S
A
S
V
S
S
A
S
S
S
G
S
Site 55
S450
P
A
S
A
S
V
S
S
A
S
S
S
G
S
T
Site 56
S452
S
A
S
V
S
S
A
S
S
S
G
S
T
L
E
Site 57
S453
A
S
V
S
S
A
S
S
S
G
S
T
L
E
C
Site 58
T457
S
A
S
S
S
G
S
T
L
E
C
I
L
Y
K
Site 59
Y463
S
T
L
E
C
I
L
Y
K
A
E
G
A
P
P
Site 60
S486
P
C
K
A
P
G
A
S
G
C
L
L
P
R
D
Site 61
S497
L
P
R
D
G
L
P
S
T
S
A
S
A
A
A
Site 62
S499
R
D
G
L
P
S
T
S
A
S
A
A
A
A
G
Site 63
Y525
N
G
L
P
Q
L
G
Y
Q
A
A
V
L
K
E
Site 64
Y538
K
E
G
L
P
Q
V
Y
P
P
Y
L
N
Y
L
Site 65
Y541
L
P
Q
V
Y
P
P
Y
L
N
Y
L
R
P
D
Site 66
Y544
V
Y
P
P
Y
L
N
Y
L
R
P
D
S
E
A
Site 67
S549
L
N
Y
L
R
P
D
S
E
A
S
Q
S
P
Q
Site 68
S552
L
R
P
D
S
E
A
S
Q
S
P
Q
Y
S
F
Site 69
S554
P
D
S
E
A
S
Q
S
P
Q
Y
S
F
E
S
Site 70
Y557
E
A
S
Q
S
P
Q
Y
S
F
E
S
L
P
Q
Site 71
S558
A
S
Q
S
P
Q
Y
S
F
E
S
L
P
Q
K
Site 72
S561
S
P
Q
Y
S
F
E
S
L
P
Q
K
I
C
L
Site 73
Y579
D
E
A
S
G
C
H
Y
G
V
L
T
C
G
S
Site 74
Y601
A
M
E
G
Q
H
N
Y
L
C
A
G
R
N
D
Site 75
S666
P
V
G
V
P
N
E
S
Q
A
L
S
Q
R
F
Site 76
S670
P
N
E
S
Q
A
L
S
Q
R
F
T
F
S
P
Site 77
T674
Q
A
L
S
Q
R
F
T
F
S
P
G
Q
D
I
Site 78
S676
L
S
Q
R
F
T
F
S
P
G
Q
D
I
Q
L
Site 79
Y700
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
Site 80
T706
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
Site 81
T710
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
Site 82
S711
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
Site 83
S713
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
Site 84
T716
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
Site 85
S717
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Site 86
S728
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
Site 87
S735
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
Site 88
Y768
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
Site 89
S792
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
Site 90
S793
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
Site 91
Y795
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Site 92
S837
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
Site 93
T839
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
Site 94
S847
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
Site 95
Y848
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
Site 96
S866
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
Site 97
S867
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
Site 98
Y871
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
Site 99
T874
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation