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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HSP90AA1
Full Name:
Heat shock protein HSP 90-alpha
Alias:
FLJ31884; Heat shock 90kDa protein 1, alpha; Heat shock protein 90kDa alpha (cytosolic) class A member 1; HS90A; HSP 86; Hsp89; Hsp90; HSP90-alpha; HSP90N; HSPC1; HSPCA
Type:
Chaperone protein
Mass (Da):
84660
Number AA:
732
UniProt ID:
P07900
International Prot ID:
IPI00784295
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0042470
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0030911
GO:0030235
PhosphoSite+
KinaseNET
Biological Process:
GO:0034619
GO:0070096
GO:0006839
Phosida
TranscriptoNet
STRING
Kinexus Products
Heat shock protein HSP 90-alpha pan-specific antibody AB-NN061-19#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN061-19#Heat shock protein HSP 90-alpha/beta pan-specific antibody AB-NN061-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN061-2#Heat shock protein HSP 90-alpha pan-specific antibody AB-NN061-4#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN061-4#Heat shock protein HSP 90-alpha pan-specific antibody AB-NN061-9#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN061-9#Heat shock protein HSP 90-alpha pan-specific antibody AB-NN164#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN164#Heat shock protein alpha (K255-E268, human) peptide - Powder PE-01ABK95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ABK95#Heat shock protein 90 (E223-E237, human) peptide - Powder PE-01ANE80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ANE80
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
_
P
E
E
T
Q
T
Q
D
Q
P
M
Site 2
T7
_
_
P
E
E
T
Q
T
Q
D
Q
P
M
E
E
Site 3
T19
M
E
E
E
E
V
E
T
F
A
F
Q
A
E
I
Site 4
Y38
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
Site 5
Y61
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
Site 6
S63
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
L
Site 7
T65
K
I
R
Y
E
S
L
T
D
P
S
K
L
D
S
Site 8
S68
Y
E
S
L
T
D
P
S
K
L
D
S
G
K
E
Site 9
S72
T
D
P
S
K
L
D
S
G
K
E
L
H
I
N
Site 10
T88
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
Site 11
T90
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
Site 12
T94
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
Site 13
T99
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
Site 14
T109
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
Site 15
S113
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
Site 16
Y160
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
Site 17
S164
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
Site 18
S169
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
Site 19
T171
S
S
A
G
G
S
F
T
V
R
T
D
T
G
E
Site 20
T174
G
G
S
F
T
V
R
T
D
T
G
E
P
M
G
Site 21
T176
S
F
T
V
R
T
D
T
G
E
P
M
G
R
G
Site 22
T184
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
Site 23
T195
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
Site 24
Y197
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
Site 25
S211
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
Site 26
T219
Q
F
I
G
Y
P
I
T
L
F
V
E
K
E
R
Site 27
S231
K
E
R
D
K
E
V
S
D
D
E
A
E
E
K
Site 28
S252
K
E
K
E
E
K
E
S
E
D
K
P
E
I
E
Site 29
S263
P
E
I
E
D
V
G
S
D
E
E
E
E
K
K
Site 30
Y284
K
K
K
I
K
E
K
Y
I
D
Q
E
E
L
N
Site 31
T293
D
Q
E
E
L
N
K
T
K
P
I
W
T
R
N
Site 32
T305
T
R
N
P
D
D
I
T
N
E
E
Y
G
E
F
Site 33
Y309
D
D
I
T
N
E
E
Y
G
E
F
Y
K
S
L
Site 34
Y313
N
E
E
Y
G
E
F
Y
K
S
L
T
N
D
W
Site 35
S315
E
Y
G
E
F
Y
K
S
L
T
N
D
W
E
D
Site 36
T317
G
E
F
Y
K
S
L
T
N
D
W
E
D
H
L
Site 37
Y364
K
K
N
N
I
K
L
Y
V
R
R
V
F
I
M
Site 38
S391
F
I
R
G
V
V
D
S
E
D
L
P
L
N
I
Site 39
S399
E
D
L
P
L
N
I
S
R
E
M
L
Q
Q
S
Site 40
S406
S
R
E
M
L
Q
Q
S
K
I
L
K
V
I
R
Site 41
Y434
L
A
E
D
K
E
N
Y
K
K
F
Y
E
Q
F
Site 42
Y438
K
E
N
Y
K
K
F
Y
E
Q
F
S
K
N
I
Site 43
S442
K
K
F
Y
E
Q
F
S
K
N
I
K
L
G
I
Site 44
S453
K
L
G
I
H
E
D
S
Q
N
R
K
K
L
S
Site 45
S460
S
Q
N
R
K
K
L
S
E
L
L
R
Y
Y
T
Site 46
Y465
K
L
S
E
L
L
R
Y
Y
T
S
A
S
G
D
Site 47
Y466
L
S
E
L
L
R
Y
Y
T
S
A
S
G
D
E
Site 48
T467
S
E
L
L
R
Y
Y
T
S
A
S
G
D
E
M
Site 49
S468
E
L
L
R
Y
Y
T
S
A
S
G
D
E
M
V
Site 50
S470
L
R
Y
Y
T
S
A
S
G
D
E
M
V
S
L
Site 51
S476
A
S
G
D
E
M
V
S
L
K
D
Y
C
T
R
Site 52
Y480
E
M
V
S
L
K
D
Y
C
T
R
M
K
E
N
Site 53
T482
V
S
L
K
D
Y
C
T
R
M
K
E
N
Q
K
Site 54
Y492
K
E
N
Q
K
H
I
Y
Y
I
T
G
E
T
K
Site 55
Y493
E
N
Q
K
H
I
Y
Y
I
T
G
E
T
K
D
Site 56
T498
I
Y
Y
I
T
G
E
T
K
D
Q
V
A
N
S
Site 57
S505
T
K
D
Q
V
A
N
S
A
F
V
E
R
L
R
Site 58
Y528
M
I
E
P
I
D
E
Y
C
V
Q
Q
L
K
E
Site 59
T540
L
K
E
F
E
G
K
T
L
V
S
V
T
K
E
Site 60
S543
F
E
G
K
T
L
V
S
V
T
K
E
G
L
E
Site 61
T566
K
K
Q
E
E
K
K
T
K
F
E
N
L
C
K
Site 62
S589
K
V
E
K
V
V
V
S
N
R
L
V
T
S
P
Site 63
T603
P
C
C
I
V
T
S
T
Y
G
W
T
A
N
M
Site 64
Y604
C
C
I
V
T
S
T
Y
G
W
T
A
N
M
E
Site 65
S623
A
Q
A
L
R
D
N
S
T
M
G
Y
M
A
A
Site 66
T624
Q
A
L
R
D
N
S
T
M
G
Y
M
A
A
K
Site 67
Y627
R
D
N
S
T
M
G
Y
M
A
A
K
K
H
L
Site 68
S641
L
E
I
N
P
D
H
S
I
I
E
T
L
R
Q
Site 69
T645
P
D
H
S
I
I
E
T
L
R
Q
K
A
E
A
Site 70
S658
E
A
D
K
N
D
K
S
V
K
D
L
V
I
L
Site 71
T669
L
V
I
L
L
Y
E
T
A
L
L
S
S
G
F
Site 72
S677
A
L
L
S
S
G
F
S
L
E
D
P
Q
T
H
Site 73
T683
F
S
L
E
D
P
Q
T
H
A
N
R
I
Y
R
Site 74
Y689
Q
T
H
A
N
R
I
Y
R
M
I
K
L
G
L
Site 75
T704
G
I
D
E
D
D
P
T
A
D
D
T
S
A
A
Site 76
T708
D
D
P
T
A
D
D
T
S
A
A
V
T
E
E
Site 77
S709
D
P
T
A
D
D
T
S
A
A
V
T
E
E
M
Site 78
T713
D
D
T
S
A
A
V
T
E
E
M
P
P
L
E
Site 79
T725
P
L
E
G
D
D
D
T
S
R
M
E
E
V
D
Site 80
S726
L
E
G
D
D
D
T
S
R
M
E
E
V
D
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation