PhosphoNET

           
Protein Info 
   
Short Name:  PFKM
Full Name:  6-phosphofructokinase, muscle type
Alias:  K6PF; K6PF_HUMAN; PFK-1; PFK-A; PFKX; Phosphofructo-1-kinase isozyme A; Phosphofructokinase 1; Phosphofructokinase, muscle; Phosphofructokinase-M; Phosphohexokinase
Type:  Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - fructose and mannose; Kinase (non-protein); EC 2.7.1.11; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway
Mass (Da):  85183
Number AA:  780
UniProt ID:  P08237
International Prot ID:  IPI00743142
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005945  GO:0016324   Uniprot OncoNet
Molecular Function:  GO:0003872  GO:0005524  GO:0042802 PhosphoSite+ KinaseNET
Biological Process:  GO:0006002  GO:0006096  GO:0046716 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S72IKEATWESVSMMLQL
Site 2T82MMLQLGGTVIGSARC
Site 3S86LGGTVIGSARCKDFR
Site 4Y103EGRLRAAYNLVKRGI
Site 5T123IGGDGSLTGADTFRS
Site 6T127GSLTGADTFRSEWSD
Site 7S137SEWSDLLSDLQKAGK
Site 8S153TDEEATKSSYLNIVG
Site 9T193MEIVDAITTTAQSHQ
Site 10T202TAQSHQRTFVLEVMG
Site 11S248EHLCRRLSETRTRGS
Site 12T250LCRRLSETRTRGSRL
Site 13T252RRLSETRTRGSRLNI
Site 14S255SETRTRGSRLNIIIV
Site 15T291VKRLGYDTRVTVLGH
Site 16T294LGYDTRVTVLGHVQR
Site 17T304GHVQRGGTPSAFDRI
Site 18S306VQRGGTPSAFDRILG
Site 19S377ALKLRGRSFMNNWEV
Site 20S396AHVRPPVSKSGSHTV
Site 21S398VRPPVSKSGSHTVAV
Site 22S400PPVSKSGSHTVAVMN
Site 23Y455IEEAGWSYVGGWTGQ
Site 24T469QGGSKLGTKRTLPKK
Site 25T472SKLGTKRTLPKKSFE
Site 26S477KRTLPKKSFEQISAN
Site 27T486EQISANITKFNIQGL
Site 28S536VSNNVPGSDFSVGAD
Site 29Y576IIETMGGYCGYLATM
Site 30T601YIFEEPFTIRDLQAN
Site 31T618HLVQKMKTTVKRGLV
Site 32Y635NEKCNENYTTDFIFN
Site 33Y644TDFIFNLYSEEGKGI
Site 34S654EGKGIFDSRKNVLGH
Site 35S667GHMQQGGSPTPFDRN
Site 36T669MQQGGSPTPFDRNFA
Site 37S694MSGKIKESYRNGRIF
Site 38Y695SGKIKESYRNGRIFA
Site 39T704NGRIFANTPDSGCVL
Site 40T761KYEIDLDTSDHAHLE
Site 41S762YEIDLDTSDHAHLEH
Site 42S775EHITRKRSGEAAV__
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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