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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADRA2A
Full Name:
Alpha-2A adrenergic receptor
Alias:
A2AA; ADA2A; ADRA2; ADRA2R; ADRAR; Adrenergic receptor, alpha-2A; Adrenergic, alpha-2A-, receptor; Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; Alpha-2A-adrenergic receptor; Alpha-2AAR subtype C10
Type:
G protein-coupled 7TM receptor
Mass (Da):
48957
Number AA:
450
UniProt ID:
P08913
International Prot ID:
IPI00031712
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0004938
GO:0015459
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0007266
GO:0030036
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
Q
P
D
A
G
N
A
S
W
N
G
T
E
A
P
Site 2
T16
G
N
A
S
W
N
G
T
E
A
P
G
G
G
A
Site 3
T26
P
G
G
G
A
R
A
T
P
Y
S
L
Q
V
T
Site 4
Y28
G
G
A
R
A
T
P
Y
S
L
Q
V
T
L
T
Site 5
Y132
C
A
I
S
L
D
R
Y
W
S
I
T
Q
A
I
Site 6
S134
I
S
L
D
R
Y
W
S
I
T
Q
A
I
E
Y
Site 7
T136
L
D
R
Y
W
S
I
T
Q
A
I
E
Y
N
L
Site 8
Y141
S
I
T
Q
A
I
E
Y
N
L
K
R
T
P
R
Site 9
T146
I
E
Y
N
L
K
R
T
P
R
R
I
K
A
I
Site 10
S171
I
S
F
P
P
L
I
S
I
E
K
K
G
G
G
Site 11
Y196
E
I
N
D
Q
K
W
Y
V
I
S
S
C
I
G
Site 12
T227
Y
Q
I
A
K
R
R
T
R
V
P
P
S
R
R
Site 13
S232
R
R
T
R
V
P
P
S
R
R
G
P
D
A
V
Site 14
S258
N
G
L
G
P
E
R
S
A
G
P
G
G
A
E
Site 15
T271
A
E
A
E
P
L
P
T
Q
L
N
G
A
P
G
Site 16
T288
A
P
A
G
P
R
D
T
D
A
L
D
L
E
E
Site 17
S296
D
A
L
D
L
E
E
S
S
S
S
D
H
A
E
Site 18
S297
A
L
D
L
E
E
S
S
S
S
D
H
A
E
R
Site 19
S298
L
D
L
E
E
S
S
S
S
D
H
A
E
R
P
Site 20
S299
D
L
E
E
S
S
S
S
D
H
A
E
R
P
P
Site 21
S324
G
K
G
K
A
R
A
S
Q
V
K
P
G
D
S
Site 22
S331
S
Q
V
K
P
G
D
S
L
P
R
R
G
P
G
Site 23
T340
P
R
R
G
P
G
A
T
G
I
G
T
P
A
A
Site 24
T344
P
G
A
T
G
I
G
T
P
A
A
G
P
G
E
Site 25
S360
R
V
G
A
A
K
A
S
R
W
R
G
R
Q
N
Site 26
T373
Q
N
R
E
K
R
F
T
F
V
L
A
V
V
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation