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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TPM1
Full Name:
Tropomyosin alpha-1 chain
Alias:
alpha-tropomyosin; TMSA; Tropomyosin-1
Type:
Contractile protein
Mass (Da):
32709
Number AA:
284
UniProt ID:
P09493
International Prot ID:
IPI00014581
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0032059
GO:0005862
GO:0032587
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005200
GO:0008307
PhosphoSite+
KinaseNET
Biological Process:
GO:0060048
GO:0006928
GO:0034614
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S36
K
K
A
A
E
D
R
S
K
Q
L
E
D
E
L
Site 2
S45
Q
L
E
D
E
L
V
S
L
Q
K
K
L
K
G
Site 3
Y60
T
E
D
E
L
D
K
Y
S
E
A
L
K
D
A
Site 4
S61
E
D
E
L
D
K
Y
S
E
A
L
K
D
A
Q
Site 5
S87
D
A
E
A
D
V
A
S
L
N
R
R
I
Q
L
Site 6
T108
R
A
Q
E
R
L
A
T
A
L
Q
K
L
E
E
Site 7
S123
A
E
K
A
A
D
E
S
E
R
G
M
K
V
I
Site 8
Y162
A
E
D
A
D
R
K
Y
E
E
V
A
R
K
L
Site 9
S174
R
K
L
V
I
I
E
S
D
L
E
R
A
E
E
Site 10
S186
A
E
E
R
A
E
L
S
E
G
K
C
A
E
L
Site 11
T199
E
L
E
E
E
L
K
T
V
T
N
N
L
K
S
Site 12
T201
E
E
E
L
K
T
V
T
N
N
L
K
S
L
E
Site 13
S206
T
V
T
N
N
L
K
S
L
E
A
Q
A
E
K
Site 14
Y214
L
E
A
Q
A
E
K
Y
S
Q
K
E
D
R
Y
Site 15
S215
E
A
Q
A
E
K
Y
S
Q
K
E
D
R
Y
E
Site 16
Y221
Y
S
Q
K
E
D
R
Y
E
E
E
I
K
V
L
Site 17
S229
E
E
E
I
K
V
L
S
D
K
L
K
E
A
E
Site 18
S245
R
A
E
F
A
E
R
S
V
T
K
L
E
K
S
Site 19
T247
E
F
A
E
R
S
V
T
K
L
E
K
S
I
D
Site 20
S252
S
V
T
K
L
E
K
S
I
D
D
L
E
D
E
Site 21
Y261
D
D
L
E
D
E
L
Y
A
Q
K
L
K
Y
K
Site 22
Y267
L
Y
A
Q
K
L
K
Y
K
A
I
S
E
E
L
Site 23
S271
K
L
K
Y
K
A
I
S
E
E
L
D
H
A
L
Site 24
T282
D
H
A
L
N
D
M
T
S
I
_
_
_
_
_
Site 25
S283
H
A
L
N
D
M
T
S
I
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation