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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SNRNP70
Full Name:
U1 small nuclear ribonucleoprotein 70 kDa
Alias:
RNPU1Z; RPU1; RU17; Small nuclear ribonucleoprotein 70kDa (U1); SnRNP70; SNRP70; U1 small nuclear ribonucleoprotein 70 kDa; U1 snRNP 70 kDa; U1-70K; U1AP1
Type:
RNA binding protein
Mass (Da):
51557
Number AA:
437
UniProt ID:
P08621
International Prot ID:
IPI00290204
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005681
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0000166
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0000398
GO:0043484
Phosida
TranscriptoNet
STRING
Kinexus Products
U1 small nuclear ribonucleoprotein 70 kDa Y126 phosphosite-specific antibody AB-PN537#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN537#U1 small nuclear ribonucleoprotein 70 kDa (F123-I129, human) pY126 phosphopeptide - Powder PE-04AFF99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AFF99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y21
A
P
R
D
P
I
P
Y
L
P
P
L
E
K
L
Site 2
Y38
E
K
H
H
N
Q
P
Y
C
G
I
A
P
Y
I
Site 3
Y44
P
Y
C
G
I
A
P
Y
I
R
E
F
E
D
P
Site 4
T62
P
P
P
T
R
A
E
T
R
E
E
R
M
E
R
Site 5
T84
R
R
Q
Q
E
V
E
T
E
L
K
M
W
D
P
Site 6
Y112
L
F
V
A
R
V
N
Y
D
T
T
E
S
K
L
Site 7
T114
V
A
R
V
N
Y
D
T
T
E
S
K
L
R
R
Site 8
T115
A
R
V
N
Y
D
T
T
E
S
K
L
R
R
E
Site 9
S117
V
N
Y
D
T
T
E
S
K
L
R
R
E
F
E
Site 10
Y126
L
R
R
E
F
E
V
Y
G
P
I
K
R
I
H
U1 small nuclear ribonucleoprotein 70 kDa Y126 phosphosite-specific antibody AB-PN537#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN537#U1 small nuclear ribonucleoprotein 70 kDa (F123-I129, human) pY126 phosphopeptide - Powder PE-04AFF99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AFF99
Site 11
Y136
I
K
R
I
H
M
V
Y
S
K
R
S
G
K
P
Site 12
S137
K
R
I
H
M
V
Y
S
K
R
S
G
K
P
R
Site 13
S140
H
M
V
Y
S
K
R
S
G
K
P
R
G
Y
A
Site 14
Y146
R
S
G
K
P
R
G
Y
A
F
I
E
Y
E
H
Site 15
Y151
R
G
Y
A
F
I
E
Y
E
H
E
R
D
M
H
Site 16
Y161
E
R
D
M
H
S
A
Y
K
H
A
D
G
K
K
Site 17
T183
V
D
V
E
R
G
R
T
V
K
G
W
R
P
R
Site 18
T199
L
G
G
G
L
G
G
T
R
R
G
G
A
D
V
Site 19
S211
A
D
V
N
I
R
H
S
G
R
D
D
T
S
R
Site 20
T216
R
H
S
G
R
D
D
T
S
R
Y
D
E
R
P
Site 21
S217
H
S
G
R
D
D
T
S
R
Y
D
E
R
P
G
Site 22
Y219
G
R
D
D
T
S
R
Y
D
E
R
P
G
P
S
Site 23
S226
Y
D
E
R
P
G
P
S
P
L
P
H
R
D
R
Site 24
S245
E
R
E
R
R
E
R
S
R
E
R
D
K
E
R
Site 25
S257
K
E
R
E
R
R
R
S
R
S
R
D
R
R
R
Site 26
S259
R
E
R
R
R
S
R
S
R
D
R
R
R
R
S
Site 27
S266
S
R
D
R
R
R
R
S
R
S
R
D
K
E
E
Site 28
S268
D
R
R
R
R
S
R
S
R
D
K
E
E
R
R
Site 29
S277
D
K
E
E
R
R
R
S
R
E
R
S
K
D
K
Site 30
S281
R
R
R
S
R
E
R
S
K
D
K
D
R
D
R
Site 31
S292
D
R
D
R
K
R
R
S
S
R
S
R
E
R
A
Site 32
S293
R
D
R
K
R
R
S
S
R
S
R
E
R
A
R
Site 33
S295
R
K
R
R
S
S
R
S
R
E
R
A
R
R
E
Site 34
S320
G
G
D
M
A
E
P
S
E
A
G
D
A
P
P
Site 35
S357
R
D
R
E
R
R
R
S
H
R
S
E
R
E
R
Site 36
S360
E
R
R
R
S
H
R
S
E
R
E
R
R
R
D
Site 37
S385
H
K
R
G
E
R
G
S
E
R
G
R
D
E
A
Site 38
S410
L
E
G
L
G
N
D
S
R
D
M
Y
M
E
S
Site 39
Y414
G
N
D
S
R
D
M
Y
M
E
S
E
G
G
D
Site 40
S417
S
R
D
M
Y
M
E
S
E
G
G
D
G
Y
L
Site 41
Y423
E
S
E
G
G
D
G
Y
L
A
P
E
N
G
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation