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Updated November 2019
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Protein Info
Short Name:
GLI1
Full Name:
Zinc finger protein GLI1
Alias:
Glioma-associated oncogene;Oncogene GLI
Type:
Transcription protein
Mass (Da):
117904
Number AA:
1106
UniProt ID:
P08151
International Prot ID:
IPI00027451
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0016563
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0009913
GO:0001649
GO:0045740
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
S
M
T
P
P
P
I
S
S
Y
G
E
P
C
C
Site 2
S12
M
T
P
P
P
I
S
S
Y
G
E
P
C
C
L
Site 3
Y13
T
P
P
P
I
S
S
Y
G
E
P
C
C
L
R
Site 4
S29
L
P
S
Q
G
A
P
S
V
G
T
E
G
L
S
Site 5
S36
S
V
G
T
E
G
L
S
G
P
P
F
C
H
Q
Site 6
S52
N
L
M
S
G
P
H
S
Y
G
P
A
R
E
T
Site 7
T59
S
Y
G
P
A
R
E
T
N
S
C
T
E
G
P
Site 8
S61
G
P
A
R
E
T
N
S
C
T
E
G
P
L
F
Site 9
T63
A
R
E
T
N
S
C
T
E
G
P
L
F
S
S
Site 10
S69
C
T
E
G
P
L
F
S
S
P
R
S
A
V
K
Site 11
S70
T
E
G
P
L
F
S
S
P
R
S
A
V
K
L
Site 12
S73
P
L
F
S
S
P
R
S
A
V
K
L
T
K
K
Site 13
S84
L
T
K
K
R
A
L
S
I
S
P
L
S
D
A
Site 14
S86
K
K
R
A
L
S
I
S
P
L
S
D
A
S
L
Site 15
T97
D
A
S
L
D
L
Q
T
V
I
R
T
S
P
S
Site 16
T115
A
F
I
N
S
R
C
T
S
P
G
G
S
Y
G
Site 17
S116
F
I
N
S
R
C
T
S
P
G
G
S
Y
G
H
Site 18
S120
R
C
T
S
P
G
G
S
Y
G
H
L
S
I
G
Site 19
S125
G
G
S
Y
G
H
L
S
I
G
T
M
S
P
S
Site 20
S146
M
N
H
Q
K
G
P
S
P
S
F
G
V
Q
P
Site 21
S148
H
Q
K
G
P
S
P
S
F
G
V
Q
P
C
G
Site 22
S159
Q
P
C
G
P
H
D
S
A
R
G
G
M
I
P
Site 23
S170
G
M
I
P
H
P
Q
S
R
G
P
F
P
T
C
Site 24
T176
Q
S
R
G
P
F
P
T
C
Q
L
K
S
E
L
Site 25
S200
E
P
L
E
G
D
M
S
S
P
N
S
T
G
I
Site 26
S201
P
L
E
G
D
M
S
S
P
N
S
T
G
I
Q
Site 27
S204
G
D
M
S
S
P
N
S
T
G
I
Q
D
P
L
Site 28
T205
D
M
S
S
P
N
S
T
G
I
Q
D
P
L
L
Site 29
S231
E
E
K
R
E
P
E
S
V
Y
E
T
D
C
R
Site 30
Y233
K
R
E
P
E
S
V
Y
E
T
D
C
R
W
D
Site 31
T235
E
P
E
S
V
Y
E
T
D
C
R
W
D
G
C
Site 32
S248
G
C
S
Q
E
F
D
S
Q
E
Q
L
V
H
H
Site 33
T296
V
V
H
M
R
R
H
T
G
E
K
P
H
K
C
Site 34
T304
G
E
K
P
H
K
C
T
F
E
G
C
R
K
S
Site 35
S311
T
F
E
G
C
R
K
S
Y
S
R
L
E
N
L
Site 36
Y312
F
E
G
C
R
K
S
Y
S
R
L
E
N
L
K
Site 37
T320
S
R
L
E
N
L
K
T
H
L
R
S
H
T
G
Site 38
S324
N
L
K
T
H
L
R
S
H
T
G
E
K
P
Y
Site 39
T326
K
T
H
L
R
S
H
T
G
E
K
P
Y
M
C
Site 40
Y331
S
H
T
G
E
K
P
Y
M
C
E
H
E
G
C
Site 41
S343
E
G
C
S
K
A
F
S
N
A
S
D
R
A
K
Site 42
S346
S
K
A
F
S
N
A
S
D
R
A
K
H
Q
N
Site 43
Y362
T
H
S
N
E
K
P
Y
V
C
K
L
P
G
C
Site 44
Y373
L
P
G
C
T
K
R
Y
T
D
P
S
S
L
R
Site 45
T374
P
G
C
T
K
R
Y
T
D
P
S
S
L
R
K
Site 46
S377
T
K
R
Y
T
D
P
S
S
L
R
K
H
V
K
Site 47
S378
K
R
Y
T
D
P
S
S
L
R
K
H
V
K
T
Site 48
T385
S
L
R
K
H
V
K
T
V
H
G
P
D
A
H
Site 49
T394
H
G
P
D
A
H
V
T
K
R
H
R
G
D
G
Site 50
S408
G
P
L
P
R
A
P
S
I
S
T
V
E
P
K
Site 51
S410
L
P
R
A
P
S
I
S
T
V
E
P
K
R
E
Site 52
T411
P
R
A
P
S
I
S
T
V
E
P
K
R
E
R
Site 53
S427
G
G
P
I
R
E
E
S
R
L
T
V
P
E
G
Site 54
T430
I
R
E
E
S
R
L
T
V
P
E
G
A
M
K
Site 55
S441
G
A
M
K
P
Q
P
S
P
G
A
Q
S
S
C
Site 56
S446
Q
P
S
P
G
A
Q
S
S
C
S
S
D
H
S
Site 57
S447
P
S
P
G
A
Q
S
S
C
S
S
D
H
S
P
Site 58
S449
P
G
A
Q
S
S
C
S
S
D
H
S
P
A
G
Site 59
S450
G
A
Q
S
S
C
S
S
D
H
S
P
A
G
S
Site 60
S453
S
S
C
S
S
D
H
S
P
A
G
S
A
A
N
Site 61
S457
S
D
H
S
P
A
G
S
A
A
N
T
D
S
G
Site 62
T461
P
A
G
S
A
A
N
T
D
S
G
V
E
M
T
Site 63
S463
G
S
A
A
N
T
D
S
G
V
E
M
T
G
N
Site 64
S474
M
T
G
N
A
G
G
S
T
E
D
L
S
S
L
Site 65
T475
T
G
N
A
G
G
S
T
E
D
L
S
S
L
D
Site 66
S479
G
G
S
T
E
D
L
S
S
L
D
E
G
P
C
Site 67
S480
G
S
T
E
D
L
S
S
L
D
E
G
P
C
I
Site 68
T490
E
G
P
C
I
A
G
T
G
L
S
T
L
R
R
Site 69
S493
C
I
A
G
T
G
L
S
T
L
R
R
L
E
N
Site 70
S521
T
R
G
L
K
L
P
S
L
S
H
T
G
T
T
Site 71
S523
G
L
K
L
P
S
L
S
H
T
G
T
T
V
S
Site 72
T525
K
L
P
S
L
S
H
T
G
T
T
V
S
R
R
Site 73
T527
P
S
L
S
H
T
G
T
T
V
S
R
R
V
G
Site 74
S530
S
H
T
G
T
T
V
S
R
R
V
G
P
P
V
Site 75
S538
R
R
V
G
P
P
V
S
L
E
R
R
S
S
S
Site 76
S543
P
V
S
L
E
R
R
S
S
S
S
S
S
I
S
Site 77
S544
V
S
L
E
R
R
S
S
S
S
S
S
I
S
S
Site 78
S545
S
L
E
R
R
S
S
S
S
S
S
I
S
S
A
Site 79
S546
L
E
R
R
S
S
S
S
S
S
I
S
S
A
Y
Site 80
S547
E
R
R
S
S
S
S
S
S
I
S
S
A
Y
T
Site 81
S548
R
R
S
S
S
S
S
S
I
S
S
A
Y
T
V
Site 82
S550
S
S
S
S
S
S
I
S
S
A
Y
T
V
S
R
Site 83
S551
S
S
S
S
S
I
S
S
A
Y
T
V
S
R
R
Site 84
Y553
S
S
S
I
S
S
A
Y
T
V
S
R
R
S
S
Site 85
T554
S
S
I
S
S
A
Y
T
V
S
R
R
S
S
L
Site 86
S556
I
S
S
A
Y
T
V
S
R
R
S
S
L
A
S
Site 87
S559
A
Y
T
V
S
R
R
S
S
L
A
S
P
F
P
Site 88
S560
Y
T
V
S
R
R
S
S
L
A
S
P
F
P
P
Site 89
S563
S
R
R
S
S
L
A
S
P
F
P
P
G
S
P
Site 90
S569
A
S
P
F
P
P
G
S
P
P
E
N
G
A
S
Site 91
S576
S
P
P
E
N
G
A
S
S
L
P
G
L
M
P
Site 92
S577
P
P
E
N
G
A
S
S
L
P
G
L
M
P
A
Site 93
Y587
G
L
M
P
A
Q
H
Y
L
L
R
A
R
Y
A
Site 94
Y593
H
Y
L
L
R
A
R
Y
A
S
A
R
G
G
G
Site 95
S595
L
L
R
A
R
Y
A
S
A
R
G
G
G
T
S
Site 96
S602
S
A
R
G
G
G
T
S
P
T
A
A
S
S
L
Site 97
T604
R
G
G
G
T
S
P
T
A
A
S
S
L
D
R
Site 98
S608
T
S
P
T
A
A
S
S
L
D
R
I
G
G
L
Site 99
S622
L
P
M
P
P
W
R
S
R
A
E
Y
P
G
Y
Site 100
Y626
P
W
R
S
R
A
E
Y
P
G
Y
N
P
N
A
Site 101
Y629
S
R
A
E
Y
P
G
Y
N
P
N
A
G
V
T
Site 102
S640
A
G
V
T
R
R
A
S
D
P
A
Q
A
A
D
Site 103
S659
A
R
V
Q
R
F
K
S
L
G
C
V
H
T
P
Site 104
T668
G
C
V
H
T
P
P
T
V
A
G
G
G
Q
N
Site 105
Y679
G
G
Q
N
F
D
P
Y
L
P
T
S
V
Y
S
Site 106
T682
N
F
D
P
Y
L
P
T
S
V
Y
S
P
Q
P
Site 107
S683
F
D
P
Y
L
P
T
S
V
Y
S
P
Q
P
P
Site 108
Y685
P
Y
L
P
T
S
V
Y
S
P
Q
P
P
S
I
Site 109
S686
Y
L
P
T
S
V
Y
S
P
Q
P
P
S
I
T
Site 110
S691
V
Y
S
P
Q
P
P
S
I
T
E
N
A
A
M
Site 111
S712
E
E
P
E
V
G
T
S
M
V
G
S
G
L
N
Site 112
Y721
V
G
S
G
L
N
P
Y
M
D
F
P
P
T
D
Site 113
T727
P
Y
M
D
F
P
P
T
D
T
L
G
Y
G
G
Site 114
T729
M
D
F
P
P
T
D
T
L
G
Y
G
G
P
E
Site 115
Y732
P
P
T
D
T
L
G
Y
G
G
P
E
G
A
A
Site 116
Y743
E
G
A
A
A
E
P
Y
G
A
R
G
P
G
S
Site 117
S750
Y
G
A
R
G
P
G
S
L
P
L
G
P
G
P
Site 118
T759
P
L
G
P
G
P
P
T
N
Y
G
P
N
P
C
Site 119
Y761
G
P
G
P
P
T
N
Y
G
P
N
P
C
P
Q
Site 120
Y772
P
C
P
Q
Q
A
S
Y
P
D
P
T
Q
E
T
Site 121
T776
Q
A
S
Y
P
D
P
T
Q
E
T
W
G
E
F
Site 122
S785
E
T
W
G
E
F
P
S
H
S
G
L
Y
P
G
Site 123
S787
W
G
E
F
P
S
H
S
G
L
Y
P
G
P
K
Site 124
Y790
F
P
S
H
S
G
L
Y
P
G
P
K
A
L
G
Site 125
S801
K
A
L
G
G
T
Y
S
Q
C
P
R
L
E
H
Site 126
S824
E
Q
G
C
P
V
G
S
D
S
T
G
L
A
P
Site 127
S838
P
C
L
N
A
H
P
S
E
G
P
P
H
P
Q
Site 128
S849
P
H
P
Q
P
L
F
S
H
Y
P
Q
P
S
P
Site 129
Y851
P
Q
P
L
F
S
H
Y
P
Q
P
S
P
P
Q
Site 130
S855
F
S
H
Y
P
Q
P
S
P
P
Q
Y
L
Q
S
Site 131
Y859
P
Q
P
S
P
P
Q
Y
L
Q
S
G
P
Y
T
Site 132
S862
S
P
P
Q
Y
L
Q
S
G
P
Y
T
Q
P
P
Site 133
Y865
Q
Y
L
Q
S
G
P
Y
T
Q
P
P
P
D
Y
Site 134
T866
Y
L
Q
S
G
P
Y
T
Q
P
P
P
D
Y
L
Site 135
Y872
Y
T
Q
P
P
P
D
Y
L
P
S
E
P
R
P
Site 136
S875
P
P
P
D
Y
L
P
S
E
P
R
P
C
L
D
Site 137
S885
R
P
C
L
D
F
D
S
P
T
H
S
T
G
Q
Site 138
T887
C
L
D
F
D
S
P
T
H
S
T
G
Q
L
K
Site 139
S889
D
F
D
S
P
T
H
S
T
G
Q
L
K
A
Q
Site 140
Y901
K
A
Q
L
V
C
N
Y
V
Q
S
Q
Q
E
L
Site 141
S924
D
A
P
A
Q
E
P
S
Y
Q
S
P
K
F
L
Site 142
Y925
A
P
A
Q
E
P
S
Y
Q
S
P
K
F
L
G
Site 143
S927
A
Q
E
P
S
Y
Q
S
P
K
F
L
G
G
S
Site 144
S934
S
P
K
F
L
G
G
S
Q
V
S
P
S
R
A
Site 145
S937
F
L
G
G
S
Q
V
S
P
S
R
A
K
A
P
Site 146
S939
G
G
S
Q
V
S
P
S
R
A
K
A
P
V
N
Site 147
T947
R
A
K
A
P
V
N
T
Y
G
P
G
F
G
P
Site 148
Y948
A
K
A
P
V
N
T
Y
G
P
G
F
G
P
N
Site 149
S961
P
N
L
P
N
H
K
S
G
S
Y
P
T
P
S
Site 150
S963
L
P
N
H
K
S
G
S
Y
P
T
P
S
P
C
Site 151
Y964
P
N
H
K
S
G
S
Y
P
T
P
S
P
C
H
Site 152
T966
H
K
S
G
S
Y
P
T
P
S
P
C
H
E
N
Site 153
S968
S
G
S
Y
P
T
P
S
P
C
H
E
N
F
V
Site 154
S982
V
V
G
A
N
R
A
S
H
R
A
A
A
P
P
Site 155
T1007
G
P
L
K
V
G
G
T
N
P
S
C
G
H
P
Site 156
S1010
K
V
G
G
T
N
P
S
C
G
H
P
E
V
G
Site 157
Y1026
L
G
G
G
P
A
L
Y
P
P
P
E
G
Q
V
Site 158
S1039
Q
V
C
N
P
L
D
S
L
D
L
D
N
T
Q
Site 159
S1060
L
D
E
P
Q
G
L
S
P
P
P
S
H
D
Q
Site 160
S1064
Q
G
L
S
P
P
P
S
H
D
Q
R
G
S
S
Site 161
S1070
P
S
H
D
Q
R
G
S
S
G
H
T
P
P
P
Site 162
S1071
S
H
D
Q
R
G
S
S
G
H
T
P
P
P
S
Site 163
T1074
Q
R
G
S
S
G
H
T
P
P
P
S
G
P
P
Site 164
S1078
S
G
H
T
P
P
P
S
G
P
P
N
M
A
V
Site 165
S1094
N
M
S
V
L
L
R
S
L
P
G
E
T
E
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation